Emetine: Advances in Pharmacology, Toxicology, and Chromatographic Approaches.

IF 4.2 2区化学 Q1 CHEMISTRY, ANALYTICAL

Critical reviews in analytical chemistry Pub Date : 2025-07-15 DOI:10.1080/10408347.2025.2529458

Weldejeworgis Gebrehiwot, Kenan Can Tok, Jamilah S Alkhashi, Oladapo Bakare, Mehmet Gumustas

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引用次数: 0

Abstract

Emetine, derived from Psychotria ipecacuanha, is a tetrahydroisoquinoline alkaloid known for its diverse pharmacological activities, making it a versatile candidate for therapeutic applications. It has demonstrated efficacy against various conditions, including cancer and other viral infections by disrupting viral protein synthesis and assembly, particularly against influenza and Ebola viruses. Despite its therapeutic potential, concerns about cardiotoxicity have limited its clinical use, prompting exploration into safer administration routes and novel formulations. Emetine's anti-cancer properties involve inhibiting the Wnt/β-catenin pathway in breast cancer cells and showing promise in treating pulmonary arterial hypertension by suppressing pulmonary artery smooth muscle cell proliferation. Liquid chromatography plays a pivotal role in characterizing and quantifying emetine and related compounds, crucial for drug development and quality control by enhancing detection sensitivity and specificity in samples. Addressing concerns over emetine's toxicity novel approaches like pH-dependent prodrugs and targeted delivery systems are under development to improve safety and efficacy profiles. This review consolidates current knowledge on emetine's pharmacology and the essential role of analytical methodologies in its study and development. It focuses on recent advancements from 1979 to 2024 in liquid chromatography analysis and applications of emetine and its derivatives in drug research, health sciences, as well as forensic purposes.

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艾美汀：药理学、毒理学和色谱方法的进展。

艾美汀是一种四氢异喹啉生物碱，以其多种药理活性而闻名，是治疗应用的多功能候选药物。它已证明对各种疾病有效，包括通过破坏病毒蛋白的合成和组装，对癌症和其他病毒感染，特别是对流感和埃博拉病毒有效。尽管其具有治疗潜力，但对心脏毒性的担忧限制了其临床应用，促使人们探索更安全的给药途径和新配方。Emetine的抗癌特性包括抑制乳腺癌细胞中的Wnt/β-catenin通路，并通过抑制肺动脉平滑肌细胞增殖来治疗肺动脉高压。液相色谱法通过提高样品的检测灵敏度和特异性，在表征和定量分析艾美汀及其相关化合物方面发挥着关键作用，对药物开发和质量控制至关重要。为了解决对艾美汀毒性的担忧，人们正在开发新的方法，如ph依赖性前药和靶向给药系统，以提高安全性和有效性。本文综述了目前对艾美汀药理学的认识以及分析方法在其研究和开发中的重要作用。它侧重于1979年至2024年在液相色谱分析和艾美汀及其衍生物在药物研究、健康科学以及法医目的中的应用方面的最新进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Critical reviews in analytical chemistry 化学-分析化学

CiteScore

12.00

自引率

4.00%

发文量

137

审稿时长

6 months

期刊介绍： Critical Reviews in Analytical Chemistry continues to be a dependable resource for both the expert and the student by providing in-depth, scholarly, insightful reviews of important topics within the discipline of analytical chemistry and related measurement sciences. The journal exclusively publishes review articles that illuminate the underlying science, that evaluate the field''s status by putting recent developments into proper perspective and context, and that speculate on possible future developments. A limited number of articles are of a "tutorial" format written by experts for scientists seeking introduction or clarification in a new area. This journal serves as a forum for linking various underlying components in broad and interdisciplinary means, while maintaining balance between applied and fundamental research. Topics we are interested in receiving reviews on are the following: · chemical analysis; · instrumentation; · chemometrics; · analytical biochemistry; · medicinal analysis; · forensics; · environmental sciences; · applied physics; · and material science.