Croatian Medical Journal最新文献

Regulator of calcineurin 3 as a novel predictor of diagnosis and prognosis in pan-cancer. 作为泛癌症诊断和预后新预测指标的钙神经蛋白 3 调节器

IF 1.5 4区医学

Croatian Medical Journal Pub Date : 2024-08-31

Yuan Liang, Wenjuan Diao, Xuefen Yang, Yue Tao, Longnian Hong, Wenle Li

{"title":"Regulator of calcineurin 3 as a novel predictor of diagnosis and prognosis in pan-cancer.","authors":"Yuan Liang, Wenjuan Diao, Xuefen Yang, Yue Tao, Longnian Hong, Wenle Li","doi":"","DOIUrl":"","url":null,"abstract":"Aim: To assess diagnostic and prognostic value of regulator of calcineurin 3 (RCAN3) in various malignancies.Methods: RCAN3 expression levels were assessed across pan-cancer data sets including various molecular and immune subtypes. Receiver operating characteristic (ROC) and Kaplan-Meier curves were employed to determine the diagnostic and prognostic value of RCAN3 in pan-cancer, respectively. Enrichment analyses were used to identify RCAN3-associated terms and pathways. A special focus was placed on cervical squamous cell carcinoma and endocervical adenocarcinoma cervical cancer (CESC); we assessed the prognostic value of RCAN expression within distinct clinical subgroups and its effect on m6A modifications and immune infiltration.Results: RCAN3 expression varied not only in different cancer types but also in different molecular and immune subtypes of cancers. RCAN3 displayed high accuracy in diagnosing and predicting cancers, and RCAN3 expression level was associated with the prognosis of certain cancers. CESC patients with a high RCAN3 level had a worse overall survival, disease-specific survival, and progression-free interval. RCAN3 expression was related to multiple m6A modifier genes and immune cells.Conclusion: In general, RCAN3 can serve as a novel biomarker for the diagnosis and prognosis in pan-cancer, especially in CESC. It may represent a promising molecular target for developing new treatments. However, our analysis is limited to bioinformatic predictions, and further biological experiments are necessary to verify our results.","PeriodicalId":10796,"journal":{"name":"Croatian Medical Journal","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11399725/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142105183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparing ChatGPT's ability to write and review papers: then what? 比较 ChatGPT 撰写和审阅论文的能力：然后呢？

IF 1.5 4区医学

Croatian Medical Journal Pub Date : 2024-08-31

Shigeki Matsubara

引用次数: 0

The promise of cerebrospinal fluid biomarkers in idiopathic normal pressure hydrocephalus. 特发性正常压力脑积水脑脊液生物标志物的前景。

IF 1.5 4区医学

Croatian Medical Journal Pub Date : 2024-08-31

Romana Perković, Fran Borovečki

引用次数: 0

Is perfect prompting possible for chatbots? In Reply to: Comparing ChatGPT's ability between writing versus reviewing papers: Then what? 聊天机器人有可能实现完美提示吗？回复比较 ChatGPT 写作与审阅论文的能力：然后呢？

IF 1.5 4区医学

Croatian Medical Journal Pub Date : 2024-08-31

Gültekin Kadi, Mehmet Ali Aslaner

引用次数: 0

Limitations of life-sustaining treatments in intensive care units in Croatia: a multicenter retrospective study. 克罗地亚重症监护室中维持生命疗法的局限性：一项多中心回顾性研究。

IF 1.5 4区医学

Croatian Medical Journal Pub Date : 2024-08-31

Diana Špoljar, Radovan Radonić, Zdravka Poljaković, Višnja Nesek, Marinko Vučić, Jasminka Peršec, Tatjana Kereš, Nenad Karanović, Krešimir Čaljkušić, Željko Župan, Igor Grubješić, Mia Golubić, Ana Jozepović, Bojana Nevajdić, Ana Borovečki, Dinko Tonković

{"title":"Limitations of life-sustaining treatments in intensive care units in Croatia: a multicenter retrospective study.","authors":"Diana Špoljar, Radovan Radonić, Zdravka Poljaković, Višnja Nesek, Marinko Vučić, Jasminka Peršec, Tatjana Kereš, Nenad Karanović, Krešimir Čaljkušić, Željko Župan, Igor Grubješić, Mia Golubić, Ana Jozepović, Bojana Nevajdić, Ana Borovečki, Dinko Tonković","doi":"","DOIUrl":"","url":null,"abstract":"Aim: In order to gain insight into the current prevailing practices regarding the limitation of life-sustaining treatment in intensive care units (ICUs) in Croatia, we assessed the frequency of limitation and provision of certain treatment modalities, as well as the associated patient and ICU-related factors.Methods: A multicenter retrospective cross-sectional study was conducted in 17 ICUs in Croatia. We reviewed the medical records of patients deceased in 2017 and extracted data on demographic, clinical, and health care variables. A logistic regression analysis was conducted to determine the associations between these variables and treatment modalities.Results: The study enrolled 1095 patients (55% male; mean age 69.9±13.7). Analgesia and sedation were discontinued before the patient's death in 23% and 34% of the cases, respectively. Patients older than 71 years were less often mechanically ventilated (P<0.001), and less frequently received inotropes and vasoactive therapy (P=0.002) than younger patients. Patients hospitalized in the ICU for less than 7 days less frequently had discontinuation of mechanical ventilation and inotropes and vasoactive therapy than patients hospitalized for 8 days and longer (P<0.001). Logistic regression analysis showed that ICU type was a crucial determinant, with multidisciplinary and surgical ICUs being associated with higher odds of intubation, mechanical ventilation, vasoactive and inotropic therapy, analgesia, and sedation.Conclusion: Older patients and those diagnosed with stroke and intracranial hemorrhage received fewer therapeutic modalities. All the observed treatment modalities were more frequently discontinued in patients who were hospitalized in the ICU for a prolonged time.","PeriodicalId":10796,"journal":{"name":"Croatian Medical Journal","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11399720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142105181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Possible drug-drug interactions among elderly patients receiving antiviral therapy for chronic hepatitis B. 接受慢性乙型肝炎抗病毒治疗的老年患者可能出现的药物相互作用。

IF 1.5 4区医学

Croatian Medical Journal Pub Date : 2024-08-31

Mehmet Çelik, Yusuf Arslan, Taylan Önder, Sevil Alkan, Ahmet Şahin, Fethiye Akgül

{"title":"Possible drug-drug interactions among elderly patients receiving antiviral therapy for chronic hepatitis B.","authors":"Mehmet Çelik, Yusuf Arslan, Taylan Önder, Sevil Alkan, Ahmet Şahin, Fethiye Akgül","doi":"","DOIUrl":"","url":null,"abstract":"Aim: To identify possible drug-drug interactions in patients taking medications for other comorbidities while on antiviral therapy for chronic hepatitis B.Methods: The study enrolled patients with chronic hepatitis B aged ≥60 years who were treated with antiviral therapy in five hospitals in Turkey between January 1 and March 1, 2023. The Lexicomp® Drug Interactions program was used to identify possible drug-drug interactions.Results: The study included 213 patients (119 [55.9%] men). The mean age was 68.5 years. A potential drug-drug interaction was identified in 112 patients (52.6%). The most common type of interaction was type C (\"follow the treatment\") (71.54%). The number of potential drug-drug interactions increased with an increase in the number of drugs used by the patients. A robust and affirmative correlation was observed between the number of medications used and the number of possible drug-drug interactions (r=0.791, P<0.001). Adverse interactions (interactions of types C and D, 3.7% of cases) were limited to patients receiving tenofovir disoproxil fumarate.Conclusion: Nonsteroidal anti-inflammatory medications should be used cautiously in elderly patients with chronic hepatitis B treated with tenofovir disoproxil fumarate due to the increased risk of renal toxicity.","PeriodicalId":10796,"journal":{"name":"Croatian Medical Journal","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11399722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142105182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond the business-to-client model: how the business-to-business model can transform the complex patient care. 超越企业对客户模式：企业对企业模式如何改变复杂的病人护理。

IF 1.5 4区医学

Croatian Medical Journal Pub Date : 2024-08-31

Dorja Vočanec, Aleksandar Džakula

引用次数: 0

Biomarker changes in suspected idiopathic normal-pressure hydrocephalus patients undergoing external lumbar drainage: a pilot study. 接受腰椎外引流术的疑似特发性正常压力脑积水患者的生物标志物变化：一项试点研究。

IF 1.5 4区医学

Croatian Medical Journal Pub Date : 2024-08-31

Klara Brgić Mandić, Goran Mrak, Hrvoje Barić, Sergej Marasanov, Goran Šimić, Ena Španić Popovački, Marijan Klarica

{"title":"Biomarker changes in suspected idiopathic normal-pressure hydrocephalus patients undergoing external lumbar drainage: a pilot study.","authors":"Klara Brgić Mandić, Goran Mrak, Hrvoje Barić, Sergej Marasanov, Goran Šimić, Ena Španić Popovački, Marijan Klarica","doi":"","DOIUrl":"","url":null,"abstract":"Aim: To examine whether changes in biomarker concentrations in patients with idiopathic normal-pressure hydrocephalus (iNPH) during 72 h of external lumbar drainage (ELD) can differentiate between responders and non-responders.Methods: Twenty patients with clinical and neuroradiological signs of iNPH underwent ELD over a period of 72 h. During this period, changes in cerebrospinal fluid (CSF) concentrations of biomarkers (amyloid-β, total and phosphorylated tau proteins) and intracranial pressure were monitored, and the volume of drained CSF was measured. Changes in the concentrations of selected biomarkers at three time points (0, 36, and 72 h) during ELD were tested for association with changes in clinical condition.Results: Ten patients showed significant clinical improvement after ELD, quantified as a difference of two or more points on the Mini-Mental State Examination and/or Japanese iNPH grading scale. The concentration of all tested biomarkers increased during the first 36 h. Respondents had higher Aβ 1-42 at all time points, with a significant difference seen after 72 h. They also had a significantly higher Aβ1-42/Aβ1-40 ratio at all time points.Conclusion: A gradual increase in Aβ 1-42 concentration during three-day ELD represents a possible positive prognostic factor for the placement of permanent CSF drainage in patients with iNPH.","PeriodicalId":10796,"journal":{"name":"Croatian Medical Journal","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11399721/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142105175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The card game of publish or perish: a satirical approach to the reality of academic publishing. 出版或毁灭的纸牌游戏：对学术出版现实的讽刺。

IF 1.5 4区医学

Croatian Medical Journal Pub Date : 2024-08-31

Marko Lucijanić

引用次数: 0

Strong and weak points in the quality of life of school-age children with newly diagnosed uncomplicated epilepsy over the first six months: golden hours for prevention. 新确诊的无并发症癫痫学龄儿童头六个月生活质量的强项和弱项：预防的黄金时间。

IF 1.5 4区医学

Croatian Medical Journal Pub Date : 2024-08-31

Željka Rogač, Dimitrije Nikolić, Aleksandar Dimitrijević, Ivana Andrić, Goran Milošević, Dejan Stevanović

{"title":"Strong and weak points in the quality of life of school-age children with newly diagnosed uncomplicated epilepsy over the first six months: golden hours for prevention.","authors":"Željka Rogač, Dimitrije Nikolić, Aleksandar Dimitrijević, Ivana Andrić, Goran Milošević, Dejan Stevanović","doi":"","DOIUrl":"","url":null,"abstract":"Aim: To determine changes in the quality of life associated with epilepsy in school-age children with newly diagnosed uncomplicated epilepsy over the first six months after diagnosis to find points relevant for the early prevention of deterioration in quality of life.Methods: This prospective follow-up study, performed in University Children's Hospital in Belgrade, enrolled 60 school-aged children with recently diagnosed epilepsy, along with their parents. The respondents completed the Children with Epilepsy Quality of Life immediately following the diagnosis of epilepsy and six months later.Results: Significant decline was observed in the domains related to intrapersonal/emotional relationships by both children (P<0.001) and their parents (P=0.03), and in the need to keep epilepsy a secret as observed by parents (P = 0.04). Significant improvement was found in the Interpersonal/Social domain as rated by parents (P=0.001). Total quality-of-life scores, as assessed by children and parents, did not change significantly.Conclusion: Bearing in mind that stigma and intrapersonal struggles are the major factors affecting the quality of life in children with epilepsy, psychological and social support is highly recommended in the first six months following an epilepsy diagnosis. Since intrapersonal relationships improved over six months, compensating for other deteriorations in the quality of life, children with epilepsy should be encouraged to socialize with their peers and to join organizations and actions that encourage social contact.","PeriodicalId":10796,"journal":{"name":"Croatian Medical Journal","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11399723/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142105184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0