The beneficial Effects of Eriobotrya Japonica Lindl. Leaves Extract on Body Weight, Glycemic Control, and Lipid Profile.

Background: Eriobotrya japonica Lindl, also known as loquat, is a subtropical fruit tree widely used in traditional Chinese medicine for thousands of years to treat many diseases such as asthma and chronic cough. Traditional healers also use it for weight reduction. In our present study, we validated the impact of E. japonica leaf extract on body weight, glycemic control, and lipid profile.

Methods: The anti-obesity, anti-diabetic, and antihyperlipidemic effects of E. japonica leaf extract were screened in high-fat diet-fed rats. After treatment with different E. japonica leaf extract concentrations, body weight, blood glucose levels, HBA1c, and lipid profile were determined.

Results: The high-fat diet group treated with Loquat leaf extract >= 200 mg/ml/kg showed significant weight loss and a beneficial lipid marker profile. However, the glycemic markers were not significantly different.

Conclusion: The findings demonstrate that E. japonica leaf extract at doses of ≥200 mg/kg significantly reduces body weight and improves lipid markers in HFD-fed rats. However, glycemic markers such as blood glucose and HbA1c were not significantly affected. These results highlight the potential of E. japonica as a natural weight loss and lipid control aid, warranting further investigation into its mechanisms and clinical applicability.