Recent advances in genome mining and synthetic biology for discovery and biosynthesis of natural products.

IF 8.1 2区 工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Mingpeng Wang, Lei Chen, Zhaojie Zhang, Qinhong Wang
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引用次数: 0

Abstract

Natural products have long served as critical raw materials in chemical and pharmaceutical manufacturing, primarily which can provide superior scaffolds or intermediates for drug discovery and development. Over the last century, natural products have contributed to more than a third of therapeutic drug production. However, traditional methods of producing drugs from natural products have become less efficient and more expensive over the past few decades. The combined utilization of genome mining and synthetic biology based on genome sequencing, bioinformatics tools, big data analytics, genetic engineering, metabolic engineering, and systems biology promises to counter this trend. Here, we reviewed recent (2020-2023) examples of genome mining and synthetic biology used to resolve challenges in the production of natural products, such as less variety, poor efficiency, and low yield. Additionally, the emerging efficient tools, design principles, and building strategies of synthetic biology and its application prospects in NPs synthesis have also been discussed.

基因组挖掘和合成生物学在天然产品的发现和生物合成方面的最新进展。
长期以来,天然产品一直是化学和医药生产中的重要原材料,主要为药物发现和开发提供优质支架或中间体。在过去的一个世纪中,天然产品占治疗药物生产的三分之一以上。然而,在过去几十年里,利用天然产品生产药物的传统方法效率越来越低,成本越来越高。基于基因组测序、生物信息学工具、大数据分析、基因工程、代谢工程和系统生物学的基因组挖掘和合成生物学的综合利用有望应对这一趋势。在此,我们回顾了近期(2020-2023 年)利用基因组挖掘和合成生物学解决天然产品生产难题的实例,如品种少、效率低、产量低等。此外,我们还讨论了合成生物学的新兴高效工具、设计原理和构建策略,及其在 NPs 合成中的应用前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Critical Reviews in Biotechnology
Critical Reviews in Biotechnology 工程技术-生物工程与应用微生物
CiteScore
20.80
自引率
1.10%
发文量
71
审稿时长
4.8 months
期刊介绍: Biotechnological techniques, from fermentation to genetic manipulation, have become increasingly relevant to the food and beverage, fuel production, chemical and pharmaceutical, and waste management industries. Consequently, academic as well as industrial institutions need to keep abreast of the concepts, data, and methodologies evolved by continuing research. This journal provides a forum of critical evaluation of recent and current publications and, periodically, for state-of-the-art reports from various geographic areas around the world. Contributing authors are recognized experts in their fields, and each article is reviewed by an objective expert to ensure accuracy and objectivity of the presentation.
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