Neuroinflammation-mediated relationship between oral microbiome and neurodegenerative diseases.

IF 6 2区生物学 Q1 MICROBIOLOGY

Critical Reviews in Microbiology Pub Date : 2025-03-25 DOI:10.1080/1040841X.2025.2479533

Ziyan Kong, Shunjiayi Hu, Xiaoyue Lei, Hang Yang, Ying Liu, Yuan Wang, Shuli Deng

引用次数: 0

Abstract

Neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS), affect millions of people worldwide. While considerable progress has been made to elucidate the pathogenesis of these diseases in recent years, their specific mechanisms remain largely unknown. Many research study results have proven a certain association between the oral microbiome and neurodegenerative diseases. This review focuses on the relationship between the oral microbiome and neurodegenerative diseases, with a particular focus on the mechanisms of neuroinflammation.

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口腔微生物组与神经退行性疾病之间的神经炎症介导关系。

神经退行性疾病，如阿尔茨海默病（AD）、帕金森病（PD）和多发性硬化症（MS），影响着全世界数百万人。虽然近年来在阐明这些疾病的发病机制方面取得了相当大的进展，但它们的具体机制在很大程度上仍然未知。许多研究结果已经证明口腔微生物群与神经退行性疾病之间存在一定的联系。本文综述了口腔微生物群与神经退行性疾病之间的关系，特别关注神经炎症的机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Critical Reviews in Microbiology 生物-微生物学

CiteScore

14.70

自引率

0.00%

发文量

期刊介绍： Critical Reviews in Microbiology is an international, peer-reviewed journal that publishes comprehensive reviews covering all areas of microbiology relevant to humans and animals, including medical and veterinary microbiology, public health and environmental microbiology. These may include subjects related to microbial molecular biology, immunopathogenicity, physiology, biochemistry, structure, and epidemiology. Of particular interest are reviews covering clinical aspects of bacterial, virological, fungal and parasitic diseases. All reviews must be analytical, comprehensive, and balanced in nature. Editors welcome uninvited submissions, as well as suggested topics for reviews accompanied by an abstract.