Croatian Medical Journal最新文献_第9页

Benign fasciculation syndrome and migraine aura without headache as possible adverse events after BNT162b2 mRNA vaccination: a web-based survey. BNT162b2 mRNA 疫苗接种后可能出现的不良反应：一项网络调查。

IF 1.9 4区医学

Croatian Medical Journal Pub Date : 2023-12-31

Grgur Salai, Đivo Ljubičić, Ruđer Novak, Lovorka Grgurević

{"title":"Benign fasciculation syndrome and migraine aura without headache as possible adverse events after BNT162b2 mRNA vaccination: a web-based survey.","authors":"Grgur Salai, Đivo Ljubičić, Ruđer Novak, Lovorka Grgurević","doi":"","DOIUrl":"","url":null,"abstract":"Aim: To determine the characteristics of patients who experienced muscle fasciculations and migraine auras without headache after BNT162b2 immunization.Methods: In January 2022, we published a case report that described a 48-year-old female patient who experienced muscle twitching and migraine auras without headache following BNT162b2 immunization. A self-administered online survey was sent to people who had written to us and complained of similar symptoms described in the case report (N=20).Results: The survey was completed by 11 participants, of whom 10 reported muscle twitching following BNT162b2 immunization lasting a median of 14 (4-36.5) days. Five of these participants (50%) reported migraine auras without headache. Participants further reported on self-identified triggers that altered the intensity of their symptoms, such as anxiety or caffeine. Fifty percent of participants who got an acute SARS-CoV-2 infection (3/6) experienced increased muscle symptom intensity during the acute phase of the disease.Conclusion: To the best of our knowledge, our survey is the first to summarize patients' experiences of these phenomena occurring after BNT162b2 immunization. It is important to note that no causal relationship between vaccination and these phenomena can be inferred.","PeriodicalId":10796,"journal":{"name":"Croatian Medical Journal","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10797237/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139086227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cognitive functioning is prognostic in patients with IDH1-wild type and MGMT-unmethylated high-grade gliomas. 认知功能对IDH1-野生型和MGMT-未甲基化高级别胶质瘤患者的预后有影响。

IF 1.9 4区医学

Croatian Medical Journal Pub Date : 2023-12-31

Uroš Smrdel, Andreja Cirila Škufca Smrdel, Anja Podlesek, Marija Skoblar Vidmar, Gregor Kos, Jana Markovic, Jana Jereb, Jana Knific, Tina Rus

{"title":"Cognitive functioning is prognostic in patients with IDH1-wild type and MGMT-unmethylated high-grade gliomas.","authors":"Uroš Smrdel, Andreja Cirila Škufca Smrdel, Anja Podlesek, Marija Skoblar Vidmar, Gregor Kos, Jana Markovic, Jana Jereb, Jana Knific, Tina Rus","doi":"","DOIUrl":"","url":null,"abstract":"Aim: To investigate the prognostic factors of survival in patients with high-grade gliomas without isocitrate dehydrogenase-1 (IDH) mutation and O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation.Methods: The study enrolled Slovenian patients with high-grade gliomas. Postoperatively, they completed a battery of neuropsychological tests. Demographics and clinical data were collected. The results of cognitive tests were converted to standardized scores and dichotomized based on impairment. A univariate Cox proportional hazard regression model was used to determine clinical predictors, and a multivariate Cox model was used to determine the prognostic value of cognitive test results. Kaplan-Meier curves were constructed, and survival was compared with the log rank test.Results: The study enrolled 49 patients with IDH wild-type, MGMT-unmethylated high-grade gliomas. The median time to progression was 9.92 months (7.25, 12.59) and the overall median survival was 12.19 months (8.95, 15.4). Age and the extent of surgery were significant prognostic factors for survival. After controlling for these factors, cognitive functioning in the domain of verbal fluency remained a significant predictor of survival outcomes.Conclusion: Cognitive functioning in the domain of verbal fluency was associated with overall survival independently of age and the extent of surgery. Cognitive functioning could be an important stratifying tool in this group of patients lacking other predictors.","PeriodicalId":10796,"journal":{"name":"Croatian Medical Journal","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10797236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139086229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Informal care: the indispensable pillar of care for complex patients. 非正式护理：复杂病人护理不可或缺的支柱。

IF 1.9 4区医学

Croatian Medical Journal Pub Date : 2023-12-31

Aleksandar Džakula, Maja Banadinović, Karmen Lončarek, Dorja Vočanec

引用次数: 0

Cultivating Andrija Štampar's legacy: from international health and positive health to person-centered care. 培养 Andrija Štampar 的遗产：从国际健康和积极健康到以人为本的护理。

IF 1.9 4区医学

Croatian Medical Journal Pub Date : 2023-12-31

Juan E Mezzich, Marijana Braš, Veljko Đorđević, Slavko Orešković, Neda Pjevač, Snježana Kaštelan

引用次数: 0

Bilateral facial nerve palsy as a presentation of coexisting neuroborreliosis and post-acute COVID-19 syndrome. 双侧面神经麻痹是神经源性疾病和急性 COVID-19 后综合征并存的一种表现。

IF 1.9 4区医学

Croatian Medical Journal Pub Date : 2023-12-31

Katarina Blažina, Ivan Martinez, Manuela Foro Znika

{"title":"Bilateral facial nerve palsy as a presentation of coexisting neuroborreliosis and post-acute COVID-19 syndrome.","authors":"Katarina Blažina, Ivan Martinez, Manuela Foro Znika","doi":"","DOIUrl":"","url":null,"abstract":"Bilateral simultaneous facial nerve palsy is an extremely rare condition that may be induced by infection (bacterial, viral, or fungal) or noninfective causes (autoimmune, traumatic, or structural). The treatment depends on the underlying disorder, and, if it is introduced on time, the disease is in most cases completely reversible. We report on a patient with bilateral simultaneous facial nerve palsy without an obvious cause. The possible causes were SARS-CoV-2 infection and postvaccination syndrome. After we excluded the SARS-CoV-2 infection, a wide range of diagnostic tests were conducted. Magnetic resonance imaging after gadolinium intravenous application showed bilateral facial nerve enhancement. Serological tests revealed Borrelia burgdorferi, and the result was confirmed by an enzyme-linked immunosorbent assay (IgM positivity). After 14 days of antibiotic therapy, the symptoms resolved completely without sequelae. This report shows that the symptoms of bilateral simultaneous facial nerve palsy may completely resolve if thorough clinical investigation and an appropriate early treatment are applied.","PeriodicalId":10796,"journal":{"name":"Croatian Medical Journal","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10797239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139086228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Benign and malignant prostate neoplasms show different spatial organization of collagen. 良性和恶性前列腺肿瘤显示出不同的胶原蛋白空间组织。

IF 1.9 4区医学

Croatian Medical Journal Pub Date : 2023-12-31

Taras Zadvornyi, Nataliia Lukianova, Oleksandr Mushii, Anna Pavlova, Olena Voronina, Vasyl Chekhun

{"title":"Benign and malignant prostate neoplasms show different spatial organization of collagen.","authors":"Taras Zadvornyi, Nataliia Lukianova, Oleksandr Mushii, Anna Pavlova, Olena Voronina, Vasyl Chekhun","doi":"","DOIUrl":"","url":null,"abstract":"Aim: To compare the indicators of the spatial organization of collagen and its regulating factors between benign and malignant prostate neoplasms.Methods: The study involved tumor tissue samples from 40 patients with stage II-III prostate cancer (PCa) and 20 patients with benign prostatic hyperplasia (BPH). The localization of collagen was determined with a Masson trichrome stain. To establish quantitative indicators of the spatial organization of collagen, morphometric studies were carried out with the CurveAlign and ImageJ programs.Results: PCa tissue had two times lower collagen density (P<0.0001) and 1.3 times lower levels of collagen alignment (P=0.018) compared with BPH tissue. In PCa tissue, collagen fibers were shorter (by 24.2%; P<0.001) and thicker (by 15.5%; P<0.001). PCa tissue samples showed significantly higher levels of metalloproteinase (MMP)-2 (by 2.4 times; P=0.001), MMP-8 (by 2.3 times; P=0.007), and MMP-13 (by 1.9 times; P=0.004).Conclusions: Collagen matrix spatial organization features, as well as its regulatory factors, could be potential biomarkers of malignant prostate neoplasms.","PeriodicalId":10796,"journal":{"name":"Croatian Medical Journal","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10797232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139086226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Forty years of successful assisted reproductive technologies in Croatia. 克罗地亚辅助生殖技术成功四十年。

IF 1.9 4区医学

Croatian Medical Journal Pub Date : 2023-12-31

Velimir Šimunić

引用次数: 0

Successful treatment of late obstetric ethylene glycol intoxication with ethanol via the enteral route: a case report. 通过肠道途径用乙醇成功治疗晚期产科乙二醇中毒：病例报告。

IF 1.9 4区医学

Croatian Medical Journal Pub Date : 2023-12-31

Dinka Lulić, Ivan Gornik, Jadranka Pavičić Šarić, Mirjana Mirić, Anita Lukić, Ileana Lulić

{"title":"Successful treatment of late obstetric ethylene glycol intoxication with ethanol via the enteral route: a case report.","authors":"Dinka Lulić, Ivan Gornik, Jadranka Pavičić Šarić, Mirjana Mirić, Anita Lukić, Ileana Lulić","doi":"","DOIUrl":"","url":null,"abstract":"Late obstetric ethylene glycol intoxication represents a diagnostic challenge for acute care physicians and an impending life threat with life-long implications for both the mother and the fetus. The metabolism of ethylene glycol to its toxic metabolites during late pregnancy is unpredictable due to maternal physiological changes. Namely, the hallmark signs and symptoms of ethylene glycol intoxication can mimic those of late pregnancy-related high blood pressure disorders, which makes it difficult to correctly diagnose the condition. Therefore, it is crucial to promptly recognize late obstetric ethylene glycol intoxication and initiate specific treatment, but evidence-based recommendations are not available to guide its most effective emergent treatment. We present our department's emergent management of late-obstetric ethylene glycol intoxication. The parturient was stabilized by inhibiting ethylene glycol metabolism, alongside general supportive care measures. The enhancement of its toxic metabolites was eliminated by administering ethanol via the enteral route, which progressively improved the parturient's clinical course and led to the on-term delivery of a healthy child. Our case shows the importance of a meticulous emergent assessment, prompt diagnosis, and carefully planned multidisciplinary treatment in the emergency department in improving outcomes after ethylene glycol intoxication in late pregnancy.","PeriodicalId":10796,"journal":{"name":"Croatian Medical Journal","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10797234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139086235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formation and elimination of soluble fibrin and D-dimer in the bloodstream. 血液中可溶性纤维蛋白和 D-二聚体的形成和清除。

IF 1.9 4区医学

Croatian Medical Journal Pub Date : 2023-12-31

Anastasiia Udovenko, Yevgen Makogonenko, Daria Korolova, Nadiya Druzhyna, Volodymyr Chernyshenko, Serhiy Komisarenko

{"title":"Formation and elimination of soluble fibrin and D-dimer in the bloodstream.","authors":"Anastasiia Udovenko, Yevgen Makogonenko, Daria Korolova, Nadiya Druzhyna, Volodymyr Chernyshenko, Serhiy Komisarenko","doi":"","DOIUrl":"","url":null,"abstract":"Soluble fibrin is composed mainly of desA fibrin and fibrinogen oligomers consisting of fewer than 16 monomers partially cross-linked by factor XIIIa. Soluble fibrin cannot stimulate Glu-plasminogen activation by tissue plasminogen activator (t-PA); therefore, it may not be a direct predecessor of D-dimer. However, within the microcirculatory system, soluble fibrin oligomers may form microclots. Fibrin microclots stimulate Glu-plasminogen activation by t-PA, a process resulting in the formation of Glu-plasmin. Glu-plasmin dissolves the microclots, forming D-dimer. In normal and pathological blood plasma samples, soluble fibrin levels are substantially higher than those of D-dimer. Their concentrations in the plasma are also regulated by transendothelial transfer, absorption by blood macrophages, and binding and internalization with low-density lipoprotein receptors of the cells of the reticuloendothelial system. Therefore, the exact mechanisms of fibrin clots formation and elimination in normal and pathological conditions remain unclear. In this study, we reviewed findings on the molecular mechanisms of the formation and dissolution of fibrin clots, fibrin-dependent activation of Glu-plasminogen by t-PA, and blood plasma behavior in the microcirculatory system. Finally, we proposed a model that explains the relations of D-dimer and soluble fibrin underlying the common and separate mechanisms of their formation and elimination.","PeriodicalId":10796,"journal":{"name":"Croatian Medical Journal","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10797241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139086232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of the oxygen reserve index in detecting and preventing hyperoxia in critically ill patients on mechanical ventilation: a randomized controlled trial. 氧储备指数在检测和预防机械通气重症患者高氧症方面的效果：随机对照试验。

IF 1.9 4区医学

Croatian Medical Journal Pub Date : 2023-12-31

Aykut Sarıtaş, Pelin Uzun Sarıtaş, Uğur Uzun

{"title":"Effectiveness of the oxygen reserve index in detecting and preventing hyperoxia in critically ill patients on mechanical ventilation: a randomized controlled trial.","authors":"Aykut Sarıtaş, Pelin Uzun Sarıtaş, Uğur Uzun","doi":"","DOIUrl":"","url":null,"abstract":"Aim: To assess the effectiveness of fraction of inspired oxygen (FiO2) titration guided by oxygen reserve index (ORi) in preventing hyperoxia in intensive care unit (ICU) patients receiving mechanical ventilator support.Methods: Patients aged 18 years and older who were admitted to a tertiary ICU and required mechanical ventilator support were randomly divided into two groups: the control group (n=30) and the oxygen saturation (SpO2) +ORi group (n=30). In the SpO2+ORi group, the goal was to maintain SpO2 between 95% and 98% and ORi at 0.00. In both groups, SpO2, ORi, partial pressure of oxygen (PaO2), partial pressure of carbon dioxide, positive end-expiratory pressure, FiO2, and hemodynamic parameters were recorded every six hours for two consecutive days.Results: A very strong positive linear correlation was found between PaO2 and ORi (r=0.937; P<0.001). In the ORi+SpO2 group, PaO2 values were significantly lower and decreased with FiO2 titration over time. Severe hyperoxia was observed in 24.8% of the control group and in only 3.3% of the ORi+SpO2 group. When PaO2>120 mm Hg, FiO2>0.40 was found in 83.5% of the control group, and in 40% of the ORi+SpO2 group.Conclusion: FiO2 titration guided by ORi+SpO2 effectively prevents hyperoxia and reduces the exposure time to hyperoxia in critically ill patients.","PeriodicalId":10796,"journal":{"name":"Croatian Medical Journal","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10797238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139086231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0