Knot-knot chronicles: unveiling the G-quadruplexes.

IF 7.7 2区工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Critical Reviews in Biotechnology Pub Date : 2025-08-01 Epub Date: 2025-01-06 DOI:10.1080/07388551.2024.2435960

Himanshi Sharma, Rohini Garg

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引用次数: 0

Abstract

G-quadruplex structures (GQSes) are the intricate molecular knots or marvels that play diverse roles in various cellular processes, such as replication, transcription, and translation, which regulate gene expression. Even though GQSes can be found throughout the genome, they are more prevalent in certain genomic regions like promoters and 5'-UTRs. This review discusses the functionality of GQSes across various regions of the genome and draws attention to the intriguing world of DNA and RNA GQSes. We highlight the uniqueness and similarities of GQSes in DNA and RNA. The functional roles of various proteins that interact with GQSes are also discussed. In addition, the role of GQSes in the context of plant development has been elaborated. The approaches for detecting GQSes using different methods and their influence in regulating gene regulation are also described. We provide insights into how GQSes can be used as potential game changers in plant biotechnology by utilizing them as regulatory switches to control various aspects of transcriptional and post-transcriptional processes depending on the arrangement of GQSes.

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结结编年史：揭秘g -四肢。

g -四重结构（GQSes）是复杂的分子结或奇迹，在各种细胞过程中起着不同的作用，如复制、转录和翻译，调节基因表达。尽管gqse可以在整个基因组中找到，但它们在某些基因组区域更普遍，如启动子和5'- utr。这篇综述讨论了gqse在基因组各个区域的功能，并将注意力吸引到DNA和RNA gqse的有趣世界。我们强调了DNA和RNA中gqse的独特性和相似性。还讨论了与gqse相互作用的各种蛋白质的功能作用。此外，还阐述了gqse在植物发育中的作用。本文还介绍了不同方法检测gqse的方法及其对基因调控的影响。我们通过利用gqse作为调控开关，根据gqse的排列方式来控制转录和转录后过程的各个方面，从而深入了解gqse如何在植物生物技术中作为潜在的游戏规则改变者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Critical Reviews in Biotechnology 工程技术-生物工程与应用微生物

CiteScore

20.80

自引率

1.10%

发文量

审稿时长

4.8 months

期刊介绍： Biotechnological techniques, from fermentation to genetic manipulation, have become increasingly relevant to the food and beverage, fuel production, chemical and pharmaceutical, and waste management industries. Consequently, academic as well as industrial institutions need to keep abreast of the concepts, data, and methodologies evolved by continuing research. This journal provides a forum of critical evaluation of recent and current publications and, periodically, for state-of-the-art reports from various geographic areas around the world. Contributing authors are recognized experts in their fields, and each article is reviewed by an objective expert to ensure accuracy and objectivity of the presentation.