Critical Reviews in Biotechnology最新文献

筛选
英文 中文
Farm to fork applications: how vibrational spectroscopy can be used along the whole value chain? 从农场到餐桌的应用:如何在整个价值链中使用振动光谱?
IF 8.1 2区 工程技术
Critical Reviews in Biotechnology Pub Date : 2024-11-04 DOI: 10.1080/07388551.2024.2409124
Ravi Pandiselvam, Alev Yüksel Aydar, Zeynep Aksoylu Özbek, Didem Sözeri Atik, Özge Süfer, Bilge Taşkin, Emine Olum, Seema Ramniwas, Sarvesh Rustagi, Daniel Cozzolino
{"title":"Farm to fork applications: how vibrational spectroscopy can be used along the whole value chain?","authors":"Ravi Pandiselvam, Alev Yüksel Aydar, Zeynep Aksoylu Özbek, Didem Sözeri Atik, Özge Süfer, Bilge Taşkin, Emine Olum, Seema Ramniwas, Sarvesh Rustagi, Daniel Cozzolino","doi":"10.1080/07388551.2024.2409124","DOIUrl":"https://doi.org/10.1080/07388551.2024.2409124","url":null,"abstract":"<p><p>Vibrational spectroscopy is a nondestructive analysis technique that depends on the periodic variations in dipole moments and polarizabilities resulting from the molecular vibrations of molecules/atoms. These methods have important advantages over conventional analytical techniques, including (a) their simplicity in terms of implementation and operation, (b) their adaptability to on-line and on-farm applications, (c) making measurement in a few minutes, and (d) the absence of dangerous solvents throughout sample preparation or measurement. Food safety is a concept that requires the assurance that food is free from any physical, chemical, or biological hazards at all stages, from farm to fork. Continuous monitoring should be provided in order to guarantee the safety of the food. Regarding their advantages, vibrational spectroscopic methods, such as Fourier-transform infrared (FTIR), near-infrared (NIR), and Raman spectroscopy, are considered reliable and rapid techniques to track food safety- and food authenticity-related issues throughout the food chain. Furthermore, coupling spectral data with chemometric approaches also enables the discrimination of samples with different kinds of food safety-related hazards. This review deals with the recent application of vibrational spectroscopic techniques to monitor various hazards related to various foods, including crops, fruits, vegetables, milk, dairy products, meat, seafood, and poultry, throughout harvesting, transportation, processing, distribution, and storage.</p>","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":null,"pages":null},"PeriodicalIF":8.1,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biosynthesis, acquisition, regulation, and upcycling of heme: recent advances. 血红素的生物合成、获取、调节和再循环:最新进展。
IF 8.1 2区 工程技术
Critical Reviews in Biotechnology Pub Date : 2024-11-01 Epub Date: 2024-01-16 DOI: 10.1080/07388551.2023.2291339
Fei Yu, Ziwei Wang, Zihan Zhang, Jingwen Zhou, Jianghua Li, Jian Chen, Guocheng Du, Xinrui Zhao
{"title":"Biosynthesis, acquisition, regulation, and upcycling of heme: recent advances.","authors":"Fei Yu, Ziwei Wang, Zihan Zhang, Jingwen Zhou, Jianghua Li, Jian Chen, Guocheng Du, Xinrui Zhao","doi":"10.1080/07388551.2023.2291339","DOIUrl":"10.1080/07388551.2023.2291339","url":null,"abstract":"<p><p>Heme, an iron-containing tetrapyrrole in hemoproteins, including: hemoglobin, myoglobin, catalase, cytochrome c, and cytochrome P450, plays critical physiological roles in different organisms. Heme-derived chemicals, such as biliverdin, bilirubin, and phycocyanobilin, are known for their antioxidant and anti-inflammatory properties and have shown great potential in fighting viruses and diseases. Therefore, more and more attention has been paid to the biosynthesis of hemoproteins and heme derivatives, which depends on the adequate heme supply in various microbial cell factories. The enhancement of endogenous biosynthesis and exogenous uptake can improve the intracellular heme supply, but the excess free heme is toxic to the cells. Therefore, based on the heme-responsive regulators, several sensitive biosensors were developed to fine-tune the intracellular levels of heme. In this review, recent advances in the: biosynthesis, acquisition, regulation, and upcycling of heme were summarized to provide a solid foundation for the efficient production and application of high-value-added hemoproteins and heme derivatives.</p>","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":null,"pages":null},"PeriodicalIF":8.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139478380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Every road leads to Rome: diverse biosynthetic regulation of plant cell wall-degrading enzymes in filamentous fungi Penicillium oxalicum and Trichoderma reesei. 条条大路通罗马:丝状真菌草青霉和里氏木霉中植物细胞壁降解酶的多种生物合成调控。
IF 8.1 2区 工程技术
Critical Reviews in Biotechnology Pub Date : 2024-11-01 Epub Date: 2023-11-30 DOI: 10.1080/07388551.2023.2280810
Shuai Zhao, Ting Zhang, Tomohisa Hasunuma, Akihiko Kondo, Xin-Qing Zhao, Jia-Xun Feng
{"title":"Every road leads to Rome: diverse biosynthetic regulation of plant cell wall-degrading enzymes in filamentous fungi <i>Penicillium oxalicum</i> and <i>Trichoderma reesei</i>.","authors":"Shuai Zhao, Ting Zhang, Tomohisa Hasunuma, Akihiko Kondo, Xin-Qing Zhao, Jia-Xun Feng","doi":"10.1080/07388551.2023.2280810","DOIUrl":"10.1080/07388551.2023.2280810","url":null,"abstract":"<p><p>Cellulases and xylanases are plant cell wall-degrading enzymes (CWDEs) that are critical to sustainable bioproduction based on renewable lignocellulosic biomass to reduce carbon dioxide emission. Currently, these enzymes are mainly produced from filamentous fungi, especially <i>Trichoderma reesei</i> and <i>Penicillium oxalicum</i>. However, an in-depth comparison of these two producers has not been performed. Although both <i>P. oxalicum</i> and <i>T. reesei</i> harbor CWDE systems, they exhibit distinct features regulating the production of these enzymes, mainly through different transcriptional regulatory networks. This review presents the strikingly different modes of genome-wide regulation of cellulase and xylanase biosynthesis in <i>P. oxalicum</i> and <i>T. reesei</i>, including sugar transporters, signal transduction cascades, transcription factors, chromatin remodeling, and three-dimensional organization of chromosomes. In addition, different molecular breeding approaches employed, based on the understanding of the regulatory networks, are summarized. This review highlights the existence of very different regulatory modes leading to the efficient regulation of CWDE production in filamentous fungi, akin to the adage that \"every road leads to Rome.\" An understanding of this divergence may help further improvements in fungal enzyme production through the metabolic engineering and synthetic biology of certain fungal species.</p>","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":null,"pages":null},"PeriodicalIF":8.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138458393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microbial alchemy: upcycling of brewery spent grains into high-value products through fermentation. 微生物炼金术:通过发酵将酿酒废弃谷物转化为高价值产品。
IF 8.1 2区 工程技术
Critical Reviews in Biotechnology Pub Date : 2024-11-01 Epub Date: 2024-01-01 DOI: 10.1080/07388551.2023.2286430
Vishal Ahuja, Shikha Chauhan, Sukhvinder Singh Purewal, Sanjeet Mehariya, Anil Kumar Patel, Gopalakrishnan Kumar, Mallavarapu Megharaj, Yung-Hun Yang, Shashi Kant Bhatia
{"title":"Microbial alchemy: upcycling of brewery spent grains into high-value products through fermentation.","authors":"Vishal Ahuja, Shikha Chauhan, Sukhvinder Singh Purewal, Sanjeet Mehariya, Anil Kumar Patel, Gopalakrishnan Kumar, Mallavarapu Megharaj, Yung-Hun Yang, Shashi Kant Bhatia","doi":"10.1080/07388551.2023.2286430","DOIUrl":"10.1080/07388551.2023.2286430","url":null,"abstract":"<p><p>Spent grains are one of the lignocellulosic biomasses available in abundance, discarded by breweries as waste. The brewing process generates around 25-30% of waste in different forms and spent grains alone account for 80-85% of that waste, resulting in a significant global waste volume. Despite containing essential nutrients, i.e., carbohydrates, fibers, proteins, fatty acids, lipids, minerals, and vitamins, efficient and economically viable valorization of these grains is lacking. Microbial fermentation enables the valorization of spent grain biomass into numerous commercially valuable products used in energy, food, healthcare, and biomaterials. However, the process still needs more investigation to overcome challenges, such as transportation, cost-effective pretreatment, and fermentation strategy. to lower the product cost and to achieve market feasibility and customer affordability. This review summarizes the potential of spent grains valorization <i>via</i> microbial fermentation and associated challenges.</p>","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":null,"pages":null},"PeriodicalIF":8.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139073573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bacteriophages: a potential game changer in food processing industry. 噬菌体:食品加工业的潜在变革者。
IF 8.1 2区 工程技术
Critical Reviews in Biotechnology Pub Date : 2024-11-01 Epub Date: 2024-01-16 DOI: 10.1080/07388551.2023.2299768
Vandana Chaudhary, Priyanka Kajla, Deepika Lather, Nisha Chaudhary, Priya Dangi, Punit Singh, Ravi Pandiselvam
{"title":"Bacteriophages: a potential game changer in food processing industry.","authors":"Vandana Chaudhary, Priyanka Kajla, Deepika Lather, Nisha Chaudhary, Priya Dangi, Punit Singh, Ravi Pandiselvam","doi":"10.1080/07388551.2023.2299768","DOIUrl":"10.1080/07388551.2023.2299768","url":null,"abstract":"<p><p>In the food industry, despite the widespread use of interventions such as preservatives and thermal and non-thermal processing technologies to improve food safety, incidences of foodborne disease continue to happen worldwide, prompting the search for alternative strategies. Bacteriophages, commonly known as phages, have emerged as a promising alternative for controlling pathogenic bacteria in food. This review emphasizes the potential applications of phages in biological sciences, food processing, and preservation, with a particular focus on their role as biocontrol agents for improving food quality and preservation. By shedding light on recent developments and future possibilities, this review highlights the significance of phages in the food industry. Additionally, it addresses crucial aspects such as regulatory status and safety concerns surrounding the use of bacteriophages. The inclusion of up-to-date literature further underscores the relevance of phage-based strategies in reducing foodborne pathogenic bacteria's presence in both food and the production environment. As we look ahead, new phage products are likely to be targeted against emerging foodborne pathogens. This will further advance the efficacy of approaches that are based on phages in maintaining the safety and security of food.</p>","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":null,"pages":null},"PeriodicalIF":8.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139478378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Utilizing proteomics to identify and optimize microalgae strains for high-quality dietary protein: a review. 利用蛋白质组学技术鉴定和优化微藻菌株获取优质膳食蛋白质的研究进展。
IF 8.1 2区 工程技术
Critical Reviews in Biotechnology Pub Date : 2024-11-01 Epub Date: 2023-11-30 DOI: 10.1080/07388551.2023.2283376
Sara Hamzelou, Damien Belobrajdic, James A Broadbent, Angéla Juhász, Kim Lee Chang, Ian Jameson, Peter Ralph, Michelle L Colgrave
{"title":"Utilizing proteomics to identify and optimize microalgae strains for high-quality dietary protein: a review.","authors":"Sara Hamzelou, Damien Belobrajdic, James A Broadbent, Angéla Juhász, Kim Lee Chang, Ian Jameson, Peter Ralph, Michelle L Colgrave","doi":"10.1080/07388551.2023.2283376","DOIUrl":"10.1080/07388551.2023.2283376","url":null,"abstract":"<p><p>Algae-derived protein has immense potential to provide high-quality protein foods for the expanding human population. To meet its potential, a broad range of scientific tools are required to identify optimal algal strains from the hundreds of thousands available and identify ideal growing conditions for strains that produce high-quality protein with functional benefits. A research pipeline that includes proteomics can provide a deeper interpretation of microalgal composition and biochemistry in the pursuit of these goals. To date, proteomic investigations have largely focused on pathways that involve lipid production in selected microalgae species. Herein, we report the current state of microalgal proteome measurement and discuss promising approaches for the development of protein-containing food products derived from algae.</p>","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":null,"pages":null},"PeriodicalIF":8.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138458394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Global regulator IrrE on stress tolerance: a review. 关于抗逆性的全球调控因子 IrrE:综述。
IF 8.1 2区 工程技术
Critical Reviews in Biotechnology Pub Date : 2024-11-01 Epub Date: 2024-01-21 DOI: 10.1080/07388551.2023.2299766
Li Wang, Yong-Shui Tan, Kai Chen, Samuel Ntakirutimana, Zhi-Hua Liu, Bing-Zhi Li, Ying-Jin Yuan
{"title":"Global regulator IrrE on stress tolerance: a review.","authors":"Li Wang, Yong-Shui Tan, Kai Chen, Samuel Ntakirutimana, Zhi-Hua Liu, Bing-Zhi Li, Ying-Jin Yuan","doi":"10.1080/07388551.2023.2299766","DOIUrl":"10.1080/07388551.2023.2299766","url":null,"abstract":"<p><p>Stress tolerance is a vital attribute for all living beings to cope with environmental adversities. IrrE (also named PprI) from <i>Deinococcus radiodurans</i> enhances resistance to extreme radiation stress by functioning as a global regulator, mediating the transcription of genes involved in deoxyribonucleic acid (DNA) damage response (DDR). The expression of IrrE augmented the resilience of various species to heat, radiation, oxidation, osmotic stresses and inhibitors, encompassing bacterial, fungal, plant, and mammalian cells. Moreover, IrrE was employed in a global regulator engineering strategy to broaden its applications in stress tolerance. The regulatory impacts of heterologously expressed IrrE have been investigated at the molecular and systems level, including the regulation of genes, proteins, modules, or pathways involved in DNA repair, detoxification proteins, protective molecules, native regulators and other aspects. In this review, we discuss the regulatory role and mechanism of IrrE in the antiradiation response of <i>D. radiodurans</i>. Furthermore, the applications and regulatory effects of heterologous expression of IrrE to enhance abiotic stress tolerance are summarized in particular.</p>","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":null,"pages":null},"PeriodicalIF":8.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139512046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ascorbic acid: a metabolite switch for designing stress-smart crops. 抗坏血酸:设计抗逆作物的代谢开关。
IF 8.1 2区 工程技术
Critical Reviews in Biotechnology Pub Date : 2024-11-01 Epub Date: 2024-01-01 DOI: 10.1080/07388551.2023.2286428
Shefali Mishra, Ankush Sharma, Ashish Kumar Srivastava
{"title":"Ascorbic acid: a metabolite switch for designing stress-smart crops.","authors":"Shefali Mishra, Ankush Sharma, Ashish Kumar Srivastava","doi":"10.1080/07388551.2023.2286428","DOIUrl":"10.1080/07388551.2023.2286428","url":null,"abstract":"<p><p>Plant growth and productivity are continually being challenged by a diverse array of abiotic stresses, including: water scarcity, extreme temperatures, heavy metal exposure, and soil salinity. A common theme in these stresses is the overproduction of reactive oxygen species (ROS), which disrupts cellular redox homeostasis causing oxidative damage. Ascorbic acid (AsA), commonly known as vitamin C, is an essential nutrient for humans, and also plays a crucial role in the plant kingdom. AsA is synthesized by plants through the d-mannose/l-galactose pathway that functions as a powerful antioxidant and protects plant cells from ROS generated during photosynthesis. AsA controls several key physiological processes, including: photosynthesis, respiration, and carbohydrate metabolism, either by acting as a co-factor for metabolic enzymes or by regulating cellular redox-status. AsA's multi-functionality uniquely positions it to integrate and recalibrate redox-responsive transcriptional/metabolic circuits and essential biological processes, in accordance to developmental and environmental cues. In recognition of this, we present a systematic overview of current evidence highlighting AsA as a central metabolite-switch in plants. Further, a comprehensive overview of genetic manipulation of genes involved in AsA metabolism has been provided along with the bottlenecks and future research directions, that could serve as a framework for designing \"stress-smart\" crops in future.</p>","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":null,"pages":null},"PeriodicalIF":8.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139073572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in high-throughput screening approaches for biosurfactants: current trends, bottlenecks and perspectives. 生物表面活性剂高通量筛选方法的进展:当前趋势、瓶颈和前景。
IF 8.1 2区 工程技术
Critical Reviews in Biotechnology Pub Date : 2024-11-01 Epub Date: 2024-01-17 DOI: 10.1080/07388551.2023.2290981
Muneer Ahmed Qazi, Irfan Ali Phulpoto, Qinhong Wang, Zongjie Dai
{"title":"Advances in high-throughput screening approaches for biosurfactants: current trends, bottlenecks and perspectives.","authors":"Muneer Ahmed Qazi, Irfan Ali Phulpoto, Qinhong Wang, Zongjie Dai","doi":"10.1080/07388551.2023.2290981","DOIUrl":"10.1080/07388551.2023.2290981","url":null,"abstract":"<p><p>The market size of biosurfactants (BSs) has been expanding at an extremely fast pace due to their broad application scope. Therefore, the re-construction of cell factories with modified genomic and metabolic profiles for desired industrial performance has been an intriguing aspect. Typical mutagenesis approaches generate huge mutant libraries, whereas a battery of specific, robust, and cost-effective high-throughput screening (HTS) methods is requisite to screen target strains for desired phenotypes. So far, only a few specialized HTS assays have been developed for BSs that were successfully applied to obtain anticipated mutants. The most important milestones to reach, however, continue to be: specificity, sensitivity, throughput, and the potential for automation. Here, we discuss important colorimetric and fluorometric HTS approaches for possible intervention on automated HTS platforms. Moreover, we explain current bottlenecks in developing specialized HTS platforms for screening high-yielding producers and discuss possible perspectives for addressing such challenges.</p>","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":null,"pages":null},"PeriodicalIF":8.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139485388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Critical analysis of analytical techniques developed for statins in biological fluids, environmental and fermentation samples. 对针对生物液体、环境和发酵样品中他汀类药物开发的分析技术进行批判性分析。
IF 8.1 2区 工程技术
Critical Reviews in Biotechnology Pub Date : 2024-10-21 DOI: 10.1080/07388551.2024.2412128
Seenivasan Ayothiraman, Nithya Murugesan, Gautam Sethi
{"title":"Critical analysis of analytical techniques developed for statins in biological fluids, environmental and fermentation samples.","authors":"Seenivasan Ayothiraman, Nithya Murugesan, Gautam Sethi","doi":"10.1080/07388551.2024.2412128","DOIUrl":"https://doi.org/10.1080/07388551.2024.2412128","url":null,"abstract":"<p><p>Statins are the most prescribed drug for regulating the high cholesterol level in the blood, which can lead to severe complications, such as cardiovascular diseases and other health complications. A wide range of analytical techniques have been employed for the quantification of statins from various origins, including fermentation derived (lovastatin, pravastatin, and compactin), semi-synthetic (simvastatin), and synthetic (atorvastatin, rosuvastatin, and fluvastatin) routes. The presence of more than one structural form and structural analogue generated in the biosynthesis pathway, as well as reaction intermediates and macromolecules in the clinical sample, complicates the quantification of statins. Furthermore, significant concentrations of statins in environmental samples pose serious health and ecology hazards, and estimating statins in those diluted samples is extremely difficult. On the other hand, the: cost, accurate estimation of the desired one from other structural forms, sample complexity, time, limits of detection and quantification, were major criteria distinguishing the usability of each technique. As a result, the current manuscript focuses on analytical techniques such as molecular spectroscopy (normal and derivatives UV-Visible spectrophotometer), chromatography (TLC, HP-TLC, HPLC, GC, swing column, micellar, and supercritical fluid), mass spectroscopy (HPLC-MS/MS and GC-MS/MS), sequential flow injection, capillary electrophoresis, and cyclic voltammetry, as well as their: optimal operating conditions, limits of detection and quantification, advancements, and limitations. Furthermore, various online and offline sample preparations (precipitation, solid phase extraction, liquid-liquid extraction, and micellar extraction) have been highlighted as an essential pretreatment technique to avoid the interference caused by structural analogues and other macromolecules. The greener and more sustainable concepts used in analytical approaches for the quantification statins are also highlighted with current advancements.</p>","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":null,"pages":null},"PeriodicalIF":8.1,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信