Critical reviews in analytical chemistry最新文献

{"title":"Innovation of Ratiometric Sensing Strategies Based on Graphitic Carbon Nitride.","authors":"Rui Xu, Juncai Jiang, Lan Ding, Daqian Song, Yanhua Chen","doi":"10.1080/10408347.2025.2486213","DOIUrl":"https://doi.org/10.1080/10408347.2025.2486213","url":null,"abstract":"<p><p>Graphitic carbon nitride (g-C₃N₄), a π-conjugated semiconductor with visible-light absorption, has emerged as a versatile material for ratiometric sensing due to its thermal/chemical stability, biocompatibility, and tunable optoelectronic properties. This review highlights recent advances in g-C₃N₄-based ratiometric electrochemiluminescence (ECL), fluorescence (FL), and photoelectrochemical (PEC) sensors for ultrasensitive detection of diverse analytes. Ratiometric ECL platforms achieved remarkable detection limits, such as 0.2 nM for Hg²⁺ and 59 aM for SARS-CoV-2 RdRp gene, leveraging dual-potential or dual-wavelength strategies. FL sensors enabled selective quantification of analysts, such as Ce³⁺ (6.4 × 10^-8mol/L) and tetracycline (5.0 nM) via aggregation-induced emission or inner filter effect mechanisms. In PEC sensing, spatial-resolved dual-electrode systems attained ultrahigh sensitivity for <i>Escherichia coli</i> (0.66 cfu/mL) and alpha-fetoprotein (0.2 pg/mL). These g-C₃N₄-based sensors demonstrated enhanced sensitivity and reliability across environmental, biomedical, and food safety applications. The synergy of g-C₃N₄'s structural advantages and ratiometric design principles demonstrates broad application prospects in fields such as food and environmental safety analysis, as well as early disease diagnosis.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-25"},"PeriodicalIF":4.2,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoding Xanthine Derivatives: Advanced Analytical, Extraction, and Quantification Techniques in Pharma and Biofluids - A Comprehensive Review.","authors":"Soundaryashree N R, Sinchana B Gopalaiah, Aparna Inamdar, Sanjay G Walode, Erica Alves, Karthika Paul, Bannimath Gurupadayya, Akshay Kumar K S, Chandan R S","doi":"10.1080/10408347.2025.2481401","DOIUrl":"https://doi.org/10.1080/10408347.2025.2481401","url":null,"abstract":"<p><p>Xanthine derivatives, such as bamifylline hydrochloride (BMFH), theophylline (THP), aminophylline (AMI), and diprophylline (DPH), are potent adenosine-receptor antagonists widely used in managing respiratory disorders like chronic obstructive pulmonary disease, asthma, and cardiac asthma due to their cardiovascular and diuretic properties. Despite their clinical utility, the complexity of their bioanalysis and limited advancements in analytical methodologies exhibit challenges to their broader application. This review evaluates advanced analytical, extraction, and quantification techniques for selected xanthine derivatives, emphasizing their applicability in pharmaceutical and biofluid matrices. A comprehensive review was conducted using databases like Scopus, PubMed, Web of Science, and ScienceDirect, utilizing keywords UV-visible spectrophotometric, chromatographic (high-performance liquid chromatography [HPLC], high-performance thin-layer chromatography [HPTLC]), and hyphenated (liquid chromatography-mass spectrometry [LC-MS]) techniques. A detailed analysis of extraction methods, including solid-phase extraction (SPE), liquid-liquid extraction (LLE), and protein precipitation (PPE), was included. The findings demonstrate that HPLC, often combined with SPE, offers superior sensitivity and specificity for quantifying xanthine derivatives. BMFH is effectively analyzed using HPLC with methanol (MeOH)-ammonium acetate mobile phases, achieving limits of detection <2 ng/mL. THP exhibits broad applicability in respiratory treatments, with UV-visible spectroscopy being widely used for its quantification. However, limited data for bioanalytical techniques, particularly for AMI and DPH, highlights the need for further development. Hyphenated techniques provide significant advantages in pharmacokinetic studies but remain underutilized for xanthines. This review refines analytical methods for xanthine derivatives to enhance their clinical and research applications. Future directions include developing high-throughput, automated techniques and expanding the bioanalytical profiling of underexplored derivatives like BMFH and AMI.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-23"},"PeriodicalIF":4.2,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Physicochemical Properties and Plausible Implication of Deep Eutectic Solvents in Analytical Techniques.","authors":"Vahishta K Katrak, Nensi A Patel, Sushma P Ijardar","doi":"10.1080/10408347.2025.2486209","DOIUrl":"https://doi.org/10.1080/10408347.2025.2486209","url":null,"abstract":"<p><p>Volatile organic solvents and fluoride-containing ionic liquids (ILs) have few drawbacks like toxicity, non-biodegradability, and environmental issues. Even though ILs are considered as new safest solvent for their lower volatility. They pose toxicity and sustainability concerns. Deep eutectic solvents (DESs) have garnered significant attention as substitutes for these solvents, addressing their drawbacks and aligning with specific principles of green chemistry, such as reduced toxicity, biodegradability, and the use of renewable resources. This review thoroughly explains the emergence and inception of DESs through their development. It deals with the physicochemical properties like density, polarity, and viscosity. The factors dealing with variation in density and viscosity of DES have been discussed. The preparation and operation of DESs, encompassing their various variants such as hydrophobic and hydrophilic types are examined to provide a comprehensive grasp of their chemical properties. Beyond basic characteristics, the article delves into a few specific DES applications to demonstrate their flexibility. DESs show promising multifarious utility, ranging from acting as extractant to critical roles in sorbent-based extractions, solvent-based extractions, and their role in various analytical techniques. The article covers the opportunities and difficulties associated with DESs, offering a prospective viewpoint on future advancements and difficulties. The review outlines different facets of DES research, emphasizing the level of knowledge at the moment and their potential influence in the emerging subject of DESs.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-24"},"PeriodicalIF":4.2,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrochemical biosensing methods for analysis of trace biomarkers: a review.","authors":"Baorong Zhang, Zhuomin Zhang, Gongke Li","doi":"10.1080/10408347.2025.2479032","DOIUrl":"https://doi.org/10.1080/10408347.2025.2479032","url":null,"abstract":"<p><p>Electrochemical biosensing methods have many advantages such as high sensitivity, portable instruments, fast response, low cost, etc. In recent years, electrochemical biosensing methods have been widely used for the analysis of biomarkers and demonstrated rapid progress. This review systematically covers the recent progress in electrochemical biosensing methods for trace biomarker analysis, with a primary focus on developments over the past decade. The article discusses advancements in probe preparation using metal coordination materials, metal nanomaterials, organic redox materials, and polymer nanocomposites, and highlights the construction of electrochemical DNA biosensing strategy, electrochemical aptamer biosensing strategy, and electrochemical immune-biosensing strategy. Typical applications of electrochemical biosensing methods for metal ions, virus biomarkers, and short non-protein coding RNAs are further summarized. Challenges and future perspectives are also discussed to guide further research in bioanalysis and electrochemistry.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-18"},"PeriodicalIF":4.2,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analytical Methods for the Determination of Apixaban in Pharmaceuticals and Biological Matrices: A Systematic Review.","authors":"Wanbing Rao, Chenxia Zhang, Shuming Wu, Shaoyu Cai, Zhongqing Wang","doi":"10.1080/10408347.2025.2483367","DOIUrl":"https://doi.org/10.1080/10408347.2025.2483367","url":null,"abstract":"<p><p>Apixaban (APX) is a direct oral anticoagulant (DOAC) developed by Bristol Myers Squibb and Pfizer for the prevention of stroke and systemic embolism in patients with non valvular atrial fibrillation (NVAF), as well as for the prophylaxis of deep vein thrombosis (DVT) and the reduction of recurrent DVT and pulmonary embolism risk following initial therapy. This paper provides a comprehensive review of physicochemical properties of APX and the analytical methodologies for its quantification in bulk drug, pharmaceutical formulations, and in biological fluids. The analytical methods reported to date have been summarized, with an emphasis on major techniques such as spectrophotometry, and reverse-phase high performance liquid chromatography (RP-HPLC) coupled to ultraviolet (UV) detection or mass spectrometry (MS). Sample pretreatment methods for the analysis of biological matrices have also been systematically discussed. Additionally, the \"whiteness\" of the reported methods for the determination of APX in biological matrix are assessed according to the RGB 12 algorithm.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-16"},"PeriodicalIF":4.2,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review of Progress of Pretreatment and Analysis Methods for Insulinotropic Agents in Complex Matrices.","authors":"Yun-Qi Ning, Yuan Zhang, Yu Bian, Yu Tong, Xue-Song Feng","doi":"10.1080/10408347.2025.2486211","DOIUrl":"https://doi.org/10.1080/10408347.2025.2486211","url":null,"abstract":"<p><p>Insulinotropic agents are a common class of antihyperglycemic drugs. Insulinotropic agents mainly include glinides and sulfonylureas. Because it can reduce postprandial blood glucose in patients with type 2 diabetes, it has been widely used in clinical practice. However, the rate of metabolism of such drugs varies in different patients, and doctors need to optimize treatment according to the metabolism of the drug in the patient's body. Therefore, there is a need to establish rapid, environmentally friendly, and effective techniques for the analysis of insulinotropic agents in substances, such as biological samples. In this paper, the pretreatment and analysis methods for insulinotropic agents in various samples since 2014 were summarized in detail. Pretreatment techniques encompass liquid-liquid extraction, liquid phase microextraction, solid phase extraction, and solid phase microextraction, with the latter, particularly when employing innovative nanomaterials, showcasing heightened extraction efficiency and expedited enrichment times. Analytical methodologies encompass liquid chromatography-based techniques, sensor approaches, among others. Notably, electrochemical sensors harnessing novel materials have significantly enhanced detection sensitivity. Furthermore, the review comprehensively examines technologies and materials aligned with green chemistry principles, highlighting future research avenues for the eco-friendly pretreatment and detection methodologies of insulinotropic agents.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-22"},"PeriodicalIF":4.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progress of Pretreatment and Analysis Methods for Brucine and Strychnine: An Update Since 2013.","authors":"Lian Xu, Yuan Zhang, Yu Bian, Yu Zhou, Xue-Song Feng","doi":"10.1080/10408347.2025.2482143","DOIUrl":"https://doi.org/10.1080/10408347.2025.2482143","url":null,"abstract":"<p><p>Brucine and strychnine, primary bioactive constituents in traditional Chinese medicine, are extensively utilized in healthcare products due to their pharmacological and biochemical properties, including the enhancement of blood circulation, alleviation of cancer-related pain, and their anti-inflammatory and anti-angiogenesis effects. While brucine and strychnine possess indispensable pharmacological properties, they also pose serious toxicity and threats to human health. Consequently, it is imperative to develop reliable and sensitive methodologies for their pretreatment and quantification in various matrices. This comprehensive review encapsulates the prevailing pretreatment and analytical methodologies for brucine and strychnine in diverse samples from 2013 onwards. The routinely employed pretreatment techniques for target extraction and purification encompass liquid-liquid extraction, solid-phase extraction, and a range of microextraction methods. The determination strategies incorporate liquid chromatography-based methods, capillary electrophoresis methods, sensor methods, among others. Moreover, we have identified the strengths and weaknesses of each method and have forecast their future developmental prospects.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-20"},"PeriodicalIF":4.2,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Potential of Optical Technologies in Early Virus Detection; Prospects in Addressing Future Viral Outbreaks.","authors":"Mehdi Kheirollahpour, Nader Shokoufi, Mohsen Lotfi","doi":"10.1080/10408347.2025.2481406","DOIUrl":"10.1080/10408347.2025.2481406","url":null,"abstract":"<p><p>The urgent need for sensitive, rapid, and reliable diagnostic methodologies to control and prevent life-threatening pandemic infectious disease, such as COVID-19, remains a critical priority. Timely and on-site detection of viral pathogens is essential for effective disease management and mitigation of societal disruptions. Recent advancements in optical diagnostic methods have positioned them at the forefront of healthcare diagnostics, offering high sensitivity and specificity as viable alternatives to conventional techniques such as the Polymerase Chain Reaction (PCR), which often suffer from time delays and limited accessibility in resource-constrained environments. This review elucidates the potential of various optical diagnostic techniques, highlighting their advantages over traditional methods. It encompasses a range of optical modalities, including fluorescence-based approaches, Raman spectroscopy (RS), Plasmonic techniques (e.g., surface plasmon resonance (SPR), localized SPR, (LSPR), surface-enhanced Raman spectroscopy (SERS), and surface-enhanced fluorescence (SEF)), super resolution microscopies (SRMs), attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), and integrated platforms such as waveguides and molecularly imprinted polymer (MIP)-based biosensors. Additionally, the evolution of novel biosensors, particularly 5th and 6th generation biosensors, in healthcare and the challenges related to these technologies were discussed. This studies reviewed aims to advance the development of portable, sensitive, specific, and cost-effective point-of-care (POC) diagnostic devices for the rapid detection of viral pathogens.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-29"},"PeriodicalIF":4.2,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review of Recent Trends in the Development of Analytical Methods for Useful Compounds and Contaminations in Fruits Juices.","authors":"Ebraheem Abdu Musad Saleh, Hiba M Saleem, Mohammed Asiri, Subasini Uthirapathy, Subbulakshmi Ganesan, Piyus Kumar Pathak, Rsk Sharma, Bhanu Juneja, Naher H S, Ayham Sameer Faaq","doi":"10.1080/10408347.2025.2477536","DOIUrl":"https://doi.org/10.1080/10408347.2025.2477536","url":null,"abstract":"<p><p>In modern lifestyles, the consumption of fruit juice is increasing among different societies. Many people consider fruit juices to be safe beverages with numerous health benefits for human bodies. Although fruit juices contain several useful compounds that can promote human health, there is a probability of both microbiological and non-microbiological contaminations in these juices. It is important to have reliable detection methods to analyze the useful and harmful compounds present in different fruit juices. In fruit juice industry, various analytical methods have been used for analyzing different parameters, contaminations, and useful compounds in fruit juices. However, some limitations restrict their application in this field. Biosensors, as newly emerging sensing approaches, have been developed in this field. The sensitivity, selectivity, portability, and accuracy are key considerations in developing biosensors for detection of contaminations and antioxidants. This was achieved by the application of bioreceptors, nanomaterials, and novel designed technologies. In this review, the role of different techniques, nanomaterials, and bioreceptors is reviewed for development new biosensors in terms of analyzing fruit juices. In addition, the future prospects and challenges are also examined.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-20"},"PeriodicalIF":4.2,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CRISPR/Cas System-Based Fluorescent Sensor for Analysis and Detection.","authors":"Huiru Niu, Lina Zou, Yanan Liu, Zheng Li, Huanyu Ren, Hao Liao, Xiaojing Zhang, Shanshan An, Fei Ren, Xiuhong Ge, Lang Cheng, Feiyan Yang, Hongzhi Pan, Shengzhong Rong, Dong Chang, Hongkun Ma","doi":"10.1080/10408347.2025.2481409","DOIUrl":"https://doi.org/10.1080/10408347.2025.2481409","url":null,"abstract":"<p><p>Fluorescent sensor is an important tool to reliaze qualitative or quantitative detection of target analyte based on the fluorescence principle. Clustered regularly interspaced short palindromic repeats/CRISPR-associated protein (CRISPR/Cas) has been utilized to develop as a precise, efficient, and highly sensitive molecular diagnostic tool due to its efficient targeting and gene editing ability. At present, CRISPR/Cas system-based fluorescent sensors have shown excellent performance in the field of analysis and detection, and have received widespread attention. Therefore, this paper reviews the mechanism of the CRISPR/Cas system, the characteristics of different Cas proteins, and the principle and characteristics of the fluorescent sensor, with a focus on summarizing the application of the CRISPR/Cas system-based fluorescent sensor for analysis and detection.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-16"},"PeriodicalIF":4.2,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}