Critical reviews in analytical chemistry最新文献

{"title":"Modern Sample Pretreatment Approaches for β-Lactam Antibiotics in Complex Matrices: Challenges and Innovations.","authors":"Ying-Mei Xing, Yu Bian, Hong-Yu Yang, Yuan Zhang, Xue-Song Feng","doi":"10.1080/10408347.2026.2747723","DOIUrl":"https://doi.org/10.1080/10408347.2026.2747723","url":null,"abstract":"<p><p>β-lactam antibiotics, widely used in human and veterinary medicine, can trigger serious public health concerns through misuse-including antimicrobial resistance and drug residues. The detection of β-lactam antibiotics faces three challenges: unstable β-lactam rings prone to hydrolysis, complex metabolism requiring multi-residue analysis, and trace-level concentrations (μg/kg) with severe matrix interference demanding high sensitivity and accuracy. Thus, systematically optimizing sample analytical methods is essential to enhance monitoring programs and ensure food safety. This review offers a comprehensive overview of contemporary pretreatment methodologies, encompassing well-established techniques such as solid-phase extraction and dispersive liquid-liquid microextraction, as well as innovative approaches including solidification floating organic droplet liquid-liquid microextraction and electromembrane extraction. Recent advancements in pretreatment strategies for β-lactam antibiotics are increasingly oriented toward achieving high extraction and purification efficiency, enhancing environmental sustainability, and improving the reusability of extraction materials. By critically evaluating the advantages and limitations of various techniques, this review aims to support progress in detection accuracy and reliability, increase analytical throughput and efficiency, and reduce operational costs.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-26"},"PeriodicalIF":7.7,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-Emission COF-Based Platforms for Ratiometric Fluorescence Detection of Contaminants in Food Matrices: Mechanisms and Applications.","authors":"Saad Mohammed Almohya, Nasser S Alqahtani","doi":"10.1080/10408347.2026.2746770","DOIUrl":"https://doi.org/10.1080/10408347.2026.2746770","url":null,"abstract":"<p><p>Covalent organic frameworks (COFs), characterized by their high specific surface area, admirable stability, and tunable pore structures, offer ideal platforms for ratiometric fluorescence sensing systems. By measuring the intensity ratio between two emission signals, these sensors inherently provide built-in self-calibration capabilities. This approach addresses the limitations of single-signal probes, which are vulnerable to environmental interferences, thereby enhancing the reliability, sensitivity, and selectivity of contaminant detection in complex food matrices. This review systematically examines the design strategies employed in the progress of dual-emission COF-based ratiometric sensors for food safety applications. These strategies include intrinsic doping-induced dual emission, backbone dual emission, and heterostructure- or hybrid-induced dual emission mechanisms. For each approach, the associated advantages, limitations, and potential directions for future research are critically analyzed. Common structural challenges and their corresponding mitigation strategies are thoroughly explored to enhance the efficiency and reliability of these sensors. Furthermore, the application of these materials in detecting a wide range of food contaminants, such as pesticide residues, heavy metal ions, illegal additives, and antibiotics, is reviewed with emphasis on selectivity, sensitivity, and real-sample analysis. Relevant sensing principles, like excited-state intramolecular proton transfer (ESIPT) and Förster resonance energy transfer (FRET), as well as the interconnections among construction approaches, response modes, and detection procedures, have been discussed. Finally, future perspectives and current challenges are outlined to guide the rational design of advanced COF-based ratiometric sensors for ensuring food safety and public health.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-24"},"PeriodicalIF":7.7,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanomaterial-Based Electrochemical Immunosensors for the Detection of <i>Mycobacterium avium</i> subsp. <i>paratuberculosis</i>: Advancement, Challenges, and Future Perceptions.","authors":"Madhu Jangra, Vikas Raj, Subodh Kumar, Mousam Chhillar, Neetu Hooda, Mohammad Murtaza Mehdi, Anjum Gahlaut","doi":"10.1080/10408347.2026.2742466","DOIUrl":"https://doi.org/10.1080/10408347.2026.2742466","url":null,"abstract":"<p><p><i>Mycobacterium avium</i> subsp. <i>paratuberculosis</i> (MAP) causes Johne's disease, a chronic infectious disease of ruminants associated with substantial economic losses in the livestock and dairy industries. Conventional diagnostic methods, including culture, polymerase chain reaction (PCR), and enzyme-linked immunosorbent assay (ELISA), have limitations related to analysis time, laboratory requirements, infection stage, matrix effects, and diagnostic performance. Nanomaterial-based electrochemical immunosensors have emerged as promising platforms for rapid, sensitive, miniaturized, and potentially field-compatible MAP detection was conducted using PubMed, Scopus, Web of Science, and Google Scholar, primarily covering studies published between 2015 and 2026. The review evaluates metal nanoparticles, carbon-based nanomaterials, magnetic nanoparticles, and hybrid nanomaterials in relation to electrode surface area, biomolecule immobilization, electron transfer, signal generation, analytical performance, and real-sample validation. Key challenges includes matrix interference, nonspecific adsorption, stability, reproducibility, and standardization. Emerging approaches, including microfluidic integration, portable potentiostats, multiplexed sensing, flexible platforms, and artificial intelligence-assisted analysis. Overall, nanomaterial-based electrochemical immunosensors show considerable promise for MAP detection, but standardized validation using diverse field samples and robust manufacturing strategies is required before routine on-farm implementation.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-17"},"PeriodicalIF":7.7,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review of Current Techniques for Tracking as Behavior Across Micro-Interfaces in Paddy.","authors":"Hong Luo, Mengfan Zhou, William R Horwath, Williamson Gustave, Jiejun Xi, Bin He, Ting Guo, Mouliang Xiao, Yongfu Li, Zhenke Zhu, Tida Ge, Zhao-Feng Yuan","doi":"10.1080/10408347.2026.2746764","DOIUrl":"https://doi.org/10.1080/10408347.2026.2746764","url":null,"abstract":"<p><p>Arsenic (As) in rice poses health risks, and the soil micro-interface is the key zone controlling As transformation and migration in the soil-water-rice system. Sharp redox transitions along the soil-water interface and rhizosphere cause simultaneous millimeter-scale changes in redox-sensitive elements like Fe and As, influenced by disturbances such as overlying water changes. These factors make it challenging to track As behavior across soil micro-interfaces. Sampling techniques like soil slicing and the Rhizon sampler provide limited information on As due to their low-resolution (cm level) and high soil disturbance (particularly for soil slicing). Micro-electrode and optode sensors are useful to measure soil parameters (e.g., Eh, pH, and dissolved O₂) that are closely associated with As transformation in micro-interfaces, yet cannot detect its elemental concentration. By integrating those methods with high resolution porewater samplers (e.g., In situ equilibrium dialysis samplers (Peeper), diffusive equilibration in thin films (DET), diffusive gradients in thin films (DGT), and the Integrated Porewater Injection (IPI) sampler), the understanding of As behavior has been largely improved. This review synthesizes approaches for tracking As across paddy micro-interfaces and offers insights for redox-sensitive elemental biogeochemistry in other saturated soils or sediments.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-19"},"PeriodicalIF":7.7,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can Forensic Crime Scene Investigation be Aided by Spectroscopy and Chemometric Techniques?-A Comprehensive Review.","authors":"Anusree T K Gangadharan, Daniel T Thangadurai, Kasi Nehru","doi":"10.1080/10408347.2026.2733899","DOIUrl":"https://doi.org/10.1080/10408347.2026.2733899","url":null,"abstract":"<p><p>This review examines the forensic applications, advantages, and limitations of key spectroscopic techniques, including Raman, infrared (IR), near-infrared (NIR), nuclear magnetic resonance (NMR), X-ray fluorescence (XRF), and mass spectrometry, in crime scene and laboratory investigations. These techniques are discussed in the context of analyzing evidence, detecting illicit substances (including biological fluids, explosives, and narcotics), and reconstructing crime scenes. The benefits and limitations of each method are highlighted, along with their potential for enhancing forensic investigations. The integration of artificial intelligence (AI) and machine learning (ML) with spectroscopic techniques is also briefly explored, noting their role in improving data analysis and interpretation. Challenges such as sensitivity, specificity, and implementation in field settings are discussed, alongside future directions for advancing spectroscopic applications in forensics. This review aims to provide a balanced overview of spectroscopic techniques in forensic science for researchers, forensic scientists, and law enforcement agencies.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-17"},"PeriodicalIF":7.7,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Imaging Technologies in Analytical Chemistry: A Critical Review of Mass Spectrometry Imaging, Raman Imaging, Imaging Mass Cytometry, and Emerging Spatial Analytical Platforms.","authors":"Hemn A H Barzani, Rebaz Anwar Omer, Khalamala Ibrahim Salih Barzani, Hazha Omar Othman, Ali Sedeeq Noaman, Seerwan Hamadameen Sulaiman","doi":"10.1080/10408347.2026.2742470","DOIUrl":"https://doi.org/10.1080/10408347.2026.2742470","url":null,"abstract":"<p><p>Molecular imaging technologies have transformed analytical chemistry by enabling molecular identification and spatial localization within intact biological specimens. Advances in mass spectrometry imaging (MSI), Raman imaging, imaging mass cytometry (IMC), and emerging spatial analytical platforms have expanded the investigation of tissue heterogeneity and molecular organization. However, quantitative reliability, reproducibility, standardization, computational complexity, and clinical translation remain significant challenges. This review critically evaluates the analytical performance of current molecular imaging technologies, emphasizing spatial resolution, sensitivity, molecular coverage, quantitative capability, multiplexing, reproducibility, computational integration, artificial intelligence (AI)-assisted analysis, and clinical readiness. No single modality simultaneously provides optimal spatial resolution, molecular coverage, quantitative accuracy, throughput, and reproducibility. MSI enables comprehensive molecular profiling, Raman imaging provides label-free chemical specificity, IMC supports highly multiplexed protein analysis, and emerging spatial omics platforms offer systems-level biological insights. Nevertheless, matrix effects, workflow variability, computational demands, limited standardization, and insufficient multicenter validation restrict broader analytical and clinical implementation. AI-assisted analysis and multimodal data integration offer opportunities to improve performance but require transparent validation and harmonized workflows. Future progress will depend on standardized analytical protocols, quantitative validation, explainable AI, multimodal integration, automated quality control, and international harmonization to establish molecular imaging as robust, reproducible, and clinically translatable analytical platforms.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-27"},"PeriodicalIF":7.7,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the RNA Census: A Literature-Derived Measurement-Claim Framework for Low-Copy, Transient, Spatial, and Native-State RNA Analysis.","authors":"Hidenori Tani","doi":"10.1080/10408347.2026.2746769","DOIUrl":"https://doi.org/10.1080/10408347.2026.2746769","url":null,"abstract":"<p><p>An analytical envelope, not biotype, sets a class of RNA measurement problem: one to a hundred copies per cell, lifetimes of minutes to one or two hours, or confinement finer than a dissociated cell. Inside it, short-read endpoint sequencing forfeits a figure of merit at a specific step, and information discarded upstream cannot be reconstructed downstream. This review audits that workflow stage by stage, then assesses nine modality families. The evidence base was assembled by a structured but non-exhaustive search: 40 query axes in PubMed, extended by targeted searches of every unfilled cell, 43 axes in OpenAlex, and a wider date window. Retrieval was capped, one author screened, and every supporting record appraised on five items. The outcome is a literature-derived decision framework that infers, rather than demonstrates, its ordering: a measurement claim returns the quantity to preserve, the modalities that preserve it, the disqualifying failure mode, and the recommended validation. Among the modalities represented in the retrieved evidence, none was shown to maximize counting fidelity, spatial coverage, absence of measurement-induced perturbation of a live process, and native-state preservation together. Among the literature retrieved here, no commutable reference material establishes traceability between <i>in situ</i> counting and extract-based quantification.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-31"},"PeriodicalIF":7.7,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Advances in Sorbent- and Solvent-Based Sample Preparation Techniques for Antidepressant Analysis: Trends, Comparison, and Perspectives.","authors":"Tuğçe Özyiğit, Sercan Yıldırım","doi":"10.1080/10408347.2026.2736085","DOIUrl":"https://doi.org/10.1080/10408347.2026.2736085","url":null,"abstract":"<p><p>Antidepressants are widely prescribed pharmaceuticals, making their reliable determination essential for therapeutic drug monitoring (TDM), forensic toxicology, and environmental surveillance. Since they exist at trace levels in biological and environmental matrices, sample preparation remains the critical step determining the sensitivity and reliability of the analysis. This review surveys sample preparation techniques for antidepressants published between 2021 and 2026. The methods are classified into sorbent- and solvent-based families, evaluated with respect to operating principles, analytical performance, applicability, and practical limitations. Across both categories, the dominant trends emphasize miniaturization, a shift from generic hydrophobic retention toward tailored molecular recognition, using molecularly imprinted polymers (MIPs), metal-organic frameworks (MOFs), and engineered nanomaterials, as well as the integration of green chemistry principles through deep eutectic solvents (DESs), switchable solvents (SSs), ionic liquids (ILs), and bio-based sorbents. A comparative assessment shows that extraction time is governed primarily by the mass-transfer mechanism rather than by the physical state of the extracting phase. Furthermore, while attainable sensitivity is strongly influenced by the detection system and preconcentration capability, the sample matrix remains a central criterion for method selection. Based on these findings, matrix-oriented guidance is provided to facilitate the rational selection of extraction strategies in antidepressant analysis.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-36"},"PeriodicalIF":7.7,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149147973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metal-Sulfonamide Interactions as an Overlooked Factor in Analytical Monitoring and Degradation Studies.","authors":"Sandra Brzeska, Paulina Truszkowska, Magdalena Stasiuk, Mariusz Makowski","doi":"10.1080/10408347.2026.2743807","DOIUrl":"https://doi.org/10.1080/10408347.2026.2743807","url":null,"abstract":"<p><p>Sulfonamides as antibacterial drugs are widespread environmental contaminants, and their determination and removal assessment are complicated by trace-level occurrence, matrix effects, and transformation products. A largely overlooked source of uncertainty is their interaction with metal ions present in environmental matrices or introduced during treatment. This critical review evaluates strategies for sulfonamide monitoring and degradation analysis from a metal-induced speciation perspective, focusing on sample preparation, chromatographic and mass-spectrometric determination, high-resolution mass spectrometry for suspect and non-target screening, and emerging sensing platforms. Rather than treating metals solely as matrix constituents or process catalysts, we examine them as speciation-controlling agents that can alter extraction recovery, chromatographic behavior, ionization, adsorption, and apparent degradation kinetics. Metal ions can enhance sulfonamide retention through coordination-mediated bridging, modify sorbent properties, activate peroxide- and persulfate-based oxidants, and redistribute sulfonamides between phases, potentially altering physicochemical properties, biodegradability, toxicity, and transformation pathways. This may cause decreases in measured dissolved concentrations to be misinterpreted as degradation or removal. Key gaps include distinguishing free from metal-bound sulfonamides, assessing how complexation affects mass-spectrometric ionization and fragmentation, and integrating speciation analysis with transformation-product identification and toxicological assessment. Future studies should incorporate metal-sulfonamide interactions as an analytical variable to improve quantitative reliability, mechanistic interpretation, and environmental risk assessment.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-31"},"PeriodicalIF":7.7,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149135311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends of Pretreatment and Analysis Methods for Carotenoids in Food.","authors":"Xin-Rong Liang, Yu Bian, Si-Han Cui, Yuan Zhang, Xue-Song Feng","doi":"10.1080/10408347.2026.2739587","DOIUrl":"https://doi.org/10.1080/10408347.2026.2739587","url":null,"abstract":"<p><p>Carotenoids are analytically challenging food constituents because their structural diversity, chemical instability, low abundance, and strong matrix dependence impose simultaneous demands on extraction selectivity, analyte preservation, chromatographic resolution, and detection sensitivity. This review critically evaluates recent advances in the pretreatment and analytical determination of carotenoids in food, with emphasis on the physicochemical and matrix-related factors governing method performance rather than on technique-by-technique description. Pretreatment strategies are examined in terms of extraction mechanisms, matrix compatibility, mass transfer, cleanup selectivity, analyte stability, and operational tradeoffs, with particular attention to microextraction, green solvent systems, QuEChERS, and advanced sorbent-based approaches. Analytical platforms, including chromatographic, mass-spectrometric, spectroscopic, and portable optical methods, are comparatively assessed with respect to isomer resolution, sensitivity, selectivity, qualitative capability, throughput, matrix effects, and practical applicability. The review further considers analytical greenness and the emerging integration of automation, digital analysis, and artificial intelligence/machine learning. Across these developments, no universally optimal workflow is evident; instead, analytical performance depends on matching analyte properties and matrix characteristics with appropriate pretreatment and determination strategies. By integrating these considerations, the review provides a matrix- and mechanism-oriented framework for method selection and identifies the major tradeoffs and technological priorities shaping future carotenoid analysis.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-39"},"PeriodicalIF":7.7,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149149849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}