Critical reviews in analytical chemistry最新文献

Metabolomics as a Tool for Unraveling the Impact of Enantioselectivity in Cellular Metabolism.

IF 4.2 2区化学

Critical reviews in analytical chemistry Pub Date : 2025-03-04 DOI: 10.1080/10408347.2025.2468926

Ana Sofia Almeida, Paula Guedes de Pinho, Fernando Remião, Carla Fernandes

{"title":"Metabolomics as a Tool for Unraveling the Impact of Enantioselectivity in Cellular Metabolism.","authors":"Ana Sofia Almeida, Paula Guedes de Pinho, Fernando Remião, Carla Fernandes","doi":"10.1080/10408347.2025.2468926","DOIUrl":"https://doi.org/10.1080/10408347.2025.2468926","url":null,"abstract":"Metabolomics is an emerging interdisciplinary field focused on the comprehensive analysis of all metabolites within biological samples, making it valuable for areas such as drug development, and environmental analysis. Many compounds, including pharmaceuticals and agrochemicals that have been extensively studied by metabolomics are chiral. The intrinsic chirality of biological targets can lead to a selective recognition of enantiomers resulting in distinct pharmacokinetic, pharmacodynamic and/or toxicological profiles (enantioselectivity). Given that metabolomics captures an instant snapshot of an organism's metabolic state, it serves as a powerful tool to investigate chiral compounds and understand enantioselective effects. Herein, a systematic compilation of scientific literature was performed and 48 enantioselectivity studies using metabolomics were selected. These studies revealed an increasing focus on chiral pesticides (77%), the use of animal models (59%), reliance on LC-MS techniques (52%), and predominantly untargeted approaches (83%). Enantioselective effects were described in most studies. This review describes significant advances in this emerging field and highlights the use of metabolomics to unravel the role of stereochemistry in cellular metabolism by the examination of enantiomer-specific metabolic effects. Furthermore, it elucidates enantioselectivity mechanism that can be further applied to other groups of chiral compounds.","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-21"},"PeriodicalIF":4.2,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Statement of Retraction: Recent Progress in Aptamer-Functionalized Metal-Organic Frameworks-Based Optical and Electrochemical Sensors for Detection of Mycotoxins.

IF 4.2 2区化学

Critical reviews in analytical chemistry Pub Date : 2025-02-21 DOI: 10.1080/10408347.2024.2437855

引用次数: 0

Statement of Retraction: Current Progress in Aptasensor for Ultra-Low Level Monitoring of Parkinson's Disease Biomarkers.

IF 4.2 2区化学

Critical reviews in analytical chemistry Pub Date : 2025-02-21 DOI: 10.1080/10408347.2024.2437859

引用次数: 0

Statement of Retraction: Optical and Electrochemical Aptasensors Developed for the Detection of Alpha-Fetoprotein.

IF 4.2 2区化学

Critical reviews in analytical chemistry Pub Date : 2025-02-21 DOI: 10.1080/10408347.2024.2437857

引用次数: 0

Recent Developments in Colorimetric and Fluorimetric Chemosensors for the Detection of Mn²⁺ Ions: A Review (2010-2024).

IF 4.2 2区化学

Critical reviews in analytical chemistry Pub Date : 2025-02-19 DOI: 10.1080/10408347.2025.2460091

Eid H Alosaimi

{"title":"Recent Developments in Colorimetric and Fluorimetric Chemosensors for the Detection of Mn2+ Ions: A Review (2010-2024).","authors":"Eid H Alosaimi","doi":"10.1080/10408347.2025.2460091","DOIUrl":"https://doi.org/10.1080/10408347.2025.2460091","url":null,"abstract":"Manganese is an essential metal ion involved in various biological and environmental processes, but its excess can lead to toxicity, particularly affecting the nervous system. Therefore, developing selective and sensitive detection methods for Mn2+ ions is of paramount importance. Colorimetric and fluorimetric chemosensors have emerged as promising tools for the detection of Mn2+ due to their simplicity, cost-effectiveness, and real-time monitoring capabilities. This review discusses recent advances in the colorimetric and fluorimetric chemosensors that exhibit distinct color or fluorescence changes upon interaction with Mn2+ ions. The review explores different organic and nanomaterials, focusing on their mechanisms of sensing, sensitivity, selectivity, and practical applications in environmental monitoring, healthcare, and food safety. The article also provides insights into future research directions aimed at overcoming these challenges, improving chemosensor performance, and expanding the applicability of colorimetric and fluorimetric chemosensors for Mn2+ detection in diverse real-world scenarios.","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-21"},"PeriodicalIF":4.2,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analytical Capabilities and Future Perspectives of Chemometrics in Omics for Food Microbial Investigation.

IF 4.2 2区化学

Critical reviews in analytical chemistry Pub Date : 2025-02-13 DOI: 10.1080/10408347.2025.2463430

Feifei Sun, Yu Zhang, Chin Ping Tan, Ying Gu, Yuanfa Liu, Yong-Jiang Xu

{"title":"Analytical Capabilities and Future Perspectives of Chemometrics in Omics for Food Microbial Investigation.","authors":"Feifei Sun, Yu Zhang, Chin Ping Tan, Ying Gu, Yuanfa Liu, Yong-Jiang Xu","doi":"10.1080/10408347.2025.2463430","DOIUrl":"https://doi.org/10.1080/10408347.2025.2463430","url":null,"abstract":"Microbiomes significantly impact food flavor, food quality and human health. The development of omics technologies has revolutionized our understanding of the microbiome, the generated complex datasets, as well as their processing and interpretation need to be taken seriously. Currently, chemometrics has shown huge potential in omics data analysis, which is crucial to reveal the functional attributes and mechanisms of microbiomes in food nutrition and safety. However, various chemometric tools have their own characteristics, selecting appropriate technologies and performing multiomics data fusion analysis to improve the precision and reliability of food microbial investigations is still a huge challenge. In this review, we summarized the omics technologies used in food microbiome studies, overviewed the principle and applicability of chemometrics in omics, and discussed the challenges and prospects of chemometrics. The urgent need for chemometrics is to integrate deep learning (DL) and artificial intelligence algorithms to enhance its analytical capabilities and prediction accuracy. We hope this review will provide valuable insights of the integration of multiomics and bioinformatics combined with various chemometric techniques in data analysis for food microbial investigation. In the future, chemometrics combined with modern technologies for multiomics data analysis will further deepen our understanding of food microbiology and improve food safety.","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-14"},"PeriodicalIF":4.2,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Application of Inductively Coupled Plasma Mass Spectrometry in Cancer Research.

IF 4.2 2区化学

Critical reviews in analytical chemistry Pub Date : 2025-02-13 DOI: 10.1080/10408347.2025.2463437

Zhikun Zang, Xiaolan Liu, Meng Wang, Zhibin Wang

{"title":"The Application of Inductively Coupled Plasma Mass Spectrometry in Cancer Research.","authors":"Zhikun Zang, Xiaolan Liu, Meng Wang, Zhibin Wang","doi":"10.1080/10408347.2025.2463437","DOIUrl":"https://doi.org/10.1080/10408347.2025.2463437","url":null,"abstract":"Inductively coupled plasma mass spectrometry (ICP-MS) technology has demonstrated immense potential in cancer research. This paper explores the diverse applications and significance of ICP-MS in this field. ICP-MS plays a pivotal role in tumor marker detection by enabling the identification of cancer-related biomolecules through elemental labeling, such as metallic labeling of antibodies or nucleic acids, and by detecting cancer cell surface markers. Additionally, it facilitates the discovery of potential biomarkers by analyzing elemental changes and their metabolites in biological fluids and tissue samples. Single-cell ICP-MS techniques provide insights into cell-to-cell heterogeneity, offering cell-level information for cancer studies. In the realm of metallic anticancer drug research, ICP-MS is employed to investigate drug uptake and distribution. This includes analyzing metallodrug uptake in cells, and distribution in tissues and organs at the single-cell level, and elucidating anticancer mechanisms by monitoring the distribution and metabolism of these metallodrugs. The application of ICP-MS in cancer research offers robust technical support for early diagnosis, treatment evaluation, and drug discovery, promising broad prospects in this domain.","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-25"},"PeriodicalIF":4.2,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Importance and Use of Polydopamine in Molecularly Imprinted Polymer-Based Electrochemical Sensor Design. 聚多巴胺在基于分子印迹聚合物的电化学传感器设计中的重要性和用途。

IF 4.2 2区化学

Critical reviews in analytical chemistry Pub Date : 2025-02-11 DOI: 10.1080/10408347.2025.2463442

Goksu Ozcelikay-Akyıldız, S Irem Kaya, Seyda Nur Samanci, Sibel A Ozkan

{"title":"The Importance and Use of Polydopamine in Molecularly Imprinted Polymer-Based Electrochemical Sensor Design.","authors":"Goksu Ozcelikay-Akyıldız, S Irem Kaya, Seyda Nur Samanci, Sibel A Ozkan","doi":"10.1080/10408347.2025.2463442","DOIUrl":"https://doi.org/10.1080/10408347.2025.2463442","url":null,"abstract":"Due to their natural biocompatibility, cost-effectiveness, and strong interfacial adhesion, biopolymers have highly favorable properties for electrochemical biosensors. Due to this endogenous catecholamine's versatile chemistry, dopamine's oxidation and self-polymerization have recently attracted considerable interest. Polydopamine (PDA)'s application to surface deposition, molecular imprinting, and electrochemistry is especially noteworthy. This review aims to propose the role of PDA in quantitative applications, evaluate the analytical performance, cost, reproducibility, and versatility of the methods developed, and evaluate standard (bio)analytical platforms. First, the parameters and methods that influence the polymerization of dopamine are discussed. Then, different functionalities of PDA and its recent applications for different biosensing purposes are reviewed to build bioanalytical platforms. The discussion concludes with emerging applications of PDA-integrated biosensor platforms. Finally, future perspectives for improved use of PDA in bioanalytical applications are discussed.","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-18"},"PeriodicalIF":4.2,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Review of Modern Spectrometric Techniques for Monitoring Cadmium in Water and Enhancing Public Health.

IF 4.2 2区化学

Critical reviews in analytical chemistry Pub Date : 2025-02-08 DOI: 10.1080/10408347.2025.2457391

B K Vinay, Sivaramakrishnan Ganesan, T R Suranjan, B M Vivek

{"title":"Review of Modern Spectrometric Techniques for Monitoring Cadmium in Water and Enhancing Public Health.","authors":"B K Vinay, Sivaramakrishnan Ganesan, T R Suranjan, B M Vivek","doi":"10.1080/10408347.2025.2457391","DOIUrl":"https://doi.org/10.1080/10408347.2025.2457391","url":null,"abstract":"Cadmium (Cd) contamination in aquatic ecosystems poses significant threats to environmental and public health due to its high toxicity and persistence. Even at trace levels, Cd can cause severe health issues, including kidney damage, bone disorders, and an increased risk of cancer, making its detection and monitoring critical. This review focuses on spectrometry techniques for detecting and quantifying Cd in water, evaluating its sensitivity, specificity, and adaptability to diverse environmental conditions. It highlights advancements in modern technologies that enhance the precision, speed, and reliability of these methods while addressing limitations such as high costs and operational complexity. The review also emphasizes the importance of integrating innovative approaches to improve portability and accessibility for real-time monitoring in resource-limited settings. By providing insights into current challenges and potential solutions, this study aims to guide the development of more efficient detection systems that support effective environmental management and safeguard public health from the harmful effects of cadmium contamination.","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-22"},"PeriodicalIF":4.2,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143373589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances and Challenges in Molecularly Imprinted Electrochemical Sensors for Application in Environmental, Biomedicine, and Food Safety.

IF 4.2 2区化学

Critical reviews in analytical chemistry Pub Date : 2025-02-06 DOI: 10.1080/10408347.2025.2460751

Rui Liu, Meiting Zhao, Xin Zhang, Chaojun Zhang, Binqiao Ren, Jing Ma

{"title":"Advances and Challenges in Molecularly Imprinted Electrochemical Sensors for Application in Environmental, Biomedicine, and Food Safety.","authors":"Rui Liu, Meiting Zhao, Xin Zhang, Chaojun Zhang, Binqiao Ren, Jing Ma","doi":"10.1080/10408347.2025.2460751","DOIUrl":"https://doi.org/10.1080/10408347.2025.2460751","url":null,"abstract":"Molecularly imprinted electrochemical sensors (MIECSs) are a specialized class of sensors based on molecularly imprinted derivative materials (MIDPs), which have been extensively applied in environmental monitoring, biomedicine, and food safety, allowing for high selectivity and sensitivity in detecting target molecules. This review provides an in-depth exploration of the most innovative and successful nanomaterials employed for modifying imprinted polymers, highlighting their crucial role in enhancing sensor performance, including carbon-based nanomaterials, meal derivatives, magnetic nanomaterials, polymeric and composite nanomaterials. In addition to reviewing advances in derivative materials design, this article delves into the current challenges facing molecularly imprinted sensors, such as issues related to template removal, nonspecific binding, and fabrication reproducibility. These challenges limit the practical application of MIECSs, particularly in complex real-world environments. The review also discusses representative applications of these sensors, including environmental monitoring, biomedicine and food safety, which demonstrate their versatility and potential. Finally, the review outlines future research directions aimed at overcoming these challenges. This includes strategies for improving the stability and reusability of MIECSs, enhancing their selectivity and sensitivity, and developing novel imprinting techniques. By addressing these issues, researchers can pave the way for the next generation of electrochemical sensors, which will be more robust, reliable, and suitable for a wide range of industrial and clinical applications.","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-19"},"PeriodicalIF":4.2,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0