Critical Reviews in Microbiology最新文献_第3页

Bacterial outer membrane vesicles in oral diseases: from pathogenic mediators to theranostic platforms. 口腔疾病中的细菌外膜囊泡：从致病介质到治疗平台。

IF 7 2区生物学

Critical Reviews in Microbiology Pub Date : 2026-08-08 DOI: 10.1080/1040841X.2026.2713518

Yuluan Bu, Zixin Fan, Lu Li

{"title":"Bacterial outer membrane vesicles in oral diseases: from pathogenic mediators to theranostic platforms.","authors":"Yuluan Bu, Zixin Fan, Lu Li","doi":"10.1080/1040841X.2026.2713518","DOIUrl":"https://doi.org/10.1080/1040841X.2026.2713518","url":null,"abstract":"Bacterial outer membrane vesicles (bOMVs) are nanoscale structures derived from Gram-negative (G-) bacteria that play an important role in oral diseases. As key mediators of host-microbe interactions, bOMVs contribute to the pathogenesis of periodontitis, oral squamous cell carcinoma (OSCC), and oral lichen planus (OLP) by disrupting immune homeostasis and promoting tissue destruction. Beyond the oral cavity, bOMVs serve as critical vectors in the oral-systemic axis, disseminating virulence factors to distant organs and contributing to atherosclerotic cardiovascular diseases (ACVDs), Alzheimer's disease (AD), and gastrointestinal (GI) disorders. Concurrently, their inherent properties, including cargo-loading capacity, immunogenicity, and biofilm penetration, position them as promising platforms for noninvasive diagnostics and targeted therapeutics. This review systematically integrates current knowledge on bOMVs biogenesis, pathogenic mechanisms in oral and systemic diseases, and emerging applications in diagnosis and treatment. We also highlight key challenges and future directions for translating bOMVs-based strategies into clinical practice, emphasizing their potential as next-generation theranostic tools (combining therapeutic and diagnostic functions) for oral diseases.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"1-19"},"PeriodicalIF":7.0,"publicationDate":"2026-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148697090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antimicrobial peptides and enzymes: synergistic mechanisms and strategies for disrupting biofilm-associated infections. 抗菌肽和酶：破坏生物膜相关感染的协同机制和策略。

IF 7 2区生物学

Critical Reviews in Microbiology Pub Date : 2026-08-05 DOI: 10.1080/1040841X.2026.2709509

Shivangi Dhavalkumar Shukla, Bragadish D Iyer

{"title":"Antimicrobial peptides and enzymes: synergistic mechanisms and strategies for disrupting biofilm-associated infections.","authors":"Shivangi Dhavalkumar Shukla, Bragadish D Iyer","doi":"10.1080/1040841X.2026.2709509","DOIUrl":"https://doi.org/10.1080/1040841X.2026.2709509","url":null,"abstract":"Medical biofilms are a significant problem in chronic diseases like diabetic ulcers that do not heal, infections of medical devices and CF. The extracellular polymeric matrix is a barrier to antibiotic penetration. In search of an alternative, approaches based on antimicrobial peptides (AMPs) and enzymes have been developed to tackle the multi-drug resistance. This review collates the existing literature on zoonotic and bacterial origin AMPs, along with the matrix-disrupting and quorum-quenching enzymes, highlighting those which have proven to be effective in vitro/in vivo against clinical isolates from patients. Enzymes (e.g. cellulase, alginate lyase, and dispersin B) can break down matrix components or block critical signaling molecules and can be seen to have strong synergy with antibiotics, whereas AMPs disrupt cell membranes and downregulate genes that encode biofilm-forming proteins. Our analysis reveals however, a key translational bottleneck: there were no clinical trials in human subjects identified despite strong preclinical evidence of activity. This review discusses these encouraging pre-clinical findings and identifies specific physiological and challenges that need to be overcome to take these alternative therapies to clinical practice.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"1-18"},"PeriodicalIF":7.0,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148673109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reprogramming human health through the microbiome and precision medicine. 通过微生物组和精准医学重新编程人类健康。

IF 7 2区生物学

Critical Reviews in Microbiology Pub Date : 2026-08-01 Epub Date: 2026-02-09 DOI: 10.1080/1040841X.2026.2629269

Jhommara Bautista, Emillie Bazantes-Rodríguez, Hanah Cedeño, Celina Anrango-Flores, Francisco Carrera-Cruz, Zain Cisneros-Nieto, Andrés López-Cortés

{"title":"Reprogramming human health through the microbiome and precision medicine.","authors":"Jhommara Bautista, Emillie Bazantes-Rodríguez, Hanah Cedeño, Celina Anrango-Flores, Francisco Carrera-Cruz, Zain Cisneros-Nieto, Andrés López-Cortés","doi":"10.1080/1040841X.2026.2629269","DOIUrl":"10.1080/1040841X.2026.2629269","url":null,"abstract":"The human microbiome, comprising trillions of microorganisms across multiple body sites, is increasingly recognized as a key contributor to host immunity, metabolism, and neurobiology, influencing development and disease susceptibility throughout life. Rather than acting in isolation, microbial communities operate within a complex host-environment system shaped by genetics, diet, lifestyle, and medical exposures. Conceptually, the microbiome can be understood as part of a host-microbe meta-organism and, from a translational perspective, as a dynamic and potentially modifiable organ system. While short-term perturbations such as antibiotics may transiently disrupt microbial ecosystems, persistent maladaptive configurations, commonly termed dysbiosis, are associated with metabolic disease, chronic inflammation, neurodevelopmental disorders, and cancer, although causality remains context dependent. This review synthesizes the functional roles of beneficial microbes and their metabolites, the mechanistic and clinical implications of dysbiosis, and immune pathways shaped by microbial signals. We further discuss emerging therapeutic strategies, including dietary modulation, probiotics, engineered microbial consortia, postbiotics, and fecal microbiota transplantation, enabled by multi-omics technologies, organoid models, and computational frameworks. Key challenges include defining context-specific microbial health, ensuring durable engraftment, and addressing regulatory and ethical considerations. Framing the microbiome as a dynamic component of host physiology provides a foundation for microbiome-guided precision and preventive medicine.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"734-748"},"PeriodicalIF":7.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146140858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Friends and foes: impact of bacteria on genome stability. 朋友与敌人：细菌对基因组稳定性的影响。

IF 7 2区生物学

Critical Reviews in Microbiology Pub Date : 2026-08-01 Epub Date: 2026-03-18 DOI: 10.1080/1040841X.2026.2641726

Goran Gajski, Olga Szewczyk-Roszczenko, Piotr Roszczenko, Yegor Vassetzky, Nikolajs Sjakste

{"title":"Friends and foes: impact of bacteria on genome stability.","authors":"Goran Gajski, Olga Szewczyk-Roszczenko, Piotr Roszczenko, Yegor Vassetzky, Nikolajs Sjakste","doi":"10.1080/1040841X.2026.2641726","DOIUrl":"10.1080/1040841X.2026.2641726","url":null,"abstract":"Bacteria, present in normal conditions in the microbiome or during infections, exert profound effects on genome stability, with both genotoxic and genoprotective consequences. Certain pathogenic bacteria, such as Escherichia coli (colibactin-producing strains), Helicobacter pylori, Fusobacterium nucleatum, and Campylobacter jejuni, induce DNA damage and are implicated in cancer development through direct toxin production, chronic inflammation, immune modulation, and disruption of host cell signaling. Genotoxins such as colibactin, the cytolethal distending toxin, and the typhoid toxin induce DNA double-strand breaks, chromosomal instability, and impair DNA repair pathways, contributing to carcinogenesis. These effects occur upon gastrointestinal, urogenital, systemic (sepsis), and neurological (meningitis) infections, in both humans and animals. Conversely, commensal and probiotic bacteria, notably Lactobacillus and Bifidobacterium species, play a protective role by reducing oxidative DNA damage, modulating immune responses, and enhancing DNA repair. Their beneficial actions are partly mediated by metabolites such as short-chain fatty acids (e.g. butyrate), which influence gene regulation, apoptosis, and mucosal health. Probiotic bacteria can mitigate the genotoxic effects of dietary and bacterial toxins, offering a potential preventive strategy against genome instability and cancer. This review highlights the dualistic nature of bacterial influence on host genome integrity and underscores the importance of maintaining microbial balance.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"749-761"},"PeriodicalIF":7.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147472941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathogenesis of leptospirosis-induced coagulopathy and hemorrhages. 钩端螺旋体病引起的凝血功能障碍和出血的发病机制。

IF 7 2区生物学

Critical Reviews in Microbiology Pub Date : 2026-08-01 Epub Date: 2026-01-14 DOI: 10.1080/1040841X.2026.2613962

Lucas Jorge Da Silva Fernandes, Mônica Larucci Vieira

{"title":"Pathogenesis of leptospirosis-induced coagulopathy and hemorrhages.","authors":"Lucas Jorge Da Silva Fernandes, Mônica Larucci Vieira","doi":"10.1080/1040841X.2026.2613962","DOIUrl":"10.1080/1040841X.2026.2613962","url":null,"abstract":"Physiological hemostasis is a balance between pro- and anticoagulant pathways, with multiple factors, regulators, and cellular components. Hemostasis is also closely associated with inflammation and immune response. In leptospirosis, a zoonotic disease caused by pathogenic spirochetal bacteria of the genus Leptospira, the hemostatic equilibrium is disturbed, resulting in coagulopathies that ultimately result in hemorrhages. Thrombocytopenia is a common complication in the affected patients and is often associated with poor clinical outcomes and high mortality. To date, the reports unraveling the origin of the molecular pathogenesis of leptospirosis hemostatic disturbances are scarce. In this review article, we summarize and analyze the complex pathophysiology of hemostatic impairment in the illness with a focus on the role of endotheliopathy, induction of pro-coagulant and pro-inflammatory states, and platelet dysfunction. We believe this can guide future studies aiming to unravel the molecular mechanisms underlying coagulopathy in leptospirosis to improve our understanding based on evidence, which will give insight into novel interventions to tackle the disease.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"682-696"},"PeriodicalIF":7.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145965536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thermophiles in the genomic Era (2015-2025): a review on biodiversity, metagenome-assembled genomes, and future directions. 基因组时代的嗜热微生物（2015-2025）：生物多样性、宏基因组组装基因组及未来发展方向综述

IF 7 2区生物学

Critical Reviews in Microbiology Pub Date : 2026-08-01 Epub Date: 2026-01-14 DOI: 10.1080/1040841X.2026.2614431

Kian Mau Goh, Nur Azmira Alea Nurhazli, Jia Hao Tan, Kok Jun Liew, Kok-Gan Chan, Stephen B Pointing, Rajesh K Sani

{"title":"Thermophiles in the genomic Era (2015-2025): a review on biodiversity, metagenome-assembled genomes, and future directions.","authors":"Kian Mau Goh, Nur Azmira Alea Nurhazli, Jia Hao Tan, Kok Jun Liew, Kok-Gan Chan, Stephen B Pointing, Rajesh K Sani","doi":"10.1080/1040841X.2026.2614431","DOIUrl":"10.1080/1040841X.2026.2614431","url":null,"abstract":"Thermophile research has been transformed over the past decade by advances in genome sequencing. Once centered on culture collections and physiological studies of terrestrial hot springs and deep-sea hydrothermal vents, the field now employs amplicon sequencing, shotgun metagenomics, and long-read platforms to reveal the diversity, ecology, and genomic potential of thermophiles. Metagenome-assembled genomes (MAGs), metatranscriptomes, and metaproteomes have become crucial for linking taxonomy with function, uncovering previously hidden microbial dark matter in heated ecosystems. Bioinformatics, increasingly integrated with machine learning, has expanded insights into microbial biology, biomolecules, and ecological interactions. These advances highlight the broader environmental significance of thermophiles, spanning fundamental roles in ecosystem processes to practical applications. In 2015, we published Thermophiles in the Genomic Era: Biodiversity, Science, and Application to capture early next-generation sequencing milestones. A decade later, with tremendous progress achieved, this review revisits the field by synthesizing recent advances across viruses, planktonic thermophiles, and biofilm communities, emphasizing the power of genome-resolved approaches. We also highlight overlooked areas, opportunities for ecological integration and predictive modeling, and the importance of translating discoveries into biotechnological innovation. Our aim is to provide young researchers with a roadmap of emerging questions and strategies likely to shape the next decade of thermophile research.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"697-714"},"PeriodicalIF":7.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145965610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The resilient microbiome: how baseline gut microbial composition influences response to cancer treatment. 弹性微生物组：基线肠道微生物组成如何影响癌症治疗的反应。

IF 7 2区生物学

Critical Reviews in Microbiology Pub Date : 2026-08-01 Epub Date: 2026-01-01 DOI: 10.1080/1040841X.2025.2610215

Nicole S L Chan, Courtney Cross, Clive A Prestidge, Hannah R Wardill, Joanne Bowen, Paul Joyce

{"title":"The resilient microbiome: how baseline gut microbial composition influences response to cancer treatment.","authors":"Nicole S L Chan, Courtney Cross, Clive A Prestidge, Hannah R Wardill, Joanne Bowen, Paul Joyce","doi":"10.1080/1040841X.2025.2610215","DOIUrl":"10.1080/1040841X.2025.2610215","url":null,"abstract":"The human gut microbiome is increasingly recognized as a key modulator of health and disease, with growing evidence supporting its influence on responses to cancer therapy. An important aspect of this relationship is gut microbial resilience, defined as the ability of the microbiome to recover its ecological equilibrium following disruption. Individual variations in microbial composition significantly influence resilience and, consequently, personalized responses to cancer treatments. However, the underlying functional characteristics of a resilient microbiome remain incompletely understood. Identifying specific microbial profiles with greater resilience to cancer therapies could improve the ability to predict treatment responses and mitigate adverse events. However, despite growing interest, a lack of longitudinal and mechanistic studies currently limits their clinical translation. This review examines current literature on gut microbiome compositions and individual treatment response to cancer therapy, with a focus on microbial features linked to resilience which could enable prediction of adverse response. While the use of microbial metabolites as predictive biomarkers (e.g. short-chain fatty acids and bile acids) is promising, further longitudinal and interventional studies are essential to support clinical application. Establishing specific microbial and metabolite profiles that promote resilience is essential to advance this emerging field of personalized gut-microbiome therapy.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"646-663"},"PeriodicalIF":7.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145877861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microbial bioemulsifiers as tools in biofilm disruption and prevention: state-of-the-art and emerging frontiers. 微生物生物乳化剂作为生物膜破坏和预防的工具：最新的和新兴的前沿。

IF 7 2区生物学

Critical Reviews in Microbiology Pub Date : 2026-08-01 Epub Date: 2026-01-01 DOI: 10.1080/1040841X.2025.2611085

G R Dias, Erica de Souza Monteiro, B F R de Oliveira, Marinella Silva Laport

{"title":"Microbial bioemulsifiers as tools in biofilm disruption and prevention: state-of-the-art and emerging frontiers.","authors":"G R Dias, Erica de Souza Monteiro, B F R de Oliveira, Marinella Silva Laport","doi":"10.1080/1040841X.2025.2611085","DOIUrl":"10.1080/1040841X.2025.2611085","url":null,"abstract":"Although biofilms pose significant challenges in healthcare and in different industries, main antibiofilm agents currently used for surface disinfection and clinical applications often exhibit harmful side effects and contribute to the development of antimicrobial resistance. To tackle this challenge many biomolecules have been studied as alternatives, including bioemulsifiers, amphiphilic polymers that exhibit low toxicity and high biodegradability yet remain largely unexplored to date. By covering publications from 1983 to early 2025, this review aims to compile the current knowledge on bioemulsifiers from different microbial sources with a focus on their relevant properties as promising antibiofilm agents. Research on probiotics, often involving producer strains isolated from dairy products and animal microbiomes, focusing on marine-derived microorganisms were the most prominent fields benefiting from these molecules. Among different molecules, polysaccharides stood out, especially those from cultivable bacteria. This review focuses on key physico-chemical properties, such as their ability to alter surface hydrophobicity and to inhibit quorum sensing, while providing a comprehensive overview of their putative antibiofilm mechanisms. Finally, we highlight several identified bottlenecks and discuss key strategies and recent advances in metabolic and molecular engineering to instigate the research appetite on unlocking the full potential of microbial bioemulsifiers for biofilm control and prevention.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"664-681"},"PeriodicalIF":7.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145877832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retraction Notice. 收回通知。

IF 7 2区生物学

Critical Reviews in Microbiology Pub Date : 2026-08-01 Epub Date: 2026-05-08 DOI: 10.1080/1040841X.2026.2653284

引用次数: 0

Integrating multi-omics and network pharmacology: a novel approach to elucidate Chinese medicine mechanisms in Crohn's disease treatment. 结合多组学和网络药理学：阐明克罗恩病中医治疗机制的新途径

IF 7 2区生物学

Critical Reviews in Microbiology Pub Date : 2026-08-01 Epub Date: 2026-02-13 DOI: 10.1080/1040841X.2026.2623245

Zhan Su, Jun Fang, Shuangshuang Wang, Gang Liu

{"title":"Integrating multi-omics and network pharmacology: a novel approach to elucidate Chinese medicine mechanisms in Crohn's disease treatment.","authors":"Zhan Su, Jun Fang, Shuangshuang Wang, Gang Liu","doi":"10.1080/1040841X.2026.2623245","DOIUrl":"10.1080/1040841X.2026.2623245","url":null,"abstract":"Since the 19th-century industrial revolution, Crohn's disease (CD), a chronic inflammatory bowel condition, has gained increasing recognition in both medical and public spheres. This review aims to critically analyze the integration of multi-omics data-encompassing genomics, transcriptomics, proteomics, and metabolomics-with network pharmacology to uncover the complex therapeutic mechanisms of Traditional Chinese Medicine (TCM) interventions for CD. By examining multi-omics profiles from CD patients treated with specific TCM formulations or their active components, network pharmacology can effectively pinpoint key biological pathways and molecular targets influenced by TCM. These pathways include, but are not limited to, the regulation of gut microbiota composition, modulation of inflammatory cytokine networks (such as TNF-α and IL-17), and the restoration of intestinal mucosal integrity. This integrated methodology not only aids in identifying active constituents but also facilitates the prediction of synergistic effects and clarifies the molecular interactions within TCM. Consequently, it establishes a solid framework for rational drug discovery and the formulation of personalized therapeutic strategies for CD. The primary focus of this review will be to explore the mechanisms and therapeutic potential of TCM for CD through the lens of network pharmacology, emphasizing its application in addressing this complex condition.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"715-733"},"PeriodicalIF":7.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146178128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0