Croatian Medical Journal最新文献_第10页

Pachydermodactily - the great imitator of arthritis: a case series. 厚皮性-关节炎的伟大模仿者：一个案例系列。

IF 1.5 4区医学

Croatian Medical Journal Pub Date : 2025-05-07

Iva Rukavina, Marijan Frković, Mario Sestan, Ivana Brnadic, Alenka Gagro, Suzana Ožanić Bulić, Marija Jelusic

{"title":"Pachydermodactily - the great imitator of arthritis: a case series.","authors":"Iva Rukavina, Marijan Frković, Mario Sestan, Ivana Brnadic, Alenka Gagro, Suzana Ožanić Bulić, Marija Jelusic","doi":"","DOIUrl":"","url":null,"abstract":"Pachydermodactily is a rare digital fibromatosis of unknown origin, mainly affecting adolescent boys. It presents as symmetrical, painless thickening of the soft tissues, usually around the proximal interphalangeal joints (PIP). Patients often experience delayed diagnoses, receive unnecessary treatments, or are misdiagnosed with chronic inflammatory arthritis. Although the exact cause remains unclear, pachydermodactyly may be associated with repetitive mechanical trauma, such as rubbing or interlacing the fingers, which can lead to secondary skin thickening. Treatment is often not required given its benign prognosis, although some patients ask for therapy due to the cosmetic impact of the condition. The aim of this study was to present the characteristics of seven patients diagnosed with pachydermodactily at pediatric rheumatology outpatient clinics in Zagreb. Additionally, we performed a comprehensive literature review of reported cases published from 1975 to 2024 using PubMed and Google Scholar. The primary symptom observed was swelling of the soft tissues around the PIP and metacarpophalangeal joints, with some patients presenting with hyperkeratotic plaques resembling knuckle pads. One patient experienced hand pain. Clinical examination and diagnostic workup were performed (laboratory tests specific for rheumatologic diseases, radiological tests such as joint ultrasound, x-ray or magnetic resonance imaging, or skin biopsy) to exclude other conditions with similar clinical features and etiologies, such as juvenile idiopathic arthritis. None of the patients met the criteria for juvenile idiopathic arthritis according to the classification criteria of the International League of Associations for Rheumatology. Increasing awareness of pachydermodactyly and achieving accurate diagnoses can reduce unnecessary diagnostic tests, treatments, and patient anxiety.","PeriodicalId":10796,"journal":{"name":"Croatian Medical Journal","volume":"66 2","pages":"164-172"},"PeriodicalIF":1.5,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12093116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aeroallergen sensitization rate and its multifactorial influences in continental Croatia: a cross-sectional study. 克罗地亚大陆空气过敏原致敏率及其多因素影响：一项横断面研究。

IF 1.5 4区医学

Croatian Medical Journal Pub Date : 2025-05-07

Vesna Vukičević Lazarević, Ivan Marković

{"title":"Aeroallergen sensitization rate and its multifactorial influences in continental Croatia: a cross-sectional study.","authors":"Vesna Vukičević Lazarević, Ivan Marković","doi":"","DOIUrl":"","url":null,"abstract":"Aims: To assess the rate of sensitization to airborne allergens in continental Croatia and the related variables. A secondary aim was to assess the frequency of pollen-food syndrome.Methods: This cross-sectional study enrolled 2133 participants referred to Special Hospital for Pulmonary Diseases, Zagreb, from January 2 to December 31, 2022. Patients underwent skin prick test, and data on age, area of residence, smoking status, referring physician, and the presence of respiratory disease were gathered from electronic health records.Results: The rate of sensitization in our sample was 48.86%, and rate of polysensitization was 75.91%, with grass pollen being the predominant allergen. Sensitization rates to all airborne allergens significantly increased compared with a 2003-2006 cohort. Men had higher rates of sensitization, and sensitivity to certain allergens varied based on age. Patients diagnosed with rhinitis exhibited the highest rates of sensitization and mostly sought medical attention from allergists. Conversely, asthma patients who did not have rhinitis exhibited reduced rates of sensitization and were mostly treated by pulmonologists. Birch tree pollen was the primary aeroallergen responsible for pollen-food syndrome, regardless of the age group.Conclusions: Our findings contribute to the existing body of research on sensitization to aeroallergens in Europe and stress the importance of multidisciplinary management of allergic respiratory disorders.","PeriodicalId":10796,"journal":{"name":"Croatian Medical Journal","volume":"66 2","pages":"82-91"},"PeriodicalIF":1.5,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12093119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of behavioral characteristics and mental health indices in a large nationwide representative sample of schoolchildren aged 11-15 years in Albania. 阿尔巴尼亚全国11-15岁学童代表性大样本的行为特征与心理健康指数的关系。

IF 1.5 4区医学

Croatian Medical Journal Pub Date : 2025-05-07

Iris Mone, Alketa Qosja, Gentiana Qirjako, Rudina Çumashi, Enver Roshi, Genc Burazeri

{"title":"Association of behavioral characteristics and mental health indices in a large nationwide representative sample of schoolchildren aged 11-15 years in Albania.","authors":"Iris Mone, Alketa Qosja, Gentiana Qirjako, Rudina Çumashi, Enver Roshi, Genc Burazeri","doi":"","DOIUrl":"","url":null,"abstract":"Aim: To assess the independent associations of behavioral factors with many mental health indices among children in Albania.Methods: This cross-sectional study carried out in Albania in 2022 included a nationwide representative sample of 5454 schoolchildren aged 11, 13, and 15 years (52% girls; response rate: 96%). Data on ten mental health indices were collected, in addition to behavioral characteristics and sociodemographic factors. A general linear model was used to assess the independent associations of behavioral factors with mental health indices.Results: Irrespective of sociodemographic characteristics, the scores of all mental health indices were significantly worse among schoolchildren who reported lifetime smoking and alcohol consumption, those who engaged less frequently in physical activity, those who skipped breakfast at least on one weekday, and those who consumed fresh fruit less than daily compared with their counterparts who were, respectively, never smokers, had never drunk alcohol, were more physically active, consumed breakfast regularly, and consumed fresh fruit daily.Conclusions: Irrespective of sociodemographic boundaries, this study showed significant associations between behavioral characteristics and the mental health of Albanian schoolchildren. This highlights the importance of promoting healthy behaviors among children to mitigate the risk of mental health challenges. Interventions aimed at encouraging regular physical activity, consistent breakfast consumption, and daily intake of fresh fruit may enhance the mental resilience of school-aged children.","PeriodicalId":10796,"journal":{"name":"Croatian Medical Journal","volume":"66 2","pages":"125-134"},"PeriodicalIF":1.5,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12093126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dapagliflozin vs empagliflozin in patients with chronic heart failure: a registry analysis. 慢性心力衰竭患者的达格列净vs恩格列净：注册分析

IF 1.5 4区医学

Croatian Medical Journal Pub Date : 2025-05-07

Ivana Jurin, Irzal Hadžibegović, Hrvoje Jurin, Diana Rudan, Nikola Pavlović, Marija Radić, Šime Manola, Vladimir Trkulja

{"title":"Dapagliflozin vs empagliflozin in patients with chronic heart failure: a registry analysis.","authors":"Ivana Jurin, Irzal Hadžibegović, Hrvoje Jurin, Diana Rudan, Nikola Pavlović, Marija Radić, Šime Manola, Vladimir Trkulja","doi":"","DOIUrl":"","url":null,"abstract":"Aim: To assess the relative efficacy of dapagliflozin and empagliflozin in routinely treated chronic heart failure (CHF) patients.Methods: Data from a registry of prevalent and incident CHF patients were used to set up cohorts (new-user design) of patients started on dapagliflozin or empagliflozin in addition to other guideline-directed therapy. Cohorts were mutually balanced on a range of characteristics, and were assessed for the incidence of a composite of all-cause death/major adverse cardiac events (primary outcome) over the initial 6 months of treatment, and for New York Heart Association (NYHA) functional class at 6 months (secondary outcome). Frequentist and Bayes estimates were generated for the dapagliflozin vs empagliflozin comparison.Results: In both prevalent (dapagliflozin n=393, empagliflozin n=328) and incident (dapagliflozin n=124, empagliflozin n=116) patients, those prescribed dapagliflozin had somewhat higher incidence of the primary outcome, but the confidence intervals were wide (RR=1.385, 95%CI 0.882-2.173 [prevalent], RR=2.192, 95%CI 0.765-6.282 [incident]), and were more likely to present with a worse NYHA class at 6 months (OR=1.552, 95%CI 1.142-2.108 [prevalent], OR=1.503, 95%CI 0.844-2.676 [incident]). In the pooled data, primary events (n=102) were more common in dapagliflozin-prescribed patients (frequentist estimate RR=1.519, 95%CI 1.239-1.861; Bayes RR=1.380, 95%CrI 0.981-1.944). Dapagliflozin-prescribed patients were also more likely to have a worse NYHA class at 6 months (OR=1.540, 95%CI 1.208-1.962; Bayes OR=1.425, 95%CrI 1.098-1.781).Conclusion: CHF patients prescribed with dapagliflozin had poorer outcomes than their empagliflozin-prescribed peers over the initial 6 months of treatment. Data emphasize a need for a direct randomized comparison of the two treatments in this setting.","PeriodicalId":10796,"journal":{"name":"Croatian Medical Journal","volume":"66 2","pages":"135-152"},"PeriodicalIF":1.5,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12093124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ending nuclear weapons, before they end us. 在核武器终结我们之前终结它们。

IF 1.5 4区医学

Croatian Medical Journal Pub Date : 2025-05-07

Kamran Abbasi, Parveen Ali, Virginia Barbour, Marion Birch, Inga Blum, Peter Doherty, Andy Haines, Ira Helfand, Richard Horton, Kati Juva, Jose F Lapena, Robert Mash, Olga Mironova, Arun Mitra, Carlos Monteiro, Elena N Naumova, David Onazi, Tilman Ruff, Peush Sahni, James Tumwine, Carlos Umaña, Paul Yonga, Chris Zielinski

引用次数: 0

Management of complex patients in family medicine. 家庭医学中复杂病人的管理。

IF 1.5 4区医学

Croatian Medical Journal Pub Date : 2025-02-28

Aleksandar Džakula, Dorja Vočanec

引用次数: 0

Testicular tissue bank: ten years of testicular tissue cryopreservation in Croatia. 睾丸组织库：克罗地亚十年睾丸组织冷冻保存。

IF 1.5 4区医学

Croatian Medical Journal Pub Date : 2025-02-28

Marija Ćapin Vilaj, Monika Trupinić, Ante Jug, Dinko Hauptman, Zoran Zimak, Željko Kaštelan, Davor Ježek

{"title":"Testicular tissue bank: ten years of testicular tissue cryopreservation in Croatia.","authors":"Marija Ćapin Vilaj, Monika Trupinić, Ante Jug, Dinko Hauptman, Zoran Zimak, Željko Kaštelan, Davor Ježek","doi":"","DOIUrl":"","url":null,"abstract":"The Testicular Tissue Bank has been operating at the University Hospital Center (UHC) Zagreb since 2013. It aims to cryopreserve testicular tissue from patients with azoospermia. If spermatozoa are found in the collected tissue, a combined procedure known as testicular sperm extraction (TESE)/intracytoplasmic sperm injection (ICSI) is performed. During the last 10 years, our bank has deposited samples from 443 patients collected either by conventional TESE or microsurgical TESE procedure. Among them, 9% were from oncological patients whose samples were stored to preserve fertility. According to pathohistological analysis, 17% of patients were diagnosed with complete spermatogenesis or hypospermatogenesis, 11% with spermatogenic arrest, 48% with mixed atrophy of seminiferous tubules, and 24% with Sertoli cell-only phenotype or tubular fibrosis. Overall, the presence of testicular spermatozoa was found in 58% of patients, which makes them suitable for the ICSI procedure. In 21 out of 59 patients (36%) who underwent a salvage TESE, the outcome was different than that of the first spermatozoa retrieval attempt. Considering that the male factor is one of the leading causes of infertility, the results of Testicular Tissue Bank activity confirm its important role in improving the demographic picture of Croatia.","PeriodicalId":10796,"journal":{"name":"Croatian Medical Journal","volume":"66 1","pages":"71-76"},"PeriodicalIF":1.5,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11947978/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Balancing tradition and innovation: rethinking the dichotomy in anatomy teaching. 平衡传统与创新：重新思考解剖学教学中的二分法。

IF 1.5 4区医学

Croatian Medical Journal Pub Date : 2025-02-28

Marina Čavka, Zdravko Petanjek, Maura Zanze Beader, Thomas Mathew, Cecilia Brassett, András Dávid Nagy, Ana Hladnik

{"title":"Balancing tradition and innovation: rethinking the dichotomy in anatomy teaching.","authors":"Marina Čavka, Zdravko Petanjek, Maura Zanze Beader, Thomas Mathew, Cecilia Brassett, András Dávid Nagy, Ana Hladnik","doi":"","DOIUrl":"","url":null,"abstract":"Medical education has undergone a significant reform in response to evolving health care demands, technological advancements, and emerging research in biomedical and education sciences. The teaching methods in anatomy, a core component of medical education, have notably changed, with traditional cadaveric dissection being increasingly replaced by digital and hybrid alternatives. Despite research indicating no significant difference in short-term knowledge retention between students who engaged in cadaveric dissection and those engaging in alternative methods, dissection uniquely fosters professionalism, empathy, and ethical awareness - traits essential for holistic medical education. This review critically examines the dichotomy between traditional and innovative teaching methods in anatomy education, questioning the assumption that traditional methods hinder progress in modern health care. The findings suggest that changes in medical education are primarily influenced by organizational issues, which frequently results in an incomplete implementation of innovative teaching approaches. The inconsistent application of innovative teaching methods makes it difficult to assess their effectiveness and compare them with traditional methods. Reliable data on their long-term impact can only be generated by randomized controlled trials and longitudinal studies. In the meantime, we need to ensure that current medical students receive high-quality education by incorporating best practices from diverse teaching methods based on valuable insights from experienced educators and current students' learning preferences.","PeriodicalId":10796,"journal":{"name":"Croatian Medical Journal","volume":"66 1","pages":"62-70"},"PeriodicalIF":1.5,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11947982/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chiari malformation type 1 with combined nuclear PAX1 and DKK1 genes and mitochondrial D-loop variants: a case report. 合并核PAX1和DKK1基因和线粒体D-loop变异的1型Chiari畸形1例报告

IF 1.5 4区医学

Croatian Medical Journal Pub Date : 2025-02-28

Siti Nornazihah Mohd Rosdi, Suzuanhafizan Omar, Mazira Mohamad Ghazali, Ab Rahman Izaini Ghani, Abdul Aziz Mohamed Yusoff

{"title":"Chiari malformation type 1 with combined nuclear PAX1 and DKK1 genes and mitochondrial D-loop variants: a case report.","authors":"Siti Nornazihah Mohd Rosdi, Suzuanhafizan Omar, Mazira Mohamad Ghazali, Ab Rahman Izaini Ghani, Abdul Aziz Mohamed Yusoff","doi":"","DOIUrl":"","url":null,"abstract":"Chiari malformation type 1 (CM 1) is a rare and complex neurological condition. This congenital condition affects the lower posterior fossa, where the brain connects to the spinal cord. Although the exact cause of CM 1 remains unclear, genetic predisposition plays a considerable role in structural defects of the cerebellum. Here, we report on a 15-year-old female patient with CM 1 who exhibited both nuclear and mitochondrial genetic variants, a combination that has not been previously described. We identified a silent mutation in exon 2 (c. 556 G>A, p. Lys185=) of PAX1 and a DKK1 variant in intron 3 (548-3 t>C) in the nuclear DNA. We also screened the D-loop region of mitochondrial DNA as it exhibits a higher susceptibility to mutations than other mitochondrial DNA regions. Several hotspot variants were revealed, including those in positions 303-309 and 16519 (t>C), as well as some variants that had not been documented in MITOMAP. Our findings highlight the potential role of genetic alterations in D-loop in CM 1.","PeriodicalId":10796,"journal":{"name":"Croatian Medical Journal","volume":"66 1","pages":"56-61"},"PeriodicalIF":1.5,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11947974/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patients prefer human psychiatrists over chatbots: a cross-sectional study. 病人更喜欢人类精神病医生而不是聊天机器人：一项横断面研究。

IF 1.5 4区医学

Croatian Medical Journal Pub Date : 2025-02-28

Goran Arbanas, Ante Periša, Ivan Biliškov, Jelena Sušac, Mirela Badurina, Dahna Arbanas

{"title":"Patients prefer human psychiatrists over chatbots: a cross-sectional study.","authors":"Goran Arbanas, Ante Periša, Ivan Biliškov, Jelena Sušac, Mirela Badurina, Dahna Arbanas","doi":"","DOIUrl":"","url":null,"abstract":"Aim: To rate the level of patients' satisfaction with responses on questions regarding mental health provided by human psychiatrists, pharmacists, and chatbot platforms.Methods: This cross-sectional study enrolled 89 patients who were pharmacologically treated for their mental disorder in one institution in Croatia and one in Bosnia and Herzegovina during October 2023. They asked psychiatrists, pharmacists, ChatGPT, and one Croatian chatbot questions about their mental disorder and medications and rated the satisfaction with the responses.Results: Almost half of the patients had used ChatGPT before the study, and only 12.4% had used the Croatian platform. The patients were most satisfied with the information provided by psychiatrists (4.67 out of 5 about mental disorder and 4.51 about medications), followed by pharmacists (3.94 about medications), ChatGPT (3.66 about mental disorder and 3.45 about medications), and the Croatian platform (3.66 about mental disorder and 3.44 about medications). Almost half of the participants believed it was easier for them to put a question to a psychiatrist than to a chatbot, and only 10% claimed it was easier to ask ChatGPT.Conclusion: Patients with mental health disorders were more satisfied with responses from their psychiatrists than from chatbots, and satisfaction with chatbots' knowledge on mental disorders and medications was still too low to justify their usage in these patients.","PeriodicalId":10796,"journal":{"name":"Croatian Medical Journal","volume":"66 1","pages":"13-19"},"PeriodicalIF":1.5,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11947973/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0