Critical Reviews in Biotechnology最新文献_第9页

Molecular approaches to enhance astaxanthin biosynthesis; future outlook: engineering of transcription factors in Haematococcus pluvialis. 增强虾青素生物合成的分子方法；未来展望：血球藻转录因子工程。

IF 9 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2024-06-01 Epub Date: 2023-06-28 DOI: 10.1080/07388551.2023.2208284

Sadaf-Ilyas Kayani, Saeed-Ur -Rahman, Qian Shen, Yi Cui, Wei Liu, Xinjuan Hu, Feifei Zhu, Shuhao Huo

{"title":"Molecular approaches to enhance astaxanthin biosynthesis; future outlook: engineering of transcription factors in Haematococcus pluvialis.","authors":"Sadaf-Ilyas Kayani, Saeed-Ur -Rahman, Qian Shen, Yi Cui, Wei Liu, Xinjuan Hu, Feifei Zhu, Shuhao Huo","doi":"10.1080/07388551.2023.2208284","DOIUrl":"10.1080/07388551.2023.2208284","url":null,"abstract":"Microalgae are the preferred species for producing astaxanthin because they pose a low toxicity risk than chemical synthesis. Astaxanthin has multiple health benefits and is being used in: medicines, nutraceuticals, cosmetics, and functional foods. Haematococcus pluvialis is a model microalga for astaxanthin biosynthesis; however, its natural astaxanthin content is low. Therefore, it is necessary to develop methods to improve the biosynthesis of astaxanthin to meet industrial demands, making its commercialization cost-effective. Several strategies related to cultivation conditions are employed to enhance the biosynthesis of astaxanthin in H. pluvialis. However, the mechanism of its regulation by transcription factors is unknown. For the first time, this study critically reviewed the studies on identifying transcription factors, progress in H. pluvialis genetic transformation, and use of phytohormones that increase the gene expression related to astaxanthin biosynthesis. In addition, we propose future approaches, including (i) Cloning and characterization of transcription factors, (ii) Transcriptional engineering through overexpression of positive regulators or downregulation/silencing of negative regulators, (iii) Gene editing for enrichment or deletion of transcription factors binding sites, (iv) Hormonal modulation of transcription factors. This review provides considerable knowledge about the molecular regulation of astaxanthin biosynthesis and the existing research gap. Besides, it provides the basis for transcription factors mediated metabolic engineering of astaxanthin biosynthesis in H. pluvialis.","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":" ","pages":"514-529"},"PeriodicalIF":9.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9686504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enzyme hybrid nanoflowers and enzyme@metal-organic frameworks composites: fascinating hybrid nanobiocatalysts. 酶杂化纳米花和酶@金属有机框架复合材料：迷人的杂化纳米生物催化剂。

IF 9 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2024-06-01 Epub Date: 2023-04-09 DOI: 10.1080/07388551.2023.2189548

Zichen Wang, Ruirui Wang, Zixin Geng, Xiuyan Luo, Jiahui Jia, Saizhao Pang, Xianwei Fan, Muhammad Bilal, Jiandong Cui

{"title":"Enzyme hybrid nanoflowers and enzyme@metal-organic frameworks composites: fascinating hybrid nanobiocatalysts.","authors":"Zichen Wang, Ruirui Wang, Zixin Geng, Xiuyan Luo, Jiahui Jia, Saizhao Pang, Xianwei Fan, Muhammad Bilal, Jiandong Cui","doi":"10.1080/07388551.2023.2189548","DOIUrl":"10.1080/07388551.2023.2189548","url":null,"abstract":"Hybrid nanomaterials have recently emerged as a new interface of nanobiocatalysis, serving as a host platform for enzyme immobilization. Enzyme immobilization in inorganic crystal nanoflowers and metal-organic frameworks (MOFs) has sparked the bulk of scientific interest due to their superior performances. Many breakthroughs have been achieved recently in the preparation of various types of enzyme@MOF and enzyme-hybrid nanoflower composites. However, it is unfortunate that there are few reviews in the literature related to enzyme@MOF and enzyme-hybrid nanoflower composites and their improved synthesis strategies and their applications in biotechnology. In this review, innovative synthetic strategies for enzyme@MOF composites and enzyme-hybrid nanoflower composites are discussed. Enzyme@MOF composites and enzyme-hybrid nanoflower composites are reviewed in terms of biotechnological applications and potential research directions. We are convinced that a fundamental study and application of enzyme@MOF composites and enzyme-hybrid nanoflower composites will be understood by the reader as a result of this work. The summary of different synthetic strategies for enzyme@MOF composites and enzyme-hybrid nanoflower composites and the improvement of their synthetic strategies will also benefit the readers and provide ideas and thoughts in the future research process.","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":" ","pages":"674-697"},"PeriodicalIF":9.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9619376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Developed and emerging 1,4-butanediol commercial production strategies: forecasting the current status and future possibility. 已开发和新兴的 1,4-丁二醇商业生产战略：预测现状和未来可能性。

IF 9 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2024-06-01 Epub Date: 2023-06-07 DOI: 10.1080/07388551.2023.2176740

Pradeep Kumar, HyunA Park, Yong Yuk, Hayan Kim, Jihwan Jang, Raviteja Pagolu, SeoA Park, Chanseo Yeo, Kwon-Young Choi

{"title":"Developed and emerging 1,4-butanediol commercial production strategies: forecasting the current status and future possibility.","authors":"Pradeep Kumar, HyunA Park, Yong Yuk, Hayan Kim, Jihwan Jang, Raviteja Pagolu, SeoA Park, Chanseo Yeo, Kwon-Young Choi","doi":"10.1080/07388551.2023.2176740","DOIUrl":"10.1080/07388551.2023.2176740","url":null,"abstract":"1,4-Butanediol (1,4-BDO) is a valuable industrial chemical that is primarily produced via several energy-intensive petrochemical processes based on fossil-based raw materials, leading to issues related to: non-renewability, environmental contamination, and high production costs. 1,4-BDO is used in many chemical reactions to develop a variety of useful, valuable products, such as: polyurethane, Spandex intermediates, and polyvinyl pyrrolidone (PVP), a water-soluble polymer with numerous personal care and pharmaceutical uses. In recent years, to satisfy the growing need for 1,4-BDO, there has been a major shift in focus to sustainable bioproduction via microorganisms using: recombinant strains, metabolic engineering, synthetic biology, enzyme engineering, bioinformatics, and artificial intelligence-guided algorithms. This article discusses the current status of the development of: various chemical and biological production techniques for 1,4-BDO, advances in biological pathways for 1,4-BDO biosynthesis, prospects for future production strategies, and the difficulties associated with environmentally friendly and bio-based commercial production strategies.","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":" ","pages":"530-546"},"PeriodicalIF":9.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9591936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanobiosensors and their role in detection of adulterants and contaminants in food products. 纳米生物传感器及其在检测食品中掺假物质和污染物方面的作用。

IF 8.1 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2024-06-01 Epub Date: 2023-02-26 DOI: 10.1080/07388551.2023.2175196

Gurlovleen Kaur, Ranjeeta Bhari, Kuldeep Kumar

引用次数: 0

Electrospun wound dressings with antibacterial function: a critical review of plant extract and essential oil incorporation. 具有抗菌功能的电纺伤口敷料：对植物提取物和精油掺入的深入研究。

IF 8.1 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2024-06-01 Epub Date: 2023-05-08 DOI: 10.1080/07388551.2023.2193859

Cláudia Mouro, Isabel C Gouveia

{"title":"Electrospun wound dressings with antibacterial function: a critical review of plant extract and essential oil incorporation.","authors":"Cláudia Mouro, Isabel C Gouveia","doi":"10.1080/07388551.2023.2193859","DOIUrl":"10.1080/07388551.2023.2193859","url":null,"abstract":"Among the many different types of wound dressings, nanofiber-based materials produced through electrospinning are claimed to be ideal because of their advantageous intrinsic properties and the feasibility of employing several strategies to load bioactive compounds into their structure. Bioactive compounds with antimicrobial properties have been incorporated into different wound dressings to promote healing as well as prevent and treat bacterial infections. Among these, natural products, such as medicinal plant extracts and essential oils (EOs), have proven particularly attractive thanks to their nontoxic nature, minor side effects, desirable bioactive properties, and favorable effects on the healing process. To this end, the present review provides an exhaustive and up-to-date revision of the most prominent medicinal plant extracts and EOs with antimicrobial properties that have been incorporated into nanofiber-based wound dressings. The most common methods used for incorporating bioactive compounds into electrospun nanofibers include: pre-electrospinning (blend, encapsulation, coaxial, and emulsion electrospinning), post-electrospinning (physical adsorption, chemical immobilization, and layer-by-layer assembly), and nanoparticle loading. Furthermore, a general overview of the benefits of EOs and medicinal plant extracts is presented, describing their intrinsic properties and biotechniques for their incorporation into wound dressings. Finally, the current challenges and safety issues that need to be adequately clarified and addressed are discussed.","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":" ","pages":"641-659"},"PeriodicalIF":8.1,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9431918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dissecting dietary alkylresorcinols: a compile of their distribution, biosynthesis, extraction and functional properties. 剖析膳食中的烷基间苯二酚：其分布、生物合成、提取和功能特性汇编。

IF 8.1 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2024-06-01 Epub Date: 2023-05-08 DOI: 10.1080/07388551.2023.2193860

Rehan M El-Shabasy, Mohamed A Farag

{"title":"Dissecting dietary alkylresorcinols: a compile of their distribution, biosynthesis, extraction and functional properties.","authors":"Rehan M El-Shabasy, Mohamed A Farag","doi":"10.1080/07388551.2023.2193860","DOIUrl":"10.1080/07388551.2023.2193860","url":null,"abstract":"Alkylresorcinols (ARs) are natural bioactive ingredients produced by: bacteria, fungi, sponges, and higher plants, possessing a lipophilic polyphenol structure with a myriad of biological properties. Focusing on the importance of ARs, several analogs can be extracted from different natural resources. Interestingly, the composition of ARs is usually reflective of their source, with structural differences to exist among ARs isolated from different natural sources. The identified compounds from marine are distinguished by sulfur atom and disulfide bond, while the alkyl chain of bacterial homologs are recognized for their saturated fatty acid chains. ARs occurrence in fungi is still poorly documented however most of the isolated fungal molecules are characterized by a sugar unit attached to their alkylated side chains. The biosynthetic pathway of ARs is postulated via a type III polyketide synthase in which the fatty-acyl chain is elongated and cyclized to generate ARs. The structure-activity relationship (SAR) has gained an increasing interest to mediate for ARs biological activities as discussed herein for the first time from their different resources. ARs extraction procedures showed much progress compared to classical methods compiling organic solvents with supercritical extraction appearing as a potential technique for producing highly purified food-grade of AR homologs. The current review also presents on the rapid qualitative and quantitative determination of ARs to increase accessibility for screening cereals as potential sources of these bioactives.","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":" ","pages":"581-617"},"PeriodicalIF":8.1,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9431921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lignocellulosic materials valorization in second generation biorefineries: an opportunity to produce fungal biopigments. 第二代生物炼油厂中木质纤维素材料的增值：生产真菌生物颜料的机会。

IF 9 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2024-05-30 DOI: 10.1080/07388551.2024.2349581

Gabriel L Arruda, Maria Teresa F R Raymundo, Mónica M Cruz-Santos, Vinícius P Shibukawa, Fanny M Jofre, Carina A Prado, Silvio S da Silva, Solange I Mussatto, Júlio C Santos

{"title":"Lignocellulosic materials valorization in second generation biorefineries: an opportunity to produce fungal biopigments.","authors":"Gabriel L Arruda, Maria Teresa F R Raymundo, Mónica M Cruz-Santos, Vinícius P Shibukawa, Fanny M Jofre, Carina A Prado, Silvio S da Silva, Solange I Mussatto, Júlio C Santos","doi":"10.1080/07388551.2024.2349581","DOIUrl":"https://doi.org/10.1080/07388551.2024.2349581","url":null,"abstract":"Second generation biorefineries play an important role in the production of renewable energy and fuels, utilizing forest and agro-industrial residues and by-products as raw materials. The integration of novel bioproducts, such as: xylitol, β-carotene, xylooligosaccharides, and biopigments into the biorefinery's portfolio can offer economic benefits in the valorization of lignocellulosic materials, particularly cellulosic and hemicellulosic fractions. Fungal biopigments, known for their additional antioxidant and antimicrobial properties, are appealing to consumers and can have applications in various industrial sectors, including food and pharmaceuticals. The use of lignocellulosic materials as carbon and nutrient sources for the growth medium helps to reduce production costs, increasing the competitiveness of fungal biopigments in the market. In addition, the implementation of biopigment production in biorefineries allows the utilization of underutilized fractions, such as hemicellulose, for value-added bioproducts. This study deals with the potential of fungal biopigments production in second generation biorefineries in order to diversify the produced biomolecules together with energy generation. A comprehensive and critical review of the recent literature on this topic has been conducted, covering the major possible raw materials, general aspects of second generation biorefineries, the fungal biopigments and their potential for incorporation into biorefineries.","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":" ","pages":"1-20"},"PeriodicalIF":9.0,"publicationDate":"2024-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141179114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A close-up of regulatory networks and signaling pathways of MKK5 in biotic and abiotic stresses. MKK5在生物和非生物胁迫中的调控网络和信号通路特写。

IF 9 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2024-05-26 DOI: 10.1080/07388551.2024.2344584

Ali Movahedi, Delight Hwarari, Raphael Dzinyela, Siyi Ni, Liming Yang

{"title":"A close-up of regulatory networks and signaling pathways of MKK5 in biotic and abiotic stresses.","authors":"Ali Movahedi, Delight Hwarari, Raphael Dzinyela, Siyi Ni, Liming Yang","doi":"10.1080/07388551.2024.2344584","DOIUrl":"https://doi.org/10.1080/07388551.2024.2344584","url":null,"abstract":"Mitogen-activated protein Kinase Kinase 5 (MKK5) is a central hub in the complex phosphorylation chain reaction of the Mitogen-activated protein kinases (MAPK) cascade, regulating plant responses to biotic and abiotic stresses. This review manuscript aims to provide a comprehensive analysis of the regulatory mechanism of the MKK5 involved in stress adaptation. This review will delve into the intricate post-transcriptional and post-translational modifications of the MKK5, discussing how they affect its expression, activity, and subcellular localization in response to stress signals. We also discuss the integration of the MKK5 into complex signaling pathways, orchestrating plant immunity against pathogens and its modulating role in regulating abiotic stresses, such as: drought, cold, heat, and salinity, through the phytohormonal signaling pathways. Furthermore, we highlight potential applications of the MKK5 for engineering stress-resilient crops and provide future perspectives that may pave the way for future studies. This review manuscript aims to provide valuable insights into the mechanisms underlying MKK5 regulation, bridge the gap from numerous previous findings, and offer a firm base in the knowledge of MKK5, its regulating roles, and its involvement in environmental stress regulation.","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":" ","pages":"1-18"},"PeriodicalIF":9.0,"publicationDate":"2024-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141154774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthetic biology for the food industry: advances and challenges. 食品工业的合成生物学：进步与挑战。

IF 9 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2024-05-26 DOI: 10.1080/07388551.2024.2340530

Ruipeng Chen, Shuyue Ren, Shuang Li, Huanying Zhou, Xuexia Jia, Dianpeng Han, Zhixian Gao

{"title":"Synthetic biology for the food industry: advances and challenges.","authors":"Ruipeng Chen, Shuyue Ren, Shuang Li, Huanying Zhou, Xuexia Jia, Dianpeng Han, Zhixian Gao","doi":"10.1080/07388551.2024.2340530","DOIUrl":"https://doi.org/10.1080/07388551.2024.2340530","url":null,"abstract":"As global environmental pollution increases, climate change worsens, and population growth continues, the challenges of securing a safe, nutritious, and sustainable food supply have become enormous. This has led to new requirements for future food supply methods and functions. The use of synthetic biology technology to create cell factories suitable for food industry production and renewable raw material conversion into: important food components, functional food additives, and nutritional chemicals, represents an important method of solving the problems faced by the food industry. Here, we review the recent progress and applications of synthetic biology in the food industry, including alternatives to: traditional (artificial pigments, meat, starch, and milk), functional (sweeteners, sugar substitutes, nutrients, flavoring agents), and green (green fiber, degradable packing materials, green packaging materials and food traceability) foods. Furthermore, we discuss the future prospects of synthetic biology-based applications in the food industry. Thus, this review may serve as a reference for research on synthetic biology in the: food safety, food nutrition, public health, and health-related fields.","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":" ","pages":"1-25"},"PeriodicalIF":9.0,"publicationDate":"2024-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141154777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New strategies to study in depth the metabolic mechanism of astaxanthin biosynthesis in Phaffia rhodozyma. 深入研究 Phaffia rhodozyma 虾青素生物合成代谢机制的新策略。

IF 9 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2024-05-26 DOI: 10.1080/07388551.2024.2344578

Zhipeng Li, Li You, Xiping Du, Haoyi Yang, Liang Yang, Yanbing Zhu, Lijun Li, Zedong Jiang, Qingbiao Li, Ning He, Rui Lin, Zhen Chen, Hui Ni

{"title":"New strategies to study in depth the metabolic mechanism of astaxanthin biosynthesis in Phaffia rhodozyma.","authors":"Zhipeng Li, Li You, Xiping Du, Haoyi Yang, Liang Yang, Yanbing Zhu, Lijun Li, Zedong Jiang, Qingbiao Li, Ning He, Rui Lin, Zhen Chen, Hui Ni","doi":"10.1080/07388551.2024.2344578","DOIUrl":"https://doi.org/10.1080/07388551.2024.2344578","url":null,"abstract":"Astaxanthin, a ketone carotenoid known for its high antioxidant activity, holds significant potential for application in nutraceuticals, aquaculture, and cosmetics. The increasing market demand necessitates a higher production of astaxanthin using Phaffia rhodozyma. Despite extensive research efforts focused on optimizing fermentation conditions, employing mutagenesis treatments, and utilizing genetic engineering technologies to enhance astaxanthin yield in P. rhodozyma, progress in this area remains limited. This review provides a comprehensive summary of the current understanding of rough metabolic pathways, regulatory mechanisms, and preliminary strategies for enhancing astaxanthin yield. However, further investigation is required to fully comprehend the intricate and essential metabolic regulation mechanism underlying astaxanthin synthesis. Specifically, the specific functions of key genes, such as crtYB, crtS, and crtI, need to be explored in detail. Additionally, a thorough understanding of the action mechanism of bifunctional enzymes and alternative splicing products is imperative. Lastly, the regulation of metabolic flux must be thoroughly investigated to reveal the complete pathway of astaxanthin synthesis. To obtain an in-depth mechanism and improve the yield of astaxanthin, this review proposes some frontier methods, including: omics, genome editing, protein structure-activity analysis, and synthetic biology. Moreover, it further elucidates the feasibility of new strategies using these advanced methods in various effectively combined ways to resolve these problems mentioned above. This review provides theory and method for studying the metabolic pathway of astaxanthin in P. rhodozyma and the industrial improvement of astaxanthin, and provides new insights into the flexible combined use of multiple modern advanced biotechnologies.","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":" ","pages":"1-19"},"PeriodicalIF":9.0,"publicationDate":"2024-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141154776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0