Croatian Medical Journal最新文献_第7页

Adherence to denosumab therapy and fracture risk associated with drug withdrawal: a retrospective study. 依从地诺单抗治疗与停药相关的骨折风险：一项回顾性研究。

IF 2.3 4区医学

Croatian Medical Journal Pub Date : 2025-10-31

Hande Özdemir, Nur Kakilli, Filiz Tuna, Buket Yılmaz Bülbül, Mehmet Çelik, Selçuk Korkmaz, Derya Demirbağ Kabayel

{"title":"Adherence to denosumab therapy and fracture risk associated with drug withdrawal: a retrospective study.","authors":"Hande Özdemir, Nur Kakilli, Filiz Tuna, Buket Yılmaz Bülbül, Mehmet Çelik, Selçuk Korkmaz, Derya Demirbağ Kabayel","doi":"","DOIUrl":"","url":null,"abstract":"Aim: To assess the prevalence of fragility fractures after denosumab discontinuation and to identify the factors affecting treatment adherence.Methods: We retrospectively reviewed the medical records of 3876 osteoporosis patients who were treated with denosumab at Trakya University Osteoporosis Clinic between 2015 and 2021. A total of 210 patients who received at least two regular doses of denosumab were eligible for inclusion. Patients were categorized as denosumab-adherent and denosumab-non-adherent. Adherence was defined as receiving the six-month scheduled dose with a maximum delay of up to eight weeks.Results: Overall, 124 (59.05%) patients were denosumab-adherent and 86 patients (40.95%) were denosumab-non-adherent. New fragility fractures were identified in 32 patients: 17 in the denosumab-adherent group and 15 in the denosumab-non-adherent group. The groups did not significantly differ in the risk or types of new fractures, irrespective of patients' fracture history.Conclusions: Our findings suggest that some fractures after denosumab discontinuation may stem from the natural progression of osteoporosis rather than from the rebound effect. Still, unscheduled treatment discontinuation should be prevented.","PeriodicalId":10796,"journal":{"name":"Croatian Medical Journal","volume":"66 5","pages":"334-344"},"PeriodicalIF":2.3,"publicationDate":"2025-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12623255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145457645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mortality of female and male Croatian Olympic athletes: a 1948-2016 cohort study. 克罗地亚奥运会男女运动员死亡率：1948-2016年队列研究

IF 2.3 4区医学

Croatian Medical Journal Pub Date : 2025-10-31

Vedran Radonić, Mario Šekerija, Marijan Erceg, Ivana Jurin, Irzal Hadžibegović, Miran Martinac, Tomislav Letilović

{"title":"Mortality of female and male Croatian Olympic athletes: a 1948-2016 cohort study.","authors":"Vedran Radonić, Mario Šekerija, Marijan Erceg, Ivana Jurin, Irzal Hadžibegović, Miran Martinac, Tomislav Letilović","doi":"","DOIUrl":"","url":null,"abstract":"Aim: To compare the overall mortality of Croatian male and female Olympic athletes who represented Yugoslavia or Croatia in the Olympic Games from 1948 to 2016 with the mortality of the general Croatian population standardized by age, sex, and time period.Methods: Overall mortality analysis included 652 male and 158 female Olympians. The cause-specific analysis included 642 male Olympians; due to the small sample size, this analysis was not possible for female Olympians. Information on causes of death was obtained from specialized registers of countries where deaths occurred, if available. Alternatively, data were obtained by interviews with families or acquaintances of the deceased, based on the World Health Organization verbal autopsy principles. Croatian general population mortality data were obtained from the Croatian Bureau of Statistics and World Health Organization's databases. Overall and disease-specific standardized mortality ratios (SMR) were calculated.Results: At the endpoint of the study, 2 female and 142 male Olympians had died. Overall mortality was lower for women (SMR 0.23; P=0.013) and men (SMR 0.56; P<0.001) compared with the general population. Male Olympians had significantly reduced mortality from cardiovascular (SMR 0.51; P<0.001), neoplastic (SMR 0.55; P<0.001), respiratory (SMR 0.24; P=0.003), and digestive (SMR 0.42; P=0.015) causes of death.Conclusions: Croatian male and female Olympians experience reduced overall mortality compared with the Croatian general population. Croatian male Olympians have reduced cardiovascular, neoplastic, digestive, and respiratory mortalities compared with the Croatian general population.","PeriodicalId":10796,"journal":{"name":"Croatian Medical Journal","volume":"66 5","pages":"309-320"},"PeriodicalIF":2.3,"publicationDate":"2025-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12623252/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145457649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and impact of workplace violence against healthcare workers in Bosnia and Herzegovina. 在波斯尼亚和黑塞哥维那，针对保健工作者的工作场所暴力的普遍程度和影响。

IF 2.3 4区医学

Croatian Medical Journal Pub Date : 2025-10-31

Vedad Herenda, Elvedina Žiga, Dženana Hrlović

引用次数: 0

The efficacy of a hunger-induced two-week tube-weaning program: a retrospective study. 一项回顾性研究：饥饿诱导的两周管断程序的效果。

IF 2.3 4区医学

Croatian Medical Journal Pub Date : 2025-08-31

Maria Elena Papagni, Sara Sila, Tena Niseteo, Tihana Koren, Ivana Bukovina, Mara Vukadin Petković, Zrinjka Mišak, Ana Močić Pavić, Sanja Kolaček, Iva Hojsak

{"title":"The efficacy of a hunger-induced two-week tube-weaning program: a retrospective study.","authors":"Maria Elena Papagni, Sara Sila, Tena Niseteo, Tihana Koren, Ivana Bukovina, Mara Vukadin Petković, Zrinjka Mišak, Ana Močić Pavić, Sanja Kolaček, Iva Hojsak","doi":"","DOIUrl":"","url":null,"abstract":"Aim: To assess the efficacy of a multidisciplinary tube-weaning program.Methods: This retrospective cohort study enrolled children with feeding tube dependency who had not responded to standard tube-weaning interventions. All participants underwent a structured two-week multidisciplinary tube weaning delivered in a day-hospital setting at the Children's Hospital Zagreb in the period from August 2016 to February 2023. The program was based on a hunger-induction approach and combined with mealtime therapy, sensory integration therapy, parental group therapy and individual support, nutritional counseling, and a workshop for parents. The outcomes were evaluated at the beginning of the program, the end of the program, 3-6 months after the program, and at the last follow-up.Results: The study enrolled 30 patients (mean age 2.6±1.9 years; 60.0% girls). All patients had complex medical conditions and were tube-dependent for a mean of 29±22 months. The majority (70.0%) had a psychomotor delay. At the end of the program, 27 (90.0%) patients showed improved oral intake, and 10 (33.3%) were completely weaned off tube feeding. During follow-up (mean 40.5 months, n=24 children), 18 children (78.0%) were weaned off tube feeding.Conclusions: A two-week program effectively improved oral intake and resulted in a high success rate for tube weaning in the long term.","PeriodicalId":10796,"journal":{"name":"Croatian Medical Journal","volume":"66 4","pages":"282-288"},"PeriodicalIF":2.3,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12426866/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145014109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An optimal position for elbow arthrodesis to accommodate modern daily living activities. 肘关节融合术的最佳位置，以适应现代日常生活活动。

IF 2.3 4区医学

Croatian Medical Journal Pub Date : 2025-08-31

Ivo Buhač, Damjan Dimnjaković, Igor Knežević, Ivan Bojanić

{"title":"An optimal position for elbow arthrodesis to accommodate modern daily living activities.","authors":"Ivo Buhač, Damjan Dimnjaković, Igor Knežević, Ivan Bojanić","doi":"","DOIUrl":"","url":null,"abstract":"Aim: To assess the optimal fusion angle of the elbow to accommodate the activities of daily living.Methods: The study enrolled 30 healthy adult volunteers (mean age 24 years), who performed 29 activities with an elbow brace fixed at various flexion angles (30°, 50°, 70°, 90°, 110°, 120°). The activities were divided into three groups: the activities of daily living, personal care and hygiene, and modern activities of daily living. Activity performance was scored on a scale previously designed to assess the difficulty of performing a particular activity. Results, The highest overall score for all activities was at 90° elbow flexion (79.70±4.11), followed by 110° (76.17±4.01) and 70° (75.43±6.64). For modern activities of daily living, the highest score (43.77±1.33) was also at 90°. The 90° angle also allowed the highest percentage (86.6%) of task completion in all activity groups. Conclusion, Our study supports making elbow arthrodesis at 90° of flexion, which may also be applied to modern daily living activities. However, patients should be consulted about the preferred angle for elbow arthrodesis, as no single fusion angle allows for the performance of all modern daily living activities.","PeriodicalId":10796,"journal":{"name":"Croatian Medical Journal","volume":"66 4","pages":"273-281"},"PeriodicalIF":2.3,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12424214/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145014096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-medication practices and the content of home pharmacies in the households of pharmacy and medical students in Zagreb, Croatia, in 2022 with a reference to the findings from 2001 and 1977. 2022年克罗地亚萨格勒布药房和医科学生家庭的自我药疗做法和家庭药房的内容，并参考2001年和1977年的调查结果。

IF 2.3 4区医学

Croatian Medical Journal Pub Date : 2025-08-31

Vedrana Aljinović-Vučić, Ana-Marija Vargantolić, Davor Virag, Marin Vučić, Zdravko Lacković, Vladimir Trkulja

{"title":"Self-medication practices and the content of home pharmacies in the households of pharmacy and medical students in Zagreb, Croatia, in 2022 with a reference to the findings from 2001 and 1977.","authors":"Vedrana Aljinović-Vučić, Ana-Marija Vargantolić, Davor Virag, Marin Vučić, Zdravko Lacković, Vladimir Trkulja","doi":"","DOIUrl":"","url":null,"abstract":"Aim: To inventory the content of home pharmacies and evaluate drug keeping and self-medication practices in the households of medical and pharmacy students at Zagreb University in 2022, and to relate the findings to two previous surveys.Methods: A cross-sectional survey enrolled 178 students who inventoried drug supplies in their family households, and interviewed household members on drug keeping and self-medication practices. Previous surveys included 287 (in 2001) and 225 (in 1977) students/households.Results: In most households, medicines were kept at a designated place (around 65%, all surveys) but commonly contained products past the expiry dates or of unknown purpose (59% vs 27%-32% previously). Analgesics-antipyretics were kept in practically all households (93%-97% across all surveys), followed by cough-cold relief products (55% vs 30%-33% households) and anti-allergic drugs (systemic) (44% vs 25% households). These drug classes were commonly used for self-medication (all surveys). Of the typical prescription drugs, the most common were benzodiazepines (34% vs 24% previously), which were at least occasionally used for self-medication in 40% of such households. Systemic antibiotics were found in 17% of the households (vs 40%-46% previously), and the tendency of self-medication was less common (20% vs around 40% of the households).Conclusions: The patterns observed in households with expected above-average drug literacy and access (future health care professionals, health care professionals common among household members) in three surveys completed across 50 years were discrepant with \"responsible self-medication\" (drug handling, storage, usage). As such, they emphasize a general need for improved awareness about this topic.","PeriodicalId":10796,"journal":{"name":"Croatian Medical Journal","volume":"66 4","pages":"247-255"},"PeriodicalIF":2.3,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12424192/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145014119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The promises and perils of artificial intelligence in clinical medicine: a dual perspective from internal medicine and pediatrics. 人工智能在临床医学中的前景和危险：从内科和儿科的双重视角。

IF 2.3 4区医学

Croatian Medical Journal Pub Date : 2025-08-31

Lovro Lamot, Robert Likić

引用次数: 0

The effect of cooled endotracheal tubes on postoperative sore throat: a randomized controlled study. 冷却气管内管对术后喉咙痛的影响：一项随机对照研究。

IF 2.3 4区医学

Croatian Medical Journal Pub Date : 2025-08-31

Sibel Çatalca, Özlem Özmete, Oya Yalçın Çok, Caner İncekaş, Nesrin Bozdoğan Özyılkan

{"title":"The effect of cooled endotracheal tubes on postoperative sore throat: a randomized controlled study.","authors":"Sibel Çatalca, Özlem Özmete, Oya Yalçın Çok, Caner İncekaş, Nesrin Bozdoğan Özyılkan","doi":"","DOIUrl":"","url":null,"abstract":"Aim: To evaluate the effect of cooled endotracheal tubes on the incidence of postoperative sore throat, hoarseness, coughing, and dysphagia after endotracheal intubation.Methods: This randomized controlled trial enrolled patients undergoing elective surgery under general anesthesia with endotracheal intubation at Adana Dr Turgut Noyan Hospital between April and September 2023. The patients were randomly assigned to be intubated with endotracheal tubes refrigerated at +4 °C for 4-6 hours before intubation (n=66) or with endotracheal tubes kept at the operating room temperature (+20-23 °C) (n=70). The incidence of sore throat, hoarseness, coughing, and dysphagia was recorded at 1, 4, 12, and 24 hours postoperatively.Results: The groups did not significantly differ in the incidence of sore throat, hoarseness, and coughing at 1 hour and 24 hours. They also did not differ in the incidence of dysphagia at 24 hours.Conclusion: Cooled endotracheal tubes are not superior to tubes kept at operating room temperature in reducing postoperative sore throat, hoarseness, coughing, or dysphagia.","PeriodicalId":10796,"journal":{"name":"Croatian Medical Journal","volume":"66 4","pages":"256-264"},"PeriodicalIF":2.3,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12424190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145014054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breast lump as the initial presentation of metastatic uterine leiomyosarcoma. 乳房肿块为转移性子宫平滑肌肉瘤的初始表现。

IF 2.3 4区医学

Croatian Medical Journal Pub Date : 2025-08-31

Ilker Sengul, Demet Sengul

引用次数: 0

The effect of sleep-oriented non-pharmacological interventions in preventing delirium: a systematic review of randomized controlled trials. 以睡眠为导向的非药物干预在预防谵妄中的作用：随机对照试验的系统回顾。

IF 2.3 4区医学

Croatian Medical Journal Pub Date : 2025-08-31

Ezgi Mutluay Yayla, Emine Kaplan Serin

{"title":"The effect of sleep-oriented non-pharmacological interventions in preventing delirium: a systematic review of randomized controlled trials.","authors":"Ezgi Mutluay Yayla, Emine Kaplan Serin","doi":"","DOIUrl":"","url":null,"abstract":"Aim: To systematically review randomized controlled trials evaluating the efficacy of sleep-oriented non-pharmacological interventions for delirium prevention in intensive care units.Methods: We searched PubMed, Web of Science, Scopus, and the Cochrane Library for randomized controlled trials evaluating the efficacy of sleep-oriented, non-pharmacological interventions for delirium prevention in intensive care units published in English between 2019 and 2024. The methodological quality of the included studies was independently evaluated by two researchers using the Joanna Briggs Institute tool.Results: This review included eight randomized controlled trials (n = 649). Six studies assessed the effect of earplugs and masks on delirium prevention in intensive care patients. Three studies indicated that earplugs and eye masks effectively prevented delirium, while three studies found no effect. One study assessed the use of earplugs and masks as part of a bundle of interventions and reported a positive effect. Four studies showed an effect on sleep. None of the sleep-oriented non-pharmacological interventions assessed in these studies reported any harmful effects.Conclusion: Although several high-quality studies showed that these interventions significantly lowered delirium incidence, some trials found no effect, highlighting variability in outcomes.","PeriodicalId":10796,"journal":{"name":"Croatian Medical Journal","volume":"66 4","pages":"289-298"},"PeriodicalIF":2.3,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12426865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145014063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0