Croatian Medical Journal最新文献_第10页

Neurological side effects after SARS-CoV-2 vaccinations require thorough and comprehensive investigations. 接种 SARS-CoV-2 疫苗后出现的神经系统副作用需要进行彻底和全面的检查。

IF 1.9 4区医学

Croatian Medical Journal Pub Date : 2024-04-30

Josef Finsterer

引用次数: 0

The effect of somatic mutations in mitochondrial DNA on the survival of patients with primary brain tumors. 线粒体 DNA 的体细胞突变对原发性脑肿瘤患者生存期的影响。

IF 1.9 4区医学

Croatian Medical Journal Pub Date : 2024-04-30

Siti Zulaikha Nashwa Mohd Khair, Siti Muslihah Ab Radzak, Zamzuri Idris, Anani Aila Mat Zin, Wan Muhamad Amir Wan Ahmad, Abdul Aziz Mohamed Yusoff

{"title":"The effect of somatic mutations in mitochondrial DNA on the survival of patients with primary brain tumors.","authors":"Siti Zulaikha Nashwa Mohd Khair, Siti Muslihah Ab Radzak, Zamzuri Idris, Anani Aila Mat Zin, Wan Muhamad Amir Wan Ahmad, Abdul Aziz Mohamed Yusoff","doi":"","DOIUrl":"","url":null,"abstract":"Aim: To assess the presence of mitochondrial (mt) DNA somatic mutations, determine the relationship between clinicopathological characteristics and mutations, and assess the survival outcomes in Malay patients with primary brain tumors.Methods: The study enrolled 54 patients with primary brain tumors. DNA extracted from paired tissue and blood samples was subjected to Sanger sequencing to identify alterations in the entire mtDNA. The associations between clinicopathological characteristics and mutations were evaluated. Cox-regression multivariate analysis was conducted to identify factors significantly associated with survival, and Kaplan-Meier analysis was used to compare the survival of patients with and without mutations.Results: Overall, 29.6% of the patients harbored 19 somatic mutations distributed across 15 loci within the mtDNA. Notably, 36.8% of these mutations were not previously documented in MITOMAP. One newly identified mutation caused a frameshift in the ATPase6 gene, resulting in a premature stop codon. Three mutations were classified as deleterious in the MitImpact2 database. Overall, 1097 mtDNA polymorphisms were identified across 331 different locations. Patients with mutations exhibited significantly shorter survival than patients without mutations.Conclusions: mtDNA mutations negatively affected the survival outcomes of Malaysian patients with primary brain tumors. However, studies with larger samples are needed to confirm the association between mutation burden and survival rates.","PeriodicalId":10796,"journal":{"name":"Croatian Medical Journal","volume":"65 2","pages":"111-121"},"PeriodicalIF":1.9,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11074945/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140862393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Scientists from small countries on the hunt for scientometric figures - global indicators and local finances. 小国科学家寻找科学计量学数字--全球指标和地方财政。

IF 1.9 4区医学

Croatian Medical Journal Pub Date : 2024-04-30

Damir Stanzer

引用次数: 0

The mediating role of depressive, anxiety, and physical symptoms on work ability index in employed women with breast cancer: a prospective study from Croatia. 抑郁、焦虑和躯体症状对患有乳腺癌的在职妇女工作能力指数的中介作用：克罗地亚的一项前瞻性研究。

IF 1.9 4区医学

Croatian Medical Journal Pub Date : 2024-04-30

Ivana Prga Borojević, Ines Amber Kincaid, Martina Bago, Tajana Prga Bajić, Ružica Valent, Klaudia Knezić, Bojana Knežević, Darko Marčinko

{"title":"The mediating role of depressive, anxiety, and physical symptoms on work ability index in employed women with breast cancer: a prospective study from Croatia.","authors":"Ivana Prga Borojević, Ines Amber Kincaid, Martina Bago, Tajana Prga Bajić, Ružica Valent, Klaudia Knezić, Bojana Knežević, Darko Marčinko","doi":"","DOIUrl":"","url":null,"abstract":"Aim: To explore the relationship between the current work ability index (WAI) and depressive and anxiety symptoms in breast cancer (BC) patients and the role of depressive, anxiety, and physical symptoms in mediating this relationship.Methods: This prospective study enrolled 83 employed women with BC. At baseline assessment (in the first three months following BC diagnosis) and follow-up assessment (one year after baseline), participants completed the WAI, Beck Depression Inventory-II, State-Trait Anxiety Inventory, and European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire with a breast cancer-specific module. Mediation analyses were conducted to explore the mechanism by which depressive, anxiety, and physical symptoms influenced the relationship between WAI and depressive and anxiety symptoms.Results: WAI was negatively associated with depressive and anxiety symptoms. The effect of baseline depressive and trait anxiety symptoms on WAI at follow-up was mediated by both depressive and trait anxiety symptoms, as well as by physical symptoms at follow-up. The effect of baseline state anxiety symptoms on WAI at follow-up was mediated only by state anxiety symptoms at follow-up.Conclusions: Baseline depressive and anxiety symptoms affect WAI at follow-up not only through persisting depressive and anxiety symptoms observed at follow-up but also through physical symptoms at follow-up. This indicates that efforts aimed at improving psychological health may result in simultaneous improvements in both psychological and physical health, as well as the resulting WAI.","PeriodicalId":10796,"journal":{"name":"Croatian Medical Journal","volume":"65 2","pages":"101-110"},"PeriodicalIF":1.9,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11074940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140849833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breast lump as the initial presentation of metastatic uterine leiomyosarcoma: a case report and comprehensive literature review. 以乳房肿块为首发表现的转移性子宫肌层肉瘤：一份病例报告和全面的文献综述。

IF 1.9 4区医学