Critical Reviews in Biotechnology最新文献

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Advances in Vibrio-related infection management: an integrated technology approach for aquaculture and human health. 弧菌相关感染管理的进展:促进水产养殖和人类健康的综合技术方法。
IF 9 2区 工程技术
Critical Reviews in Biotechnology Pub Date : 2024-05-05 DOI: 10.1080/07388551.2024.2336526
Anshuman Mishra, Heui-Soo Kim, Rajender Kumar, Vaibhav Srivastava
{"title":"Advances in <i>Vibrio</i>-related infection management: an integrated technology approach for aquaculture and human health.","authors":"Anshuman Mishra, Heui-Soo Kim, Rajender Kumar, Vaibhav Srivastava","doi":"10.1080/07388551.2024.2336526","DOIUrl":"https://doi.org/10.1080/07388551.2024.2336526","url":null,"abstract":"<p><p><i>Vibrio</i> species pose significant threats worldwide, causing mortalities in aquaculture and infections in humans. Global warming and the emergence of worldwide strains <i>of Vibrio</i> diseases are increasing day by day. Control of <i>Vibrio</i> species requires effective monitoring, diagnosis, and treatment strategies at the global scale. Despite current efforts based on chemical, biological, and mechanical means, <i>Vibrio</i> control management faces limitations due to complicated implementation processes. This review explores the intricacies and challenges of <i>Vibrio</i>-related diseases, including accurate and cost-effective diagnosis and effective control. The global burden due to emerging <i>Vibrio</i> species further complicates management strategies. We propose an innovative integrated technology model that harnesses cutting-edge technologies to address these obstacles. The proposed model incorporates advanced tools, such as biosensing technologies, the Internet of Things (IoT), remote sensing devices, cloud computing, and machine learning. This model offers invaluable insights and supports better decision-making by integrating real-time ecological data and biological phenotype signatures. A major advantage of our approach lies in leveraging cloud-based analytics programs, efficiently extracting meaningful information from vast and complex datasets. Collaborating with data and clinical professionals ensures logical and customized solutions tailored to each unique situation. Aquaculture biotechnology that prioritizes sustainability may have a large impact on human health and the seafood industry. Our review underscores the importance of adopting this model, revolutionizing the prognosis and management of <i>Vibrio</i>-related infections, even under complex circumstances. Furthermore, this model has promising implications for aquaculture and public health, addressing the United Nations Sustainable Development Goals and their development agenda.</p>","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":null,"pages":null},"PeriodicalIF":9.0,"publicationDate":"2024-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140847233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chromatin modifications and memory in regulation of stress-related polyphenols: finding new ways to control flavonoid biosynthesis 应激相关多酚调控中的染色质修饰和记忆:寻找控制类黄酮生物合成的新方法
IF 9 2区 工程技术
Critical Reviews in Biotechnology Pub Date : 2024-05-02 DOI: 10.1080/07388551.2024.2336529
Victor P. Bulgakov
{"title":"Chromatin modifications and memory in regulation of stress-related polyphenols: finding new ways to control flavonoid biosynthesis","authors":"Victor P. Bulgakov","doi":"10.1080/07388551.2024.2336529","DOIUrl":"https://doi.org/10.1080/07388551.2024.2336529","url":null,"abstract":"The influence of epigenetic factors on plant defense responses and the balance between growth and defense is becoming a central area in plant biology. It is believed that the biosynthesis of second...","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":null,"pages":null},"PeriodicalIF":9.0,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140841866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bioproduction of porphyrins, phycobilins, and their proteins using microbial cell factories: engineering, metabolic regulations, challenges, and perspectives. 利用微生物细胞工厂进行卟啉、藻青素及其蛋白质的生物生产:工程、代谢调节、挑战和前景。
IF 9 2区 工程技术
Critical Reviews in Biotechnology Pub Date : 2024-05-01 Epub Date: 2023-02-12 DOI: 10.1080/07388551.2023.2168512
Young Jin Ko, Myeong-Eun Lee, Byeong-Hyeon Cho, Minhye Kim, Jeong Eun Hyeon, Joo Hee Han, Sung Ok Han
{"title":"Bioproduction of porphyrins, phycobilins, and their proteins using microbial cell factories: engineering, metabolic regulations, challenges, and perspectives.","authors":"Young Jin Ko, Myeong-Eun Lee, Byeong-Hyeon Cho, Minhye Kim, Jeong Eun Hyeon, Joo Hee Han, Sung Ok Han","doi":"10.1080/07388551.2023.2168512","DOIUrl":"10.1080/07388551.2023.2168512","url":null,"abstract":"<p><p>Porphyrins, phycobilins, and their proteins have abundant π-electrons and strongly absorb visible light, some of which bind a metal ion in the center. Because of the structural and optical properties, they not only play critical roles as an essential component in natural systems but also have attracted much attention as a high value specialty chemical in various fields, including renewable energy, cosmetics, medicines, and foods. However, their commercial application seems to be still limited because the market price of porphyrins and phycobilins is generally expensive to apply them easily. Furthermore, their petroleum-based chemical synthesis is energy-intensive and emits a pollutant. Recently, to replace petroleum-based production, many studies on the bioproduction of metalloporphyrins, including Zn-porphyrin, Co-porphyrin, and heme, porphyrin derivatives including chlorophyll, biliverdin, and phycobilins, and their proteins including hemoproteins, phycobiliproteins, and phytochromes from renewable carbon sources using microbial cell factories have been reported. This review outlines recent advances in the bioproduction of porphyrins, phycobilins, and their proteins using microbial cell factories developed by various microbial biotechnology techniques, provides well-organized information on metabolic regulations of the porphyrin metabolism, and then critically discusses challenges and future perspectives. Through these, it is expected to be able to achieve possible solutions and insights and to develop an outstanding platform to be applied to the industry in future research.</p>","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":null,"pages":null},"PeriodicalIF":9.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10753330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular modification and biotechnological applications of microbial aspartic proteases. 微生物天冬氨酸蛋白酶的分子改造和生物技术应用。
IF 9 2区 工程技术
Critical Reviews in Biotechnology Pub Date : 2024-05-01 Epub Date: 2023-02-26 DOI: 10.1080/07388551.2023.2171850
Richard Ansah Herman, Ellen Ayepa, Wen-Xin Zhang, Zong-Nan Li, Xuan Zhu, Michael Ackah, Shuang-Shuang Yuan, Shuai You, Jun Wang
{"title":"Molecular modification and biotechnological applications of microbial aspartic proteases.","authors":"Richard Ansah Herman, Ellen Ayepa, Wen-Xin Zhang, Zong-Nan Li, Xuan Zhu, Michael Ackah, Shuang-Shuang Yuan, Shuai You, Jun Wang","doi":"10.1080/07388551.2023.2171850","DOIUrl":"10.1080/07388551.2023.2171850","url":null,"abstract":"<p><p>The growing preference for incorporating microbial aspartic proteases in industries is due to their high catalytic function and high degree of substrate selectivity. These properties, however, are attributable to molecular alterations in their structure and a variety of other characteristics. Molecular tools, functional genomics, and genome editing technologies coupled with other biotechnological approaches have aided in improving the potential of industrially important microbial proteases by addressing some of their major limitations, such as: low catalytic efficiency, low conversion rates, low thermostability, and less enzyme yield. However, the native folding within their full domain is dependent on a surrounding structure which challenges their functionality in substrate conversion, mainly due to their mutual interactions in the context of complex systems. Hence, manipulating their structure and controlling their expression systems could potentially produce enzymes with high selectivity and catalytic functions. The proteins produced by microbial aspartic proteases are industrially capable and far-reaching in regulating certain harmful distinctive industrial processes and the benefits of being eco-friendly. This review provides: an update on current trends and gaps in microbial protease biotechnology, exploring the relevant recombinant strategies and molecular technologies widely used in expression platforms for engineering microbial aspartic proteases, as well as their potential industrial and biotechnological applications.</p>","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":null,"pages":null},"PeriodicalIF":9.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10768901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microbial assisted multifaceted amelioration processes of heavy-metal remediation: a clean perspective toward sustainable and greener future. 微生物辅助的多方面重金属修复过程:迈向可持续和更绿色未来的清洁视角。
IF 9 2区 工程技术
Critical Reviews in Biotechnology Pub Date : 2024-05-01 Epub Date: 2023-02-27 DOI: 10.1080/07388551.2023.2170862
Komal Agrawal, Tannu Ruhil, Vijai Kumar Gupta, Pradeep Verma
{"title":"Microbial assisted multifaceted amelioration processes of heavy-metal remediation: a clean perspective toward sustainable and greener future.","authors":"Komal Agrawal, Tannu Ruhil, Vijai Kumar Gupta, Pradeep Verma","doi":"10.1080/07388551.2023.2170862","DOIUrl":"10.1080/07388551.2023.2170862","url":null,"abstract":"<p><p>Rapidly increasing heavy metal waste has adversely affected the environment and the Earth's health. The lack of appropriate remediation technologies has worsened the issue globally, especially in developing countries. Heavy-metals contaminants have severely impacted the environment and led to devastating conditions owing to their abundance and reactivity. As they are nondegradable, the potential risk increases even at a low concentration. However, heavy-metal remediation has increased with the up-gradation of technologies and integration of new approaches. Also, of all the treatment methodologies, microbial-assisted multifaceted approach for ameliorating heavy metals is a promising strategy for propagating the idea of a green and sustainable environment with minimal waste aggregation. Microbial remediation combined with different biotechniques could aid in unraveling new methods for eradicating heavy metals. Thus, the present review focuses on various microbial remediation approaches and their affecting factors, enabling recapitulation of the interplay between heavy-metals ions and microorganisms. Additionally, heavy-metals remediation mechanisms adapted by microorganisms, the role of genetically modified (GM) microorganisms, life cycle assessment (LCA), techno-economic assessment (TEA) limitations, and prospects of microbial-assisted amelioration of heavy-metals have been elaborated in the current review with focus toward \"<i>sustainable and greener future</i>.\"</p>","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":null,"pages":null},"PeriodicalIF":9.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9358560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing plastic biodegradation process: strategies and opportunities. 加强塑料生物降解过程:战略和机遇。
IF 9 2区 工程技术
Critical Reviews in Biotechnology Pub Date : 2024-05-01 Epub Date: 2023-02-14 DOI: 10.1080/07388551.2023.2170861
Xue Er Crystal Thew, Sewn Cen Lo, Ramakrishnan Nagasundara Ramanan, Beng Ti Tey, Nguyen Duc Huy, Ooi Chien Wei
{"title":"Enhancing plastic biodegradation process: strategies and opportunities.","authors":"Xue Er Crystal Thew, Sewn Cen Lo, Ramakrishnan Nagasundara Ramanan, Beng Ti Tey, Nguyen Duc Huy, Ooi Chien Wei","doi":"10.1080/07388551.2023.2170861","DOIUrl":"10.1080/07388551.2023.2170861","url":null,"abstract":"<p><p>Plastic biodegradation has emerged as a sustainable approach and green alternative in handling the ever-increasing accumulation of plastic wastes in the environment. The complete biodegradation of polyethylene terephthalate is one of the most recent breakthroughs in the field of plastic biodegradation. Despite the success, the effective and complete biodegradation of a wide variety of plastics is still far from the practical implementation, and an on-going effort has been mainly devoted to the exploration of novel microorganisms and enzymes for plastic biodegradation. However, alternative strategies which enhance the existing biodegradation process should not be neglected in the continuous advancement of this field. Thus, this review highlights various strategies which have shown to improve the biodegradation of plastics, which include the pretreatment of plastics using UV irradiation, thermal, or chemical treatments to increase the susceptibility of plastics toward microbial action. Alternative pretreatment strategies are also suggested and compared with the existing techniques. Besides, the effects of additives such as pro-oxidants, natural polymers, and surfactants on plastic biodegradation are discussed. In addition, considerations governing the biodegradation performance, such as the formulation of biodegradation medium, cell-free biocatalysis, and physico-chemical properties of plastics, are addressed. Lastly, the challenges and future prospects for the advancement of plastic biodegradation are also highlighted.</p>","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":null,"pages":null},"PeriodicalIF":9.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10716827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Production of L-serine and its derivative L-cysteine from renewable feedstocks using Corynebacterium glutamicum: advances and perspectives. 利用谷氨酸棒杆菌从可再生原料中生产 L-丝氨酸及其衍生物 L-半胱氨酸:进展与前景。
IF 9 2区 工程技术
Critical Reviews in Biotechnology Pub Date : 2024-05-01 Epub Date: 2023-03-21 DOI: 10.1080/07388551.2023.2170863
Guoqiang Xu, Xiaomei Zhang, Wenhan Xiao, Jinsong Shi, Zhenghong Xu
{"title":"Production of L-serine and its derivative L-cysteine from renewable feedstocks using <i>Corynebacterium glutamicum</i>: advances and perspectives.","authors":"Guoqiang Xu, Xiaomei Zhang, Wenhan Xiao, Jinsong Shi, Zhenghong Xu","doi":"10.1080/07388551.2023.2170863","DOIUrl":"10.1080/07388551.2023.2170863","url":null,"abstract":"<p><p>L-serine and its derivative L-cysteine have broad industrial applications, and their direct fermentative production from renewable biomass is gaining increasing attention. <i>Corynebacterium glutamicum</i> is an extensively studied and well-established industrial microorganism, which is a predominant microbial host for producing amino acids. In this review, updated information on the genetics and molecular mechanisms underlying L-serine and L-cysteine production using <i>C. glutamicum</i> is presented, including their synthesis and degradation pathways, and other intracellular processes related to their production, as well as the mechanisms underlying substrate import and product export are also analyzed. Furthermore, metabolic strategies for strain improvement are systematically discussed, and conclusions and future perspectives for bio-based L-serine and L-cysteine production using <i>C. glutamicum</i> are presented. This review can provide a thorough understanding of L-serine and L-cysteine metabolic pathways to facilitate metabolic engineering modifications of <i>C. glutamicum</i> and development of more efficient industrial fermentation processes for L-serine and L-cysteine production.</p>","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":null,"pages":null},"PeriodicalIF":9.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9164103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fast-growing cyanobacterial chassis for synthetic biology application. 用于合成生物学应用的快速生长蓝藻底盘。
IF 9 2区 工程技术
Critical Reviews in Biotechnology Pub Date : 2024-05-01 Epub Date: 2023-02-26 DOI: 10.1080/07388551.2023.2166455
Zhixiang Li, Shubin Li, Lei Chen, Tao Sun, Weiwen Zhang
{"title":"Fast-growing cyanobacterial chassis for synthetic biology application.","authors":"Zhixiang Li, Shubin Li, Lei Chen, Tao Sun, Weiwen Zhang","doi":"10.1080/07388551.2023.2166455","DOIUrl":"10.1080/07388551.2023.2166455","url":null,"abstract":"<p><p>Carbon neutrality by 2050 has become one of the most urgent challenges the world faces today. To address the issue, it is necessary to develop and promote new technologies related with CO<sub>2</sub> recycling. Cyanobacteria are the only prokaryotes performing oxygenic photosynthesis, capable of fixing CO<sub>2</sub> into biomass under sunlight and serving as one of the most important primary producers on earth. Notably, recent progress on synthetic biology has led to utilizing model cyanobacteria such as <i>Synechocystis</i> sp. PCC 6803 and <i>Synechococcus elongatus</i> PCC 7942 as chassis for \"light-driven autotrophic cell factories\" to produce several dozens of biofuels and various fine chemicals directly from CO<sub>2</sub>. However, due to the slow growth rate and low biomass accumulation in the current chassis, the productivity for most products is still lower than the threshold necessary for large-scale commercial application, raising the importance of developing high-efficiency cyanobacterial chassis with fast growth and/or higher biomass accumulation capabilities. In this article, we critically reviewed recent progresses on identification, systems biology analysis, and engineering of fast-growing cyanobacterial chassis. Specifically, fast-growing cyanobacteria identified in recent years, such as <i>S. elongatus</i> UTEX 2973, <i>S. elongatus</i> PCC 11801, <i>S. elongatus</i> PCC 11802 and <i>Synechococcus</i> sp. PCC 11901 was comparatively analyzed. In addition, the progresses on their recent application in converting CO<sub>2</sub> into chemicals, and genetic toolboxes developed for these new cyanobacterial chassis were discussed. Finally, the article provides insights into future challenges and perspectives on the synthetic biology application of cyanobacterial chassis.</p>","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":null,"pages":null},"PeriodicalIF":9.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10768902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in the metabolic engineering of Saccharomyces cerevisiae and Yarrowia lipolytica for the production of β-carotene. 生产β-胡萝卜素的酿酒酵母和脂肪分解酵母代谢工程研究进展。
IF 9 2区 工程技术
Critical Reviews in Biotechnology Pub Date : 2024-05-01 Epub Date: 2023-02-13 DOI: 10.1080/07388551.2023.2166809
Qi Guo, Qian-Qian Peng, Ya-Wen Li, Fang Yan, Yue-Tong Wang, Chao Ye, Tian-Qiong Shi
{"title":"Advances in the metabolic engineering of <i>Saccharomyces cerevisiae</i> and <i>Yarrowia lipolytica</i> for the production of <b>β</b>-carotene.","authors":"Qi Guo, Qian-Qian Peng, Ya-Wen Li, Fang Yan, Yue-Tong Wang, Chao Ye, Tian-Qiong Shi","doi":"10.1080/07388551.2023.2166809","DOIUrl":"10.1080/07388551.2023.2166809","url":null,"abstract":"<p><p>β-Carotene is one kind of the most important carotenoids. The major functions of β-carotene include the antioxidant and anti-cardiovascular properties, which make it a growing market. Recently, the use of metabolic engineering to construct microbial cell factories to synthesize β-carotene has become the latest model for its industrial production. Among these cell factories, yeasts including <i>Saccharomyces cerevisiae</i> and <i>Yarrowia lipolytica</i> have attracted the most attention because of the: security, mature genetic manipulation tools, high flux toward carotenoids using the native mevalonate pathway and robustness for large-scale fermentation. In this review, the latest strategies for β-carotene biosynthesis, including protein engineering, promoters engineering and morphological engineering are summarized in detail. Finally, perspectives for future engineering approaches are proposed to improve β-carotene production.</p>","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":null,"pages":null},"PeriodicalIF":9.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9248098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
It comes from the sea: macroalgae-derived bioactive compounds with anti-cancer potential. 它来自海洋:从大型藻类中提取的生物活性化合物具有抗癌潜力。
IF 9 2区 工程技术
Critical Reviews in Biotechnology Pub Date : 2024-05-01 Epub Date: 2023-02-26 DOI: 10.1080/07388551.2023.2174068
Paulo Nova, Ana Maria Gomes, Ana R Costa-Pinto
{"title":"It comes from the sea: macroalgae-derived bioactive compounds with anti-cancer potential.","authors":"Paulo Nova, Ana Maria Gomes, Ana R Costa-Pinto","doi":"10.1080/07388551.2023.2174068","DOIUrl":"10.1080/07388551.2023.2174068","url":null,"abstract":"<p><p>Nature derived compounds represent a valuable source of bioactive molecules with enormous potential. The sea is one of the richest environments, full of skilled organisms, where algae stand out due to their unique characteristics. Marine macroalgae adapt their phenotypic characteristics, such as chemical composition, depending on the environmental conditions where they live. The compounds produced by these organisms show tremendous potential to be used in the biomedical field, due to their antioxidant, anti-inflammatory, immunomodulatory, and anti-cancer properties.Cancer is one of the deadliest diseases in the world, and the lack of effective treatments highlights the urgent need for the development of new therapeutic strategies. This review provides an overview of the current advances regarding the anti-cancer activity of the three major groups of marine macroalgae, i.e., red algae (<i>Rhodophyta</i>), brown algae (<i>Phaeophyceae</i>), and green algae (<i>Chlorophyta</i>) on pancreatic, lung, breast, cervical, colorectal, liver, and gastric cancers as well as leukemia and melanoma. In addition, future perspectives, and limitations regarding this field of work are also discussed.</p>","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":null,"pages":null},"PeriodicalIF":9.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9322764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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