Critical Reviews in Biotechnology最新文献_第10页

Insulin fibrillation under physicochemical parameters of bioprocessing and intervention by peptides and surface-active agents. 生物加工理化参数下的胰岛素纤维化以及肽和表面活性物质的干预。

IF 8.1 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2024-08-14 DOI: 10.1080/07388551.2024.2387167

Chinmaya Panda, Sachin Kumar, Sharad Gupta, Lalit M Pandey

{"title":"Insulin fibrillation under physicochemical parameters of bioprocessing and intervention by peptides and surface-active agents.","authors":"Chinmaya Panda, Sachin Kumar, Sharad Gupta, Lalit M Pandey","doi":"10.1080/07388551.2024.2387167","DOIUrl":"https://doi.org/10.1080/07388551.2024.2387167","url":null,"abstract":"Even after the centenary celebration of insulin discovery, there prevail challenges concerning insulin aggregation, not only after repeated administration but also during industrial production, storage, transport, and delivery, significantly impacting protein quality, efficacy, and effectiveness. The aggregation reduces insulin bioavailability, increasing the risk of heightened immunogenicity, posing a threat to patient health, and creating a dent in the golden success story of insulin therapy. Insulin experiences various physicochemical and mechanical stresses due to modulations in pH, temperature, ionic strength, agitation, shear, and surface chemistry, during the upstream and downstream bioprocessing, resulting in insulin unfolding and subsequent fibrillation. This has fueled research in the pharmaceutical industry and academia to unveil the mechanistic insights of insulin aggregation in an attempt to devise rational strategies to regulate this unwanted phenomenon. The present review briefly describes the impacts of environmental factors of bioprocessing on the stability of insulin and correlates with various intermolecular interactions, particularly hydrophobic and electrostatic forces. The aggregation-prone regions of insulin are identified and interrelated with biophysical changes during stress conditions. The quest for novel additives, surface-active agents, and bioderived peptides in decelerating insulin aggregation, which results in overall structural stability, is described. We hope this review will help tackle the real-world challenges of insulin aggregation encountered during bioprocessing, ensuring safer, stable, and globally accessible insulin for efficient management of diabetes.","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":" ","pages":"1-22"},"PeriodicalIF":8.1,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141981916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Strategic approaches for designing yeast strains as protein secretion and display platforms. 设计酵母菌株作为蛋白质分泌和展示平台的战略方法。

IF 8.1 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2024-08-13 DOI: 10.1080/07388551.2024.2385996

Luping Xu, Xingjian Bai, Eun Joong Oh

引用次数: 0

Application of protein engineering to ene-reductase for the synthesis of chiral compounds through asymmetric reaction. 将蛋白质工程学应用于烯还原酶，通过不对称反应合成手性化合物。

IF 8.1 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2024-08-12 DOI: 10.1080/07388551.2024.2382957

Jiacheng Feng, Huiru Ye, Changxin Lu, Linyan Pan, Hanchi Chen, Linjiang Zhu, Xiaolong Chen

{"title":"Application of protein engineering to ene-reductase for the synthesis of chiral compounds through asymmetric reaction.","authors":"Jiacheng Feng, Huiru Ye, Changxin Lu, Linyan Pan, Hanchi Chen, Linjiang Zhu, Xiaolong Chen","doi":"10.1080/07388551.2024.2382957","DOIUrl":"https://doi.org/10.1080/07388551.2024.2382957","url":null,"abstract":"Ene-reductase (ER) has been widely applied for asymmetrical synthesis of chiral intermediates due to its substrate promiscuity, photoexcited reactivity, and excellent property with producing two chiral centers at a time. Natural ERs often exhibit the same stereoselectivity, and they need to be engineered for opposite configuration of chiral compounds. The hydrogenation process toward activated alkenes by ERs is composed of reductive half reaction and oxidative half reaction, which are dependent upon two cofactors NAD(P)H and flavin mononucleotide. The catalytic activity of ERs will be affected by the size of the substrate, the activating strength of the electron-withdrawing groups, redox potential of cofactors, and the loop flexibility around catalytic cavity. Currently, protein engineering to ERs has been successfully employed to enhance various catalytic properties, including photoexcited asymmetric synthesis. This review summarizes the approaches to reverse the stereoselectivity and enhance catalytic activity of ERs and new applications of the engineered ERs in photobiocatalytic asymmetric synthesis, besides the discussion with the existing molecular mechanisms of mutants regarding the improved catalytic performance.","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":" ","pages":"1-18"},"PeriodicalIF":8.1,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141970750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Airborne microbes: sampling, detection, and inactivation. 空气中的微生物：取样、检测和灭活。

IF 8.1 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2024-08-11 DOI: 10.1080/07388551.2024.2377191

Saisai Yan, Qing Liu, Bing Liang, Miao Zhang, Wujun Chen, Daijun Zhang, Chao Wang, Dongming Xing

{"title":"Airborne microbes: sampling, detection, and inactivation.","authors":"Saisai Yan, Qing Liu, Bing Liang, Miao Zhang, Wujun Chen, Daijun Zhang, Chao Wang, Dongming Xing","doi":"10.1080/07388551.2024.2377191","DOIUrl":"https://doi.org/10.1080/07388551.2024.2377191","url":null,"abstract":"The human living environment serves as a habitat for microorganisms and the presence of ubiquitous airborne microbes significantly impacts the natural material cycle. Through ongoing experimentation with beneficial microorganisms, humans have greatly benefited from airborne microbes. However, airborne pathogens endanger human health and have the potential to induce fatal diseases. Tracking airborne microbes is a critical prerequisite for a better understanding of bioaerosols, harnessing their potential advantages, and mitigating associated risks. Although technological breakthroughs have enabled significant advancements in accurately monitoring airborne pathogens, many puzzles about these microbes remain unanswered due to their high variability and environmental diffusibility. Consequently, advanced techniques and strategies for special identification, early warning, and efficient eradication of microbial contamination are continuously being sought. This review presents a comprehensive overview of the research status of airborne microbes, concentrating on the recent advances and challenges in sampling, detection, and inactivation. Particularly, the fundamental design principles for the collection and timely detection of airborne pathogens are described in detail, as well as critical factors for eliminating microbial contamination and enhancing indoor air quality. In addition, future research directions and perspectives for controlling airborne microbes are also suggested to promote the translation of basic research into real products.","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":" ","pages":"1-35"},"PeriodicalIF":8.1,"publicationDate":"2024-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141916252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reprogramming cellular metabolism to increase the efficiency of microbial cell factories. 重新规划细胞新陈代谢，提高微生物细胞工厂的效率。

IF 8.1 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2024-08-01 Epub Date: 2023-06-28 DOI: 10.1080/07388551.2023.2208286

Qiang Ding, Liming Liu

引用次数: 0

Magnetic nanoflowers: a hybrid platform for enzyme immobilization. 磁性纳米花：酶固定化的混合平台。

IF 8.1 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2024-08-01 Epub Date: 2023-07-16 DOI: 10.1080/07388551.2023.2230518

Pravin D Patil, Radhika K Kelkar, Neha P Patil, Pradnya V Pise, Sadhana P Patil, Arundhatti S Patil, Nishant S Kulkarni, Manishkumar S Tiwari, Ajay N Phirke, Shamraja S Nadar

{"title":"Magnetic nanoflowers: a hybrid platform for enzyme immobilization.","authors":"Pravin D Patil, Radhika K Kelkar, Neha P Patil, Pradnya V Pise, Sadhana P Patil, Arundhatti S Patil, Nishant S Kulkarni, Manishkumar S Tiwari, Ajay N Phirke, Shamraja S Nadar","doi":"10.1080/07388551.2023.2230518","DOIUrl":"10.1080/07388551.2023.2230518","url":null,"abstract":"The use of organic-inorganic hybrid nanoflowers as a support material for enzyme immobilization has gained significant attention in recent years due to their high stability, ease of preparation, and enhanced catalytic activity. However, a major challenge in utilizing these hybrid nanoflowers for enzyme immobilization is the difficulty in handling and separating them due to their low density and high dispersion. To address this issue, magnetic nanoflowers have emerged as a promising alternative enzyme immobilization platform due to their easy separation, structural stability, and ability to enhance catalytic efficiency. This review focuses on different methods for designing magnetic nanoflowers, as well as future research directions. Additionally, it provides examples of enzymes immobilized in the form of magnetic nanoflowers and their applications in environmental remediation, biosensors, and food industries. Finally, the review discusses possible ways to improve the material for enhanced catalytic activity, structural stability, and scalability.","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":" ","pages":"795-816"},"PeriodicalIF":8.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9783886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting Induced Local Lesions in Genomes (TILLING): advances and opportunities for fast tracking crop breeding. 瞄准基因组中诱导的局部病变（TILLING）：快速跟踪作物育种的进展和机遇。

IF 8.1 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2024-08-01 Epub Date: 2023-07-16 DOI: 10.1080/07388551.2023.2231630

Dharmendra Singh, Priya Chaudhary, Jyoti Taunk, Chandan Kumar Singh, Viswanathan Chinnusamy, Amitha Mithra Sevanthi, Vikram Jeet Singh, Madan Pal

{"title":"Targeting Induced Local Lesions in Genomes (TILLING): advances and opportunities for fast tracking crop breeding.","authors":"Dharmendra Singh, Priya Chaudhary, Jyoti Taunk, Chandan Kumar Singh, Viswanathan Chinnusamy, Amitha Mithra Sevanthi, Vikram Jeet Singh, Madan Pal","doi":"10.1080/07388551.2023.2231630","DOIUrl":"10.1080/07388551.2023.2231630","url":null,"abstract":"The intensification of food production via conventional crop breeding alone is inadequate to cater for global hunger. The development of precise and expeditious high throughput reverse genetics approaches has hugely benefited modern plant breeding programs. Targeting Induced Local Lesions in Genomes (TILLING) is one such reverse genetics approach which employs chemical/physical mutagenesis to create new genetic sources and identifies superior/novel alleles. Owing to technical limitations and sectional applicability of the original TILLING protocol, it has been timely modified. Successions include: EcoTILLING, Double stranded EcoTILLING (DEcoTILLING), Self-EcoTILLING, Individualized TILLING (iTILLING), Deletion-TILLING (De-TILLING), PolyTILLING, and VeggieTILLING. This has widened its application to a variety of crops and needs. They can characterize mutations in coding as well as non-coding regions and can overcome complexities associated with the large genomes. Combining next generation sequencing tools with the existing TILLING protocols has enabled screening of huge germplasm collections and mutant populations for the target genes. In silico TILLING platforms have transformed TILLING into an exciting breeding approach. The present review outlines these multifarious TILLING modifications for precise mutation detection and their application in advance breeding programmes together with relevant case studies. Appropriate use of these protocols will open up new avenues for crop improvement in the twenty first century.","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":" ","pages":"817-836"},"PeriodicalIF":8.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9781753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stimuli-responsive biomaterials: smart avenue toward 4D bioprinting. 刺激响应型生物材料：实现 4D 生物打印的智能途径。

IF 8.1 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2024-08-01 Epub Date: 2023-07-13 DOI: 10.1080/07388551.2023.2213398

Maedeh Rahimnejad, Sepideh Jahangiri, Shahrzad Zirak Hassan Kiadeh, Seyedkamaladdin Rezvaninejad, Zarrin Ahmadi, Sepideh Ahmadi, Moein Safarkhani, Navid Rabiee

{"title":"Stimuli-responsive biomaterials: smart avenue toward 4D bioprinting.","authors":"Maedeh Rahimnejad, Sepideh Jahangiri, Shahrzad Zirak Hassan Kiadeh, Seyedkamaladdin Rezvaninejad, Zarrin Ahmadi, Sepideh Ahmadi, Moein Safarkhani, Navid Rabiee","doi":"10.1080/07388551.2023.2213398","DOIUrl":"10.1080/07388551.2023.2213398","url":null,"abstract":"3D bioprinting is an advanced technology combining cells and bioactive molecules within a single bioscaffold; however, this scaffold cannot change, modify or grow in response to a dynamic implemented environment. Lately, a new era of smart polymers and hydrogels has emerged, which can add another dimension, e.g., time to 3D bioprinting, to address some of the current approaches' limitations. This concept is indicated as 4D bioprinting. This approach may assist in fabricating tissue-like structures with a configuration and function that mimic the natural tissue. These scaffolds can change and reform as the tissue are transformed with the potential of specific drug or biomolecules released for various biomedical applications, such as biosensing, wound healing, soft robotics, drug delivery, and tissue engineering, though 4D bioprinting is still in its early stages and more works are required to advance it. In this review article, the critical challenge in the field of 4D bioprinting and transformations from 3D bioprinting to 4D phases is reviewed. Also, the mechanistic aspects from the chemistry and material science point of view are discussed too.","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":" ","pages":"860-891"},"PeriodicalIF":8.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10152888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Buckwheat OMICS: present status and future prospects. 荞麦 OMICS：现状与前景。

IF 8.1 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2024-08-01 Epub Date: 2023-07-23 DOI: 10.1080/07388551.2023.2229511

Sajad Majeed Zargar, Ammarah Hami, Madhiya Manzoor, Rakeeb Ahmad Mir, Reetika Mahajan, Kaiser A Bhat, Umar Gani, Najeebul Rehman Sofi, Parvaze A Sofi, Antonio Masi

{"title":"Buckwheat OMICS: present status and future prospects.","authors":"Sajad Majeed Zargar, Ammarah Hami, Madhiya Manzoor, Rakeeb Ahmad Mir, Reetika Mahajan, Kaiser A Bhat, Umar Gani, Najeebul Rehman Sofi, Parvaze A Sofi, Antonio Masi","doi":"10.1080/07388551.2023.2229511","DOIUrl":"10.1080/07388551.2023.2229511","url":null,"abstract":"Buckwheat (Fagopyrum spp.) is an underutilized resilient crop of North Western Himalayas belonging to the family Polygonaceae and is a source of essential nutrients and therapeutics. Common Buckwheat and Tatary Buckwheat are the two main cultivated species used as food. It is the only grain crop possessing rutin, an important metabolite with high nutraceutical potential. Due to its inherent tolerance to various biotic and abiotic stresses and a short life cycle, Buckwheat has been proposed as a model crop plant. Nutritional security is one of the major concerns, breeding for a nutrient-dense crop such as Buckwheat will provide a sustainable solution. Efforts toward improving Buckwheat for nutrition and yield are limited due to the lack of available: genetic resources, genomics, transcriptomics and metabolomics. In order to harness the agricultural importance of Buckwheat, an integrated breeding and OMICS platforms needs to be established that can pave the way for a better understanding of crop biology and developing commercial varieties. This, coupled with the availability of the genome sequences of both Buckwheat species in the public domain, should facilitate the identification of alleles/QTLs and candidate genes. There is a need to further our understanding of the molecular basis of the genetic regulation that controls various economically important traits. The present review focuses on: the food and nutritional importance of Buckwheat, its various omics resources, utilization of omics approaches in understanding Buckwheat biology and, finally, how an integrated platform of breeding and omics will help in developing commercially high yielding nutrient rich cultivars in Buckwheat.","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":" ","pages":"717-734"},"PeriodicalIF":8.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9858738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DNA nanotechnology in ionic liquids and deep eutectic solvents. 离子液体和深共晶溶剂中的 DNA 纳米技术。

IF 8.1 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2024-08-01 Epub Date: 2023-07-30 DOI: 10.1080/07388551.2023.2229950

Beñat Olave

引用次数: 0