How do probiotics alleviate constipation? A narrative review of mechanisms.

IF 8.1 2区 工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Yu-Ping Huang, Jie-Yan Shi, Xin-Tao Luo, Si-Chen Luo, Peter C K Cheung, Harold Corke, Qiong-Qiong Yang, Bo-Bo Zhang
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引用次数: 0

Abstract

Constipation is a common gastrointestinal condition, which may occur at any age and affects countless people. The search for new treatments for constipation is ongoing as current drug treatments fail to provide fully satisfactory results. In recent years, probiotics have attracted much attention because of their demonstrated therapeutic efficacy and fewer side effects than pharmaceutical products. Many studies attempted to answer the question of how probiotics can alleviate constipation. It has been shown that different probiotic strains can alleviate constipation by different mechanisms. The mechanisms on probiotics in relieving constipation were associated with various aspects, including regulation of the gut microbiota composition, the level of short-chain fatty acids, aquaporin expression levels, neurotransmitters and hormone levels, inflammation, the intestinal environmental metabolic status, neurotrophic factor levels and the body's antioxidant levels. This paper summarizes the perception of the mechanisms on probiotics in relieving constipation and provides some suggestions on new research directions.

益生菌如何缓解便秘?机制综述。
便秘是一种常见的肠胃疾病,可能发生在任何年龄段,影响着无数人。由于目前的药物治疗无法提供完全令人满意的效果,人们一直在寻找治疗便秘的新方法。近年来,益生菌因其疗效显著且副作用小于药物而备受关注。许多研究试图回答益生菌如何缓解便秘的问题。研究表明,不同的益生菌株可以通过不同的机制缓解便秘。益生菌缓解便秘的机制与多方面有关,包括调节肠道微生物群组成、短链脂肪酸水平、aquaporin表达水平、神经递质和激素水平、炎症、肠道环境代谢状态、神经营养因子水平和机体抗氧化剂水平。本文总结了对益生菌缓解便秘机制的认识,并就新的研究方向提出了一些建议。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Critical Reviews in Biotechnology
Critical Reviews in Biotechnology 工程技术-生物工程与应用微生物
CiteScore
20.80
自引率
1.10%
发文量
71
审稿时长
4.8 months
期刊介绍: Biotechnological techniques, from fermentation to genetic manipulation, have become increasingly relevant to the food and beverage, fuel production, chemical and pharmaceutical, and waste management industries. Consequently, academic as well as industrial institutions need to keep abreast of the concepts, data, and methodologies evolved by continuing research. This journal provides a forum of critical evaluation of recent and current publications and, periodically, for state-of-the-art reports from various geographic areas around the world. Contributing authors are recognized experts in their fields, and each article is reviewed by an objective expert to ensure accuracy and objectivity of the presentation.
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