Croatian Medical Journal最新文献_第2页

Correction to: Non-invasive prenatal testing of beta-hemoglobinopathies using next generation sequencing, in-silico sequence size selection, and haplotyping. 更正：使用下一代测序、计算机序列大小选择和单倍型对β -血红蛋白病进行无创产前检测。

IF 2.3 4区医学

Croatian Medical Journal Pub Date : 2026-03-20 DOI: 10.3325/cmj.2026.67.51

Henry A Erlich, Lily Ko, Jiyae Lee, Katrina Eaton, Cassandra D Calloway, Ashutosh Lal, Reena Das, Manu Jamwal, Christian Lopez-Pena, Steven J Mack

引用次数: 0

Artificial intelligence literacy and readiness in future health care professionals: a cross-sectional study. 未来卫生保健专业人员的人工智能素养和准备：一项横断面研究。

IF 2.3 4区医学

Croatian Medical Journal Pub Date : 2026-03-20

Funda Catan-Inan

{"title":"Artificial intelligence literacy and readiness in future health care professionals: a cross-sectional study.","authors":"Funda Catan-Inan","doi":"","DOIUrl":"","url":null,"abstract":"Aim: To examine the relationship between artificial intelligence (AI) literacy and readiness for medical AI among medical and nursing students, and to explore demographic and educational factors affecting AI literacy and readiness for AI.Methods: This cross-sectional study enrolled 443 students attending the Faculty of Medicine and the Department of Nursing at Bilecik Seyh Edebali University between May and June 2025. Data were collected using a general demographic questionnaire, Medical Artificial Intelligence Readiness Scale (MAIRS), and Artificial Intelligence Literacy Scale (AILS).Results: Medical students showed higher AI readiness (P<0.001) and literacy (P=0.032) scores than nursing students. AI literacy was moderately and positively correlated with readiness for medical AI (r=0.338, P<0.001), and the associations were strongest on the Awareness and Usage dimensions. In multivariable models, MAIRS scores were independently associated with the study year, department, and single-item readiness to use AI, while AILS scores were independently associated with the readiness to use AI and the belief that AI could partially replace health care workers. Internal consistency of the questionnaires was high (MAIRS ?=0.972; AILS ?=0.878).Conclusion: The findings support the integration of structured, practical, and ethically informed AI education into health science curricula, as this may be associated with greater student readiness for future AI-supported health care environments.","PeriodicalId":10796,"journal":{"name":"Croatian Medical Journal","volume":"67 1","pages":"4-13"},"PeriodicalIF":2.3,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13014291/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147497805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Before PAX1, DKK1, and D-loop variants are held responsible for the Chiari-I malformation, the pathogenicity of each variant must be proven. 在认为PAX1、DKK1和D-loop变异体是导致chari - i畸形的原因之前，必须证明每种变异体的致病性。

IF 2.3 4区医学

Croatian Medical Journal Pub Date : 2026-03-20

Josef Finsterer

引用次数: 0

Too complex, too busy, yet paid the same: why university tertiary hospitals need a new model. 太复杂，太忙，但报酬一样：为什么大学三级医院需要一种新模式。

IF 2.3 4区医学

Croatian Medical Journal Pub Date : 2026-03-20

Mislav Puljević

{"title":"Too complex, too busy, yet paid the same: why university tertiary hospitals need a new model.","authors":"Mislav Puljević","doi":"","DOIUrl":"","url":null,"abstract":"University tertiary hospitals in Croatia carry a disproportionate share of complex care, teaching, and research responsibilities, yet they are reimbursed under the same Diagnosis-Related Group framework as smaller secondary hospitals. This structural misalignment contributes to workforce strain, physician migration, and inefficiencies in patient flow, while challenging long-term system sustainability. This narrative review and policy analysis synthesizes biomedical literature, international policy reports, and national documents published between 2000 and 2024 to examine workforce shortages, burnout, migration patterns, financing models, and the Croatian context. Croatia reports 3.4 physicians per 1000 inhabitants compared with the European Union average of 4.1, while maintaining a highly centralized referral structure. Burnout prevalence among physicians is estimated at 30-50%, and in 2021 approximately 7% of Croatian physicians applied for certificates enabling employment abroad. Germany, France, the United Kingdom, Scandinavian countries, and Canada have introduced differentiated financing mechanisms that compensate tertiary hospitals for case complexity, referral flows, and academic responsibilities. A pilot Workload Index model is proposed to align reimbursement with case mix, teaching load, referral inflow, and occupational risk exposure. Linking financing to measurable workload indicators may support fairer resource allocation, workforce protection, and improved access to complex care within Croatia's tertiary health services.","PeriodicalId":10796,"journal":{"name":"Croatian Medical Journal","volume":"67 1","pages":"22-29"},"PeriodicalIF":2.3,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13014289/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147497460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of craniectomy on cerebrospinal fluid pressure gradient in the craniospinal space in different body positions of cats. 开颅手术对猫不同体位颅脊髓间隙脑脊液压力梯度的影响。

IF 2.3 4区医学

Croatian Medical Journal Pub Date : 2026-03-20

Marijan Klarica, Gorislav Erceg, Sergej Mihailovič Marasanov, Milan Radoš, Filip Njavro, Darko Orešković, Ivana Jurjević

{"title":"Effects of craniectomy on cerebrospinal fluid pressure gradient in the craniospinal space in different body positions of cats.","authors":"Marijan Klarica, Gorislav Erceg, Sergej Mihailovič Marasanov, Milan Radoš, Filip Njavro, Darko Orešković, Ivana Jurjević","doi":"","DOIUrl":"","url":null,"abstract":"Aim: To assess whether a cranial defect in anesthetized cats alters cerebrospinal fluid (CSF) pressure distribution across the craniospinal axis in different body positions in the setting of intracranial normotension.Methods: After standardized parietal craniectomy, intracranial and lumbar CSF pressures were simultaneously measured in eight adult anesthetized (?-chloralose, i.p. 100 mg/kg) cats in different body positions: horizontal (0°), head-up (45°; 90°), and head-down (225°; 270°). CSF pressure gradient represents the difference between CSF pressure values in the lateral ventricle (LV) and lumbar subarachnoid space (LSS) in each body position.Results: At 0°, CSF pressures in the LV and LSS were similar (16.2±0.9 vs 15.8±1.2 cm H2O, respectively). In the 90° head-up position, LV pressure was subatmospheric (?1.5±0.5 cm H2O), while LSS pressure simultaneously increased (31.4±1.0 cm H2O). Conversely, in the head-down 270° position, LSS pressure was negative (?1.7±1.5 cm H2O) and LV pressure increased (30.0?±?1.8 cm H2O). Difference between LV and LSS pressures is strongly correlated with hydrostatic difference between the two recording points in the head-up and the head-down position. LV pressure at 90° in the craniectomy group was significantly higher than previously published in cats with an intact cranium in the same position (P<0.001).Conclusion: Hydrostatic CSF pressure gradient across the craniospinal axis remained unaltered by craniectomy. The finding that craniectomy in the head-up position of animals without intracranial pathology resulted in an intracranial pressure increase may offer additional explanation for the trephined syndrome pathophysiology.","PeriodicalId":10796,"journal":{"name":"Croatian Medical Journal","volume":"67 1","pages":"14-21"},"PeriodicalIF":2.3,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13014296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147497848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Craniospinal cerebrospinal fluid volume changes after extreme bilateral frontotemporoparietal craniectomy and cranioplasty: a volumetric magnetic resonance imaging case report. 极端双侧额颞顶颅骨切除术和颅骨成形术后颅脊髓脑脊液体积变化：体积磁共振成像病例报告。

IF 2.3 4区医学

Croatian Medical Journal Pub Date : 2026-03-20

Sergej Mihailovič Marasanov, Milan Radoš, Filip Njavro, Miroslav Vukić, Ivana Jurjević, Marijan Klarica

{"title":"Craniospinal cerebrospinal fluid volume changes after extreme bilateral frontotemporoparietal craniectomy and cranioplasty: a volumetric magnetic resonance imaging case report.","authors":"Sergej Mihailovič Marasanov, Milan Radoš, Filip Njavro, Miroslav Vukić, Ivana Jurjević, Marijan Klarica","doi":"","DOIUrl":"","url":null,"abstract":"We report on an 18-year-old woman who sustained severe traumatic brain injury in a traffic accident. The resulting refractory intracranial hypertension required emergency bilateral frontotemporoparietal decompressive craniectomies, which left a large bilateral skull defect. Postoperatively, she developed a bilateral sinking skin flap syndrome, consistent with atmospheric pressure-driven collapse of the cranial compartment. She underwent full neuraxis 3D craniospinal imaging before and three months after elective bilateral cranioplasty using custom implants. Pre-cranioplasty volumetric assessment showed cranial cerebrospinal fluid (CSF) volume of 100.8 mL and spinal CSF volume of 78.2 mL (179.0 mL total). After cranioplasty, cranial CSF volume increased to 152.7 mL and spinal CSF volume to 91.1 mL (243.7 mL total), with an overall CSF net gain of 64.7 mL without relevant change in brain parenchyma volume. Clinically, after neurosurgical and neurointensive rehabilitation, the patient remained neurologically stable, with no new focal deficits, able to continue everyday life, finish high school, and enter university. The volumetric findings suggested global redistribution and expansion of neurofluids within the craniospinal axis when cranial boundaries were restored. Such findings are difficult to explain with the traditional model of CSF production and unidirectional circulation, but align with the Bulat-Klarica-Orešković hypothesis, which views CSF, intravascular and interstitial fluid as a single, hydrostatic, and osmotic capillary-driven system. This case indicates that quantitative craniospinal volumetry after cranioplasty can provide in vivo support for contemporary concepts of CSF physiology and may help guide cranioplasty timing in decompressive craniectomy patients.","PeriodicalId":10796,"journal":{"name":"Croatian Medical Journal","volume":"67 1","pages":"44-49"},"PeriodicalIF":2.3,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13014290/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147497756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The (in)visibility of women in science. 女性在科学领域的知名度。

IF 2.3 4区医学

Croatian Medical Journal Pub Date : 2026-03-20

Svjetlana Kalanj Bognar, Klementina Fon Tacer, Ivana Rosenzweig

引用次数: 0

Transurethral drainage of prostatic abscess using pulsed Tm:YAG laser: a case report. 脉冲Tm:YAG激光经尿道前列腺脓肿引流术1例。

IF 2.3 4区医学

Croatian Medical Journal Pub Date : 2026-03-20

Branimir Lodeta

引用次数: 0

Ancient DNA studies performed in the forensic genetic laboratory in Slovenia: a narrative review. 在斯洛文尼亚法医遗传实验室进行的古代DNA研究：叙述性回顾。

IF 2.3 4区医学

Croatian Medical Journal Pub Date : 2026-03-20

Irena Zupanič Pajnič

{"title":"Ancient DNA studies performed in the forensic genetic laboratory in Slovenia: a narrative review.","authors":"Irena Zupanič Pajnič","doi":"","DOIUrl":"","url":null,"abstract":"Ancient DNA research is typically conducted in dedicated clean-room facilities; however, recent work in Slovenia has demonstrated that standard forensic technologies can also be successfully applied to archaeological remains. This article reviews studies conducted by our group on skeletal samples from different Slovenian sites. Comparative analyses of petrous bones from two archaeological contexts revealed how environmental conditions affect DNA preservation. Long-term storage effects were assessed by comparing freshly excavated remains with samples stored for 12 years under unregulated museum conditions. Intra-skeletal variability was examined through petrous bones, femurs, tali, calcanei, patellae, and teeth, and the potential of tooth cementum for minimally destructive extraction was evaluated. Differences in DNA quality between adult and non-adult skeletons were investigated. Genetic sexing was performed on 83 subadult skeletons to test the reliability of morphological methods, which often fail at this age. For optimized analyses, a DNA extraction protocol was developed that requires minimal bone powder. The PowerQuant real-time polymerase chain reaction (PCR) system proved a cost-effective predictor of successful short tandem repeat (STR) typing in degraded remains. Kinship studies, including that of four individuals from the 5th-6th century, demonstrated the utility of combining STR, single nucleotide polymorphism (SNP), and PCR-based massive parallel sequencing approaches, which improved statistical power and confirmed relatedness. Additionally, eye and hair color were predicted for skeletons dated to the 3rd-18th centuries. Overall, these results highlight that combining conventional forensic approaches with strict contamination control can generate reliable genetic data from archaeological samples and offer valuable insights into past populations.","PeriodicalId":10796,"journal":{"name":"Croatian Medical Journal","volume":"67 1","pages":"30-38"},"PeriodicalIF":2.3,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13014292/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147497776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-perceived quality of life, health, and physical activity among older adults: the roles of marital status and residence during the COVID-19 pandemic. 老年人自我感知的生活质量、健康和身体活动：婚姻状况和居住地在COVID-19大流行期间的作用

IF 2.3 4区医学

Croatian Medical Journal Pub Date : 2026-01-05

Nada Pjevač Keleminić, Venija Cerovečki, Mirjana Kujundžić Tiljak

{"title":"Self-perceived quality of life, health, and physical activity among older adults: the roles of marital status and residence during the COVID-19 pandemic.","authors":"Nada Pjevač Keleminić, Venija Cerovečki, Mirjana Kujundžić Tiljak","doi":"","DOIUrl":"","url":null,"abstract":"Aim: To examine the associations between marital status, place of residence, self-reported health status, quality of life, and physical activity among older adults during the COVID-19 pandemic.Methods: This cross-sectional study enrolled 962 participants aged 65 and older, surveyed between March 2020 and May 2023. Respondents were categorized according to marital status (married/living with a partner, single, divorced, widowed) and place of residence (own home vs nursing home). Standardized instruments were used: the Short Form Health Survey-36 for health status, the Personal Well-being Index for quality of life, and the Croatian short version of the International Physical Activity Questionnaire.Results: Respondents who were married or living with a partner reported significantly higher levels of physical activity, better physical and mental health, and greater life satisfaction than single, divorced, or widowed respondents (P<0.001). Community-dwelling respondents scored significantly higher on most health and quality-of-life indicators than nursing home residents, except for perceived future security.Conclusion: Marital status and living arrangements significantly affected the self-perceived health, physical activity, and quality of life of older adults during the COVID-19 pandemic. The results emphasize the importance of social support and residential context in promoting healthy aging.","PeriodicalId":10796,"journal":{"name":"Croatian Medical Journal","volume":"66 6","pages":"390-398"},"PeriodicalIF":2.3,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12893408/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145948281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0