{"title":"Electrochemical biosensing methods for analysis of trace biomarkers: a review.","authors":"Baorong Zhang, Zhuomin Zhang, Gongke Li","doi":"10.1080/10408347.2025.2479032","DOIUrl":null,"url":null,"abstract":"<p><p>Electrochemical biosensing methods have many advantages such as high sensitivity, portable instruments, fast response, low cost, etc. In recent years, electrochemical biosensing methods have been widely used for the analysis of biomarkers and demonstrated rapid progress. This review systematically covers the recent progress in electrochemical biosensing methods for trace biomarker analysis, with a primary focus on developments over the past decade. The article discusses advancements in probe preparation using metal coordination materials, metal nanomaterials, organic redox materials, and polymer nanocomposites, and highlights the construction of electrochemical DNA biosensing strategy, electrochemical aptamer biosensing strategy, and electrochemical immune-biosensing strategy. Typical applications of electrochemical biosensing methods for metal ions, virus biomarkers, and short non-protein coding RNAs are further summarized. Challenges and future perspectives are also discussed to guide further research in bioanalysis and electrochemistry.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-18"},"PeriodicalIF":4.2000,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Critical reviews in analytical chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/10408347.2025.2479032","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Electrochemical biosensing methods have many advantages such as high sensitivity, portable instruments, fast response, low cost, etc. In recent years, electrochemical biosensing methods have been widely used for the analysis of biomarkers and demonstrated rapid progress. This review systematically covers the recent progress in electrochemical biosensing methods for trace biomarker analysis, with a primary focus on developments over the past decade. The article discusses advancements in probe preparation using metal coordination materials, metal nanomaterials, organic redox materials, and polymer nanocomposites, and highlights the construction of electrochemical DNA biosensing strategy, electrochemical aptamer biosensing strategy, and electrochemical immune-biosensing strategy. Typical applications of electrochemical biosensing methods for metal ions, virus biomarkers, and short non-protein coding RNAs are further summarized. Challenges and future perspectives are also discussed to guide further research in bioanalysis and electrochemistry.
期刊介绍：
Critical Reviews in Analytical Chemistry continues to be a dependable resource for both the expert and the student by providing in-depth, scholarly, insightful reviews of important topics within the discipline of analytical chemistry and related measurement sciences. The journal exclusively publishes review articles that illuminate the underlying science, that evaluate the field''s status by putting recent developments into proper perspective and context, and that speculate on possible future developments. A limited number of articles are of a "tutorial" format written by experts for scientists seeking introduction or clarification in a new area.
This journal serves as a forum for linking various underlying components in broad and interdisciplinary means, while maintaining balance between applied and fundamental research. Topics we are interested in receiving reviews on are the following:
· chemical analysis;
· instrumentation;
· chemometrics;
· analytical biochemistry;
· medicinal analysis;
· forensics;
· environmental sciences;
· applied physics;
· and material science.
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