Critical reviews in analytical chemistry最新文献

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Electrochemical biosensing methods for analysis of trace biomarkers: a review. 痕量生物标志物分析的电化学生物传感方法综述。
IF 4.2 2区 化学
Critical reviews in analytical chemistry Pub Date : 2025-04-07 DOI: 10.1080/10408347.2025.2479032
Baorong Zhang, Zhuomin Zhang, Gongke Li
{"title":"Electrochemical biosensing methods for analysis of trace biomarkers: a review.","authors":"Baorong Zhang, Zhuomin Zhang, Gongke Li","doi":"10.1080/10408347.2025.2479032","DOIUrl":"https://doi.org/10.1080/10408347.2025.2479032","url":null,"abstract":"<p><p>Electrochemical biosensing methods have many advantages such as high sensitivity, portable instruments, fast response, low cost, etc. In recent years, electrochemical biosensing methods have been widely used for the analysis of biomarkers and demonstrated rapid progress. This review systematically covers the recent progress in electrochemical biosensing methods for trace biomarker analysis, with a primary focus on developments over the past decade. The article discusses advancements in probe preparation using metal coordination materials, metal nanomaterials, organic redox materials, and polymer nanocomposites, and highlights the construction of electrochemical DNA biosensing strategy, electrochemical aptamer biosensing strategy, and electrochemical immune-biosensing strategy. Typical applications of electrochemical biosensing methods for metal ions, virus biomarkers, and short non-protein coding RNAs are further summarized. Challenges and future perspectives are also discussed to guide further research in bioanalysis and electrochemistry.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-18"},"PeriodicalIF":4.2,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analytical Methods for the Determination of Apixaban in Pharmaceuticals and Biological Matrices: A Systematic Review. 药物和生物基质中阿哌沙班含量的分析方法综述。
IF 4.2 2区 化学
Critical reviews in analytical chemistry Pub Date : 2025-04-02 DOI: 10.1080/10408347.2025.2483367
Wanbing Rao, Chenxia Zhang, Shuming Wu, Shaoyu Cai, Zhongqing Wang
{"title":"Analytical Methods for the Determination of Apixaban in Pharmaceuticals and Biological Matrices: A Systematic Review.","authors":"Wanbing Rao, Chenxia Zhang, Shuming Wu, Shaoyu Cai, Zhongqing Wang","doi":"10.1080/10408347.2025.2483367","DOIUrl":"https://doi.org/10.1080/10408347.2025.2483367","url":null,"abstract":"<p><p>Apixaban (APX) is a direct oral anticoagulant (DOAC) developed by Bristol Myers Squibb and Pfizer for the prevention of stroke and systemic embolism in patients with non valvular atrial fibrillation (NVAF), as well as for the prophylaxis of deep vein thrombosis (DVT) and the reduction of recurrent DVT and pulmonary embolism risk following initial therapy. This paper provides a comprehensive review of physicochemical properties of APX and the analytical methodologies for its quantification in bulk drug, pharmaceutical formulations, and in biological fluids. The analytical methods reported to date have been summarized, with an emphasis on major techniques such as spectrophotometry, and reverse-phase high performance liquid chromatography (RP-HPLC) coupled to ultraviolet (UV) detection or mass spectrometry (MS). Sample pretreatment methods for the analysis of biological matrices have also been systematically discussed. Additionally, the \"whiteness\" of the reported methods for the determination of APX in biological matrix are assessed according to the RGB 12 algorithm.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-16"},"PeriodicalIF":4.2,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Review of Progress of Pretreatment and Analysis Methods for Insulinotropic Agents in Complex Matrices. 复杂基质中胰岛素药物的预处理与分析方法研究进展。
IF 4.2 2区 化学
Critical reviews in analytical chemistry Pub Date : 2025-04-01 DOI: 10.1080/10408347.2025.2486211
Yun-Qi Ning, Yuan Zhang, Yu Bian, Yu Tong, Xue-Song Feng
{"title":"A Review of Progress of Pretreatment and Analysis Methods for Insulinotropic Agents in Complex Matrices.","authors":"Yun-Qi Ning, Yuan Zhang, Yu Bian, Yu Tong, Xue-Song Feng","doi":"10.1080/10408347.2025.2486211","DOIUrl":"https://doi.org/10.1080/10408347.2025.2486211","url":null,"abstract":"<p><p>Insulinotropic agents are a common class of antihyperglycemic drugs. Insulinotropic agents mainly include glinides and sulfonylureas. Because it can reduce postprandial blood glucose in patients with type 2 diabetes, it has been widely used in clinical practice. However, the rate of metabolism of such drugs varies in different patients, and doctors need to optimize treatment according to the metabolism of the drug in the patient's body. Therefore, there is a need to establish rapid, environmentally friendly, and effective techniques for the analysis of insulinotropic agents in substances, such as biological samples. In this paper, the pretreatment and analysis methods for insulinotropic agents in various samples since 2014 were summarized in detail. Pretreatment techniques encompass liquid-liquid extraction, liquid phase microextraction, solid phase extraction, and solid phase microextraction, with the latter, particularly when employing innovative nanomaterials, showcasing heightened extraction efficiency and expedited enrichment times. Analytical methodologies encompass liquid chromatography-based techniques, sensor approaches, among others. Notably, electrochemical sensors harnessing novel materials have significantly enhanced detection sensitivity. Furthermore, the review comprehensively examines technologies and materials aligned with green chemistry principles, highlighting future research avenues for the eco-friendly pretreatment and detection methodologies of insulinotropic agents.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-22"},"PeriodicalIF":4.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Progress of Pretreatment and Analysis Methods for Brucine and Strychnine: An Update Since 2013. 马钱子碱和士的宁的预处理和分析方法研究进展(2013年以来)
IF 4.2 2区 化学
Critical reviews in analytical chemistry Pub Date : 2025-03-28 DOI: 10.1080/10408347.2025.2482143
Lian Xu, Yuan Zhang, Yu Bian, Yu Zhou, Xue-Song Feng
{"title":"Progress of Pretreatment and Analysis Methods for Brucine and Strychnine: An Update Since 2013.","authors":"Lian Xu, Yuan Zhang, Yu Bian, Yu Zhou, Xue-Song Feng","doi":"10.1080/10408347.2025.2482143","DOIUrl":"https://doi.org/10.1080/10408347.2025.2482143","url":null,"abstract":"<p><p>Brucine and strychnine, primary bioactive constituents in traditional Chinese medicine, are extensively utilized in healthcare products due to their pharmacological and biochemical properties, including the enhancement of blood circulation, alleviation of cancer-related pain, and their anti-inflammatory and anti-angiogenesis effects. While brucine and strychnine possess indispensable pharmacological properties, they also pose serious toxicity and threats to human health. Consequently, it is imperative to develop reliable and sensitive methodologies for their pretreatment and quantification in various matrices. This comprehensive review encapsulates the prevailing pretreatment and analytical methodologies for brucine and strychnine in diverse samples from 2013 onwards. The routinely employed pretreatment techniques for target extraction and purification encompass liquid-liquid extraction, solid-phase extraction, and a range of microextraction methods. The determination strategies incorporate liquid chromatography-based methods, capillary electrophoresis methods, sensor methods, among others. Moreover, we have identified the strengths and weaknesses of each method and have forecast their future developmental prospects.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-20"},"PeriodicalIF":4.2,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Potential of Optical Technologies in Early Virus Detection; Prospects in Addressing Future Viral Outbreaks. 光学技术在病毒早期检测中的潜力应对未来病毒爆发的前景。
IF 4.2 2区 化学
Critical reviews in analytical chemistry Pub Date : 2025-03-27 DOI: 10.1080/10408347.2025.2481406
Mehdi Kheirollahpour, Nader Shokoufi, Mohsen Lotfi
{"title":"The Potential of Optical Technologies in Early Virus Detection; Prospects in Addressing Future Viral Outbreaks.","authors":"Mehdi Kheirollahpour, Nader Shokoufi, Mohsen Lotfi","doi":"10.1080/10408347.2025.2481406","DOIUrl":"https://doi.org/10.1080/10408347.2025.2481406","url":null,"abstract":"<p><p>The urgent need for sensitive, rapid, and reliable diagnostic methodologies to control and prevent life-threatening pandemic infectious disease, such as COVID-19, remains a critical priority. Timely and on-site detection of viral pathogens is essential for effective disease management and mitigation of societal disruptions. Recent advancements in optical diagnostic methods have positioned them at the forefront of healthcare diagnostics, offering high sensitivity and specificity as viable alternatives to conventional techniques such as the Polymerase Chain Reaction (PCR), which often suffer from time delays and limited accessibility in resource-constrained environments. This review elucidates the potential of various optical diagnostic techniques, highlighting their advantages over traditional methods. It encompasses a range of optical modalities, including fluorescence-based approaches, Raman spectroscopy (RS), Plasmonic techniques (e.g., surface plasmon resonance (SPR), localized SPR, (LSPR), surface-enhanced Raman spectroscopy (SERS), and surface-enhanced fluorescence (SEF)), super resolution microscopies (SRMs), attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), and integrated platforms such as waveguides and molecularly imprinted polymer (MIP)-based biosensors. Additionally, the evolution of novel biosensors, particularly 5th and 6th generation biosensors, in healthcare and the challenges related to these technologies were discussed. This studies reviewed aims to advance the development of portable, sensitive, specific, and cost-effective point-of-care (POC) diagnostic devices for the rapid detection of viral pathogens.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-29"},"PeriodicalIF":4.2,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Review of Recent Trends in the Development of Analytical Methods for Useful Compounds and Contaminations in Fruits Juices. 果汁中有益化合物和污染物分析方法的研究进展。
IF 4.2 2区 化学
Critical reviews in analytical chemistry Pub Date : 2025-03-26 DOI: 10.1080/10408347.2025.2477536
Ebraheem Abdu Musad Saleh, Hiba M Saleem, Mohammed Asiri, Subasini Uthirapathy, Subbulakshmi Ganesan, Piyus Kumar Pathak, Rsk Sharma, Bhanu Juneja, Naher H S, Ayham Sameer Faaq
{"title":"A Review of Recent Trends in the Development of Analytical Methods for Useful Compounds and Contaminations in Fruits Juices.","authors":"Ebraheem Abdu Musad Saleh, Hiba M Saleem, Mohammed Asiri, Subasini Uthirapathy, Subbulakshmi Ganesan, Piyus Kumar Pathak, Rsk Sharma, Bhanu Juneja, Naher H S, Ayham Sameer Faaq","doi":"10.1080/10408347.2025.2477536","DOIUrl":"https://doi.org/10.1080/10408347.2025.2477536","url":null,"abstract":"<p><p>In modern lifestyles, the consumption of fruit juice is increasing among different societies. Many people consider fruit juices to be safe beverages with numerous health benefits for human bodies. Although fruit juices contain several useful compounds that can promote human health, there is a probability of both microbiological and non-microbiological contaminations in these juices. It is important to have reliable detection methods to analyze the useful and harmful compounds present in different fruit juices. In fruit juice industry, various analytical methods have been used for analyzing different parameters, contaminations, and useful compounds in fruit juices. However, some limitations restrict their application in this field. Biosensors, as newly emerging sensing approaches, have been developed in this field. The sensitivity, selectivity, portability, and accuracy are key considerations in developing biosensors for detection of contaminations and antioxidants. This was achieved by the application of bioreceptors, nanomaterials, and novel designed technologies. In this review, the role of different techniques, nanomaterials, and bioreceptors is reviewed for development new biosensors in terms of analyzing fruit juices. In addition, the future prospects and challenges are also examined.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-20"},"PeriodicalIF":4.2,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CRISPR/Cas System-Based Fluorescent Sensor for Analysis and Detection. 基于CRISPR/Cas系统的荧光分析检测传感器。
IF 4.2 2区 化学
Critical reviews in analytical chemistry Pub Date : 2025-03-24 DOI: 10.1080/10408347.2025.2481409
Huiru Niu, Lina Zou, Yanan Liu, Zheng Li, Huanyu Ren, Hao Liao, Xiaojing Zhang, Shanshan An, Fei Ren, Xiuhong Ge, Lang Cheng, Feiyan Yang, Hongzhi Pan, Shengzhong Rong, Dong Chang, Hongkun Ma
{"title":"CRISPR/Cas System-Based Fluorescent Sensor for Analysis and Detection.","authors":"Huiru Niu, Lina Zou, Yanan Liu, Zheng Li, Huanyu Ren, Hao Liao, Xiaojing Zhang, Shanshan An, Fei Ren, Xiuhong Ge, Lang Cheng, Feiyan Yang, Hongzhi Pan, Shengzhong Rong, Dong Chang, Hongkun Ma","doi":"10.1080/10408347.2025.2481409","DOIUrl":"https://doi.org/10.1080/10408347.2025.2481409","url":null,"abstract":"<p><p>Fluorescent sensor is an important tool to reliaze qualitative or quantitative detection of target analyte based on the fluorescence principle. Clustered regularly interspaced short palindromic repeats/CRISPR-associated protein (CRISPR/Cas) has been utilized to develop as a precise, efficient, and highly sensitive molecular diagnostic tool due to its efficient targeting and gene editing ability. At present, CRISPR/Cas system-based fluorescent sensors have shown excellent performance in the field of analysis and detection, and have received widespread attention. Therefore, this paper reviews the mechanism of the CRISPR/Cas system, the characteristics of different Cas proteins, and the principle and characteristics of the fluorescent sensor, with a focus on summarizing the application of the CRISPR/Cas system-based fluorescent sensor for analysis and detection.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-16"},"PeriodicalIF":4.2,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent Advances in Electrochemical Aptasensors for Detection of Clinical and Veterinary Drugs. 用于临床和兽药检测的电化学感应传感器研究进展。
IF 4.2 2区 化学
Critical reviews in analytical chemistry Pub Date : 2025-03-18 DOI: 10.1080/10408347.2025.2469781
Masoomeh Naseri, Ali Niazi, Atisa Yazdanipour, Kowsar Bagherzadeh
{"title":"Recent Advances in Electrochemical Aptasensors for Detection of Clinical and Veterinary Drugs.","authors":"Masoomeh Naseri, Ali Niazi, Atisa Yazdanipour, Kowsar Bagherzadeh","doi":"10.1080/10408347.2025.2469781","DOIUrl":"https://doi.org/10.1080/10408347.2025.2469781","url":null,"abstract":"<p><p>Nowadays, aptamer-based biosensors and electrochemical measurements represent one of the efficient tools for the detection of drugs in both medical and veterinary. Precise trace values analysis of chemicals, especially drugs, plays a crucial role in food and therapeutic safety evaluations that are often time-consuming and costly. Ultimately, accurate determination of therapeutic medications like antibiotics in food, environmental resources, and biological matrices is very important for protecting public health and drug monitoring (TDM) for effective treatment. This review highlights recent advancements in electrochemical aptasensors as an innovative approach offering high sensitivity, specificity, and rapid detection of clinical and veterinary drugs at lower costs. We provide a comprehensive overview of the advancements and discuss the challenges and prospects of electrochemical aptasensing in drug residue detection across various samples.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-15"},"PeriodicalIF":4.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anti-diabetic Biologicals: Exploring the Role of Different Analytical Techniques. 抗糖尿病生物制剂:探讨不同分析技术的作用。
IF 4.2 2区 化学
Critical reviews in analytical chemistry Pub Date : 2025-03-15 DOI: 10.1080/10408347.2025.2472793
Zahid Yaseen, Mukesh Nandave, Lalit Sharma
{"title":"Anti-diabetic Biologicals: Exploring the Role of Different Analytical Techniques.","authors":"Zahid Yaseen, Mukesh Nandave, Lalit Sharma","doi":"10.1080/10408347.2025.2472793","DOIUrl":"https://doi.org/10.1080/10408347.2025.2472793","url":null,"abstract":"<p><p>Antidiabetic biologicals (ADBs) have revolutionized the treatment of diabetes mellitus, once considered incurable through conventional medicine. These biological products, derived from natural sources <i>via</i> extraction, semi-synthesis, or recombinant DNA technology, include insulin and its analogs, GLP-1 receptor agonists, amylin analogs, and the recently approved monoclonal antibody teplizumab. Regulatory authorities worldwide have established QC parameters outlined in pharmacopoeias, alongside analytical techniques to ensure their safety and efficacy. This review focuses on the analytical techniques used to assess QC parameters of ADBs, including chromatographic methods, spectroscopic techniques, capillary electrophoresis, immunoassays, and endotoxin testing. Key parameters such as identification, potency, purity, and impurity profiling are thoroughly examined. The paper provides a comprehensive and up-to-date compilation of QC requirements and methodologies, along with a detailed comparison of analytical techniques. In doing so, it highlights their advantages and limitations, offering valuable insights for researchers and regulatory professionals involved in selecting suitable methods for QC assessment and understanding the complexities of ADBs evaluation. Furthermore, the article discusses the paramount importance of QC and future perspectives, emphasizing the transition to advanced versions of current techniques driven by the need for efficiency and reliability in quality testing.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-22"},"PeriodicalIF":4.2,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolomics as a Tool for Unraveling the Impact of Enantioselectivity in Cellular Metabolism. 代谢组学作为揭示细胞代谢中对映体选择性影响的工具。
IF 4.2 2区 化学
Critical reviews in analytical chemistry Pub Date : 2025-03-04 DOI: 10.1080/10408347.2025.2468926
Ana Sofia Almeida, Paula Guedes de Pinho, Fernando Remião, Carla Fernandes
{"title":"Metabolomics as a Tool for Unraveling the Impact of Enantioselectivity in Cellular Metabolism.","authors":"Ana Sofia Almeida, Paula Guedes de Pinho, Fernando Remião, Carla Fernandes","doi":"10.1080/10408347.2025.2468926","DOIUrl":"https://doi.org/10.1080/10408347.2025.2468926","url":null,"abstract":"<p><p>Metabolomics is an emerging interdisciplinary field focused on the comprehensive analysis of all metabolites within biological samples, making it valuable for areas such as drug development, and environmental analysis. Many compounds, including pharmaceuticals and agrochemicals that have been extensively studied by metabolomics are chiral. The intrinsic chirality of biological targets can lead to a selective recognition of enantiomers resulting in distinct pharmacokinetic, pharmacodynamic and/or toxicological profiles (enantioselectivity). Given that metabolomics captures an instant snapshot of an organism's metabolic state, it serves as a powerful tool to investigate chiral compounds and understand enantioselective effects. Herein, a systematic compilation of scientific literature was performed and 48 enantioselectivity studies using metabolomics were selected. These studies revealed an increasing focus on chiral pesticides (77%), the use of animal models (59%), reliance on LC-MS techniques (52%), and predominantly untargeted approaches (83%). Enantioselective effects were described in most studies. This review describes significant advances in this emerging field and highlights the use of metabolomics to unravel the role of stereochemistry in cellular metabolism by the examination of enantiomer-specific metabolic effects. Furthermore, it elucidates enantioselectivity mechanism that can be further applied to other groups of chiral compounds.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-21"},"PeriodicalIF":4.2,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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