Critical Reviews in Microbiology最新文献_第10页

Outer membrane proteins and vesicles as promising vaccine candidates against Vibrio spp. infections. 外膜蛋白和囊泡有望成为预防弧菌感染的候选疫苗。

IF 6 2区生物学

Critical Reviews in Microbiology Pub Date : 2024-08-01 Epub Date: 2023-06-05 DOI: 10.1080/1040841X.2023.2212072

Brijeshwar Singh, Surbhi Jaiswal, Prashant Kodgire

引用次数: 0

Acinetobacter baumannii subunit vaccines: recent progress and challenges. 鲍曼不动杆菌亚单位疫苗：最新进展与挑战。

IF 6 2区生物学

Critical Reviews in Microbiology Pub Date : 2024-08-01 Epub Date: 2023-05-21 DOI: 10.1080/1040841X.2023.2215303

Yi Teng Lau, Hock Siew Tan

{"title":"Acinetobacter baumannii subunit vaccines: recent progress and challenges.","authors":"Yi Teng Lau, Hock Siew Tan","doi":"10.1080/1040841X.2023.2215303","DOIUrl":"10.1080/1040841X.2023.2215303","url":null,"abstract":"Acinetobacter baumannii is a Gram-negative, opportunistic pathogen that causes nosocomial infection with a high mortality rate in immunocompromised individuals. With the frequent emergence of multidrug-resistant A. baumannii strains that have rapidly gained resistance to most antibiotics, an extensive search for an effective A. baumannii vaccine is ongoing. Over the decade, many subunit vaccine candidates were identified using reverse vaccinology and in vivo animal studies for validation. Nineteen subunit vaccine candidates with a wide range of efficacy, from 14% to 100% preclinical survival rates, were included in this review. This article provides an updated review of several outer membrane proteins (Omp) that emerged as vaccine candidates with great potential, including OmpA, Omp34, Omp22 and BamA, based on their high conservancy, antigenicity, and immune protection against A. baumannii infection. However, there is still no licenced A. baumannii vaccine currently due to several practical issues that have yet to be resolved, such as inconsistencies between validation studies, antigen variability and insolubility. Moving forward, much investigation and innovation are still required to tackle these challenges for the regulatory approval of an A. baumannii subunit vaccine, including standardisation of immunisation study parameters, improving antigen solubility and the incorporation of nucleic acid vaccine technology.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"434-449"},"PeriodicalIF":6.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9552033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Towards the discovery of novel molecular clocks in Prokaryotes. 在原核生物中发现新的分子钟。

IF 6 2区生物学

Critical Reviews in Microbiology Pub Date : 2024-08-01 Epub Date: 2023-06-18 DOI: 10.1080/1040841X.2023.2220789

Augustin Géron, Johannes Werner, Ruddy Wattiez, Sabine Matallana-Surget

{"title":"Towards the discovery of novel molecular clocks in Prokaryotes.","authors":"Augustin Géron, Johannes Werner, Ruddy Wattiez, Sabine Matallana-Surget","doi":"10.1080/1040841X.2023.2220789","DOIUrl":"10.1080/1040841X.2023.2220789","url":null,"abstract":"Diel cycle is of enormous biological importance as it imposes daily oscillation in environmental conditions, which temporally structures most ecosystems. Organisms developed biological time-keeping mechanisms - circadian clocks - that provide a significant fitness advantage over competitors by optimising the synchronisation of their biological activities. While circadian clocks are ubiquitous in Eukaryotes, they are so far only characterised in Cyanobacteria within Prokaryotes. However, growing evidence suggests that circadian clocks are widespread in the bacterial and archaeal domains. As Prokaryotes are at the heart of crucial environmental processes and are essential to human health, unravelling their time-keeping systems provides numerous applications in medical research, environmental sciences, and biotechnology. In this review, we elaborate on how novel circadian clocks in Prokaryotes offer research and development perspectives. We compare and contrast the different circadian systems in Cyanobacteria and discuss about their evolution and taxonomic distribution. We necessarily provide an updated phylogenetic analysis of bacterial and archaeal species that harbour homologs of the main cyanobacterial clock components. Finally, we elaborate on new potential clock-controlled microorganisms that represent opportunities of ecological and industrial relevance in prokaryotic groups such as anoxygenic photosynthetic bacteria, methanogenic archaea, methanotrophs or sulphate-reducing bacteria.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"491-503"},"PeriodicalIF":6.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9642323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polyamine as a microenvironment factor in resistance to antibiotics. 多胺是抗生素耐药性的微环境因素。

IF 6 2区生物学

Critical Reviews in Microbiology Pub Date : 2024-08-01 Epub Date: 2023-06-20 DOI: 10.1080/1040841X.2023.2223277

Amrita C Bhagwat, Sunil D Saroj

引用次数: 0

Fusarium and Neocosmospora: fungal priority pathogens in laboratory diagnosis. 镰刀菌和新孢子菌：实验室诊断中的真菌重点病原体。

IF 6 2区生物学

Critical Reviews in Microbiology Pub Date : 2024-07-01 DOI: 10.1080/1040841X.2024.2369693

Valeri Sáenz, Andrés Felipe Lizcano Salas, Josepa Gené, Adriana Marcela Celis Ramírez

引用次数: 0

Sensitive delivery systems and novel encapsulation technologies for live biotherapeutic products and probiotics. 用于活生物治疗产品和益生菌的敏感输送系统和新型封装技术。

IF 6 2区生物学

Critical Reviews in Microbiology Pub Date : 2024-05-01 Epub Date: 2023-04-19 DOI: 10.1080/1040841X.2023.2202237

Shuang Li, Yi-Xuan Zhang

{"title":"Sensitive delivery systems and novel encapsulation technologies for live biotherapeutic products and probiotics.","authors":"Shuang Li, Yi-Xuan Zhang","doi":"10.1080/1040841X.2023.2202237","DOIUrl":"10.1080/1040841X.2023.2202237","url":null,"abstract":"Live biotherapeutic product (LBP), a type of biological product, holds promise for the prevention or treatment of metabolic disease and pathogenic infection. Probiotics are live microorganisms that improve the intestinal microbial balance and beneficially affect the health of the host when ingested in sufficient numbers. These biological products possess the advantages of inhibition of pathogens, degradation of toxins, and modulation of immunity. The application of LBP and probiotic delivery systems has attracted great interest to researchers. The initial used technologies for LBP and probiotic encapsulation are traditional capsules and microcapsules. However, the stability and targeted delivery capability require further improved. The specific sensitive materials can greatly improve the delivery efficiency of LBPs and probiotics. The specific sensitive delivery systems show advantages over traditional ones due to their better properties of biocompatibility, biodegradability, innocuousness, and stability. Moreover, some new technologies, including layer-by-layer encapsulation, polyelectrolyte complexation, and electrohydrodynamic technology, show great potential in LBP and probiotic delivery. In this review, novel delivery systems and new technologies of LBPs and probiotics were presented, and the challenges and prospects were explored in specific sensitive materials for LBP and probiotic delivery.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"371-384"},"PeriodicalIF":6.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9737906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-Term effects of COVID-19: a review of current perspectives and mechanistic insights. COVID-19 的长期效应：当前观点和机理见解综述。

IF 6 2区生物学

Critical Reviews in Microbiology Pub Date : 2024-05-01 Epub Date: 2023-04-19 DOI: 10.1080/1040841X.2023.2190405

Christian Lenz, Mary P E Slack, Kimberly M Shea, Ralf René Reinert, Bülent N Taysi, David L Swerdlow

{"title":"Long-Term effects of COVID-19: a review of current perspectives and mechanistic insights.","authors":"Christian Lenz, Mary P E Slack, Kimberly M Shea, Ralf René Reinert, Bülent N Taysi, David L Swerdlow","doi":"10.1080/1040841X.2023.2190405","DOIUrl":"10.1080/1040841X.2023.2190405","url":null,"abstract":"Although SARS-CoV-2, responsible for COVID-19, is primarily a respiratory infection, a broad spectrum of cardiac, pulmonary, neurologic, and metabolic complications can occur. More than 50 long-term symptoms of COVID-19 have been described, and as many as 80% of patients may develop ≥1 long-term symptom. To summarize current perspectives of long-term sequelae of COVID-19, we conducted a PubMed search describing the long-term cardiovascular, pulmonary, gastrointestinal, and neurologic effects post-SARS-CoV-2 infection and mechanistic insights and risk factors for the above-mentioned sequelae. Emerging risk factors of long-term sequelae include older age (≥65 years), female sex, Black or Asian race, Hispanic ethnicity, and presence of comorbidities. There is an urgent need to better understand ongoing effects of COVID-19. Prospective studies evaluating long-term effects of COVID-19 in all body systems and patient groups will facilitate appropriate management and assess burden of care. Clinicians should ensure patients are followed up and managed appropriately, especially those in at-risk groups. Healthcare systems worldwide need to develop approaches to follow-up and support patients recovering from COVID-19. Surveillance programs can enhance prevention and treatment efforts for those most vulnerable.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"315-328"},"PeriodicalIF":6.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9440741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antimicrobial peptides as promising antibiotic adjuvants to combat drug-resistant pathogens. 抗菌肽作为抗生素佐剂，有望对抗耐药性病原体。

IF 6 2区生物学

Critical Reviews in Microbiology Pub Date : 2024-05-01 Epub Date: 2023-03-08 DOI: 10.1080/1040841X.2023.2186215

Chen Chen, Jingru Shi, Dejuan Wang, Pan Kong, Zhiqiang Wang, Yuan Liu

{"title":"Antimicrobial peptides as promising antibiotic adjuvants to combat drug-resistant pathogens.","authors":"Chen Chen, Jingru Shi, Dejuan Wang, Pan Kong, Zhiqiang Wang, Yuan Liu","doi":"10.1080/1040841X.2023.2186215","DOIUrl":"10.1080/1040841X.2023.2186215","url":null,"abstract":"The widespread antimicrobial resistance (AMR) calls for the development of new antimicrobial strategies. Antibiotic adjuvant rescues antibiotic activity and increases the life span of the antibiotics, representing a more productive, timely, and cost-effective strategy in fighting drug-resistant pathogens. Antimicrobial peptides (AMPs) from synthetic and natural sources are considered new-generation antibacterial agents. Besides their direct antimicrobial activity, growing evidence shows that some AMPs effectively enhance the activity of conventional antibiotics. The combinations of AMPs and antibiotics display an improved therapeutic effect on antibiotic-resistant bacterial infections and minimize the emergence of resistance. In this review, we discuss the value of AMPs in the age of resistance, including modes of action, limiting evolutionary resistance, and their designing strategies. We summarise the recent advances in combining AMPs and antibiotics against antibiotic-resistant pathogens, as well as their synergistic mechanisms. Lastly, we highlight the challenges and opportunities associated with the use of AMPs as potential antibiotic adjuvants. This will shed new light on the deployment of synergistic combinations to address the AMR crisis.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"267-284"},"PeriodicalIF":6.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9075998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineered probiotics as live biotherapeutics for diagnosis and treatment of human diseases. 将工程益生菌作为诊断和治疗人类疾病的活生物疗法。

IF 6 2区生物学

Critical Reviews in Microbiology Pub Date : 2024-05-01 Epub Date: 2023-03-22 DOI: 10.1080/1040841X.2023.2190392

Jiao Meng, Shufan Liu, Xin Wu

{"title":"Engineered probiotics as live biotherapeutics for diagnosis and treatment of human diseases.","authors":"Jiao Meng, Shufan Liu, Xin Wu","doi":"10.1080/1040841X.2023.2190392","DOIUrl":"10.1080/1040841X.2023.2190392","url":null,"abstract":"The use of probiotics to regulate the intestinal microbiota to prevent and treat a large number of disorders and diseases has been an international research hotspot. Although conventional probiotics have a certain regulatory role in nutrient metabolism, inhibiting pathogens, inducing immune regulation, and maintaining intestinal epithelial barrier function, they are unable to treat certain diseases. In recent years, aided by the continuous development of synthetic biology, engineering probiotics with desired characteristics and functionalities to benefit human health has made significant progress. In this article, we summarise the mechanism of action of conventional probiotics and their limitations and highlight the latest developments in the design and construction of probiotics as living diagnostics and therapeutics for the detection and treatment of a series of diseases, including pathogen infections, cancer, intestinal inflammation, metabolic disorders, vaccine delivery, cognitive health, and fatty liver. Besides we discuss the concerns regarding engineered probiotics and corresponding countermeasures and outline the desired features in the future development of engineered live biotherapeutics.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"300-314"},"PeriodicalIF":6.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9164115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring halophilic environments as a source of new antibiotics. 探索嗜卤环境作为新抗生素来源的可能性。

IF 6 2区生物学

Critical Reviews in Microbiology Pub Date : 2024-05-01 Epub Date: 2023-04-20 DOI: 10.1080/1040841X.2023.2197491

Thomas P Thompson, Brendan F Gilmore

{"title":"Exploring halophilic environments as a source of new antibiotics.","authors":"Thomas P Thompson, Brendan F Gilmore","doi":"10.1080/1040841X.2023.2197491","DOIUrl":"10.1080/1040841X.2023.2197491","url":null,"abstract":"Microbial natural products from microbes in extreme environments, including haloarchaea, and halophilic bacteria, possess a huge capacity to produce novel antibiotics. Additionally, enhanced isolation techniques and improved tools for genomic mining have expanded the efficiencies in the antibiotic discovery process. This review article provides a detailed overview of known antimicrobial compounds produced by halophiles from all three domains of life. We summarize that while halophilic bacteria, in particular actinomycetes, contribute the vast majority of these compounds the importance of understudied halophiles from other domains of life requires additional consideration. Finally, we conclude by discussing upcoming technologies- enhanced isolation and metagenomic screening, as tools that will be required to overcome the barriers to antimicrobial drug discovery. This review highlights the potential of these microbes from extreme environments, and their importance to the wider scientific community, with the hope of provoking discussion and collaborations within halophile biodiscovery. Importantly, we emphasize the importance of bioprospecting from communities of lesser-studied halophilic and halotolerant microorganisms as sources of novel therapeutically relevant chemical diversity to combat the high rediscovery rates. The complexity of halophiles will necessitate a multitude of scientific disciplines to unravel their potential and therefore this review reflects these research communities.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"341-370"},"PeriodicalIF":6.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9390485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0