Critical reviews in analytical chemistry最新文献

{"title":"Recent Advances in Organic Colorimetric and Fluorimetric Detection of Co²⁺ Ions: Strategies, Challenges, and Future Perspectives (2020-2025).","authors":"Mohsen A M Alhamami","doi":"10.1080/10408347.2025.2527741","DOIUrl":"https://doi.org/10.1080/10408347.2025.2527741","url":null,"abstract":"<p><p>Cobalt is essential in various biological systems, but their excessive accumulation can pose significant health and ecological risks. The development of sensitive, selective, and rapid detection methods is crucial for monitoring Co²⁺ contamination in water, food, and biological samples. Organic fluorimetric and colorimetric chemosensors have gained considerable attention due to their high sensitivity, simplicity, and real-time detection capabilities. These chemosensors function through fluorescence quenching/enhancement and visible color changes induced by Co²⁺ interactions, enabling efficient and portable detection. Recent advancements have focused on designing novel organic fluorophores that improve selectivity, response time, and detection limits. This review provides a comprehensive overview of recent advancements in organic fluorimetric and colorimetric detection of Co²⁺, emphasizing innovative sensing strategies, emerging materials, and detection mechanisms. It critically discusses key challenges, including sensitivity limitations, selectivity in complex environments, and stability concerns, while offering insights into future research directions aimed at enhancing detection performance, broadening applicability, and integrating advanced analytical technologies for real-world applications.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-19"},"PeriodicalIF":4.2,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liquid Biopsy-Based Smart Sensors for Ovarian Cancer Detection.","authors":"Pallavi Kumari, Anupama Aiyar, Shweta Dang","doi":"10.1080/10408347.2025.2530177","DOIUrl":"https://doi.org/10.1080/10408347.2025.2530177","url":null,"abstract":"<p><p>Ovarian cancer is one of the most aggressive gynecologic malignancies, with a vast majority of patients diagnosed at advanced stages owing to the lack of available early detection methods. Liquid biopsy, a noninvasive method for detecting circulating biomarkers such as circulating tumor cells (CTCs), cell-free DNA (cfDNA), exosomes, and a wide range of non-coding RNAs (including microRNAs, long non-coding RNAs, and circular RNAs), enables the detection of ovarian cancer using composite biomarker panels tailored for disease specificity. Liquid biopsy-based diagnostics have also made a significant leap forward in terms of sensitivity, specificity, and real-time monitoring due to integration of smart sensor technology. To meet the challenge of sensitivity, highly specific bioelectrical and electrochemical, optical as well and nanomaterial-based sensors have been developed to detect ovarian cancer biomarkers within minutes that are cost-effective and scalable. The progress of Lab-on-Chip technologies, nano-bio sensing systems, and artificial intelligence-driven diagnostic models have further redefined this field by increasing biomarker detection and facilitating clinical decision-making efficiencies. This review discusses the state-of-the-art of liquid biopsy in smart sensors, their fundamentals, and the breakthroughs of these technologies of interest for ovarian cancer detection. Moreover, both clinical utility and regulatory hurdles of this biosensing will be interpreted to decipher the translational readiness for broad clinical application. The smart biosensors will continue to evolve, determining the future of ovarian cancer diagnostics by providing early detection and personalized treatment options and quality of life for patients.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-16"},"PeriodicalIF":4.2,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emetine: Advances in Pharmacology, Toxicology, and Chromatographic Approaches.","authors":"Weldejeworgis Gebrehiwot, Kenan Can Tok, Jamilah S Alkhashi, Oladapo Bakare, Mehmet Gumustas","doi":"10.1080/10408347.2025.2529458","DOIUrl":"https://doi.org/10.1080/10408347.2025.2529458","url":null,"abstract":"<p><p>Emetine, derived from Psychotria ipecacuanha, is a tetrahydroisoquinoline alkaloid known for its diverse pharmacological activities, making it a versatile candidate for therapeutic applications. It has demonstrated efficacy against various conditions, including cancer and other viral infections by disrupting viral protein synthesis and assembly, particularly against influenza and Ebola viruses. Despite its therapeutic potential, concerns about cardiotoxicity have limited its clinical use, prompting exploration into safer administration routes and novel formulations. Emetine's anti-cancer properties involve inhibiting the Wnt/β-catenin pathway in breast cancer cells and showing promise in treating pulmonary arterial hypertension by suppressing pulmonary artery smooth muscle cell proliferation. Liquid chromatography plays a pivotal role in characterizing and quantifying emetine and related compounds, crucial for drug development and quality control by enhancing detection sensitivity and specificity in samples. Addressing concerns over emetine's toxicity novel approaches like pH-dependent prodrugs and targeted delivery systems are under development to improve safety and efficacy profiles. This review consolidates current knowledge on emetine's pharmacology and the essential role of analytical methodologies in its study and development. It focuses on recent advancements from 1979 to 2024 in liquid chromatography analysis and applications of emetine and its derivatives in drug research, health sciences, as well as forensic purposes.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-14"},"PeriodicalIF":4.2,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144636471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Organic Explosives in Plants and Soil: Accumulation, Analysis and Risk assessment - A Review.","authors":"Inga Sowik, Lena Ruzik","doi":"10.1080/10408347.2025.2517797","DOIUrl":"https://doi.org/10.1080/10408347.2025.2517797","url":null,"abstract":"<p><p>Explosives originating from military operations, industrial processes, and armed conflicts have become persistent environmental contaminants, with nitroaromatic and nitroheterocyclic compounds such as 2,4,6-trinitrotoluene (TNT) and 1,3,5-trinitro-1,3,5-triazinane (RDX) among the most hazardous. These substances can accumulate in soil and water at high concentrations and undergo chemical transformation, degradation, and plant uptake, posing serious risks to ecosystems and human health. While the analysis of explosives in water and soil has advanced significantly-primarily through techniques like LC-MS/MS-there remains a critical gap in understanding their behavior and metabolism in plant matrices. This review critically examines current analytical methodologies for detecting explosives and their transformation products in environmental samples, with special emphasis on soil and plant systems. We discuss the strengths and limitations of extraction techniques such as ultrasound-assisted extraction, pressurized liquid extraction, and accelerated solvent extraction, as well as challenges posed by matrix complexity and analyte instability. Instrumental techniques including LC-MS/MS, GC-ECD, MALDI-TOF, and emerging ambient ionization mass spectrometry approaches are evaluated in terms of sensitivity, selectivity, and field applicability. Additionally, this review highlights gaps in regulatory frameworks concerning permissible residue levels in plants and proposes future directions for standardizing methods and improving risk assessment protocols. By focusing on plant contamination-an often-overlooked yet crucial link in environmental exposure pathways-this work underscores the urgent need for integrated analytical strategies to monitor, manage, and mitigate the environmental and health impacts of explosive residues.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-14"},"PeriodicalIF":4.2,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144636472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Ternary Deep Eutectic Solvent in Liquid-Phase Microextraction Techniques.","authors":"Enoch Olvera-Ureña, Begoña Aguilar-Perez, Karen A Escamilla-Lara, Jorge Lopez-Tellez, Sandra Ramirez-Montes, Jose A Rodriguez","doi":"10.1080/10408347.2025.2527758","DOIUrl":"https://doi.org/10.1080/10408347.2025.2527758","url":null,"abstract":"<p><p>In recent years, deep eutectic solvents (DESs) have experienced widespread growth due to their potential use as \"green solvents\" replacing traditional organic solvents. DESs present important advantages such as easy preparation, high affinity, low toxicity and accessibility of their components. Therefore, they have been applied as extracting agents in liquid phase microextraction techniques. Despite the DESs advantages, some limitations have been described related to their solubility, viscosity, selectivity and stability, consequently, an alternative described is binary DESs incorporation of a third component (ternary deep eutectic solvents) have been developed as an alternative. This new type of solvents improves some physical and chemical characteristics as well as extraction efficiency and selectivity, besides to exhibit good stability in polar or nonpolar matrices, high ratio dispersion and separation from extraction media, good selectivity and affinity toward various compounds. This review classifies ternary DESs based on the components used in their synthesis, as hydrophilic ternary DESs, hydrophobic ternary DESs, magnetic ternary DESs, supramolecular ternary DESs, and polymeric ternary DESs and their sub-classifications. Emerging trends in the development of ternary DES, including the interaction mechanisms for the extraction process, their application in various matrices, and the results obtained for different target compounds, are described and discussed.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-25"},"PeriodicalIF":4.2,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comprehensive Review of Terahertz Time-Domain Spectroscopy for Agri-Food Safety Detection: Enhanced Sensing Performance Through Multidisciplinary Technology Integration.","authors":"Lintong Zhang, Shuhui Wang, Wangjincheng Yang, Xinze Liu, Zenghui Wei, Alwaseela Abdalla, Jiachen Zhang, Xiangzeng Kong, Fangfang Qu","doi":"10.1080/10408347.2025.2527748","DOIUrl":"https://doi.org/10.1080/10408347.2025.2527748","url":null,"abstract":"<p><p>The development of efficient and accurate methods for detecting contamination in agri-foods is critical for ensuring food safety. Terahertz time-domain spectroscopy (THz-TDS), distinguished by its unique spectral characteristics and nondestructive detection capabilities, emerges as a powerful tool for analyzing agri-food safety. This review systematically examines the integration of THz-TDS with frontier technologies (machine learning [ML], metamaterials [MM], microfluidics [MF], and functional nanomaterials [FN]) to enhance detection capabilities. The article delves into the advancements achieved in detecting physical, chemical, and microbial contaminants in agri-food over the past five years (2020-2024) through the integration of THz-TDS with these frontier technologies. Based on the current state of research, this article summarizes the challenges and prospects of THz-TDS with interdisciplinary integration technologies in applications. To advance THz-TDS for agri-food safety monitoring, multidisciplinary integration is required. ML is critical for deciphering complex THz spectral datasets, while MM play a pivotal role in amplifying analyte-specific spectral signatures. FN leverage their potential high-throughput specific adsorption and plasmonic resonance properties to enhance detection sensitivity and specificity. The MF systems can reduce absorption induced by water. This review aims to provide new insights into the multidisciplinary convergence to propel THz-TDS toward transformative agri-food safety applications.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-22"},"PeriodicalIF":4.2,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144590629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smart Organic Probes and Their Applications: Sequential Fluorometric and Colorimetric Sensing of Cu²⁺ and CN^- Ions: A Review (2018-2025).","authors":"Jari S Algethami","doi":"10.1080/10408347.2025.2527761","DOIUrl":"https://doi.org/10.1080/10408347.2025.2527761","url":null,"abstract":"<p><p>The detection of Cu²⁺ and CN^- ions is of significant importance due to their crucial roles in biological and environmental systems. While CN^- is widely utilized in industrial applications, its high toxicity poses severe risks to human health and the environment, necessitating precise monitoring. Similarly, Cu²⁺, an essential trace element, becomes hazardous at excessive concentrations, leading to liver damage, cardiovascular diseases, and ecological toxicity. Dual-channel sensors that employ both colorimetric and fluorometric responses have gained attention for their ability to detect multiple analytes simultaneously with high specificity, cost-effectiveness, and operational simplicity. This review highlights recent advancements (2018-2025) in smart organic probes for sequential fluorometric and colorimetric sensing of Cu²⁺ and CN^- ions. Various sensing mechanisms, including deprotonation, coordination, and addition reactions, have been explored to achieve selective recognition. The challenges associated with interference from other metal ions, solubility issues, and real-world applicability are critically analyzed. The development of multi-target sensors is emphasized, showing their potential for real-time environmental monitoring, medical diagnostics, and industrial safety applications. Future perspectives focus on improving probe performance through structural modifications, enhancing water solubility, and integrating smart materials for portable sensing platforms.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-16"},"PeriodicalIF":4.2,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144583317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends and Innovations in Tools for Processing Chromatographic Data Using Mass Spectrometry Detection: A Systematic Review.","authors":"Jelmir Craveiro de Andrade, Gislaine Natiele Dos Santos Costa, Celeste Yara Dos Santos Siqueira, Carlos Alberto Carbonezi, Regina Binotto, Vinicius Kartnaller","doi":"10.1080/10408347.2025.2528134","DOIUrl":"https://doi.org/10.1080/10408347.2025.2528134","url":null,"abstract":"<p><p>Chromatographic data processing represents an increasing challenge in analytical science, particularly due to the complexity of samples and the large volume of data generated by chromatographic techniques coupled with mass spectrometry (MS). This paper presents a systematic review of technological innovations over the last six years in the development of computational tools for processing these data. The review follows the PRISMA protocol, with a search conducted across five databases (SciFinder, Scopus, Web of Science, Embase, and ScienceDirect), utilizing strategies based on indexed descriptors and Boolean combinations. Thirty-three studies were selected that met the criteria of originality, applicability, and innovation in analytical tools. The results reveal significant advancements in algorithms for peak detection, alignment, and deconvolution, with an emphasis on machine learning, deep learning, and multivariate resolution approaches. Tools such as DeepResolution, SeA-M2Net, SLAW, QPMASS, autoGCMSDataAnal, and AntDAS demonstrate automation, scalability, and higher accuracy in critical tasks such as noise filtering, baseline correction, and compound identification. The analysis also highlights the progress of open-source software, which promotes greater access and interoperability. Although challenges such as the need for annotated data and standardization remain, recent advancements signal a shift toward more robust, accessible, and adaptable solutions for chromatographic data processing, expanding the potential of analyses across various scientific and industrial contexts. In this review, 'peak deconvolution' refers to separating co-eluting chromatographic signals, while 'spectral deconvolution' denotes reconstructing pure MS/MS spectra from mixed fragments.\"</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-20"},"PeriodicalIF":4.2,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Progress in Multi-Analytes Recognition Reinforced by Graphene Derivatives for Cardio Health Assessments.","authors":"M A H Suhaimi, S Taniselass, M K Md Arshad, Subash C B Gopinath, M F M Fathil, M M Ramli, I H Hasan","doi":"10.1080/10408347.2025.2525201","DOIUrl":"https://doi.org/10.1080/10408347.2025.2525201","url":null,"abstract":"<p><p>The escalating prevalence of cardiovascular diseases globally call for a low-cost monitoring technology for an immediate intervene and diagnoses. Advance multiplexed biosensors reinforced by graphene derivatives marks a significant progression in the field of cardiovascular health assessments. The graphene derived biosensors are designed specifically for fast detection of cardiac biomarkers with high precision to evaluate cardiovascular health. The graphene biocompatibility and fast signal transduction electronic properties provide an ideal foundation for the multiplexed technology. Despite the substantial potential of this multiplexed technologies, there remains a pressing need for further research and development to fully harness their capabilities in clinical environments. This study underscores the critical role of these biosensors in point of care applications and reviews the current landscape of research, highlighting significant progress made in graphene-based transduction and the recent trends in graphene production which give impact on biosensors performance. Key components are discussed include the assessment of vital cardiac biomarkers and the evolution of multiplex biosensing strategies that utilizes graphene nanomaterials. In summary, this review provides a comprehensive overview of the latest advancements in multi-analyte detection for cardiac healthcare. It outlines the key challenges encountered while proposing potential strategies to improve the effectiveness of multiplex biosensing platforms, thereby supporting the advancement of cardiac diagnostics. The potential of multiplexed biosensing technology leads to enhance diagnostic capabilities while reducing healthcare costs represents a significant advancement in cardiovascular healthcare, particularly for point-of-care applications.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-14"},"PeriodicalIF":4.2,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comprehensive Review on the Analytical Approaches for Antidepressant Drug Detection.","authors":"Trupesh Pethani, Dhaval Mori, Vishrut Vaghasiya, Bansari Dori, Radhika Aghera","doi":"10.1080/10408347.2025.2520892","DOIUrl":"https://doi.org/10.1080/10408347.2025.2520892","url":null,"abstract":"<p><p>The review article provides a comprehensive overview of the advancements in analytical techniques for monitoring antidepressant drugs across various matrices, including pharmaceutical, and biological samples. Depression, affecting over 280 million people globally, is associated with significant morbidity and mortality, necessitating effective treatment options. The review categorizes antidepressants into five main classes: Selective serotonin reuptake inhibitors (SSRIs), Serotonin and norepinephrine reuptake inhibitors (SNRIs), Reversible Monoamine oxidase inhibitors (MAOIs), Tricyclic antidepressants (TCAs), and atypical antidepressants. Although antidepressant medications are generally effective, many patients fail to respond adequately to treatment, underscoring the need for more comprehensive and individualized monitoring approaches, such as combining therapeutic drug monitoring (TDM), pharmacogenetic profiling, and clinical symptom tracking, to better manage treatment resistance. Monitoring drug concentrations in plasma, blood, and urine can help identify subtherapeutic levels or non-adherence, which are potential contributors to treatment resistance. For this purpose, bioanalytical methods represent the most appropriate analytical approach, enabling precise and reliable quantification of drug levels in biological matrices. The article emphasizes the importance of various analytical techniques such as liquid chromatography, mass spectrometry, and spectrophotometry. Notably, spectrometric methods are highlighted for their cost-effectiveness and reliability in analyzing low concentrations of drugs. The review fills a critical gap in the literature by consolidating data on analytical methods for monitoring antidepressant levels, while also addressing concerns like drug misuse and associated cardiovascular risks. It serves as a valuable resource for researchers and clinicians, offering insights that support the development of drug analysis techniques, delivery systems, and the clinical application of antidepressants.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-31"},"PeriodicalIF":4.2,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}