Critical reviews in analytical chemistry最新文献

{"title":"Recent Progress in Multi-Analytes Recognition Reinforced by Graphene Derivatives for Cardio Health Assessments.","authors":"M A H Suhaimi, S Taniselass, M K Md Arshad, Subash C B Gopinath, M F M Fathil, M M Ramli, I H Hasan","doi":"10.1080/10408347.2025.2525201","DOIUrl":"https://doi.org/10.1080/10408347.2025.2525201","url":null,"abstract":"<p><p>The escalating prevalence of cardiovascular diseases globally call for a low-cost monitoring technology for an immediate intervene and diagnoses. Advance multiplexed biosensors reinforced by graphene derivatives marks a significant progression in the field of cardiovascular health assessments. The graphene derived biosensors are designed specifically for fast detection of cardiac biomarkers with high precision to evaluate cardiovascular health. The graphene biocompatibility and fast signal transduction electronic properties provide an ideal foundation for the multiplexed technology. Despite the substantial potential of this multiplexed technologies, there remains a pressing need for further research and development to fully harness their capabilities in clinical environments. This study underscores the critical role of these biosensors in point of care applications and reviews the current landscape of research, highlighting significant progress made in graphene-based transduction and the recent trends in graphene production which give impact on biosensors performance. Key components are discussed include the assessment of vital cardiac biomarkers and the evolution of multiplex biosensing strategies that utilizes graphene nanomaterials. In summary, this review provides a comprehensive overview of the latest advancements in multi-analyte detection for cardiac healthcare. It outlines the key challenges encountered while proposing potential strategies to improve the effectiveness of multiplex biosensing platforms, thereby supporting the advancement of cardiac diagnostics. The potential of multiplexed biosensing technology leads to enhance diagnostic capabilities while reducing healthcare costs represents a significant advancement in cardiovascular healthcare, particularly for point-of-care applications.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-14"},"PeriodicalIF":4.2,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comprehensive Review on the Analytical Approaches for Antidepressant Drug Detection.","authors":"Trupesh Pethani, Dhaval Mori, Vishrut Vaghasiya, Bansari Dori, Radhika Aghera","doi":"10.1080/10408347.2025.2520892","DOIUrl":"https://doi.org/10.1080/10408347.2025.2520892","url":null,"abstract":"<p><p>The review article provides a comprehensive overview of the advancements in analytical techniques for monitoring antidepressant drugs across various matrices, including pharmaceutical, and biological samples. Depression, affecting over 280 million people globally, is associated with significant morbidity and mortality, necessitating effective treatment options. The review categorizes antidepressants into five main classes: Selective serotonin reuptake inhibitors (SSRIs), Serotonin and norepinephrine reuptake inhibitors (SNRIs), Reversible Monoamine oxidase inhibitors (MAOIs), Tricyclic antidepressants (TCAs), and atypical antidepressants. Although antidepressant medications are generally effective, many patients fail to respond adequately to treatment, underscoring the need for more comprehensive and individualized monitoring approaches, such as combining therapeutic drug monitoring (TDM), pharmacogenetic profiling, and clinical symptom tracking, to better manage treatment resistance. Monitoring drug concentrations in plasma, blood, and urine can help identify subtherapeutic levels or non-adherence, which are potential contributors to treatment resistance. For this purpose, bioanalytical methods represent the most appropriate analytical approach, enabling precise and reliable quantification of drug levels in biological matrices. The article emphasizes the importance of various analytical techniques such as liquid chromatography, mass spectrometry, and spectrophotometry. Notably, spectrometric methods are highlighted for their cost-effectiveness and reliability in analyzing low concentrations of drugs. The review fills a critical gap in the literature by consolidating data on analytical methods for monitoring antidepressant levels, while also addressing concerns like drug misuse and associated cardiovascular risks. It serves as a valuable resource for researchers and clinicians, offering insights that support the development of drug analysis techniques, delivery systems, and the clinical application of antidepressants.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-31"},"PeriodicalIF":4.2,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in Breast Cancer Detection: Biomarkers, Mechanisms, and Biosensor Technologies.","authors":"Shipra Goyal, Sarthak Chauhan, Deepanjali Baliyan, Baljinder Singh","doi":"10.1080/10408347.2025.2521431","DOIUrl":"https://doi.org/10.1080/10408347.2025.2521431","url":null,"abstract":"<p><p>Breast cancer (BC), the most common cancer in women, remains a global health concern. According to the World Health Organization, in the year 2022, BC caused around 6,70,000 deaths. This huge mortality number requires immediate attention and intervention in the form of early diagnosis and therapies. Existing conventional diagnostic techniques for BC include imaging techniques like MRI and ultrasound; biopsies and molecular testing for screening BC genes and biomarkers. However, these techniques have drawbacks including less sensitivity and specificity, highly invasive, radiation exposure, long response time, and are cumbersome and expensive. These drawbacks are overcome by biosensing technology by exhibiting various advantages like high specificity and sensitivity, less invasive, no exposure to radiation, portable, cost effective with multiplexing capabilities; Also, biosensor can detect different biomarkers related to BC in very low concentration, thus, enabling the early detection and preventing the spread of disease. This comprehensive review paper aims to provide an overview of BC, the role of different signaling pathways, and different types of biomarkers associated with it. Additionally, it explores biosensors, an advanced tool for detection of BC biomarkers detailing various types such as optical, electrochemical, microfluidic chips along with their performance evaluations. By examining the current status of research and the implications of these advancements on early detection, prognosis, and customized treatment strategies, we hope that this review will offer new perspectives for patients with BC.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-32"},"PeriodicalIF":4.2,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144505008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolomics Approach in Environmental Studies: Methodologies, Application and Challenges.","authors":"Abdulwasiu Olawale Salaudeen, Lim Vuanghao","doi":"10.1080/10408347.2025.2521734","DOIUrl":"https://doi.org/10.1080/10408347.2025.2521734","url":null,"abstract":"<p><p>Metabolomics is the study of low molecular weight compounds, both endogenous and exogenous, present in an organism's cells, tissues, or biological fluids. In recent years it has gained significant attention in environmental research for assessing different environmental exposures-primarily chemical pollutants-affect the metabolism of organisms, including humans. Metabolomics has therefore emerged as a crucial technique in exposome investigations, enabling the exploration of molecular-level biological effect of xenobiotics. This review highlights recent applications of metabolomics in evaluating the environmental impacts of disturbances such as pesticides, pharmaceuticals and personal care products, nanoparticles, polychlorinated biphenyls, heavy metals, polyaromatic hydrocarbons, microplastics and changes in naturally occurring compounds with an emphasis on humans, microorganisms, aquatic organisms, plants and soils. It also provides an overview of analytical technologies and recent advances in the field of ecometabolomics. Furthermore, the review acknowledges persistent challenges including sample heterogeneity, complex matrix, data overload, methodological variability, communication barriers and regulatory hurdles. Despite these challenges, metabolomics holds substantial promise in environmental applications.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-17"},"PeriodicalIF":4.2,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144483438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Applications in Analytical Techniques of Microplastics.","authors":"Meng Zhang, Jinhang Pan, Daqian Song, Jie Jiang, Yanxiao Jiang","doi":"10.1080/10408347.2025.2518328","DOIUrl":"https://doi.org/10.1080/10408347.2025.2518328","url":null,"abstract":"<p><p>Microplastics (MPs), which originate from the widespread use of plastic products, undergo aging and decomposition under environmental conditions, making them almost ubiquitous in the environment. They pose significant potential hazards to human health and the ecological environment and have become a global environmental safety issue. However, effective analysis is challenging due to the diverse types of MPs, large variations in particle size, and the complex composition of the environmental matrix. There are a few articles that provide an overview of analytical techniques for MPs, but the most review focus on the particular analytical methods and sample pretreatment techniques, lacking a comprehensive summary of systematic detection approaches. This article reviews the analytical methods for MPs developed over the past five years, emphasizing six categories of analytical technologies: fluorescent labeling, spectroscopic techniques, thermal analysis, electrochemical analysis, mass spectrometry (MS), and chromatography. It discusses the principles and applications of these methods, as well as the challenges they currently face and prospects. This work aims to provide valuable guidance for researchers in the field of MPs and promote the further development of analytical technologies.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-21"},"PeriodicalIF":4.2,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144474155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of Cytotoxic Antimetabolites in Water: Current Analytical Methods.","authors":"Selen Al, Aykut Kul, Olcay Sagirli","doi":"10.1080/10408347.2025.2520396","DOIUrl":"https://doi.org/10.1080/10408347.2025.2520396","url":null,"abstract":"<p><p>Water is an essential resource for sustaining life and plays a critical role in maintaining the balance of ecosystems. However, the accumulation of cytotoxic drugs used in cancer treatment, such as antimetabolites, in aquatic ecosystems has become a major problem threatening environmental sustainability. Since cytotoxic drugs can sustain their biochemical activity even at low concentrations, they can have toxic effects on ecological systems. This review examines in detail the analytical methods available for detecting antimetabolites in water. Due to its high sensitivity and selectivity, liquid chromatography-tandem mass spectrometry (LC-MS/MS) is the most widely used method for the detection of antimetabolites. However, in this method, matrix effects are one of the main problems. In addition, analyses have shown that conventional wastewater treatment systems cannot adequately remove these components. This situation causes antimetabolites to persist in the environmental cycle and pose potential ecotoxicological risks. In this context, advanced analytical techniques should be used to better understand the environmental effects of antimetabolites and to develop effective removal methods. This review provides a comprehensive source for researchers working in the field of environmental analytical chemistry and is expected to contribute to the existing literature and guide future research. Furthermore, future studies will allow for better modeling of the environmental dispersion of antimetabolites, development of more effective treatment methods, and more in-depth investigation of the long-term effects of these compounds on aquatic ecosystems. Research in this field is critical for reducing environmental health risks and protecting sustainable water resources.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-13"},"PeriodicalIF":4.2,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in Electrochemical Detection of Vitamins B2 and B6: A Brief Review on Practical Applications.","authors":"Gopika M G, Raril C, Beena Saraswathyamma","doi":"10.1080/10408347.2025.2519689","DOIUrl":"https://doi.org/10.1080/10408347.2025.2519689","url":null,"abstract":"<p><p>The precise measurement of vitamins B2 (VB2) and B6 (VB6) is of great concern for clinics, pharmacists, and food manufacturers, as these vitamins are of great importance and cannot be made by the body. Undoubtedly, the reliable quantification of these vitamins is a great analytical problem considering the serious metabolic disorders that can occur because of their deficiencies. Conventional HPLC, fluorescence spectroscopy, and capillary electrophoresis are highly accurate methods, but due to high costs, intricate sample preparation, and slow analysis times, their application is quite limited. The introduction of electrochemical sensing was a much-needed alternative as its simplicity, cost-effectiveness, high sensitivity, and fast response is desired within the monitoring field. Advances in the electrochemical techniques, and particularly in the voltammetric methods, as well as their electrode materials and surface modifications have improved the simultaneous detection of these vitamins. Nonetheless, sensor selectivity, reproducibility, and signal interference are significant hurdles for their practical implementation. In this review, we describe the importance of the electrochemical sensors in VB2 and VB6 detection, the current state of these sensors and their limitations, and the prospective future development work to improve their performance.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-13"},"PeriodicalIF":4.2,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Assessment, Detection and Control of Mutagenic Impurities in Pharmaceuticals: Emphasis on Nitrosamines.","authors":"Aishwarya Dande, H M Chandra Mouli, Joshita Nandy, Shambhavi Shreya, Nikhil Pallaprolu, Gananadhamu Samanthula, Ramalingam P","doi":"10.1080/10408347.2025.2517357","DOIUrl":"https://doi.org/10.1080/10408347.2025.2517357","url":null,"abstract":"<p><p>The emergence of mutagenic impurities, particularly nitrosamines and nitrosamine drug substance-related impurities (NDSRIs), has raised critical concerns across the pharmaceutical industry due to their established genotoxic and carcinogenic potential. Despite the existing regulatory frameworks, drug recalls by the USFDA continued to expose persistent gaps in the prediction, detection, and control of these impurities. The chemical origins, formation mechanisms, and risk factors associated with nitrosamines and NDSRIs remain complex, and current mitigation strategies often fail to address their variability and context-specific formation. From an analytical standpoint, quantifying these impurities at sub-ppb levels remains challenging due to matrix interference and instrumental limitations. Techniques such as LC-HRMS and GC-MS/MS provide the required sensitivity and selectivity but require rigorous compound-specific method validation. A paradigm shift toward mechanistically informed, compound-specific risk management is also essential. Structure-based computational tools such as SAR, QSAR, and QSTR and <i>in silico</i> tools such as TOPKAT, DOPMAT, and quantum mechanics offer preliminary hazard identification but demonstrate limited reliability when applied to chemically diverse or novel impurities. <i>In vitro</i> genotoxicity assays, although widely used, frequently fail to predict <i>in vivo</i> outcomes, particularly for complex nitrosamines, highlighting the indispensable role of <i>in vivo</i> studies in accurately characterizing mutagenic and carcinogenic potential, especially in borderline cases. Chemical insights into impurity formation, high-resolution analytical techniques, and integrating <i>in vivo</i> toxicological data provide, a comprehensive framework to enhance impurity control, ensure regulatory compliance, and safeguard long-term pharmaceutical safety.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-42"},"PeriodicalIF":4.2,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Terpyridine-Based Fluorescent Sensors: Investigating the Analytical Properties for Diverse Applications.","authors":"Neelam Gupta, Dheeraj Pandey, Jyoti Pandey, Saba Naqvi, Abha Sharma","doi":"10.1080/10408347.2025.2514109","DOIUrl":"https://doi.org/10.1080/10408347.2025.2514109","url":null,"abstract":"<p><p>The research area involving fluorescent probes have gained attention in recent years due to their multiple advantages including ease of visualization, simplicity of use, instant biological imaging, and cost-effectiveness. Several fluorescent cores are available that can be used to design fluorescent sensors for various applications. Terpyridine is a core that has been widely synthesized involving carbon-carbon coupling reactions or by central ring assembly. The lateral phenyl (4'-phenyl) position of terpyridine can be functionalized easily by incorporation of additional organic functionalities that makes terpyridine more advantageous and highly explored fluorescent core. The emission wavelength of terpyridine can be tuned on substitution of electron withdrawing or donating functionalities. Terpyridine based probes has been reported for their use in environmental application, such as sensing of cation and anion, nerve agent in water, food, milk, cell imaging and disease diagnosis, etc. In this review we have compiled the recent developments in terpyridine based sensors that can be utilized for biological and non-biological applications. The mechanism of sensing along with the limit of detection and photophysical parameters of terpyridine based sensors have been discussed. The applications ranging from cell imaging, sensing of pH, detection of citrate, oxygen, H₂S, nitro aromatic compounds, sulfonamide antibiotics, vitamin C, single oxygen, and radioactive metals, such as uranium in variety of sample matrix is covered in this review. In this review we have incorporated the most common synthetic methods for synthesis of terpyridine core using the cross-coupling reaction and central ring assembly.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-26"},"PeriodicalIF":4.2,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analytical Methods Developed for the Determination of Pantoprazole Sodium: Overview.","authors":"Aysen Kurt Cucu","doi":"10.1080/10408347.2025.2516603","DOIUrl":"https://doi.org/10.1080/10408347.2025.2516603","url":null,"abstract":"<p><p>Pantoprazole sodium a substituted benzimidazole derivative is an irreversible proton pump inhibitor and was developed for the treatment of acid-related gastrointestinal disorders. As with other drugs of its class (omeprazol or lansoprazole), pantoprazole reduces gastric acid secretion through inhibition of the portion on the gastric parietal cell. Analytical methods for the determination of the active drug ingredient pantoprazole sodium are available in many manuscripts. Pantoprazole sodium, alone or in combination with other drugs, in different pharmaceutical forms, industrial wastewater, and plasma samples using spectroscopic, chromatographic, electroanalytical and thermal analysis methods have been made by many researchers analyzed. Manuscripts were identified that included analytic methods developed to analyze pantoprazole sodium alone or in the presence of other drugs included. In this review, an overview of the analytical methods developed for the determination of Pantoprazole sodium and their validation will be given.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-31"},"PeriodicalIF":4.2,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}