Critical Reviews in Microbiology最新文献

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IF 5.1 2区生物学

Critical Reviews in Microbiology Pub Date : 2026-05-08 DOI: 10.1080/1040841X.2026.2653284

引用次数: 0

The dCas9-SSAP as a promising genome editing tool in malaria parasites. dCas9-SSAP作为一种有前途的疟疾寄生虫基因组编辑工具。

IF 5.1 2区生物学

Critical Reviews in Microbiology Pub Date : 2026-05-07 DOI: 10.1080/1040841X.2026.2667183

Elvis Quansah, Shijie Yang, Yonggen Jia, Li Yu, Chao Zhang

{"title":"The dCas9-SSAP as a promising genome editing tool in malaria parasites.","authors":"Elvis Quansah, Shijie Yang, Yonggen Jia, Li Yu, Chao Zhang","doi":"10.1080/1040841X.2026.2667183","DOIUrl":"https://doi.org/10.1080/1040841X.2026.2667183","url":null,"abstract":"Measures to combat the Plasmodium parasites which cause malaria have become compromised because of reliance on a small arsenal of drugs, emerging drug resistance and the lack of effective vaccines. A promising avenue for addressing these challenges is the revolutionary gene-editing technology CRISPR-Cas9, due to its high efficiency and ease of design for genetic manipulation. The catalytically inactive Cas9 (dCas9)-microbial single-stranded annealing proteins (SSAP)(dCas9-SSAP) is a recently emerged next-generation gene editing system added to the ever-growing CRISPR-Cas9-based technologies. While the classical Cas9-nuclease technologies are \"double-strand break, damage-repair systems\", the dCas9-SSAP is distinctively a \"cleavage-free\" editing tool. Unlimited to the Plasmodium genome, Cas9-nucleases imprint inheritable genetic scars on the subject genomes when applied. Here, we discussed the DSB genotoxicity pitfalls of existing nuclease-based editing tools, especially CRISPR-Cas9, and how the dCas9-SSAP presents a formidable option to the drawbacks within the context of Plasmodium genome editing. Then, we sought to infer a plausible mechanistic framework that could account for dCas9-SSAP-mediated genome editing. Finally, we discussed how dCas9-SSAP aligns with Plasmodium parasites' biology. This review would set the stage for continued research into the potential of this new, exciting technology in malaria parasites.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"1-10"},"PeriodicalIF":5.1,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elucidating the multifaceted antibacterial mechanisms of luteolin: insights, challenges, and prospects for clinical translation. 阐明木犀草素的多方面抗菌机制：见解、挑战和临床转化的前景。

IF 5.1 2区生物学

Critical Reviews in Microbiology Pub Date : 2026-05-01 Epub Date: 2025-11-24 DOI: 10.1080/1040841X.2025.2584072

Kushagra Khanna, Mogana Rajagopal, Pankaj Kumar, Ravishankar Ram Mani, K Oganeswary Kobi, Fariha Shagufta, Retno Wahyuningrum

{"title":"Elucidating the multifaceted antibacterial mechanisms of luteolin: insights, challenges, and prospects for clinical translation.","authors":"Kushagra Khanna, Mogana Rajagopal, Pankaj Kumar, Ravishankar Ram Mani, K Oganeswary Kobi, Fariha Shagufta, Retno Wahyuningrum","doi":"10.1080/1040841X.2025.2584072","DOIUrl":"10.1080/1040841X.2025.2584072","url":null,"abstract":"Novel antibacterial agents are critically needed in light of the constant menace posed by bacterial infections and subsequent emergence of antibiotic-resistant strains. Quality of life has been improved remarkably through antibiotics that have fought microbial pathogens. . Luteolin has shown effectiveness against both gram-positive and gram negative bacteria. Luteolin and its derivatives, as novel phytochemical antimicrobial agents, exhibit activity against both Gram-positive and Gram-negative bacteria . Luteolin target bacteria by disrupting their cell membranes, inhibiting nucleic acid synthesis, and interfering with key enzymes. It also blocks quorum sensing and biofilm formation, crucial for bacterial virulence and resistance. Luteolin, despite its therapeutic potential, has limited clinical use due to poor water solubility and low bioavailability, leading to reduced absorption and rapid metabolism in the body. To address these issues, researchers are exploring advanced formulations like nanoparticles and liposomes to improve its solubility and effectiveness. Recent formulation advancements aim to enhance luteolin's delivery and efficacy as an antibacterial agent. However, in-depth in vivo studies are essential to unlock its full therapeutic potential for clinical use. This review highlights luteolin's antibacterial capabilities, usage challenges, and recent progress, stressing the importance of further research to fully leverage its benefits.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"464-482"},"PeriodicalIF":5.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145586344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insight into the multifactorial effect of climate change on marine bacteria: resilience mechanisms and mitigation strategies. 深入了解气候变化对海洋细菌的多因素影响：复原机制和减缓战略。

IF 5.1 2区生物学

Critical Reviews in Microbiology Pub Date : 2026-05-01 Epub Date: 2025-11-24 DOI: 10.1080/1040841X.2025.2591753

Sonalin Rath, Sourav Kumar Panda, Surajit Das

{"title":"Insight into the multifactorial effect of climate change on marine bacteria: resilience mechanisms and mitigation strategies.","authors":"Sonalin Rath, Sourav Kumar Panda, Surajit Das","doi":"10.1080/1040841X.2025.2591753","DOIUrl":"10.1080/1040841X.2025.2591753","url":null,"abstract":"Industrialization marked a significant turning point that impacted the global climate at an unprecedented scale. Oceans, covering 71% of the surface of Earth, play a pivotal role in regulating climate change factors, serving as essential components of planetary processes. In these oceanic ecosystems, marine bacteria are intricately involved in regulating various biogeochemical cycles that are crucial to climate regulation and ecosystem functioning. However, the ongoing climatic changes pose significant challenges to marine bacteria and their associated processes. In the Anthropocene epoch, the interaction between anthropogenic pollutants and climatic stressors further amplifies their impact on marine bacteria across diverse ecological niches and their resilience mechanisms. It delves into the interactive effects of anthropogenic pollutants with climatic stressors on bacteria, particularly emphasizing on organic pollutants, heavy metals, and microplastics. The review entails the impact and resilience mechanisms of marine bacteria in response to climatic stressors. The current trajectory of climatic changes highlights the urgent need for concerted global action to mitigate greenhouse gas emissions and adapt to the inevitable impacts of climate change. In this context, various strategies employing marine bacteria in mitigating climate change for a sustainable future have also been discussed.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"518-553"},"PeriodicalIF":5.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145586350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The therapeutic potential of phage-based antifungal treatment: strategies, mechanisms, and prospects. 基于噬菌体的抗真菌治疗的治疗潜力：策略、机制和前景。

IF 5.1 2区生物学

Critical Reviews in Microbiology Pub Date : 2026-05-01 Epub Date: 2025-10-15 DOI: 10.1080/1040841X.2025.2572805

Haowen Xiao, Jiayue Xie, Zhiping Luo, Xiaomin Yu, Jumei Zeng, Yuqing Li

{"title":"The therapeutic potential of phage-based antifungal treatment: strategies, mechanisms, and prospects.","authors":"Haowen Xiao, Jiayue Xie, Zhiping Luo, Xiaomin Yu, Jumei Zeng, Yuqing Li","doi":"10.1080/1040841X.2025.2572805","DOIUrl":"10.1080/1040841X.2025.2572805","url":null,"abstract":"Human fungal infections are increasingly being recognized as a significant global health threat. The burden of fungal diseases is escalating, primarily due to the rising number of at-risk individuals, compounded by the limited availability of antifungal therapies that are both effective and minimally toxic. Phages, viruses that specifically infect and kill bacteria, have long been investigated for their therapeutic potential. However, despite their success in bacteriology, the applications of phages in antifungal therapy are under active research. Particularly, phages could be used to treat fungal infections by engineering them to express fungal antigens on their surfaces, and this would trigger specific immune responses, such as activating Th1 and Th17 responses or inducing the production of neutralizing antibodies. Phages could also be combined with photodynamic inactivation (PDI) or antimicrobials to enhance treatment efficiency. Meanwhile, phages can exert direct antifungal effects by depleting iron, a crucial nutrient for fungal growth. This paper provides a comprehensive review of the phage-based antifungal treatment.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"433-451"},"PeriodicalIF":5.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145291416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mycobacterium avium biofilms: mechanism of production, composition, and its role in pathogenesis and drug resistance. 禽分枝杆菌生物膜：产生机制、组成及其在发病和耐药中的作用。

IF 5.1 2区生物学

Critical Reviews in Microbiology Pub Date : 2026-05-01 Epub Date: 2025-10-31 DOI: 10.1080/1040841X.2025.2580269

William R McManus, Katie Mulvey, Jeffrey S Schorey

{"title":"Mycobacterium avium biofilms: mechanism of production, composition, and its role in pathogenesis and drug resistance.","authors":"William R McManus, Katie Mulvey, Jeffrey S Schorey","doi":"10.1080/1040841X.2025.2580269","DOIUrl":"10.1080/1040841X.2025.2580269","url":null,"abstract":"The genus Mycobacterium contains over 180 species, and new species are added frequently. Among these are several obligate pathogens, namely Mycobacterium leprae and the species of the Mycobacterium tuberculosis complex; however, the vast majority are environmental bacteria that occupy numerous habitats and are collectively referred to as nontuberculous mycobacteria (NTM). Most NTM are harmless to humans, but the ability of some species to cause infections in people has been increasingly recognized over the past several decades. Mycobacterium avium subs. hominissuis has emerged as one of the most common opportunistic pathogens, usually causing pulmonary infections in susceptible people following environmental exposure. Mycobacterium avium's ability to form biofilms is key to its survival in environments that place it in close proximity to susceptible populations. Their capacity to form biofilms in vivo may also be an important aspect of their pathogenesis and known antibiotic resistance. In this review, we discuss the pathogenesis of this important mycobacterial species, what we know of its ability to form biofilms in vitro and in vivo, and gaps in our knowledge of these processes. We also discuss how we may leverage our understanding of molecules involved in biofilm formation and biofilm matrix composition to develop new therapeutics targeting biofilm formation.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"452-463"},"PeriodicalIF":5.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145421218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chitin and its derivatives as potential candidates to reduce intestinal colonization of Crohn's disease-associated adherent and invasive E. coli. 几丁质及其衍生物作为减少克罗恩病相关粘附性和侵袭性大肠杆菌肠道定植的潜在候选者。

IF 5.1 2区生物学

Critical Reviews in Microbiology Pub Date : 2026-05-01 Epub Date: 2026-01-09 DOI: 10.1080/1040841X.2025.2605544

Margot Fargeas, Devon Kavanaugh, Anthony Buisson

{"title":"Chitin and its derivatives as potential candidates to reduce intestinal colonization of Crohn's disease-associated adherent and invasive E. coli.","authors":"Margot Fargeas, Devon Kavanaugh, Anthony Buisson","doi":"10.1080/1040841X.2025.2605544","DOIUrl":"10.1080/1040841X.2025.2605544","url":null,"abstract":"Crohn's disease (CD) is a chronic inflammatory bowel disease becoming a major issue for healthcare systems in most parts of the world. While the causes of the disease are still not fully understood, the role of the microbiota has been widely demonstrated including the colonization by a particular pathovar of Escherichia coli, defined as adherent and invasive E. coli (AIEC), able to adhere to, and invade the intestinal epithelium, as well as to survive within macrophages. As the involvement of AIEC within CD pathophysiology is highly suspected, developing new strategies to limit AIEC colonization is a promising area of research. In this context, chitin and its derivatives, such as chitosan and chito-oligosaccharides (COS), possessing immunomodulatory and antimicrobial properties, could be promising candidates. This review provides a structural overview of chitin and its derivatives and summarizes the existing literature in the context of the potential beneficial effects of chitinous elements in CD and CD-like models, their capability to restrict AIEC colonization via multiple mechanisms, such as of reducing AIEC growth, countering biofilm formation, blocking bacterial adhesion, or stimulating the innate immune response. Lastly, we will explore strategies based on chitin-supplemented diet as therapeutic strategy in patients with CD.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"599-610"},"PeriodicalIF":5.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145942755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanobiotics to tackle efflux-mediated resistance in bacterial pathogens. 纳米生物制剂用于解决细菌病原体外排介导的耐药性。

IF 5.1 2区生物学

Critical Reviews in Microbiology Pub Date : 2026-05-01 Epub Date: 2025-12-03 DOI: 10.1080/1040841X.2025.2597220

Barani Devi Thillai, Sudarshan Kini, Vijaya Kumar Deekshit

{"title":"Nanobiotics to tackle efflux-mediated resistance in bacterial pathogens.","authors":"Barani Devi Thillai, Sudarshan Kini, Vijaya Kumar Deekshit","doi":"10.1080/1040841X.2025.2597220","DOIUrl":"10.1080/1040841X.2025.2597220","url":null,"abstract":"Efflux-mediated resistance is a critical mechanism by which bacterial pathogens evade antibiotic treatment, posing significant challenges to effective infection management. As the first line of defence mechanism in bacteria, efflux pumps actively expel antibiotics, contributing to multidrug resistance. Recent advances in nanotechnology offer promising solutions, with nanobiotics emerging as a novel approach to combating efflux-mediated resistance. Nanobiotics are engineered nanoscale materials with antibacterial properties. They can be designed to inhibit efflux pump function, enhance drug accumulation, and disrupt bacterial cell membranes, thereby overcoming traditional resistance mechanisms. Nanobiotics can easily fuze with the bacterial cell wall and facilitate the release of antibiotics into the cytoplasm. This review provides an overview of efflux-mediated resistance mechanisms, highlights recent nanotechnology developments to design and formulate nanobiotics, and examines their potential to inhibit efflux pumps in multidrug-resistant bacterial strains. By targeting efflux systems, nanobiotics offer a potent and innovative approach to restoring the efficacy of conventional antibiotics and advancing the treatment of multidrug-resistant bacterial infections.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"554-576"},"PeriodicalIF":5.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145667691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolomics in influenza viral infection: insights into host-virus interactions and potential biomarkers of severe outcomes. 流感病毒感染的代谢组学：对宿主-病毒相互作用和严重后果的潜在生物标志物的见解

IF 5.1 2区生物学

Critical Reviews in Microbiology Pub Date : 2026-05-01 Epub Date: 2026-01-04 DOI: 10.1080/1040841X.2025.2601028

Chen Liu, Qingyun Ma, Yong Yang, Rong Rong

{"title":"Metabolomics in influenza viral infection: insights into host-virus interactions and potential biomarkers of severe outcomes.","authors":"Chen Liu, Qingyun Ma, Yong Yang, Rong Rong","doi":"10.1080/1040841X.2025.2601028","DOIUrl":"10.1080/1040841X.2025.2601028","url":null,"abstract":"Influenza viruses are highly contagious respiratory pathogens that cause seasonal outbreaks, leading to millions of infections and a significant number of deaths worldwide. To support rapid replication and transmission, influenza viruses hijack the host's metabolic pathways, including those involved in carbohydrate, amino acid, and lipid metabolism. Through this metabolic reprogramming, the virus leverages the host's metabolic resources to produce viral components and create specialized compartments necessary for replication and dissemination. In response, host cells activate a range of metabolic defense mechanisms to detect and counteract the virus-induced metabolic changes, resulting in a dynamic interplay that profoundly impacts the outcome of the infection. Advances in metabolomics have provided valuable insights into these complex host-virus interactions, identifying key metabolic biomarkers with potential for early diagnosis, real-time disease monitoring, and therapeutic response evaluation, especially in the early detection and management of severe influenza infections. In the future, these metabolic biomarkers could drive the development of new strategies for influenza prevention and treatment, providing a scientific foundation for precision medicine.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"577-598"},"PeriodicalIF":5.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145899323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Revisiting the antimicrobial potential of metalloporphyrins: from food to pharma. 重新审视金属卟啉的抗菌潜力：从食品到制药。

IF 5.1 2区生物学

Critical Reviews in Microbiology Pub Date : 2026-05-01 Epub Date: 2025-11-07 DOI: 10.1080/1040841X.2025.2584078

Igori Balta, Marta Žogota, Nicolae Corcionivoschi, Irina Chiorescu, Oleksandr Dobrovolnyi, Stefan Batrina, Ioan Pet, Aurelia Coroian, Andrejs Sitovs, Lavinia Ștef, Valentyn Mohylyuk

{"title":"Revisiting the antimicrobial potential of metalloporphyrins: from food to pharma.","authors":"Igori Balta, Marta Žogota, Nicolae Corcionivoschi, Irina Chiorescu, Oleksandr Dobrovolnyi, Stefan Batrina, Ioan Pet, Aurelia Coroian, Andrejs Sitovs, Lavinia Ștef, Valentyn Mohylyuk","doi":"10.1080/1040841X.2025.2584078","DOIUrl":"10.1080/1040841X.2025.2584078","url":null,"abstract":"Porphyrins, their derivatives, and metal ion complexes - particularly copper-substituted forms such as Cu-Chl, Cu-Chln, and Na-Cu-Chln - are increasingly recognized for their broad-spectrum antimicrobial properties. However, in the context of terminological and trivial confusions in food chemistry and pharmaceuticals, data on the chemical properties and biological activity of porphyrins remains fragmented and lacks comprehensive systematization. This review adopts a cross-disciplinary mapping approach to clarify the chemical structures, nomenclature, antimicrobial properties, and the presented mechanistic insights of porphyrins and their derivatives, highlighting their significance in both the food and pharmaceutical industries. As a result of the mapping systematization, porphyrins have been remarked as current and potential antimicrobial agents, with a specific emphasis on the compounds such as Cu-Chl, Cu-Chln, and Na-Cu-Chln. Copper complexation has been shown to enhance biological activity while maintaining low toxicity profiles. Emphasis is placed on Cu-Chl, Cu-Chln, and Na-Cu-Chln, which demonstrate promising properties and applications in nutraceuticals and therapeutics. Their bactericidal properties, which resulted in combating antibiotic-resistant infection-causative pathogens, are particularly interesting, especially in the era of addressing global challenges such as antibiotic resistance. This conceptual review remarks on the critical gaps in current knowledge and accentuates the need for systematic studies to optimize the clinical and industrial applications of porphyrins.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"500-517"},"PeriodicalIF":5.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145457992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0