Current Developments in Nutrition最新文献

{"title":"Combination Therapy with Pyridoxine and Arginine Supplementations along with a Lysine-Restricted Diet in Individuals with Pyridoxine-Dependent Epilepsy: A Comprehensive Systematic Review","authors":"Ali Jafari ,&nbsp;Mohammad Mehdi Abbasi ,&nbsp;Hamid Abbasi ,&nbsp;Sama Rahnemayan ,&nbsp;Farnush Bakhshimoghaddam ,&nbsp;Saeid Doaei","doi":"10.1016/j.cdnut.2025.107504","DOIUrl":"10.1016/j.cdnut.2025.107504","url":null,"abstract":"<div><h3>Background</h3><div>Pyridoxine-dependent epilepsy (PDE) is identified as a rare neurometabolic disease marked by biallelic pathogenic mutations of the ALDH7A1 gene. A combination therapy involving pyridoxine, arginine supplementation (AS), and a lysine-restricted diet (LRD) was frequently reported to effectively improve PDE through reducing neurotoxic lysine metabolites, improving seizure management, and enhancing neurodevelopmental outcomes.</div></div><div><h3>Objectives</h3><div>The study sought to investigate the effects of mono-(pyridoxine), dual- (pyridoxine combined with AS or LRD), and triple-therapy approaches in individuals diagnosed with PDE.</div></div><div><h3>Methods</h3><div>An extensive search was carried out across international databases, comprising Scopus, Embase, Web of Science, PubMed, and Google Scholar, to find relevant publications published before 12 November, 2024. The methodological quality assessment of chosen articles was evaluated utilizing the Newcastle-Ottawa Scale and the Joanna Briggs Institute tool.</div></div><div><h3>Results</h3><div>Among 2097 studies reviewed, 38 met inclusion criteria, covering treatment methods for individuals with PDE including monotherapy (22 articles), dual therapy (9 articles), and triple therapy (7 articles). The results indicated that pyridoxine monotherapy is a highly effective first-line treatment in PDE that improves seizure control with minimal cognitive decline. Combining pyridoxine with an LRD or AS targets metabolic issues, reducing neurotoxic metabolites and enhancing cognitive and motor functions. Early triple therapy, within the first 6 months of life, exhibited significant benefits for seizure management and cognitive performance in patients with PDE.</div></div><div><h3>Conclusions</h3><div>In summary, administration of pyridoxine is highly effective, particularly when combined with AS and an LRD. Triple therapy illustrates promise for improved seizure control and cognitive function, especially when initiated early. Further research is warranted.</div></div>","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"9 8","pages":"Article 107504"},"PeriodicalIF":3.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144749746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “The Dietary Biomarkers Development Consortium: An Initiative for Discovery and Validation of Dietary Biomarkers for Precision Nutrition. [Current Developments in Nutrition, Volume 9, Issue 5, May 2025, 107435]”","authors":"Hrishikesh Chakraborty ,&nbsp;Qi Sun ,&nbsp;Shilpa N Bhupathiraju ,&nbsp;Jeannette M Schenk ,&nbsp;Darya O Mishchuk ,&nbsp;James R Bain ,&nbsp;Xuan He ,&nbsp;Jianghao Sun ,&nbsp;James Harnly ,&nbsp;William Simmons ,&nbsp;Daniel Raftery ,&nbsp;Liming Liang ,&nbsp;John W Newman ,&nbsp;Oliver Fiehn ,&nbsp;Clary B Clish ,&nbsp;Johanna W Lampe ,&nbsp;Brian J Bennett ,&nbsp;Sandi L Navarro ,&nbsp;Ying Wang ,&nbsp;Cheng Zheng ,&nbsp;Padma Maruvada","doi":"10.1016/j.cdnut.2025.107517","DOIUrl":"10.1016/j.cdnut.2025.107517","url":null,"abstract":"","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"9 8","pages":"Article 107517"},"PeriodicalIF":3.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144886951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeted Urinary Profiling as a Biomarker of Dietary Flavonoid Intake from Fruits and Vegetables and its Relationship to the Timing of Dietary Assessment","authors":"Emily B Hill ,&nbsp;Anna Pashkova ,&nbsp;Elizabeth M Grainger ,&nbsp;Kristen M Roberts ,&nbsp;Chureeporn Chitchumroonchokchai ,&nbsp;Ashlea C Braun ,&nbsp;Robin A Ralston ,&nbsp;Ken M Riedl ,&nbsp;Colleen K Spees ,&nbsp;Steven K Clinton","doi":"10.1016/j.cdnut.2025.107520","DOIUrl":"10.1016/j.cdnut.2025.107520","url":null,"abstract":"<div><h3>Background</h3><div>Dietary intake of flavonoids, a class of plant (poly)phenols, is hypothesized to mediate a variety of beneficial health outcomes linked to fruits and vegetables (FV) intake. Absorbed flavonoids are metabolized and excreted in urine and may serve as biomarkers of FV intake and host metabolism, but defining the relationship of urinary biomarkers to the specific time of intake is unclear.</div></div><div><h3>Objectives</h3><div>To characterize a targeted panel of 6 urinary flavonoids and determine the relationship to estimated dietary flavonoid intake over time in adults.</div></div><div><h3>Methods</h3><div>Dietary flavonoid intake was estimated from both a 30-d food frequency questionnaire and 3-d diet records using the Phenol-Explorer database in 17 adults. Twenty-four-hour urine was collected, and a targeted panel of 6 urinary flavonoids (quercetin, phloretin, naringenin, hesperetin, kaempferol, and isorhamnetin) was quantified using high-pressure liquid chromatography-diode array detection (DAD).</div></div><div><h3>Results</h3><div>Compared to estimated intakes from a 1 d or 3 d diet record, total urinary flavonoids were most strongly associated with total FV (excluding potatoes) (r_s = 0.53, <em>P</em> = 0.028) and total FV flavonoid (r_s = 0.60, <em>P</em> = 0.011) intakes estimated by a 2 d diet record (including the day before and the day of the 24-h urine collection). There were no significant correlations between urinary concentrations of flavonoids and estimated FV intake using a 30-d food frequency questionnaire (r_s = 0.36, <em>P</em> = 0.16).</div></div><div><h3>Conclusions</h3><div>Targeted flavonoid concentrations in a 24-h urine collection may serve as a biomarker for estimating dietary exposures over 2 d prior to completion of the urine collection, but not more distant dietary exposures.</div><div>This trial was registered at <span><span>clinicaltrials.gov</span><svg><path></path></svg></span> as NCT03489213.</div></div>","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"9 9","pages":"Article 107520"},"PeriodicalIF":3.2,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144889501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social Interactions for Sustainable Food Choices: Meeting the Target for Meat Intake in the United Kingdom","authors":"Angela Fontan ,&nbsp;Rosemary Green ,&nbsp;Karl H Johansson ,&nbsp;Patricia Eustachio Colombo","doi":"10.1016/j.cdnut.2025.107509","DOIUrl":"10.1016/j.cdnut.2025.107509","url":null,"abstract":"<div><h3>Background</h3><div>Substantial shifts in contemporary diets are needed to halt the growing burden of chronic diseases and the accelerating climate crisis. Achieving this will require strong action and the use of policy instruments that can aid consumers in making the right dietary choices. Real-life evidence on changing dietary behaviors within complex food systems at scale demands resources and research that might not be realistic to acquire or realize.</div></div><div><h3>Objectives</h3><div>This project applied innovative models to predict the dietary and environmental effects of broad-scale strategies designed to transform dietary behaviors among consumers. Scenarios were numerically simulated using agent-based opinion-dynamics models to evaluate the impact of governmental influence on people’s consumption of meat, vegetables, pulses, and meat alternatives.</div></div><div><h3>Methods</h3><div>We considered the problem of influencing the opinions of a group of agents (representing the UK population) connected in a social network over a sequence of campaigns to achieve convergence to 2 different targets: achieving the UK Climate Change Committee’s goal of 35% and 50% average reduction in meat consumption by 2030 and 2050, respectively. The opinion dynamics comprised consumers (i.e., agents), with empirically derived baseline food intake patterns (i.e., initial opinions) and sociodemographic attributes. Changes in environmental impacts following changes in consumption were quantified.</div></div><div><h3>Results</h3><div>In a scenario of high governmental influence, uniform in the population, achievement of the 35% and 50% meat reduction goals corresponded to ∼5.2 and ∼8.1 y, respectively. As meat consumption reduced, intake of vegetables, pulses, and meat alternatives increased by 84.7%, 108.5%, and 30.8%, respectively (−35% scenario). Greenhouse gas emissions, land use, water use, and scarcity-weighted water were reduced by −23.8%, −20.2%, −0.5%, and −14.5%, respectively (−35% scenario).</div></div><div><h3>Conclusions</h3><div>The findings of this project provide valuable insights for policymakers and governmental authorities to develop effective influence strategies aimed at promoting healthy and sustainable dietary habits.</div></div>","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"9 9","pages":"Article 107509"},"PeriodicalIF":3.2,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144887331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enteral High-Dose Docosahexaenoic Acid and Neurodevelopment in Extremely Preterm Infants: A Systematic Review and Meta-analysis","authors":"Emily Shepherd ,&nbsp;Naho Ikeda ,&nbsp;Thomas R. Sullivan ,&nbsp;Isabelle Marc ,&nbsp;Mireille Guillot ,&nbsp;Andrew J McPhee ,&nbsp;Robert A Gibson ,&nbsp;Maria Makrides ,&nbsp;Jacqueline F Gould","doi":"10.1016/j.cdnut.2025.107510","DOIUrl":"10.1016/j.cdnut.2025.107510","url":null,"abstract":"<div><h3>Background</h3><div>Enteral high-dose docosahexaenoic acid (DHA) may be required for neurodevelopment, including cognition, of extremely preterm infants. High-level summative evidence is lacking.</div></div><div><h3>Objectives</h3><div>This study aims to examine associations between enteral high-dose DHA during the neonatal period and neurodevelopment in infants born ≤29 wk of gestation.</div></div><div><h3>Methods</h3><div>The following databases were searched (from inception to 11 April, 2024): CINAHL, Cochrane Library, Embase, Medline, Scopus, and Web of Science. Eligible randomized controlled trials (RCTs) in infants born ≤29 wk, assessing direct enteral administration ≥ 40 mg/kg/d DHA, or breast milk/formula with DHA ≥ 0.60% total fatty acids, reporting neurodevelopmental outcomes. Two reviewers independently screened articles, extracted data, and assessed quality using the Cochrane Handbook guidance. Data were pooled using fixed or random-effect meta-analyses. The primary outcome was global cognitive scores from a standardized test.</div></div><div><h3>Results</h3><div>We screened 1978 articles and included 3 high-quality RCTs (2028 infants born ≤29 wk). Enteral high-dose DHA was not associated with overall differences in global cognition scores at a corrected age (CA) of 18–36 mo [3 RCTs, 638 children, mean difference (MD) 0.67; 95% confidence interval (CI): –1.80, 3.15; <em>P</em> = 0.59; <em>I</em>² = 0%] or CA of 5–7 y (2 RCTs, 852 children; MD: 2.22; 95% CI: –0.14, 4.57; <em>P</em> = 0.06; <em>I</em>² = 33%); however, benefit was observed in the largest RCT with a direct enteral emulsion (656 children, CA of 5 y, MD 3.45; 95% CI: 0.38, 6.52; <em>P</em> = 0.03). Associations with most secondary outcomes were not seen; however, high-dose DHA was associated with reduced mild motor (3 RCTs, CA of 18–36 mo) and cognitive (2 RCTs, CA of 5–7 y) impairment. No negative impacts were observed.</div></div><div><h3>Conclusions</h3><div>Enteral high-dose DHA in extremely preterm infants was not associated with differences in global cognition scores on meta-analysis; however, higher scores were observed with the use of a direct emulsion. Results support contemporary recommendations.</div><div>This trial was registered at PROSPERO as CRD42022382744 (<span><span>https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022382744</span><svg><path></path></svg></span>).</div></div>","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"9 9","pages":"Article 107510"},"PeriodicalIF":3.2,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144863755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Low-Lactose, High Galacto-Oligosaccharides Milk on Gut Microbiome and Plasma Metabolome in Healthy Adults: A Randomized, Double-Blind, Controlled Clinical Trial Complemented by Ex Vivo Experiments","authors":"Léa Siegwald ,&nbsp;Anna Cherta-Murillo ,&nbsp;Stefan Christen ,&nbsp;Claire L Boulangé ,&nbsp;Chieh J Chou ,&nbsp;Francis Foata ,&nbsp;Anirban Lahiry ,&nbsp;Adrien Frézal ,&nbsp;Maria Pilar Giner ,&nbsp;Jean-Philippe Godin ,&nbsp;Olga Sakwinska","doi":"10.1016/j.cdnut.2025.107506","DOIUrl":"10.1016/j.cdnut.2025.107506","url":null,"abstract":"<div><h3>Background</h3><div>Galacto-oligosaccharides (GOS) intake has been linked to health benefits via modulation of the gut microbiome. Milk, where the majority of lactose is enzymatically converted to GOS (called here Novel or “N milk”), retains milk’s nutritional value with reduced lactose and a high amount of prebiotic GOS.</div></div><div><h3>Objectives</h3><div>The aim of this study was to investigate the effect of N milk on the gut microbiome and related changes in health-related biomarkers, complemented by ex vivo fermentation experiments.</div></div><div><h3>Methods</h3><div>In a 2-arm crossover, double-blind, randomized controlled clinical trial, 26 healthy adults consumed either N milk (containing 9 g GOS and 1.7 g of lactose per serving) or lactose-free milk (control), for 2 wk with a 2-wk washout period. Stool and fasting blood samples were collected at the start and the end of the intervention periods. Gut microbiome was analyzed using shotgun metagenomics, and metabolites using both targeted and untargeted methods. In addition, we tested lactose-free milk, N milk, and GOS in ex vivo colonic fermentation to obtain insights into the bacterial processing of substrates.</div></div><div><h3>Results</h3><div>N milk intake led to a 3-fold increase in median gut bifidobacteria (<em>P</em> &lt; 0.0001) and significant increases in plasma acetate, octanoic acid, β-alanine, and nicotinamide (all <em>P</em> &lt; 0.05). Untargeted plasma metabolomics revealed a shift in amino acid metabolism, with an increase in 3-indole propionate, accompanied by a decrease in 2 uremic toxins, p-cresol sulfate, and indoxyl-sulfate (<em>P</em> &lt; 0.05 without false discovery rate adjustment). Ex vivo fermentation experiments supported the results of the clinical study, whereby N milk increased bifidobacteria accompanied by higher production of short-chain fatty acids and a shift in microbial tryptophan metabolism, and indicated unique effects of N milk compared with GOS.</div></div><div><h3>Conclusions</h3><div>N milk resulted in a significant increase in gut bifidobacteria, along with changes in plasma metabolites previously associated with immune and metabolic health benefits.</div><div>This study was registered at <span><span>clinicaltrials.gov</span><svg><path></path></svg></span> as NCT05207839.</div></div>","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"9 9","pages":"Article 107506"},"PeriodicalIF":3.2,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contrasting Realities in Injury Management: Strategies Employed by Performance Nutritionists and Dietitians in Ireland (Part A)","authors":"Emma Finnegan,&nbsp;Ed Daly,&nbsp;Lisa Ryan","doi":"10.1016/j.cdnut.2025.107507","DOIUrl":"10.1016/j.cdnut.2025.107507","url":null,"abstract":"<div><h3>Background</h3><div>Nutrition underpins athletic performance, enhancing training, reducing injury risk, and accelerating recovery. In the event of an injury, performance dietitians (PDs) and nutritionists’ (PNs) play a vital role by tailoring nutritional strategies to support tissue repair, optimize athlete’s recoveries, and return to play.</div></div><div><h3>Objectives</h3><div>This study explored nutritional strategies recommended and employed by Irish PDs and PNs to assess, manage, and support athletes during the initial stages of sports-related injuries.</div></div><div><h3>Methods</h3><div>Seventeen PDs and PNs across Ireland participated in semistructured interviews. All interviews were transcribed verbatim, and an inductive qualitative content analysis was applied to identify initial codes and extract relevant insights from data.</div></div><div><h3>Results</h3><div>PDs and PNs in Ireland work across various sports and competitive levels. Their capacity to support injured athletes is influenced by contextual factors, particularly the quality of communication and interdisciplinary collaboration within their sporting environments. Participants reported variability in their initial injury assessment and nutrition management practices across sports, organizations, and genders. These inconsistencies influence the implementation of nutrition strategies and impact athletes’ subsequent recovery outcomes. In particular, limited or nonspecific nutritional support was linked slower or less effective recovery.</div></div><div><h3>Conclusions</h3><div>The diversity in nutritional strategies employed by Irish PDs and PNs during the initial stages of injury management highlights the need for standardized, sport- and context-specific protocols to optimize recovery outcomes. Implementing evidence-based guidelines, consistency using structured assessment tools, and enhancing multidisciplinary collaboration may reduce inconsistencies and improve support for injured athletes, particularly in resource-constrained settings. Practitioner-informed strategies such as injury-specific checklists, routine assessments, coordinated care with medical teams, and targeted nutrition education, may enhance athlete buy-in and promote more effective, recovery focused interventions.</div></div>","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"9 9","pages":"Article 107507"},"PeriodicalIF":3.2,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diet Quality and Weight Status are Predicted by Federal Nutrition Assistance Program Participation, Health, and Demographics","authors":"Lauren E Au ,&nbsp;Charles D Arnold ,&nbsp;Christabel Domfe ,&nbsp;Lorrene D Ritchie ,&nbsp;Shannon E Whaley ,&nbsp;Marianne Bitler ,&nbsp;Edward A Frongillo","doi":"10.1016/j.cdnut.2025.107505","DOIUrl":"10.1016/j.cdnut.2025.107505","url":null,"abstract":"<div><h3>Background</h3><div>Programs, such as Medicaid, the Supplemental Nutrition Assistance Program, and the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC), provide access to vital medical and nutrition services. Few studies have investigated whether demographic, social, and economic determinants of health, including length of time spent on these programs, are associated with diet quality and weight status in early childhood.</div></div><div><h3>Objectives</h3><div>Classification and regression tree analysis, a machine learning method, was used to determine health predictors to identify patterns of children with higher compared with lower diet quality and higher compared with lower weight status.</div></div><div><h3>Methods</h3><div>Using the WIC infant and toddler feeding practices study-2 (unweighted <em>N</em> = 3051; weighted <em>N</em> = 413,211), classification and regression tree identified the sequence of binary splits that best differentiated the sample on Healthy Eating Index-2020 (HEI-2020; range 0–100) and HEI-2020 subscales (adequacy and moderation), and body mass index (BMI in kg/m²) <em>z</em>-score at 2–5 y. Predictors, including maternal BMI, child birthweight, sociodemographics, and length of time spent on safety net programs, were considered.</div></div><div><h3>Results</h3><div>Higher HEI-2020 scores were primarily predicted by race and ethnicity (e.g., Hispanic, Spanish, or non-Hispanic White), and longer WIC and shorter Supplemental Nutrition Assistance Program duration. In examining HEI-2020 subscales, higher HEI adequacy was primarily predicted by higher education, older maternal age, longer WIC duration, and race and ethnicity. Higher HEI moderation was primarily predicted by race and ethnicity and longer WIC duration. Higher BMI <em>z</em>-score was primarily predicted by higher birth weight.</div></div><div><h3>Conclusions</h3><div>Child diet quality and weight status were associated with different social determinants of health, which included maternal weight status, race and ethnicity, and food assistance program participation, particularly WIC.</div></div>","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"9 8","pages":"Article 107505"},"PeriodicalIF":3.8,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144712919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Balancing Environmental Sustainability and Nutrition: Dietary Climate Impact in Relation to Micronutrient Intake and Status in a Swedish Cohort.","authors":"Anna Stubbendorff, Ulrika Ericson, Ylva Bengtsson, Yan Borné, Emily Sonestedt, Elinor Hallström","doi":"10.1016/j.cdnut.2025.107501","DOIUrl":"10.1016/j.cdnut.2025.107501","url":null,"abstract":"<p><strong>Background: </strong>Dietary shift is necessary for improving public health, mitigating climate change, and achieving the Sustainable Development Goals. Adaption of climate-friendly diets might prevent chronic diseases and reduce mortality; however, consuming diets with a low climate impact have been suggested to increase risk of some micronutrient deficiencies.</p><p><strong>Objectives: </strong>This study aimed to examine whether self-reported dietary intake varying in climate impact is associated with nutritional risks and benefits based on both dietary intakes and blood concentrations of micronutrients.</p><p><strong>Methods: </strong>In the cross-sectional Malmö Diet and Cancer cohort (MDC, <i>n</i> = 25,970), dietary data were collected using a modified diet history method (food frequency questionnaire, diary, and interview). Blood samples were drawn and analyzed for micronutrients in different subgroups. Life cycle assessment data were used to estimate dietary greenhouse gas emissions (GHGE), from farm to fork. Quintiles of dietary climate impact were examined in relation to nutrient intake and status using linear and logistic regression.</p><p><strong>Results: </strong>The mean estimated dietary GHGE were 5.9 kg of carbon dioxide equivalents per day (females: 5.4, males: 6.6). Participants consuming a more climate-friendly diet had lower proportion of animal-sourced foods, energy intake, and intake of all micronutrients assessed (<i>n</i> = 17). Prevalence of anemia was higher in females consuming more climate-friendly diets, but the rates were low across all climate-diet groups (4.6% in Q1 compared with 3.3% in Q5; <i>P</i>-trend: 0.02), but not in males (<i>P</i>-trend: 0.131). No significant trends were observed in nutrient status of vitamin D, selenium, zinc, and folate across dietary GHGE quintiles.</p><p><strong>Conclusions: </strong>Despite a lower intake of micronutrients, more climate-friendly diets did not substantially increase risk of deficiencies. The study highlights the importance of measuring both nutrient intake and status when discussing nutritional consequences of sustainable eating.</p>","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"9 8","pages":"107501"},"PeriodicalIF":3.2,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12355999/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computationally Modeling the Physiologic Impact of the Ratio of Fats to Carbohydrates in the Diet on Intake Among Metabolically Healthy Adults","authors":"Marie F Martinez ,&nbsp;Jessie Heneghan ,&nbsp;Colleen Weatherwax ,&nbsp;Timothy H Moran ,&nbsp;Britt Burton-Freeman ,&nbsp;Kavya Velmurugan ,&nbsp;José M Ordovás ,&nbsp;Sarah M Bartsch ,&nbsp;Tej D Shah ,&nbsp;Jennifer Lee ,&nbsp;Sarah L Booth ,&nbsp;Samantha Kleinberg ,&nbsp;Kevin L Chin ,&nbsp;Kayla de la Haye ,&nbsp;Alexis Dibbs ,&nbsp;Sheryl A Scannell ,&nbsp;Bruce Y Lee","doi":"10.1016/j.cdnut.2025.107487","DOIUrl":"10.1016/j.cdnut.2025.107487","url":null,"abstract":"<div><h3>Background</h3><div>When it comes to how effectively a diet can help reduce or maintain body weight, a key question is how that diet affects a person’s hunger, satiety, and subsequent eating.</div></div><div><h3>Objectives</h3><div>This study aimed to analyze modeling, from a physiologic perspective, how varying the ratio of fats to carbohydrates in a diet impacts hunger, satiety, and subsequent eating among metabolically healthy adults.</div></div><div><h3>Methods</h3><div>We developed a model representing an adult, their dietary intake, gastrointestinal tract, hunger/satiety levels, and meal consumption. We simulated agents eating fixed ratios of macronutrients and measured their subsequent eating over 24 h driven by physiologic responses.</div></div><div><h3>Results</h3><div>When increasing the proportion of energy from fats relative to carbohydrates, daily calories decrease by on mean 149 and 110 calories per 10% increase in fats for males and females, respectively. Additionally, a simulated diet with a relative ratio of energy from fats:carbohydrates of 20%:80% results in individuals snacking after 21:00 for ∼93% of days in both sexes, whereas a relative fat:carbohydrate ratio of 80%:20% results in late-night snacking ∼55% and ∼60% of days for males and females, respectively. Agents consuming at least a 40%:60% relative ratio of energy from fat:carbohydrate ratio can achieve the largest reductions in total calories consumed and late-night snacking compared with consuming higher relative proportions of carbohydrates.</div></div><div><h3>Conclusions</h3><div>Eating a diet with ≥40% of its energy from fats relative to carbohydrates can achieve the largest reductions in total calories consumed and late-night snacking each day than consuming higher proportions of carbohydrates, with even further reductions as more fat is added to the diet, when considering the physiologic responses to dietary intake alone. Future research should layer in other strong contributing factors to eating such as stress, social context, palatability, physical activity, and types of macronutrients, and also represent other metabolic profiles and ages.</div></div>","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"9 7","pages":"Article 107487"},"PeriodicalIF":3.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144571073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}