Sensitive delivery systems and novel encapsulation technologies for live biotherapeutic products and probiotics.

IF 6 2区生物学 Q1 MICROBIOLOGY

Critical Reviews in Microbiology Pub Date : 2024-05-01 Epub Date: 2023-04-19 DOI:10.1080/1040841X.2023.2202237

Shuang Li, Yi-Xuan Zhang

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引用次数: 0

Abstract

Live biotherapeutic product (LBP), a type of biological product, holds promise for the prevention or treatment of metabolic disease and pathogenic infection. Probiotics are live microorganisms that improve the intestinal microbial balance and beneficially affect the health of the host when ingested in sufficient numbers. These biological products possess the advantages of inhibition of pathogens, degradation of toxins, and modulation of immunity. The application of LBP and probiotic delivery systems has attracted great interest to researchers. The initial used technologies for LBP and probiotic encapsulation are traditional capsules and microcapsules. However, the stability and targeted delivery capability require further improved. The specific sensitive materials can greatly improve the delivery efficiency of LBPs and probiotics. The specific sensitive delivery systems show advantages over traditional ones due to their better properties of biocompatibility, biodegradability, innocuousness, and stability. Moreover, some new technologies, including layer-by-layer encapsulation, polyelectrolyte complexation, and electrohydrodynamic technology, show great potential in LBP and probiotic delivery. In this review, novel delivery systems and new technologies of LBPs and probiotics were presented, and the challenges and prospects were explored in specific sensitive materials for LBP and probiotic delivery.

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用于活生物治疗产品和益生菌的敏感输送系统和新型封装技术。

活生物治疗产品（LBP）是一种生物制品，有望预防或治疗代谢性疾病和病原体感染。益生菌是活的微生物，摄入足够数量的益生菌可改善肠道微生物平衡，对宿主的健康产生有益影响。这些生物制品具有抑制病原体、降解毒素和调节免疫等优点。枸杞多糖和益生菌输送系统的应用引起了研究人员的极大兴趣。最初使用的枸杞多糖和益生菌封装技术是传统的胶囊和微胶囊。然而，其稳定性和靶向递送能力需要进一步提高。特异性敏感材料可以大大提高枸杞多糖和益生菌的递送效率。特异性敏感给药系统具有更好的生物相容性、生物降解性、无害性和稳定性，因此比传统给药系统更具优势。此外，一些新技术，包括逐层封装、聚电解质复合和电流体力学技术，在枸杞多糖和益生菌的给药方面显示出巨大的潜力。本综述介绍了枸杞多糖和益生菌的新型递送系统和新技术，并探讨了用于枸杞多糖和益生菌递送的特定敏感材料所面临的挑战和前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Critical Reviews in Microbiology 生物-微生物学

CiteScore

14.70

自引率

0.00%

发文量

期刊介绍： Critical Reviews in Microbiology is an international, peer-reviewed journal that publishes comprehensive reviews covering all areas of microbiology relevant to humans and animals, including medical and veterinary microbiology, public health and environmental microbiology. These may include subjects related to microbial molecular biology, immunopathogenicity, physiology, biochemistry, structure, and epidemiology. Of particular interest are reviews covering clinical aspects of bacterial, virological, fungal and parasitic diseases. All reviews must be analytical, comprehensive, and balanced in nature. Editors welcome uninvited submissions, as well as suggested topics for reviews accompanied by an abstract.