Croatian Medical Journal最新文献_第8页

Planning care for nursing-home residents: cognitive impairment, functional independence, and accommodation services in nursing homes in the city of Zagreb. 养老院居民的护理规划：萨格勒布市养老院的认知障碍、功能独立和住宿服务。

IF 2.3 4区医学

Croatian Medical Journal Pub Date : 2025-08-31

Nada Tomasović Mrčela, Zrinka Mach, Marija Kušan Jukić, Marija Penava Šimac, Branko Kolarić

{"title":"Planning care for nursing-home residents: cognitive impairment, functional independence, and accommodation services in nursing homes in the city of Zagreb.","authors":"Nada Tomasović Mrčela, Zrinka Mach, Marija Kušan Jukić, Marija Penava Šimac, Branko Kolarić","doi":"","DOIUrl":"","url":null,"abstract":"Aim: To assess whether the Mini-Mental State Examination, second edition (MMSE-2), scores were associated with the category of functional independence of nursing-home residents and the level of accommodation services they received.Methods: This cross-sectional study enrolled 248 participants older than 65 residing in five county-owned nursing homes in the city of Zagreb from 2017 to 2019. Cognitive status was assessed with the standard version of the MMSE-2, and the level of functional independence with the modified Barthel scale index. We collected data on demographic, clinical, and social characteristics, including the level of accommodation services (I-III).Results: MMSE scores were associated with the category of functional independence (χ2=21.11; P<0.001) and the level of accommodation services provided to nursing-home residents (χ2=38.87; P<0.001).Conclusion: Cognitive impairment should be determined in nursing-home residents to facilitate the planning of long-term institutional care and the implementation of the prescribed standards based on the level of accommodation services.","PeriodicalId":10796,"journal":{"name":"Croatian Medical Journal","volume":"66 4","pages":"265-272"},"PeriodicalIF":2.3,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12424191/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145014087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multimodal treatment approach with sunitinib, pembrolizumab, bevacizumab, sirolimus, and zoledronic acid for locally advanced clear cell renal cell carcinoma: a case report. 舒尼替尼、派姆单抗、贝伐单抗、西罗莫司和唑来膦酸联合治疗局部晚期透明细胞肾细胞癌1例

IF 2.3 4区医学

Croatian Medical Journal Pub Date : 2025-08-31

Mahdi Mehrabi, Mohammadreza Eslami, Mehrdad Payandeh

{"title":"Multimodal treatment approach with sunitinib, pembrolizumab, bevacizumab, sirolimus, and zoledronic acid for locally advanced clear cell renal cell carcinoma: a case report.","authors":"Mahdi Mehrabi, Mohammadreza Eslami, Mehrdad Payandeh","doi":"","DOIUrl":"","url":null,"abstract":"Locally advanced renal cell carcinoma (RCC) presents significant therapeutic challenges, particularly in resource-limited settings with restricted access to new therapies. This report describes a new exploratory multimodal therapeutic approach for a patient with locally advanced clear cell RCC (ccRCC) with adrenal and lymph node metastases. A 45-year-old woman presented with an incidentally discovered 9-cm mass in the left kidney, which was later diagnosed as grade-2 ccRCC with adrenal and lymph node involvement. After radical nephrectomy, a multimodal treatment regimen consisting of sunitinib, pembrolizumab, bevacizumab, sirolimus, and zoledronic acid was initiated. Following eight cycles of treatment, computed tomography imaging and ultrasound showed considerable tumor shrinkage, with residual mass decreasing from 22 × 42 mm to 22 × 18 mm, which constituted a \"radiologically complete response.\" The patient had compensatory hypertrophy of the contralateral kidney with preserved renal function. This case illustrates the potential efficacy of a novel multimodal treatment strategy combining targeted therapies, immunotherapy, and bone-modifying agents in a resource-limited setting. Further research is needed to validate this approach in larger, diverse patient cohorts.","PeriodicalId":10796,"journal":{"name":"Croatian Medical Journal","volume":"66 4","pages":"299-304"},"PeriodicalIF":2.3,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12424197/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145014079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does the effectiveness of neuraxial morphine administration vary across different patient populations, dosing strategies, and delivery techniques? 神经轴向吗啡给药的有效性是否因不同的患者群体、给药策略和给药技术而异？

IF 1.5 4区医学