Critical Reviews in Biotechnology最新文献_第9页

A close-up of regulatory networks and signaling pathways of MKK5 in biotic and abiotic stresses. MKK5在生物和非生物胁迫中的调控网络和信号通路特写。

IF 9 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2024-05-26 DOI: 10.1080/07388551.2024.2344584

Ali Movahedi, Delight Hwarari, Raphael Dzinyela, Siyi Ni, Liming Yang

{"title":"A close-up of regulatory networks and signaling pathways of MKK5 in biotic and abiotic stresses.","authors":"Ali Movahedi, Delight Hwarari, Raphael Dzinyela, Siyi Ni, Liming Yang","doi":"10.1080/07388551.2024.2344584","DOIUrl":"https://doi.org/10.1080/07388551.2024.2344584","url":null,"abstract":"Mitogen-activated protein Kinase Kinase 5 (MKK5) is a central hub in the complex phosphorylation chain reaction of the Mitogen-activated protein kinases (MAPK) cascade, regulating plant responses to biotic and abiotic stresses. This review manuscript aims to provide a comprehensive analysis of the regulatory mechanism of the MKK5 involved in stress adaptation. This review will delve into the intricate post-transcriptional and post-translational modifications of the MKK5, discussing how they affect its expression, activity, and subcellular localization in response to stress signals. We also discuss the integration of the MKK5 into complex signaling pathways, orchestrating plant immunity against pathogens and its modulating role in regulating abiotic stresses, such as: drought, cold, heat, and salinity, through the phytohormonal signaling pathways. Furthermore, we highlight potential applications of the MKK5 for engineering stress-resilient crops and provide future perspectives that may pave the way for future studies. This review manuscript aims to provide valuable insights into the mechanisms underlying MKK5 regulation, bridge the gap from numerous previous findings, and offer a firm base in the knowledge of MKK5, its regulating roles, and its involvement in environmental stress regulation.","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":null,"pages":null},"PeriodicalIF":9.0,"publicationDate":"2024-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141154774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New strategies to study in depth the metabolic mechanism of astaxanthin biosynthesis in Phaffia rhodozyma. 深入研究 Phaffia rhodozyma 虾青素生物合成代谢机制的新策略。

IF 9 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2024-05-26 DOI: 10.1080/07388551.2024.2344578

Zhipeng Li, Li You, Xiping Du, Haoyi Yang, Liang Yang, Yanbing Zhu, Lijun Li, Zedong Jiang, Qingbiao Li, Ning He, Rui Lin, Zhen Chen, Hui Ni

{"title":"New strategies to study in depth the metabolic mechanism of astaxanthin biosynthesis in Phaffia rhodozyma.","authors":"Zhipeng Li, Li You, Xiping Du, Haoyi Yang, Liang Yang, Yanbing Zhu, Lijun Li, Zedong Jiang, Qingbiao Li, Ning He, Rui Lin, Zhen Chen, Hui Ni","doi":"10.1080/07388551.2024.2344578","DOIUrl":"https://doi.org/10.1080/07388551.2024.2344578","url":null,"abstract":"Astaxanthin, a ketone carotenoid known for its high antioxidant activity, holds significant potential for application in nutraceuticals, aquaculture, and cosmetics. The increasing market demand necessitates a higher production of astaxanthin using Phaffia rhodozyma. Despite extensive research efforts focused on optimizing fermentation conditions, employing mutagenesis treatments, and utilizing genetic engineering technologies to enhance astaxanthin yield in P. rhodozyma, progress in this area remains limited. This review provides a comprehensive summary of the current understanding of rough metabolic pathways, regulatory mechanisms, and preliminary strategies for enhancing astaxanthin yield. However, further investigation is required to fully comprehend the intricate and essential metabolic regulation mechanism underlying astaxanthin synthesis. Specifically, the specific functions of key genes, such as crtYB, crtS, and crtI, need to be explored in detail. Additionally, a thorough understanding of the action mechanism of bifunctional enzymes and alternative splicing products is imperative. Lastly, the regulation of metabolic flux must be thoroughly investigated to reveal the complete pathway of astaxanthin synthesis. To obtain an in-depth mechanism and improve the yield of astaxanthin, this review proposes some frontier methods, including: omics, genome editing, protein structure-activity analysis, and synthetic biology. Moreover, it further elucidates the feasibility of new strategies using these advanced methods in various effectively combined ways to resolve these problems mentioned above. This review provides theory and method for studying the metabolic pathway of astaxanthin in P. rhodozyma and the industrial improvement of astaxanthin, and provides new insights into the flexible combined use of multiple modern advanced biotechnologies.","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":null,"pages":null},"PeriodicalIF":9.0,"publicationDate":"2024-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141154776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D printing: trends and approaches toward achieving long-term sustainability in the food industry. 三维打印：实现食品工业长期可持续性的趋势和方法。

IF 9 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2024-05-26 DOI: 10.1080/07388551.2024.2344577

Priyamvada Thorakkattu, Nancy Awasti, Karthik Sajith Babu, Anandu Chandra Khanashyam, Aiswariya Deliephan, Kartik Shah, Punit Singh, R Pandiselvam, Nilesh Prakash Nirmal

{"title":"3D printing: trends and approaches toward achieving long-term sustainability in the food industry.","authors":"Priyamvada Thorakkattu, Nancy Awasti, Karthik Sajith Babu, Anandu Chandra Khanashyam, Aiswariya Deliephan, Kartik Shah, Punit Singh, R Pandiselvam, Nilesh Prakash Nirmal","doi":"10.1080/07388551.2024.2344577","DOIUrl":"https://doi.org/10.1080/07388551.2024.2344577","url":null,"abstract":"Global food security has recently been under serious threat from the rapid rise in the world's population, the problems brought on by climate change, and the appearance of new pandemics. As a result, the need for novel and innovative solutions to solve the existing problems and improve food sustainability has become crucial. 3D printing is expected to play a significant role in providing tangible contributions to the food industry in achieving sustainable development goals. The 3D food printing holds the potential to produce highly customized food in terms of shape, texture, flavor, structure and nutritional value and enable us to create new unique formulations and edible alternatives. The problem of whether the cost of the printed meal and 3D printing itself can be sustainably produced is becoming more and more important due to global concerns. This review intends to provide a comprehensive overview of 3D printed foods with an overview of the current printing methodologies, illustrating the technology's influencing factors, and its applications in personalized nutrition, packaging, value addition, and valorization aspects to fully integrate sustainability concerns thus exploring the potential of 3D food printing.","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":null,"pages":null},"PeriodicalIF":9.0,"publicationDate":"2024-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141154773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Escherichia coli and Pichia pastoris: microbial cell-factory platform for -full-length IgG production. 大肠杆菌和毕赤菌：生产全长 IgG 的微生物细胞工厂平台。

IF 9 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2024-05-26 DOI: 10.1080/07388551.2024.2342969

Shyam Krishna, Sang Taek Jung, Eun Yeol Lee

{"title":"Escherichia coli and Pichia pastoris: microbial cell-factory platform for -full-length IgG production.","authors":"Shyam Krishna, Sang Taek Jung, Eun Yeol Lee","doi":"10.1080/07388551.2024.2342969","DOIUrl":"https://doi.org/10.1080/07388551.2024.2342969","url":null,"abstract":"Owing to the unmet demand, the pharmaceutical industry is investigating an alternative host to mammalian cells to produce antibodies for a variety of therapeutic and research applications. Regardless of some disadvantages, Escherichia coli and Pichia pastoris are the preferred microbial hosts for antibody production. Despite the fact that the production of full-length antibodies has been successfully demonstrated in E. coli, which has mostly been used to produce antibody fragments, such as: antigen-binding fragments (Fab), single-chain fragment variable (scFv), and nanobodies. In contrast, Pichia, a eukaryotic microbial host, is mostly used to produce glycosylated full-length antibodies, though hypermannosylated glycan is a major challenge. Advanced strategies, such as the introduction of human-like glycosylation in endotoxin-edited E. coli and cell-free system-based glycosylation, are making progress in creating human-like glycosylation profiles of antibodies in these microbes. This review begins by explaining the structural and functional requirements of antibodies and continues by describing and analyzing the potential of E. coli and P. pastoris as hosts for providing a favorable environment to create a fully functional antibody. In addition, authors compare these microbes on certain features and predict their future in antibody production. Briefly, this review analyzes, compares, and highlights E. coli and P. pastoris as potential hosts for antibody production.","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":null,"pages":null},"PeriodicalIF":9.0,"publicationDate":"2024-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141154772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging alternative food protein sources: production process, quality parameters, and safety point of view 新出现的替代食品蛋白质来源：生产过程、质量参数和安全观点

IF 9 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2024-05-14 DOI: 10.1080/07388551.2024.2341902

Anandu Chandra Khanashyam, Anjaly Shanker Mundanat, Karthik Sajith Babu, P. Thorakkattu, R. Krishnan, Sajeeb Abdullah, A. Bekhit, D. Mcclements, C. Santivarangkna, N. Nirmal

引用次数: 0

IF 9 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2024-05-08 DOI: 10.1080/07388551.2024.2344583

Talha Javed, Wenzhi Wang, Benpeng Yang, Linbo Shen, Tingting Sun, San-Ji Gao, Shuzhen Zhang

{"title":"Pathogenesis related-1 proteins in plant defense: regulation and functional diversity.","authors":"Talha Javed, Wenzhi Wang, Benpeng Yang, Linbo Shen, Tingting Sun, San-Ji Gao, Shuzhen Zhang","doi":"10.1080/07388551.2024.2344583","DOIUrl":"10.1080/07388551.2024.2344583","url":null,"abstract":"Climate change-related environmental stresses can negatively impact crop productivity and pose a threat to sustainable agriculture. Plants have a remarkable innate ability to detect a broad array of environmental cues, including stresses that trigger stress-induced regulatory networks and signaling pathways. Transcriptional activation of plant pathogenesis related-1 (PR-1) proteins was first identified as an integral component of systemic acquired resistance in response to stress. Consistent with their central role in immune defense, overexpression of PR-1s in diverse plant species is frequently used as a marker for salicylic acid (SA)-mediated defense responses. Recent advances demonstrated how virulence effectors, SA signaling cascades, and epigenetic modifications modulate PR-1 expression in response to environmental stresses. We and others showed that transcriptional regulatory networks involving PR-1s could be used to improve plant resilience to stress. Together, the results of these studies have re-energized the field and provided long-awaited insights into a possible function of PR-1s under extreme environmental stress.","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":null,"pages":null},"PeriodicalIF":9.0,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140891733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How to deal with xenobiotic compounds through environment friendly approach? 如何通过环境友好型方法处理异生物化合物？

IF 9 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2024-05-06 DOI: 10.1080/07388551.2024.2336527

Mony Thakur, Vinod Yadav, Yatin Kumar, Avijit Pramanik, Kashyap Kumar Dubey

{"title":"How to deal with xenobiotic compounds through environment friendly approach?","authors":"Mony Thakur, Vinod Yadav, Yatin Kumar, Avijit Pramanik, Kashyap Kumar Dubey","doi":"10.1080/07388551.2024.2336527","DOIUrl":"https://doi.org/10.1080/07388551.2024.2336527","url":null,"abstract":"Every year, a huge amount of lethal compounds, such as synthetic dyes, pesticides, pharmaceuticals, hydrocarbons, etc. are mass produced worldwide, which negatively affect soil, air, and water quality. At present, pesticides are used very frequently to meet the requirements of modernized agriculture. The Food and Agriculture Organization of the United Nations (FAO) estimates that food production will increase by 80% by 2050 to keep up with the growing population, consequently pesticides will continue to play a role in agriculture. However, improper handling of these highly persistent chemicals leads to pollution of the environment and accumulation in food chain. These effects necessitate the development of technologies to eliminate or degrade these pollutants. Degradation of these compounds by physical and chemical processes is expensive and usually results in secondary compounds with higher toxicity. The biological strategies proposed for the degradation of these compounds are both cost-effective and eco-friendly. Microbes play an imperative role in the degradation of xenobiotic compounds that have toxic effects on the environment. This review on the fate of xenobiotic compounds in the environment presents cutting-edge insights and novel contributions in different fields. Microbial community dynamics in water bodies, genetic modification for enhanced pesticide degradation and the use of fungi for pharmaceutical removal, white-rot fungi's versatile ligninolytic enzymes and biodegradation potential are highlighted. Here we emphasize the factors influencing bioremediation, such as microbial interactions and carbon catabolism repression, along with a nuanced view of challenges and limitations. Overall, this review provides a comprehensive perspective on the bioremediation strategies.","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":null,"pages":null},"PeriodicalIF":9.0,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140874536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How do probiotics alleviate constipation? A narrative review of mechanisms. 益生菌如何缓解便秘？机制综述。

IF 9 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2024-05-06 DOI: 10.1080/07388551.2024.2336531

Yu-Ping Huang, Jie-Yan Shi, Xin-Tao Luo, Si-Chen Luo, Peter C K Cheung, Harold Corke, Qiong-Qiong Yang, Bo-Bo Zhang

{"title":"How do probiotics alleviate constipation? A narrative review of mechanisms.","authors":"Yu-Ping Huang, Jie-Yan Shi, Xin-Tao Luo, Si-Chen Luo, Peter C K Cheung, Harold Corke, Qiong-Qiong Yang, Bo-Bo Zhang","doi":"10.1080/07388551.2024.2336531","DOIUrl":"https://doi.org/10.1080/07388551.2024.2336531","url":null,"abstract":"Constipation is a common gastrointestinal condition, which may occur at any age and affects countless people. The search for new treatments for constipation is ongoing as current drug treatments fail to provide fully satisfactory results. In recent years, probiotics have attracted much attention because of their demonstrated therapeutic efficacy and fewer side effects than pharmaceutical products. Many studies attempted to answer the question of how probiotics can alleviate constipation. It has been shown that different probiotic strains can alleviate constipation by different mechanisms. The mechanisms on probiotics in relieving constipation were associated with various aspects, including regulation of the gut microbiota composition, the level of short-chain fatty acids, aquaporin expression levels, neurotransmitters and hormone levels, inflammation, the intestinal environmental metabolic status, neurotrophic factor levels and the body's antioxidant levels. This paper summarizes the perception of the mechanisms on probiotics in relieving constipation and provides some suggestions on new research directions.","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":null,"pages":null},"PeriodicalIF":9.0,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140853867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antimicrobials from endophytes as novel therapeutics to counter drug-resistant pathogens. 从内生菌中提取抗菌素，作为对抗耐药性病原体的新型疗法。

IF 9 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2024-05-06 DOI: 10.1080/07388551.2024.2342979

Pragya Tiwari, Shreya Thakkar, Laurent Dufossé

{"title":"Antimicrobials from endophytes as novel therapeutics to counter drug-resistant pathogens.","authors":"Pragya Tiwari, Shreya Thakkar, Laurent Dufossé","doi":"10.1080/07388551.2024.2342979","DOIUrl":"https://doi.org/10.1080/07388551.2024.2342979","url":null,"abstract":"The rapid increase in antimicrobial resistance (AMR) projects a \"global emergency\" and necessitates a need to discover alternative resources for combating drug-resistant pathogens or \"superbugs.\" One of the key themes in \"One Health Concept\" is based on the fact that the interconnected network of humans, the environment, and animal habitats majorly contribute to the rapid selection and spread of AMR. Moreover, the injudicious and overuse of antibiotics in healthcare, the environment, and associated disciplines, further aggravates the concern. The prevalence and persistence of AMR contribute to the global economic burden and are constantly witnessing an upsurge due to fewer therapeutic options, rising mortality statistics, and expensive healthcare. The present decade has witnessed the extensive exploration and utilization of bio-based resources in harnessing antibiotics of potential efficacies. The discovery and characterization of diverse chemical entities from endophytes as potent antimicrobials define an important yet less-explored area in natural product-mediated drug discovery. Endophytes-produced antimicrobials show potent efficacies in targeting microbial pathogens and synthetic biology (SB) mediated engineering of endophytes for yield enhancement, forms a prospective area of research. In keeping with the urgent requirements for new/novel antibiotics and growing concerns about pathogenic microbes and AMR, this paper comprehensively reviews emerging trends, prospects, and challenges of antimicrobials from endophytes and their effective production via SB. This literature review would serve as the platform for further exploration of novel bioactive entities from biological organisms as \"novel therapeutics\" to address AMR.","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":null,"pages":null},"PeriodicalIF":9.0,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140854550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comprehensive review on the recent advances for 5-aminolevulinic acid production by the engineered bacteria. 全面回顾工程菌生产 5-氨基乙酰丙酸的最新进展。

IF 9 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2024-05-05 DOI: 10.1080/07388551.2024.2336532

Ying-Ying Chen, Jia-Cong Huang, Cai-Yun Wu, Shi-Qin Yu, Yue-Tong Wang, Chao Ye, Tian-Qiong Shi, He Huang

引用次数: 0