Croatian Medical Journal最新文献

Healthcare professionals' views on training, standards, and resources for extracorporeal membrane oxygenation: a letter to the editor. 医疗保健专业人员对体外膜氧合的培训、标准和资源的看法：致编辑的一封信。

IF 2.3 4区医学

Croatian Medical Journal Pub Date : 2026-04-30

Huseyin Durmaz, Semiha Durmaz

引用次数: 0

The CMJ stays in the editor's heart. CMJ留在编辑的心里。

IF 2.3 4区医学

Croatian Medical Journal Pub Date : 2026-04-30

Svjetlana Kalanj Bognar

引用次数: 0

Trends in polysubstance use in the Croatian general population: evidence from 2011-2023 national surveys. 克罗地亚普通人群中多物质使用趋势：2011-2023年全国调查的证据。

IF 2.3 4区医学

Croatian Medical Journal Pub Date : 2026-04-30

Bruno Škovrlj, Renata Glavak Tkalić

{"title":"Trends in polysubstance use in the Croatian general population: evidence from 2011-2023 national surveys.","authors":"Bruno Škovrlj, Renata Glavak Tkalić","doi":"","DOIUrl":"","url":null,"abstract":"Aim: To examine the extent of polysubstance use in the general population of Croatia, determine trends in polysubstance use between 2011 and 2023, and identify distinct subgroups based on the patterns of polysubstance use and compare these subgroups across survey years.Methods: Four studies were conducted between 2011 and 2023 on nationally representative samples of Croatian residents aged 15 to 64, with a total of 19 730 respondents, through face-to-face surveys in private households. Last-year substance use (tobacco, alcohol, cannabis, ecstasy, amphetamines, cocaine, and LSD) was assessed using the Croatian translation of the European Model Questionnaire.Results: Across all four survey years, alcohol (71.8%-83.3%), tobacco (39.4%-43.7%), and cannabis (5.1%-10.2%) were the most commonly used substances in the Croatian general population. Last-year abstinence showed a declining trend between 2011 and 2023, single-substance use remained stable, and polysubstance use increased over this period. Latent class analysis identified three distinct subgroups: alcohol-only use, alcohol and tobacco use, and polysubstance use. Alcohol and tobacco use and polysubstance use classes increased in size from 2011 to 2023, with the polysubstance use class increasing from 0.9% in 2011 to 2.8% in 2023, alongside higher probabilities of cocaine and ecstasy use over time.Conclusion: Polysubstance use is a growing public health concern in Croatia. The trends of co-use of alcohol and tobacco and stimulants use with polysubstance use patterns were rising. These trends emphasize the need for further research and the development of targeted prevention and intervention efforts, accounting for distinct effects of polysubstance use and cultural specificities of Croatian society.","PeriodicalId":10796,"journal":{"name":"Croatian Medical Journal","volume":"67 2","pages":"95-102"},"PeriodicalIF":2.3,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in extracorporeal membrane oxygenation: investing in training of multidisciplinary teams and developing health care infrastructure. 体外膜氧合的进展：投资培训多学科团队和发展保健基础设施。

IF 2.3 4区医学

Croatian Medical Journal Pub Date : 2026-04-30

Bekzhan A Permenov, Burhan Fatih Kocyigit

引用次数: 0

Can artificial intelligence create human touch in medical writing? A pilot study. 人工智能能在医学写作中创造人情味吗？一项初步研究。

IF 2.3 4区医学

Croatian Medical Journal Pub Date : 2026-04-30

Shigeki Matsubara

引用次数: 0

The effect of tumor necrosis factor-alpha on rheumatoid arthritis-related pain: overview of evidence and mechanistic pathways. 肿瘤坏死因子- α对类风湿关节炎相关疼痛的影响：证据和机制途径综述。

IF 2.3 4区医学

Croatian Medical Journal Pub Date : 2026-04-30

Andrej Belančić, Seher Sener, Marija Rogoznica Pavlović, Mirjana Stanić Benić, Yusuf Ziya Sener, Almir Fajkić, Marijana Vučković, Josipa Radić, Mislav Radić

{"title":"The effect of tumor necrosis factor-alpha on rheumatoid arthritis-related pain: overview of evidence and mechanistic pathways.","authors":"Andrej Belančić, Seher Sener, Marija Rogoznica Pavlović, Mirjana Stanić Benić, Yusuf Ziya Sener, Almir Fajkić, Marijana Vučković, Josipa Radić, Mislav Radić","doi":"","DOIUrl":"","url":null,"abstract":"Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by debilitating pain and progressive joint destruction. Tumor necrosis factor-alpha (TNF-α), a key pro-inflammatory cytokine, has been implicated in modulating both peripheral and central pain pathways. TNF-α inhibitors, initially developed to halt structural damage in RA, have demonstrated substantial efficacy in pain relief, independent of their anti-inflammatory properties. This narrative review explores the mechanistic pathways through which TNF-α contributes to pain sensitization and highlights the role of TNF-α inhibitors in disrupting these pathways. Evidence suggests that these biologics not only reduce synovial inflammation but also modulate neuroinflammatory circuits, altering pain perception at the spinal and supraspinal levels. Despite their clinical success, variability in patient response and concerns regarding long-term safety necessitate further research into personalized therapeutic strategies. Identifying biomarkers predictive of pain relief could enhance treatment precision. Ultimately, the integration of TNF-α inhibitors into multidisciplinary pain management approaches holds promise for improving clinical outcomes and quality of life in RA.","PeriodicalId":10796,"journal":{"name":"Croatian Medical Journal","volume":"67 2","pages":"112-131"},"PeriodicalIF":2.3,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physicians' awareness of non-pharmacological therapies for insomnia in the Czech Republic. 捷克共和国医生对非药物治疗失眠的认识。

IF 2.3 4区医学

Croatian Medical Journal Pub Date : 2026-04-30

Laura Hrehova Hantak, Norbert Král, Bohumil Seifert, Peter Kalanin

{"title":"Physicians' awareness of non-pharmacological therapies for insomnia in the Czech Republic.","authors":"Laura Hrehova Hantak, Norbert Král, Bohumil Seifert, Peter Kalanin","doi":"","DOIUrl":"","url":null,"abstract":"Aim: To assess general practitioners' (GP) awareness, attitudes, and practices related to non-pharmacological treatments for insomnia.Methods: A cross-sectional online survey was conducted between January and June 2024 among 100 general practitioners across urban and rural regions of the Czech Republic. The questionnaire assessed GPs' awareness, attitudes, and practices related to non-pharmacological treatments for insomnia.Results: Most GPs (85%) reported using non-pharmacological approaches as the initial treatment, primarily sleep hygiene education (64%). Only 28% were familiar with Cognitive Behavioral Therapy for Insomnia, and fewer used structured diagnostic tools such as sleep diaries or validated scales. Hypnotics overuse was reported by 81% of respondents. Urban GPs were more likely to refer patients to sleep specialists and showed greater confidence in non-drug management. Patient interest in non-pharmacological therapies was moderate (31%), and adherence was influenced by the quality of the doctor-patient relationship.Conclusion: While Czech GPs are aware of non-pharmacological treatment options for insomnia, actual implementation - especially of CBT-I and diagnostic tools - is limited. Targeted training and better access to behavioral treatment resources could improve insomnia management in primary care and reduce reliance on pharmacological interventions.","PeriodicalId":10796,"journal":{"name":"Croatian Medical Journal","volume":"67 2","pages":"103-111"},"PeriodicalIF":2.3,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antidepressant prescribing pattern in Croatia: a retrospective, longitudinal study from 2017 to 2022. 克罗地亚抗抑郁药处方模式：2017年至2022年的回顾性纵向研究

IF 2.3 4区医学

Croatian Medical Journal Pub Date : 2026-04-30

Katarina Gvozdanović, Roberto Mužić, Helena Orehovački, Danijela Štimac Grbić

{"title":"Antidepressant prescribing pattern in Croatia: a retrospective, longitudinal study from 2017 to 2022.","authors":"Katarina Gvozdanović, Roberto Mužić, Helena Orehovački, Danijela Štimac Grbić","doi":"","DOIUrl":"","url":null,"abstract":"Aim: To assess antidepressant prescribing patterns in Croatia.Methods: This retrospective study assessed electronic prescription patterns for antidepressants (Anatomical Therapeutic Chemical code N06A) in Croatia from 2017 to 2022. We collected data on annual prescription counts, drug types, drug utilization, utilization trends, indications, and patient demographics.Results: Over six years, 8.66 million antidepressant prescriptions were issued to 415 328 patients in Croatian primary care. Utilization increased by 22.32% (from 22.4 to 27.4 defined daily doses per 1000 inhabitants per day) but remained below the European average. Selective serotonin reuptake inhibitors accounted for nearly 60% of prescriptions. Women and older adults (≥65 years) were the primary users.Conclusion: Despite rising antidepressant use, Croatia lags behind other European countries, possibly due to high benzodiazepine use. The prescribing pattern highlights the need for targeted, evidence-based mental health policies. Special attention should be given to pediatric patients, the elderly, and patients affected by war-related trauma, while also exploring socioeconomic influences on prescribing practices.","PeriodicalId":10796,"journal":{"name":"Croatian Medical Journal","volume":"67 2","pages":"55-65"},"PeriodicalIF":2.3,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Repressive regulatory function of seryl-tRNA synthetase on VEGFA gene expression is impaired in renal cell carcinoma. seryl-tRNA合成酶对VEGFA基因表达的抑制调控功能在肾细胞癌中受损。

IF 2.3 4区医学

Croatian Medical Journal Pub Date : 2026-04-30

Maja Barači, Petar Ozretić, Marijana Knezovic, Nika Foglar, Željko Kaštelan, Neda Slade, Jasmina Rokov-Plavec, Tvrtko Hudolin

{"title":"Repressive regulatory function of seryl-tRNA synthetase on VEGFA gene expression is impaired in renal cell carcinoma.","authors":"Maja Barači, Petar Ozretić, Marijana Knezovic, Nika Foglar, Željko Kaštelan, Neda Slade, Jasmina Rokov-Plavec, Tvrtko Hudolin","doi":"","DOIUrl":"","url":null,"abstract":"Aim: To assess the relationship of the mRNA and protein expression levels of seryl-tRNA synthetase (SerRS) and the expression of gene encoding vascular endothelial growth factor A (VEGFA) in patients with renal cell carcinoma (RCC).Methods: Expression levels of VEGFA and SerRS mRNA were quantified by quantitative real-time polymerase chain reaction in 31 paired RCC tumor and adjacent healthy kidney tissues, while SerRS protein levels were assessed by Western blot analysis in 19 paired samples. The association of SerRS and VEGFA with clinicopathological parameters was evaluated. In addition, bioinformatics analyses were performed using publicly available transcriptomic and proteomic data sets.Results: VEGFA expression was significantly higher in tumor tissues than in adjacent healthy tissues, while SerRS mRNA levels were similar in both. However, SerRS protein was significantly elevated in tumor tissues. Despite elevated levels of SerRS protein in RCC tumor tissues, SerRS repressive regulatory function on VEGFA was impaired. This dysregulation was associated with increased SerRS phosphorylation, upregulation of several transcriptional activators, and hypomethylation of the VEGFA promoter - factors likely contributing to VEGFA overexpression. Importantly, higher SerRS gene expression was significantly associated with improved overall survival in patients.Conclusion: The findings indicate that various factors diminish SerRS repressor function leading to the VEGFA upregulation in RCC. Survival analysis suggests that SerRS may serve as a valuable prognostic biomarker and represent a potential therapeutic target in RCC.","PeriodicalId":10796,"journal":{"name":"Croatian Medical Journal","volume":"67 2","pages":"72-84"},"PeriodicalIF":2.3,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The association of burnout with occupational stressors among physicians and medical technicians/nurses in the Federation of Bosnia and Herzegovina: a cross-sectional study. 波斯尼亚和黑塞哥维那联邦医生和医疗技术人员/护士职业压力源与职业倦怠的关系：一项横断面研究。

IF 2.3 4区医学

Croatian Medical Journal Pub Date : 2026-04-30

Ankica Mijić Marić, Marnela Palameta, Mirela Mabic, Amra Zalihić, Edita Černy Obrdalj, Anđela Pupić, Marina Berberović, Sandra Kostić

{"title":"The association of burnout with occupational stressors among physicians and medical technicians/nurses in the Federation of Bosnia and Herzegovina: a cross-sectional study.","authors":"Ankica Mijić Marić, Marnela Palameta, Mirela Mabic, Amra Zalihić, Edita Černy Obrdalj, Anđela Pupić, Marina Berberović, Sandra Kostić","doi":"","DOIUrl":"","url":null,"abstract":"Aim: To assess the prevalence of burnout syndrome and its association with occupational stressors among physicians and medical technicians/nurses in the Federation of Bosnia and Herzegovina (FBiH).Methods: This cross-sectional study was conducted between February 12 and April 12, 2025, using an anonymous online survey. Structured self-administered questionnaire scales were used to assess burnout (Copenhagen Burnout Inventory) and workplace stressors (Occupational Stress Questionnaire). The association of personal, work-related, and patient-related burnout with occupational stressors was assessed. The survey was sent to the members of the Union of Physicians and Dentists in the FBIH, who were asked to forward the link to their medical technicians and nurses.Results: Overall burnout symptoms were reported by more than half of the respondents (53.0%), with 75.7% experiencing at least one form of burnout. Personal burnout was the most prevalent (70.9%), followed by work-related burnout (54.2%) and patient-related burnout (40.1%). In multiple regression analysis, overall burnout was driven by the cumulative impact of multiple stressors rather than by any single factor. All stressors were positively correlated with burnout, but conflicts and communication at work (for personal and work burnout) and public criticism (for patient-related burnout) stood out as the strongest predictors.Conclusion: This study observed a high prevalence of burnout among physicians and medical technicians/nurses in the FBiH. All examined domains of professional stressors were correlated with all burnout dimensions. Given the importance of preventing and alleviating burnout among health care professionals, this research provides insight into key factors contributing to burnout.","PeriodicalId":10796,"journal":{"name":"Croatian Medical Journal","volume":"67 2","pages":"85-94"},"PeriodicalIF":2.3,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0