Neuroinflammation-mediated relationship between oral microbiome and neurodegenerative diseases.

Abstract

Neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS), affect millions of people worldwide. While considerable progress has been made to elucidate the pathogenesis of these diseases in recent years, their specific mechanisms remain largely unknown. Many research study results have proven a certain association between the oral microbiome and neurodegenerative diseases. This review focuses on the relationship between the oral microbiome and neurodegenerative diseases, with a particular focus on the mechanisms of neuroinflammation.