Critical Reviews in Microbiology最新文献

Marine microbial enzymes as potential antibiofilm agents: expanding the arsenal of bioactive agents targeting biofilm-forming microorganisms. 海洋微生物酶作为潜在的抗生物膜剂：扩大针对生物膜形成微生物的生物活性剂的武器库。

IF 6 2区生物学

Critical Reviews in Microbiology Pub Date : 2025-05-29 DOI: 10.1080/1040841X.2025.2510247

Anna Luiza Bauer Canellas, Gabriel Rodrigues Dias, Isabelle Rodrigues Lopes, Jéssyca Freitas-Silva, Alan D W Dobson, Marinella Silva Laport, Bruno Francesco Rodrigues de Oliveira

{"title":"Marine microbial enzymes as potential antibiofilm agents: expanding the arsenal of bioactive agents targeting biofilm-forming microorganisms.","authors":"Anna Luiza Bauer Canellas, Gabriel Rodrigues Dias, Isabelle Rodrigues Lopes, Jéssyca Freitas-Silva, Alan D W Dobson, Marinella Silva Laport, Bruno Francesco Rodrigues de Oliveira","doi":"10.1080/1040841X.2025.2510247","DOIUrl":"https://doi.org/10.1080/1040841X.2025.2510247","url":null,"abstract":"Biofilms are one of the most successful modes of life in the biosphere. In these assemblages, bacteria usually display higher resistance to environmental stressors, thus making their removal through the use of conventional approaches significantly more difficult. Currently, biofilms are one of the major challenges in healthcare settings, often resulting in higher mortality and morbidity rates. Therefore, seeking alternative approaches to manage biofilm-related infections is important. In the last decades, marine microbiomes have been increasingly harnessed as sources of molecules with wide-ranging applications in both the biomedical and pharmaceutical sectors. This review focuses on enzymes as potential antibiofilm agents, more specifically those derived from marine prokaryotes. An overview of the recent findings regarding four main classes of biofilm-disrupting enzymes and their respective marine microbial producers, namely nucleases, dextranases, alginate lyases, and peptidases is provided. Key biochemical and activity-related features from the current literature are presented to showcase the potential of these biocatalysts for biofilm control and prevention. Future research directions are also discussed, highlighting factors and strategies for successful prospecting of antibiofilm enzymes from marine microbiomes. By offering a snapshot of this infant but promising field, this review evidences the marine environment as a fruitful biocatalytic reservoirs of antibiofilm agents.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"1-18"},"PeriodicalIF":6.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibiotic heteroresistance: an important factor in the failure of Helicobacter Pylori eradication. 抗生素异源耐药：幽门螺杆菌根除失败的重要因素。

IF 6 2区生物学

Critical Reviews in Microbiology Pub Date : 2025-05-29 DOI: 10.1080/1040841X.2025.2510245

Yanhui Yu, Jing Xue, Wen Zhang, Shuying Ru, Yang Liu, Kexin Du, Feng Jiang

{"title":"Antibiotic heteroresistance: an important factor in the failure of Helicobacter Pylori eradication.","authors":"Yanhui Yu, Jing Xue, Wen Zhang, Shuying Ru, Yang Liu, Kexin Du, Feng Jiang","doi":"10.1080/1040841X.2025.2510245","DOIUrl":"https://doi.org/10.1080/1040841X.2025.2510245","url":null,"abstract":"Heteroresistance of bacteria refers to the presence of bacterial subgroups with different antibiotic sensitivity in the same strain, affecting the bacterial eradication effect. In recent years, heteroresistance has posed significant challenges to H. pylori eradication failure, while little is known about heteroresistance to H. pylori. Facing the current growing heteroresistance and declining eradication rates of H. pylori, it is necessary to comprehensively understand the epidemiology of heteroresistance as well as detection methods, and elucidate the relevant resistance mechanisms to find a more ideal precision treatment. In this study, we systematically review the current studies of H. pylori heteroresistance and summarize the detection methods and possible heteroresistance mechanisms. In brief, it is highly significant to further strengthen the general understanding for H. pylori heteroresistance. Accordingly, it is necessary to conduct extensive clinical studies on the incidence of H. pylori heteroresistance and to refine the clinical definition of H. pylori heteroresistance. The development of accurate and standardized detection technology is the key to heteroresistance diagnosis. In addition, we strongly advocate to further study the heteroresistance mechanism of H. pylori in vivo and in vitro, which will advance the development of more effective treatment strategies and facilitate the refinement of clinical guidelines.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"1-16"},"PeriodicalIF":6.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bacterial cell wall synthesis and recycling: new antimicrobial targets and vaccine development. 细菌细胞壁的合成和再循环：新的抗菌靶点和疫苗的开发。

IF 6 2区生物学

Critical Reviews in Microbiology Pub Date : 2025-05-28 DOI: 10.1080/1040841X.2025.2510250

Jihyeon Min, Bitnara Kim, Yerim Park, Yongjun Son, Woojun Park

{"title":"Bacterial cell wall synthesis and recycling: new antimicrobial targets and vaccine development.","authors":"Jihyeon Min, Bitnara Kim, Yerim Park, Yongjun Son, Woojun Park","doi":"10.1080/1040841X.2025.2510250","DOIUrl":"https://doi.org/10.1080/1040841X.2025.2510250","url":null,"abstract":"Almost all bacteria have peptidoglycan (PG) components that are essential for virulence and are absent in humans, making them a top-priority target for antibiotics and vaccines. The rise of multidrug-resistant bacteria (MRB) necessitates urgent expansion of our arsenal of inhibitors targeting the PG cell wall. This review addresses our understanding of PG biosynthesis and recycling processes, emphasizing the need to identify novel target proteins and redesign existing PG-targeted antimicrobial peptides. Building on our understanding of cell wall biochemistry and biogenesis derived from Escherichia coli, we also aim to compare and elucidate the cell wall processes in other pathogens, such as Acinetobacter baumannii and Salmonella Typhimurium, where knowledge remains incomplete. We cover in detail the distinct roles of PG-related proteins in Gram-negative bacteria, strategies to block PG biosynthesis/recycling pathways, and their potential as novel antibiotic targets to address the growing challenge of antibiotic resistance. Finally, we review the application of rigorous immuno-informatics analysis and several immune filters to construct epitope-specific vaccines displaying PG-related proteins on the surface of outer membrane vesicles (OMVs), aiming to combat MRB proliferation.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"1-20"},"PeriodicalIF":6.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144156702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanisms and regulation of iron uptake and the role of iron in pathogenesis of Candida albicans. 铁摄取的机制和调控以及铁在白色念珠菌发病机制中的作用。

IF 6 2区生物学

Critical Reviews in Microbiology Pub Date : 2025-05-24 DOI: 10.1080/1040841X.2025.2510256

Dongming Zheng, Xiaoli Zhang, Junping Ding, Daifan Yue, Fuzhou Yang, Yan Li

{"title":"Mechanisms and regulation of iron uptake and the role of iron in pathogenesis of Candida albicans.","authors":"Dongming Zheng, Xiaoli Zhang, Junping Ding, Daifan Yue, Fuzhou Yang, Yan Li","doi":"10.1080/1040841X.2025.2510256","DOIUrl":"https://doi.org/10.1080/1040841X.2025.2510256","url":null,"abstract":"Candida albicans is a primary pathogen implicated in invasive fungal infections. Through its intricate iron uptake and regulatory systems, C. albicans adeptly adapts to various iron-rich environments, circumventing the growth and virulence restrictions imposed by the host's nutritional immunity and intensifying infection severity. This fungus activates the Sef1-Sfu1-Hap43 iron homeostasis regulatory circuit via iron bioavailability sensors (iron-sulfur cluster assembly system). This activation precisely regulates multiple iron uptake pathways, including the high-affinity iron reduction system, heme-iron uptake pathway, and siderophore uptake system, as well as genes involved in iron utilization and storage, thus ensuring effective iron acquisition and maintaining iron homeostasis across diverse environmental conditions and developmental stages. Conversely, disruptions in iron metabolism markedly diminish C. albicans's pathogenic potential by impairing mitochondrial function, suppressing hyphal formation, limiting fungal colonization, and reversing antifungal drug resistance. This review presents a comprehensive analysis of the mechanisms governing iron uptake and regulation in C. albicans and examines the consequences of impaired iron homeostasis on mitochondrial function, hyphal formation, infection progression, and drug resistance. Our goal is to provide a theoretical framework to better understand the pathogenesis of C. albicans and to support the development of targeted therapeutic strategies against this resilient pathogen.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"1-18"},"PeriodicalIF":6.0,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From resistance to treatment: the ongoing struggle with Acinetobacter baumannii. 从耐药性到治疗：与鲍曼不动杆菌的持续斗争。

IF 6 2区生物学

Critical Reviews in Microbiology Pub Date : 2025-05-06 DOI: 10.1080/1040841X.2025.2497791

Naji Naseef Pathoor, Vijetha Valsa, Pitchaipillai Sankar Ganesh, Rajesh Kanna Gopal

{"title":"From resistance to treatment: the ongoing struggle with Acinetobacter baumannii.","authors":"Naji Naseef Pathoor, Vijetha Valsa, Pitchaipillai Sankar Ganesh, Rajesh Kanna Gopal","doi":"10.1080/1040841X.2025.2497791","DOIUrl":"https://doi.org/10.1080/1040841X.2025.2497791","url":null,"abstract":"Acinetobacter baumannii (A. baumannii) has become a major hospital-acquired pathogen, well-known for its rapid development of resistance to multiple antibiotics. The rising incidence of antibiotic-resistant A. baumannii presents a significant global public health challenge. Gaining a deep understanding of the mechanisms behind this resistance is essential for creating effective treatment options. This comprehensive review explores the understanding of various antibiotic resistance mechanisms in A. baumannii. It covers intrinsic resistance, acquired resistance genes, efflux pumps, changes in outer membrane permeability, alterations in drug targets, biofilm formation, and horizontal gene transfer. Additionally, the review investigates the role of mobile genetic elements and the clinical implications of antibiotic resistance in A. baumannii infections. The insights provided may inform the development of new antimicrobial agents and the design of effective infection control strategies to curb the spread of multidrug-resistant (MDR) A. baumannii strains in healthcare environments. Unlike previous reviews, this study offers a more integrative perspective by also addressing the pathogen's environmental resilience, with particular emphasis on its resistance to desiccation and the formation of robust biofilms. It further evaluates both established and emerging therapeutic strategies, thereby expanding the current understanding of A. baumannii persistence and treatment.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"1-22"},"PeriodicalIF":6.0,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endophytic fungi-bioinspired nanoparticles potential to control infectious disease. 内生真菌-生物启发纳米颗粒控制传染病的潜力。

IF 6 2区生物学

Critical Reviews in Microbiology Pub Date : 2025-05-05 DOI: 10.1080/1040841X.2025.2497795

Sohail Khan, Ashwani Mathur, Fazlurrahman Khan

{"title":"Endophytic fungi-bioinspired nanoparticles potential to control infectious disease.","authors":"Sohail Khan, Ashwani Mathur, Fazlurrahman Khan","doi":"10.1080/1040841X.2025.2497795","DOIUrl":"https://doi.org/10.1080/1040841X.2025.2497795","url":null,"abstract":"The growing demand for nanomedicine and its potentially diverse biological function required the investigation of raw materials for fabricating the nanomaterial. Current developments have emphasized the implementation of green chemistry to develop metal-oxide and metal nanoparticles. Endophytic fungi have emerged as a potential reservoir of bioactive compounds exemplified by unique structures and influential antibacterial properties. Over the past decade, substantial progress has been achieved in uncovering and profiling these valuable antibacterial compounds. These endophytic fungi-derived bioactive chemicals have diverse applications in various biological properties. Nanoparticle synthesis from materials derived from endophytic fungi, be it whole extracts or pure components, owing to their accessibility, cost-effectiveness in fabrication, material-tissue compatibility, and modest cytotoxicity toward higher organism cells. Nanoparticles from endophytic fungi have been utilized to treat various diseases, including those caused by bacterial, viral, and fungal pathogens. The present review provides a comprehensive discussion of the mechanistic insight into the synthesis and application of endophytic fungi-bioinspired nanoparticles as potential therapeutic agents to control microbial infection. The underlying action mechanism involved in the antimicrobial action of the nanoparticles has also been discussed. The discussion highlights various attributes of nanoparticles that may significantly benefit future researchers as potential therapeutic agents to control microbial infection.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"1-23"},"PeriodicalIF":6.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Macrophage biology in the pathogenesis of Helicobacter pylori infection. 幽门螺旋杆菌感染发病机制中的巨噬细胞生物学。

IF 6 2区生物学

Critical Reviews in Microbiology Pub Date : 2025-05-01 Epub Date: 2024-07-31 DOI: 10.1080/1040841X.2024.2366944

Xiao Fei, Nianshuang Li, Xinbo Xu, Yin Zhu

引用次数: 0

Host and bacterial lipid metabolism during tuberculosis infections: possibilities to synergise host- and bacteria-directed therapies. 结核病感染期间宿主和细菌的脂质代谢：协同宿主和细菌导向疗法的可能性。

IF 6 2区生物学

Critical Reviews in Microbiology Pub Date : 2025-05-01 Epub Date: 2024-06-25 DOI: 10.1080/1040841X.2024.2370979

Teun van der Klugt, Robin H G A van den Biggelaar, Anno Saris

{"title":"Host and bacterial lipid metabolism during tuberculosis infections: possibilities to synergise host- and bacteria-directed therapies.","authors":"Teun van der Klugt, Robin H G A van den Biggelaar, Anno Saris","doi":"10.1080/1040841X.2024.2370979","DOIUrl":"10.1080/1040841X.2024.2370979","url":null,"abstract":"Mycobacterium tuberculosis (Mtb) is the causative pathogen of tuberculosis, the most lethal infectious disease resulting in 1.3 million deaths annually. Treatments against Mtb are increasingly impaired by the growing prevalence of antimicrobial drug resistance, which necessitates the development of new antibiotics or alternative therapeutic approaches. Upon infecting host cells, predominantly macrophages, Mtb becomes critically dependent on lipids as a source of nutrients. Additionally, Mtb produces numerous lipid-based virulence factors that contribute to the pathogen's ability to interfere with the host's immune responses and to create a lipid rich environment for itself. As lipids, lipid metabolism and manipulating host lipid metabolism play an important role for the virulence of Mtb, this review provides a state-of-the-art overview of mycobacterial lipid metabolism and concomitant role of host metabolism and host-pathogen interaction therein. While doing so, we will emphasize unexploited bacteria-directed and host-directed drug targets, and highlight potential synergistic drug combinations that hold promise for the development of new therapeutic interventions.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"463-483"},"PeriodicalIF":6.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141445849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gut microbiota-lncRNA/circRNA crosstalk: implications for different diseases. 肠道微生物群-lncRNA/circRNA串扰：对不同疾病的影响。

IF 6 2区生物学

Critical Reviews in Microbiology Pub Date : 2025-05-01 Epub Date: 2024-07-05 DOI: 10.1080/1040841X.2024.2375516

Lei Zhang, Xin Li, Huijuan Gao, Wenguang Chang, Peifeng Li

{"title":"Gut microbiota-lncRNA/circRNA crosstalk: implications for different diseases.","authors":"Lei Zhang, Xin Li, Huijuan Gao, Wenguang Chang, Peifeng Li","doi":"10.1080/1040841X.2024.2375516","DOIUrl":"10.1080/1040841X.2024.2375516","url":null,"abstract":"The gut microbiota features an abundance of diverse microorganisms and represents an important component of human physiology and metabolic homeostasis, indicating their roles in a wide array of physiological and pathological processes in the host. Maintaining balance in the gut microbiota is critical for normal functionality as microbial dysbiosis can lead to the occurrence and development of diseases through various mechanisms. Long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) are non-coding RNAs that perform important regulatory functions for many processes. Furthermore, the gut microbiota and lncRNAs/circRNAs are known to interact in a range of both physiological and pathological activities. In this article, we review existing research relevant to the interaction between the gut microbiota and lncRNAs/circRNAs and investigate the role of their crosstalk in the pathogenesis of different diseases. Studies have shown that, the gut microbiota can target lncRNAs ENO1-IT1, BFAL1, and LINC00152 to regulate colorectal cancer development via various signaling pathways. In addition, the gut microbiota can influence mental diseases and lung tumor metastasis by modulating circRNAs such as circNF1-419, circ_0001239, circHIPK2 and mmu_circ_0000730. These findings provide a theoretical basis for disease prevention and treatment and suggest that gut microbiota-lncRNA/circRNA crosstalk has high clinical value.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"499-513"},"PeriodicalIF":6.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141533911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Damage-associated molecular patterns in viral infection: potential therapeutic targets. 病毒感染中的损伤相关分子模式：潜在的治疗目标。

IF 6 2区生物学

Critical Reviews in Microbiology Pub Date : 2025-05-01 Epub Date: 2024-08-01 DOI: 10.1080/1040841X.2024.2384885

Huizhen Tian, Qiong Liu, Xiaomin Yu, Yanli Cao, Xiaotian Huang

引用次数: 0