Suvarna Yenduri, Venkatesh K G, Pragathi Y, Naga Prashant K
{"title":"Evaluation of Environmental Impact of Solid-Phase Extraction and Microextraction Techniques in Sulfonamide Analysis.","authors":"Suvarna Yenduri, Venkatesh K G, Pragathi Y, Naga Prashant K","doi":"10.1080/10408347.2025.2550775","DOIUrl":"https://doi.org/10.1080/10408347.2025.2550775","url":null,"abstract":"<p><p>It is imperative to evaluate the environmentally conscious sample preparation techniques, as they involve the use of a variety of solvents, such as organic compounds, substances, sorbents, pH modifications, and energy inputs. Pressurized fluid extraction, liquid-liquid microextraction, accelerated solvent extraction, microwave-assisted extraction, and dispersive solid-phase extraction are among the numerous extraction methods that are employed to extract sulfonamide due to its sensitivity, efficacy, speed, versatility, and economic appeal. The greenness and sustainability of 20 methods for detecting sulfonamide in environmental, biological, and dietary samples are compared in this article using an Analytical GREEnness prep (AGREE prep), Sample Preparation Metric of Sustainability (SPMS), Blue Applicability Grade Index (BAGI), and Click Analytical Chemistry (CAC) metrics. This assessment provides substantial new information regarding the environmental consequences and sustainability of sulfonamide analysis in the preparation of samples for solid phase extraction (SPE) using HPLC and HPLC-MS/MS methods. Among these, HPLC method developed by Luo et al. & Ma et al. and LC-MS/MS method proposed by García-Galán et al. & Jian et al. reconcile analytical effectiveness with environmental sustainability since they consume less energy, are reusable, encompass fewer processes, and have minimal waste management. These features have been attributed to low energy use, excessive sample production, less waste, and environmentally suitable solvents.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-16"},"PeriodicalIF":5.2,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Advances in Silver Nanoparticles: Synthesis, Characterization, and Diverse Applications in Medicine, Environment, Antimicrobial and Antiviral Research.","authors":"Madhu Jangra, Geetanjali Saini, Parneet Sheoran, Anjum Gahlaut, Vikas Raj","doi":"10.1080/10408347.2025.2539920","DOIUrl":"https://doi.org/10.1080/10408347.2025.2539920","url":null,"abstract":"<p><p>Silver nanoparticles (AgNPs) have gained considerable attention due to their unique physicochemical properties, such as large surface area, strong antibacterial effects, and diverse applications across multiple sectors. This review provides a comprehensive overview of different studies on the synthesis processes, characterization techniques, and broad applications of AgNPs in the pharmaceutical, environmental, and antibacterial domains. The discussion covers various synthesis methodologies, including chemical processes, physical methods, and green synthesis, highlighting their respective merits and limitations. Important characterization techniques include X-ray diffraction (XRD), which determines the crystalline structure; scanning electron microscopy (SEM), which examines surface morphology; transmission electron microscopy (TEM), which reveals internal structure through high-resolution imaging; and dynamic light scattering (DLS), which determines particle size distribution. Ultraviolet-visible (UV-Vis) spectroscopy is also used to assess shape, size, and colloidal stability. This review further discusses the applications of AgNPs, including drug delivery, cancer treatment, wound healing, and antimicrobial and antiviral therapies. Although AgNPs exhibit several advantages, concerns such as toxicity and cost-effective production persist. This study suggests that with further research, AgNPs could play a crucial role in addressing significant challenges in the health and environmental sectors.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-25"},"PeriodicalIF":5.2,"publicationDate":"2025-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Versatile Application of Calixarenes and Their Derivatives: From Drug Delivery to Industrial Catalysis and Environmental Remediation.","authors":"Gopi Srinivasan, Parthiban Anaikutti, Surendiran Mohan, Murugesan Arukkani","doi":"10.1080/10408347.2025.2538731","DOIUrl":"https://doi.org/10.1080/10408347.2025.2538731","url":null,"abstract":"<p><p>Calixarenes are a structurally versatile class of macrocyclic compounds that exhibit broad functionality across pharmaceutical, analytical, industrial, and environmental domains. Their conformational flexibility and functionalize upper and lower rims facilitate selective host-guest interactions, enabling their use in targeted drug delivery systems with demonstrated antiviral, antibacterial, antifungal, and anticancer efficacy. In analytical chemistry, calixarene-based sensors have been integrated into colorimetric, fluorometric, potentiometric, and voltammetric platforms, offering high selectivity and low detection limits for analytes such as metal ions, nucleotides, and neurotransmitters. Advances in medical imaging have leveraged calixarene derivatives to enhance MRI contrast and specificity. Their strong chelating capabilities and environmental stability support their application in water purification and soil remediation. Commercial developments, including green leather tanning agents, anti-corrosion coatings, and COVID-19-era antiviral coatings, highlight their real-world potential. Furthermore, computational and AI-driven molecular modeling approaches have facilitated rational calixarene design by predicting binding affinities, dynamic conformations, and interaction energies. While promising, considerations such as low intrinsic solubility, scale-up limitations, and dose-dependent cytotoxicity require further exploration for clinical translation. This review provides a comprehensive evaluation of calixarenes, emphasizing their evolving role as supramolecular platforms in next-generation scientific and industrial innovations.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-58"},"PeriodicalIF":5.2,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Evolving Landscape of Analytical Mitochondrial Research: Mass Spectrometry, Its Proteomic and Lipidomic Insights.","authors":"Pooja Dhakne, Dnyaneshwari Aher, Rushikesh Bhutada, Pinaki Sengupta","doi":"10.1080/10408347.2025.2545295","DOIUrl":"https://doi.org/10.1080/10408347.2025.2545295","url":null,"abstract":"<p><p>Mitochondria are key cellular organelles that perform essential functions, including energy generation, calcium regulation, and cell signaling. Disruptions in mitochondrial function are linked to various conditions, such as neurodegenerative disorders, metabolic diseases, and cardiovascular issues. This review critically analyzes the intricate relationship between mitochondrial health and disease, emphasizing the role of proteomics and lipidomics in enhancing the understanding of these processes. Powerful analytical strategies including various mass spectrometric techniques employed in these omic studies have been evaluated for their suitability and effectiveness. Additionally, it highlights the broader field of omics sciences and their integration into mitochondrial research. The aim is to illustrate how omics approaches play a crucial role in advancing biological knowledge related to mitochondria, surpassing the limitations of traditional analytical methods.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-23"},"PeriodicalIF":5.2,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Niralee J Malviya, Mohammed Alqarni, Abdullah A Alshehri, Reem H Obaydo, Hardik L Varu
{"title":"Evolution of Pregabalin Analytical Methods: A Comprehensive Assessment of Performance, Accessibility, and Future Directions.","authors":"Niralee J Malviya, Mohammed Alqarni, Abdullah A Alshehri, Reem H Obaydo, Hardik L Varu","doi":"10.1080/10408347.2025.2546538","DOIUrl":"10.1080/10408347.2025.2546538","url":null,"abstract":"<p><p>Analytical determination of pregabalin presents unique challenges due to its aliphatic structure and absence of chromophoric groups, despite its classification as a BCS Class I drug with high solubility and permeability. This comprehensive review critically evaluates and compares the diverse analytical methodologies developed over the past two decades for pregabalin quantification in pharmaceutical formulations and biological matrices. We systematically analyze titrimetric, spectroscopic (UV-Vis, fluorescence, and infrared), electrochemical, chromatographic (HPTLC, HPLC, GC), and mass spectrometric techniques, with particular emphasis on derivatization strategies that overcome pregabalin's inherent detection limitations. Comparative assessment of these methods reveals significant variations in sensitivity (LOD ranging from 19.00 μg/mL to 4.9 ng/mL), selectivity, complexity, and applicability across different matrices. This review provides analytical chemists with a decision framework for method selection based on specific analytical requirements, available instrumentation, and sample characteristics. Our analysis identifies emerging trends in pregabalin analysis, including the increasing adoption of green analytical approaches, miniaturized techniques, and hyphenated systems that enhance both sensitivity and specificity while reducing environmental impact.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-21"},"PeriodicalIF":5.2,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144882385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Critical Mechanistic Insight, Technological Innovation Advances and Multi-Media Environmental Application of Colorimetry Toward Heavy Metal Detection.","authors":"Jinxin Ma, Jieping Zheng, Jiangyao Chen","doi":"10.1080/10408347.2025.2537820","DOIUrl":"https://doi.org/10.1080/10408347.2025.2537820","url":null,"abstract":"<p><p>Colorimetry, a widely employed analytical technique that leverages the visible light spectrum observable to the naked eye, has gained prominence as a straightforward and intuitive method for detecting target substances. This review provides a comprehensive overview of the development and current state of colorimetry, focusing on its origin, underlying mechanism, technological advancement, and application in environmental contexts. The historical evolution of colorimetry is initially surveyed, emphasizing key developmental milestones. The core recognition mechanisms are further elucidated, detailing heavy metal ion-induced discoloration of organic dyes, alongside adjustments in nanomaterial spacing, morphology, and alterations in catalytic performance. Then, technological progress of colorimetry is reviewed, tracing the evolution from traditional UV-visible spectrophotometry to digital image colorimetry and portable, handheld devices. Thereafter, the current state of colorimetry is comprehensively evaluated, particularly its application in detecting heavy metals across water, soil, and atmospheric particulate matter. Ultimately, this review addresses prevailing challenges, such as enhancing ultra-trace detection sensitivity and mitigating matrix interferences, while also highlights strategies to overcome these, which are vital for advancing colorimetric environmental monitoring. The review aims to underscore the potential of colorimetry in complex environmental monitoring and to provide a theoretical framework for future research and technological innovation in the field.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-33"},"PeriodicalIF":5.2,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Peijie Shen, Di Huang, Mengjun Fang, Zhinan Xu, Xiangming Fang
{"title":"Temperature-Modulation Categorization of Argonaute-Based Bioreactions Coupled with Amplification Methods for Nucleic Acid Detection.","authors":"Peijie Shen, Di Huang, Mengjun Fang, Zhinan Xu, Xiangming Fang","doi":"10.1080/10408347.2025.2538761","DOIUrl":"https://doi.org/10.1080/10408347.2025.2538761","url":null,"abstract":"<p><p>Argonaute (Ago), a programmable nuclease, has recently emerged as a promising tool for nucleic acid detection. To achieve higher sensitivity, a nucleic acid amplification step is often introduced into the Ago-based detection system, leading the process suffered from the issues of temperature compatibility and device complexity. To address these limitations, integrating multiple reactions within a portable temperature control device shows significant potential to streamline the development and practical application of these systems. However, there are few systematic studies guiding the design of the integrated Ago-based detection platforms. Here, this review summarizes the representative Ago-based bioreactions combined with different amplification methods. We begin with an overview of recent advances in Ago protein research, followed by a classification of the existing detection platforms based on their temperature regulation mechanisms: multi-temperature reactions and isothermal reactions. Additionally, the enzymatic properties of the widely used Ago proteins are also discussed in this review and their working temperatures are highlighted when integrated into a specific detection process. Finally, we explore the future prospects and challenges for integrated Ago-based detection systems, aiming to offer readers a comprehensive understanding of these bioreactions' unique characteristics, potential applications, and design principles for next-generation nucleic acid detection devices.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-19"},"PeriodicalIF":5.2,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heba E El-Nakib, Shimaa E Abdel Aziz, Julia Schaletzky, Nermin S Ahmed
{"title":"Analytical Methodologies for Anti-Infective Orphan Drugs: A Comprehensive Review of FDA Approvals (2013-2023) Part 2.","authors":"Heba E El-Nakib, Shimaa E Abdel Aziz, Julia Schaletzky, Nermin S Ahmed","doi":"10.1080/10408347.2025.2541764","DOIUrl":"https://doi.org/10.1080/10408347.2025.2541764","url":null,"abstract":"<p><p>This review is part II of the series that aims to provide a comprehensive overview of analytical methodologies for anti-infective orphan drugs that received FDA market approval over a decade (2013-2023). While in Part I anti-infective orphan drugs were addressed except for antivirals, this part concerns antiviral orphan drugs against (i) HIV (ii) HCV (iii) HSV (iv) VARV and (v) CMV. Herein, we summarize the development of antiviral orphan drugs, challenges facing their R&D and incentives offered through the orphan drug act (ODA). The mechanism of action of each class of compounds, the rationale for orphan drug designation, and their use in clinical practice are briefly outlined. The review provides an expert opinion on the state of art in the field of analysis of these drugs in bulk, in different dosage forms, and in biological samples. Stability studies of these drugs are additionally described. A comparative analysis based on performance parameters is included. The methods developed for the determination of drugs from this class mostly include RP-HPLC, spectrophotometric and electrochemical conventional procedures. Current trends such as UHPLC-MS/MS are less used. Some of the published methods lack proper validation parameters and thus were considered insufficient.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-25"},"PeriodicalIF":5.2,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"GC-IMS in Medicine: Transforming Diagnostics with Sensitivity and Speed.","authors":"Xiaoyue Zhao, Miao Zhang, Jing He, Xin Li, Xuewei Zhuang","doi":"10.1080/10408347.2025.2536822","DOIUrl":"https://doi.org/10.1080/10408347.2025.2536822","url":null,"abstract":"<p><p>Rapid, nondestructive, high-throughput volatile constituent screening and detection is becoming more and more crucial in the medical field's illness analysis. GC-IMS, or gas chromatography-ion mobility spectrometry, is a potent method for the sensitive identification and separation of volatile organic molecules. GC-IMS enables rapid detection with high sensitivity, allowing for the identification of volatile organic compounds (VOCs) in a short time, making it particularly suitable for rapid screening and on-site analysis. This technique is user-friendly, requiring no complex sample preparation and enabling direct analysis, thereby streamlining the workflow and reducing time costs. Moreover, the equipment is portable and has low maintenance costs, offering significant potential for widespread application. The operating idea of GC-IMS is briefly explained in this study, along with recent research that has used GC-IMS on various human metabolites, such as urine, feces, bile, serum, and exhaled breath, for purposes like disease and pathogenic microbe differential detection. Lastly, a summary and recommendation are made on the future development direction of GC-IMS.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-17"},"PeriodicalIF":5.2,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144728501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Recent Developments in Colorimetric and Fluorimetric Sensing of Fe<sup>2+</sup> and Fe<sup>3+</sup> Ions: A Review (2021 to 2025).","authors":"Ali Q Alorabi","doi":"10.1080/10408347.2025.2531970","DOIUrl":"https://doi.org/10.1080/10408347.2025.2531970","url":null,"abstract":"<p><p>Iron ions, Fe<sup>2+</sup> and Fe<sup>3+</sup>, play essential roles in biological, environmental, and industrial processes. However, their imbalance can lead to severe health and ecological issues, including oxidative stress-related diseases and water contamination. Both metal ions are commonly found in environmental water sources, biological fluids, and food products, necessitating their precise detection and quantification. Colorimetric and fluorimetric chemosensors are powerful tools, offering simple, rapid, and highly sensitive methods for monitoring Fe<sup>2+</sup> and Fe<sup>3+</sup> ions. These chemosensors are based on changes in color or fluorescence intensity upon interaction with target ions, providing clear and easily interpretable signals. Both types of chemosensors can be designed using organic molecules, polymers, or nanomaterials, each with unique advantages in selectivity, stability, and sensitivity, making them highly effective for environmental and biological ion detection. The aim of this review is to provide a comprehensive overview of the recent advancements in the development of colorimetric and fluorimetric chemosensors for the detection of Fe<sup>2+</sup> and Fe<sup>3+</sup> ions, with a focus on innovations from 2021 to 2025. This review explores the progress in organic, polymeric, and nanomaterial-based chemosensors, highlighting their design, sensing mechanisms, and practical applications. By examining the sensitivity, selectivity, and stability of these chemosensors, the review aims to identify key trends, challenges, and future directions in the field, offering valuable insights for researchers and practitioners working on the detection of Fe<sup>2+</sup> and Fe<sup>3+</sup> in environmental, biological, and industrial contexts.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-18"},"PeriodicalIF":4.2,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}