Croatian Medical Journal最新文献_第10页

In Reply to: Neurological side effects after SARS-CoV-2 vaccinations require thorough and comprehensive investigations. 答复接种 SARS-CoV-2 疫苗后出现神经系统副作用需要进行彻底全面的调查。

IF 1.9 4区医学

Croatian Medical Journal Pub Date : 2024-04-30

Grgur Salai, Ruđer Novak, Đivo Ljubičić, Lovorka Grgurević

引用次数: 0

The knowledge about long-term consequences of preterm birth among health professionals, educational professionals, and parents in Slovenia. 斯洛文尼亚医疗专业人员、教育专业人员和家长对早产长期后果的认识。

IF 1.9 4区医学

Croatian Medical Journal Pub Date : 2024-04-30

Kaja Hacin Beyazoglu, Darja Paro-Panjan, Breda Šušteršič, Jana Kodrič

{"title":"The knowledge about long-term consequences of preterm birth among health professionals, educational professionals, and parents in Slovenia.","authors":"Kaja Hacin Beyazoglu, Darja Paro-Panjan, Breda Šušteršič, Jana Kodrič","doi":"","DOIUrl":"","url":null,"abstract":"Aim: To assess the knowledge about the long-term consequences of preterm birth and the need for training and information among various professionals working with preterm children and parents of preterm children.Methods: In February and March 2018, physicians, psychologists, special education needs teachers, teachers, preschool teachers, and parents (N=488) filled in the Preterm Birth-Knowledge Scale and a survey regarding their perceptions and attitudes toward working with preterm children.Results: Physicians and psychologists were most knowledgeable among the groups about the long-term consequences of preterm birth. Teachers, preschool teachers, and parents had significantly lower knowledge (F=23.18, P<0.001). The majority of professionals indicated that they did not feel adequately equipped to support the learning and development of preterm children and that they had not received sufficient training in this area. More than half indicated that they had received no formal training. In general, the participants tended to underestimate the long-term problems of preterm children.Conclusion: The findings underscore the importance of integrating the issue of the long-term outcomes of preterm birth and working with preterm children into formal education, and in other forms of educational activities.","PeriodicalId":10796,"journal":{"name":"Croatian Medical Journal","volume":"65 2","pages":"76-84"},"PeriodicalIF":1.9,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11074942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140862376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Innovative statistical approaches: the use of neural networks reduces the sample size in the splenectomy-MCAO mouse model. 创新统计方法：使用神经网络减少脾切除-MCAO 小鼠模型的样本量。

IF 1.9 4区医学

Croatian Medical Journal Pub Date : 2024-04-30

Dominik Romić, Monika Berecki, Sanja Srakočić, Paula Josić Dominović, Helena Justić, Dominik Hamer, Daniela Petrinec, Marina Radmilović, Branimir Hackenberger, Srećko Gajović, Anton Glasnović

{"title":"Innovative statistical approaches: the use of neural networks reduces the sample size in the splenectomy-MCAO mouse model.","authors":"Dominik Romić, Monika Berecki, Sanja Srakočić, Paula Josić Dominović, Helena Justić, Dominik Hamer, Daniela Petrinec, Marina Radmilović, Branimir Hackenberger, Srećko Gajović, Anton Glasnović","doi":"","DOIUrl":"","url":null,"abstract":"Aim: To compare the effectiveness of artificial neural network (ANN) and traditional statistical analysis on identical data sets within the splenectomy-middle carotid artery occlusion (MCAO) mouse model.Methods: Mice were divided into the splenectomized (SPLX) and sham-operated (SPLX-sham) group. A splenectomy was conducted 14 days before middle carotid artery occlusion (MCAO). Magnetic resonance imaging (MRI), bioluminescent imaging, neurological scoring (NS), and histological analysis, were conducted at two, four, seven, and 28 days after MCAO. Frequentist statistical analyses and ANN analysis employing a multi-layer perceptron architecture were performed to assess the probability of discriminating between SPLX and SPLX-sham mice.Results: Repeated measures ANOVA showed no significant differences in body weight (F (5, 45)=0.696, P=0.629), NS (F (2.024, 18.218)=1.032, P=0.377) and brain infarct size on MRI between the SPLX and SPLX-sham groups post-MCAO (F (2, 24)=0.267, P=0.768). ANN analysis was employed to predict SPLX and SPL-sham classes. The highest accuracy in predicting SPLX class was observed when the model was trained on a data set containing all variables (0.7736±0.0234). For SPL-sham class, the highest accuracy was achieved when it was trained on a data set excluding the variable combination MR contralateral/animal mass/NS (0.9284±0.0366).Conclusion: This study validated the neuroprotective impact of splenectomy in an MCAO model using ANN for data analysis with a reduced animal sample size, demonstrating the potential for leveraging advanced statistical methods to minimize sample sizes in experimental biomedical research.","PeriodicalId":10796,"journal":{"name":"Croatian Medical Journal","volume":"65 2","pages":"122-137"},"PeriodicalIF":1.9,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11074938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140863208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Screening for diabetic peripheral neuropathy at community pharmacies in Slovakia. 斯洛伐克社区药房的糖尿病周围神经病变筛查。

IF 1.9 4区医学

Croatian Medical Journal Pub Date : 2024-04-30

Zuzana Pagáčová, Milan Grofik, Tomáš Fazekaš, Viera Žufková, Daniela Mináriková

{"title":"Screening for diabetic peripheral neuropathy at community pharmacies in Slovakia.","authors":"Zuzana Pagáčová, Milan Grofik, Tomáš Fazekaš, Viera Žufková, Daniela Mináriková","doi":"","DOIUrl":"","url":null,"abstract":"Aim: To identify diabetic patients with a potential risk of developing diabetic peripheral neuropathy (DPN) in community pharmacies in Slovakia using a modified Michigan Neuropathy Screening Instrument questionnaire (MNSIq-12).Methods: This cross-sectional study enrolled 703 patients with type 1 and type 2 diabetes mellitus who had not been diagnosed with DPN. The study took place in selected community pharmacies across Slovakia in October 2019. The MNSIq-12 was administered by pharmacy students, and a Michigan score <1.5 was considered risky. The groups divided based on the Michigan score were compared in terms of duration of diabetes, age, body mass index (BMI), sex, weekly physical activity, level of education, and smoking.Results: The risk of developing DPN was detected in 6.6% of respondents with type 1 diabetes and 13.4% with type 2 diabetes. Patients with both types of diabetes (38.2%; 67.0%) reported fatigue and heaviness in the legs as the most common clinical symptoms that may indicate the development of DPN. Those with a Michigan score <1.5 were older (P<0.0001), had a higher BMI (P<0.0001), a lower level of education (P=0.0020), and were less physically active (P<0.0001). Conclusion Approximately one-eighth of patients with diabetes who visited community pharmacies were potentially at risk for developing DPN. The modified MNSIq-12 was shown to be a simple, time-effective, and non-invasive indicative screening tool that can be applied in the environment of community pharmacies.","PeriodicalId":10796,"journal":{"name":"Croatian Medical Journal","volume":"65 2","pages":"85-92"},"PeriodicalIF":1.9,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11074941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140863209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring ChatGPT's abilities in medical article writing and peer review. 探索 ChatGPT 在医学文章写作和同行评审方面的能力。

IF 1.9 4区医学

Croatian Medical Journal Pub Date : 2024-04-30

Gültekin Kadi, Mehmet Ali Aslaner

引用次数: 0

Factors contributing to variability in metformin concentration in polycystic ovary syndrome. 导致多囊卵巢综合征二甲双胍浓度变化的因素。

IF 1.9 4区医学

Croatian Medical Journal Pub Date : 2024-04-30

Valentina N Nikolić, Milan Stefanović, Dejan Mitić, Slavica Sunarić, Maša Jović, Hristina Trajković, Sanja Stanković, Aleksandra Ignjatović, Dragana Stokanović

{"title":"Factors contributing to variability in metformin concentration in polycystic ovary syndrome.","authors":"Valentina N Nikolić, Milan Stefanović, Dejan Mitić, Slavica Sunarić, Maša Jović, Hristina Trajković, Sanja Stanković, Aleksandra Ignjatović, Dragana Stokanović","doi":"","DOIUrl":"","url":null,"abstract":"Aim: To investigate the factors affecting metformin concentrations after chronic administration in patients with polycystic ovary syndrome (PCOS), focusing on the pharmacokinetic variability and its implications for personalized therapy.Methods: This study enrolled 53 PCOS patients undergoing long-term metformin treatment at the Clinic for Gynecology and Obstetrics in Niš, Serbia, from February to December 2019. Pharmacokinetic parameters were measured from blood samples, and metformin concentrations were determined with validated analytical techniques.Results: There was a significant variability in metformin concentrations among PCOS patients, with body mass index (BMI) identified as a major influencing factor. Higher BMI was associated with lower plasma metformin levels, a finding suggesting an altered pharmacokinetic profile in obese patients.Conclusions: This study highlights the critical role of BMI in influencing metformin pharmacokinetics in PCOS patients and underscores the need for personalized treatment strategies in patients with PCOS.","PeriodicalId":10796,"journal":{"name":"Croatian Medical Journal","volume":"65 2","pages":"138-145"},"PeriodicalIF":1.9,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11074935/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140848147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toxicity of benzodiazepines in the treatment of insomnia disorders in older adults: a systematic literature review. 治疗老年人失眠症时苯二氮卓类药物的毒性：系统性文献综述。

IF 1.5 4区医学

Croatian Medical Journal Pub Date : 2024-04-30

Annemarie Kim Kozole Smid, Ajda Mlakar, Vita Štukovnik

{"title":"Toxicity of benzodiazepines in the treatment of insomnia disorders in older adults: a systematic literature review.","authors":"Annemarie Kim Kozole Smid, Ajda Mlakar, Vita Štukovnik","doi":"","DOIUrl":"","url":null,"abstract":"Aim: To review the literature data on the prevalence of benzodiazepines abuse and poisoning in older adults; the prevalence of polypharmacy with benzodiazepines in this demographic; and determine whether benzodiazepine anxiolytics or hypnotics were more frequently implicated in the cases of abuse and poisoning.Methods: We searched PubMed and Scopus for relevant studies published from January 1, 2013, to May 1, 2023. Twelve studies were included in the final selection.Results: The review highlights the diverse prevalence rates of benzodiazepine abuse and poisoning in the older adult population. Benzodiazepine anxiolytics were more frequently associated with negative outcomes than benzodiazepine hypnotics. Concurrent use of benzodiazepines, benzodiazepine-related medications, and opioids was reported, although these medications were not the only ones commonly used by the elderly.Conclusion: It is essential to increase awareness about adhering to prescribed pharmacological therapies to mitigate issues related to drug abuse and poisoning among older adults.","PeriodicalId":10796,"journal":{"name":"Croatian Medical Journal","volume":"65 2","pages":"146-155"},"PeriodicalIF":1.5,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11074939/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140851882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Person-centered care in ophthalmology: current knowledge and perspectives. 眼科以人为本的护理：当前的知识和观点。

IF 1.9 4区医学

Croatian Medical Journal Pub Date : 2024-04-30

Snježana Kaštelan, Neda Pjevač, Marijana Braš, Veljko Đorđević, Nada Pjevač Keleminić, Juan E Mezzich

引用次数: 0

Palliative care - too complex to make it simple. 姑息关怀--复杂得不能再简单。

IF 1.9 4区医学

Croatian Medical Journal Pub Date : 2024-04-30

Aleksandar Džakula, Karmen Lončarek, Dorja Vočanec

引用次数: 0

Neurological side effects after SARS-CoV-2 vaccinations require thorough and comprehensive investigations. 接种 SARS-CoV-2 疫苗后出现的神经系统副作用需要进行彻底和全面的检查。