Critical Reviews in Microbiology最新文献_第9页

Quorum sensing in biofilms: a key mechanism to target in ecotoxicological studies. 生物膜中的群体感应：生态毒理学研究中的一个关键靶点机制。

IF 6.5 2区生物学

Critical Reviews in Microbiology Pub Date : 2023-11-01 Epub Date: 2022-11-05 DOI: 10.1080/1040841X.2022.2142089

Raphaël Lami, Laurent Urios, Maëlle Molmeret, Régis Grimaud

{"title":"Quorum sensing in biofilms: a key mechanism to target in ecotoxicological studies.","authors":"Raphaël Lami, Laurent Urios, Maëlle Molmeret, Régis Grimaud","doi":"10.1080/1040841X.2022.2142089","DOIUrl":"10.1080/1040841X.2022.2142089","url":null,"abstract":"Our environment is heavily contaminated by anthropogenic compounds, and this issue constitutes a significant threat to all life forms, including biofilm-forming microorganisms. Cell-cell interactions shape microbial community structures and functions, and pollutants that affect intercellular communications impact biofilm functions and ecological roles. There is a growing interest in environmental science fields for evaluating how anthropogenic pollutants impact cell-cell interactions. In this review, we synthesize existing literature that evaluates the impacts of quorum sensing (QS), which is a widespread density-dependent communication system occurring within many bacterial groups forming biofilms. First, we examine the perturbating effects of environmental contaminants on QS circuits; and our findings reveal that QS is an essential yet underexplored mechanism affected by pollutants. Second, our work highlights that QS is an unsuspected and key resistance mechanism that assists bacteria in dealing with environmental contamination (caused by metals or organic pollutants) and that favors bacterial growth in unfavourable environments. We emphasize the value of considering QS a critical mechanism for monitoring microbial responses in ecotoxicology. Ultimately, we determine that QS circuits constitute promising targets for innovative biotechnological approaches with major perspectives for applications in the field of environmental science.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":null,"pages":null},"PeriodicalIF":6.5,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40681370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Ex vivo challenge models for infectious diseases. 传染病的离体挑战模型。

IF 6.5 2区生物学

Critical Reviews in Microbiology Pub Date : 2023-11-01 DOI: 10.1080/1040841X.2023.2274855

Bhavna Gowan Gordhan, Dale Liebenberg, Gabriella Scarlatti, Carolina Herrera, Francesca Chiodi, Neil Martinson, Julie Fox, Bavesh Davandra Kana

{"title":"Ex vivo challenge models for infectious diseases.","authors":"Bhavna Gowan Gordhan, Dale Liebenberg, Gabriella Scarlatti, Carolina Herrera, Francesca Chiodi, Neil Martinson, Julie Fox, Bavesh Davandra Kana","doi":"10.1080/1040841X.2023.2274855","DOIUrl":"https://doi.org/10.1080/1040841X.2023.2274855","url":null,"abstract":"Traditionally, molecular mechanisms of pathogenesis for infectious agents were studied in cell culture or animal models but have limitations on the extent to which the resulting data reflect natural infection in humans. The COVID-19 pandemic has highlighted the urgent need to rapidly develop laboratory models that enable the study of host-pathogen interactions, particularly the relative efficacy of preventive measures. Recently, human and animal ex vivo tissue challenge models have emerged as a promising avenue to study immune responses, screen potential therapies and triage vaccine candidates. This approach offers the opportunity to closely approximate human disease from the perspective of pathology and immune response. It has advantages compared to animal models which are expensive, lengthy and often require containment facilities. Herein, we summarize some recent advances in the development of ex vivo tissue challenge models for COVID-19, HIV-1 and other pathogens. We focus on the contribution of these models to enhancing knowledge of host-pathogen interactions, immune modulation, and their value in testing therapeutic agents. We further highlight the advantages and limitations of using ex vivo challenge models and briefly summarize how the use of organoids provides a useful advancement over current approaches. Collectively, these developments have enormous potential for the study of infectious diseases.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":null,"pages":null},"PeriodicalIF":6.5,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71421375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human gut homeostasis and regeneration: the role of the gut microbiota and its metabolites. 人类肠道稳态和再生：肠道微生物群及其代谢产物的作用。

IF 6.5 2区生物学

Critical Reviews in Microbiology Pub Date : 2023-11-01 Epub Date: 2022-11-11 DOI: 10.1080/1040841X.2022.2142088

Claudia Marcela Arenas-Gómez, Enriqueta Garcia-Gutierrez, Juan S Escobar, Paul D Cotter

{"title":"Human gut homeostasis and regeneration: the role of the gut microbiota and its metabolites.","authors":"Claudia Marcela Arenas-Gómez, Enriqueta Garcia-Gutierrez, Juan S Escobar, Paul D Cotter","doi":"10.1080/1040841X.2022.2142088","DOIUrl":"10.1080/1040841X.2022.2142088","url":null,"abstract":"The healthy human gut is a balanced ecosystem where host cells and representatives of the gut microbiota interact and communicate in a bidirectional manner at the gut epithelium. As a result of these interactions, many local and systemic processes necessary for host functionality, and ultimately health, take place. Impairment of the integrity of the gut epithelium diminishes its ability to act as an effective gut barrier, can contribute to conditions associated to inflammation processes and can have other negative consequences. Pathogens and pathobionts have been linked with damage of the integrity of the gut epithelium, but other components of the gut microbiota and some of their metabolites can contribute to its repair and regeneration. Here, we review what is known about the effect of bacterial metabolites on the gut epithelium and, more specifically, on the regulation of repair by intestinal stem cells and the regulation of the immune system in the gut. Additionally, we explore the potential therapeutic use of targeted modulation of the gut microbiota to maintain and improve gut homeostasis as a mean to improve health outcomes.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":null,"pages":null},"PeriodicalIF":6.5,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40472657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Advances on diagnosis of Helicobacter pylori infections. 幽门螺杆菌感染的诊断进展。

IF 6.5 2区生物学

Critical Reviews in Microbiology Pub Date : 2023-11-01 Epub Date: 2022-10-20 DOI: 10.1080/1040841X.2022.2125287

Cláudia Sousa, Rute Ferreira, Sílvio B Santos, Nuno F Azevedo, Luís D R Melo

{"title":"Advances on diagnosis of Helicobacter pylori infections.","authors":"Cláudia Sousa, Rute Ferreira, Sílvio B Santos, Nuno F Azevedo, Luís D R Melo","doi":"10.1080/1040841X.2022.2125287","DOIUrl":"10.1080/1040841X.2022.2125287","url":null,"abstract":"The association of Helicobacter pylori to several gastric diseases, such as chronic gastritis, peptic ulcer disease, and gastric cancer, and its high prevalence worldwide, raised the necessity to use methods for a proper and fast diagnosis and monitoring the pathogen eradication. Available diagnostic methods can be classified as invasive or non-invasive, and the selection of the best relies on the clinical condition of the patient, as well as on the sensitivity, specificity, and accessibility of the diagnostic test. This review summarises all diagnostic methods currently available, including the invasive methods: endoscopy, histology, culture, and molecular methods, and the rapid urease test (RUT), as well as the non-invasive methods urea breath test (UBT), serological assays, biosensors, and microfluidic devices and the stool antigen test (SAT). Moreover, it lists the diagnostic advantages and limitations, as well as the main advances for each methodology. In the end, research on the development of new diagnostic methods, such as bacteriophage-based H. pylori diagnostic tools, is also discussed.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":null,"pages":null},"PeriodicalIF":6.5,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40574865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Bioinformatic approaches for studying the microbiome of fermented food. 研究发酵食品微生物组的生物信息学方法。

IF 6.5 2区生物学

Critical Reviews in Microbiology Pub Date : 2023-11-01 Epub Date: 2022-10-26 DOI: 10.1080/1040841X.2022.2132850

Liam H Walsh, Mairéad Coakley, Aaron M Walsh, Paul W O'Toole, Paul D Cotter

{"title":"Bioinformatic approaches for studying the microbiome of fermented food.","authors":"Liam H Walsh, Mairéad Coakley, Aaron M Walsh, Paul W O'Toole, Paul D Cotter","doi":"10.1080/1040841X.2022.2132850","DOIUrl":"10.1080/1040841X.2022.2132850","url":null,"abstract":"High-throughput DNA sequencing-based approaches continue to revolutionise our understanding of microbial ecosystems, including those associated with fermented foods. Metagenomic and metatranscriptomic approaches are state-of-the-art biological profiling methods and are employed to investigate a wide variety of characteristics of microbial communities, such as taxonomic membership, gene content and the range and level at which these genes are expressed. Individual groups and consortia of researchers are utilising these approaches to produce increasingly large and complex datasets, representing vast populations of microorganisms. There is a corresponding requirement for the development and application of appropriate bioinformatic tools and pipelines to interpret this data. This review critically analyses the tools and pipelines that have been used or that could be applied to the analysis of metagenomic and metatranscriptomic data from fermented foods. In addition, we critically analyse a number of studies of fermented foods in which these tools have previously been applied, to highlight the insights that these approaches can provide.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":null,"pages":null},"PeriodicalIF":6.5,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45041858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Microparticles and nanoparticles-based approaches to improve oral treatment of Helicobacter pylori infection. 基于微粒和纳米粒子的方法改善幽门螺杆菌感染的口腔治疗。

IF 6.5 2区生物学

Critical Reviews in Microbiology Pub Date : 2023-10-28 DOI: 10.1080/1040841X.2023.2274835

Jessyca Aparecida Paes Dutra, Suzana Gonçalves Carvalho, Aline Soares de Oliveira, Jéssica Raquel Borges Monteiro, Jéssica Rodrigues Pereira de Oliveira Borlot, Marcela Tavares Luiz, Tais Maria Bauab, Rodrigo Rezende Kitagawa, Marlus Chorilli

{"title":"Microparticles and nanoparticles-based approaches to improve oral treatment of Helicobacter pylori infection.","authors":"Jessyca Aparecida Paes Dutra, Suzana Gonçalves Carvalho, Aline Soares de Oliveira, Jéssica Raquel Borges Monteiro, Jéssica Rodrigues Pereira de Oliveira Borlot, Marcela Tavares Luiz, Tais Maria Bauab, Rodrigo Rezende Kitagawa, Marlus Chorilli","doi":"10.1080/1040841X.2023.2274835","DOIUrl":"https://doi.org/10.1080/1040841X.2023.2274835","url":null,"abstract":"Helicobacter pylori is a gram-negative, spiral-shaped, flagellated bacterium that colonizes the stomach of half the world's population. Helicobacter pylori infection causes pathologies of varying severity. Standard oral therapy fails in 15-20% since the barriers of the oral route decrease the bioavailability of antibiotics and the intrinsic factors of bacteria increase the rates of resistance. Nanoparticles and microparticles are promising strategies for drug delivery into the gastric mucosa and targeting H. pylori. The variety of building blocks creates systems with distinct colloidal, surface, and biological properties. These features improve drug-pathogen interactions, eliminate drug depletion and overuse, and enable the association of multiple actives combating H. pylori on several fronts. Nanoparticles and microparticles are successfully used to overcome the barriers of the oral route, physicochemical inconveniences, and lack of selectivity of current therapy. They have proven efficient in employing promising anti-H. pylori compounds whose limitation is oral route instability, such as some antibiotics and natural products. However, the current challenge is the applicability of these strategies in clinical practice. For this reason, strategies employing a rational design are necessary, including in the development of nano- and microsystems for the oral route.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":null,"pages":null},"PeriodicalIF":6.5,"publicationDate":"2023-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66783626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The potential for bacteriophages and prophage elements in fighting and preventing the gonorrhea. 噬菌体和原噬菌体在对抗和预防淋病方面的潜力。

IF 6.5 2区生物学

Critical Reviews in Microbiology Pub Date : 2023-10-28 DOI: 10.1080/1040841X.2023.2274849

Monika Adamczyk-Popławska, Piotr Golec, Andrzej Piekarowicz, Agnieszka Kwiatek

{"title":"The potential for bacteriophages and prophage elements in fighting and preventing the gonorrhea.","authors":"Monika Adamczyk-Popławska, Piotr Golec, Andrzej Piekarowicz, Agnieszka Kwiatek","doi":"10.1080/1040841X.2023.2274849","DOIUrl":"https://doi.org/10.1080/1040841X.2023.2274849","url":null,"abstract":"Bacteriophages are the most numerous entities on earth and are found everywhere their bacterial hosts live. As natural bacteria killers, phages are extensively investigated as a potential cure for bacterial infections. Neisseria gonorrhoeae (the gonococcus) is the etiologic agent of a sexually transmitted disease: gonorrhea. The rapid increase of resistance of N. gonorrhoeae to antibiotics urges scientists to look for alternative treatments to combat gonococcal infections. Phage therapy has not been tested as an anti-gonococcal therapy so far. To date, no lytic phage has been discovered against N. gonorrhoeae. Nevertheless, gonococcal genomes contain both dsDNA and ssDNA prophages, and viral particle induction has been documented. In this review, we consider literature data about the attempts of hunting for a bacteriophage specific for gonococci - the gonophage. We also discuss the potential application of prophage elements in the fight against N. gonorrhoeae. Temperate phages may be useful in preventing and treating gonorrhea as a scaffold for anti-gonococcal vaccine development and as a source of lytic enzymes with anti-gonococcal activity.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":null,"pages":null},"PeriodicalIF":6.5,"publicationDate":"2023-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66783627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current types of staphylococcal cassette chromosome mec (SCCmec) in clinically relevant coagulase-negative staphylococcal (CoNS) species. 临床相关凝固酶阴性葡萄球菌（CoNS）种中葡萄球菌盒染色体mec（SCCmec）的当前类型。

IF 6.5 2区生物学

Critical Reviews in Microbiology Pub Date : 2023-10-26 DOI: 10.1080/1040841X.2023.2274841

Mariola Wolska-Gębarzewska, Jacek Międzobrodzki, Maja Kosecka-Strojek

{"title":"Current types of staphylococcal cassette chromosome mec (SCCmec) in clinically relevant coagulase-negative staphylococcal (CoNS) species.","authors":"Mariola Wolska-Gębarzewska, Jacek Międzobrodzki, Maja Kosecka-Strojek","doi":"10.1080/1040841X.2023.2274841","DOIUrl":"https://doi.org/10.1080/1040841X.2023.2274841","url":null,"abstract":"Coagulase-negative staphylococci (CoNS) colonize human skin and mucosal membranes, which is why they are considered harmless commensal bacteria. Two species, Staphylococcus epidermidis and Staphylococcus haemolyticus belong to the group of CoNS species and are most frequently isolated from nosocomial infections, including device-associated healthcare-associated infections (DA-HAIs) and local or systemic body-related infections (FBRIs). Methicillin resistance, initially described in Staphylococcus aureus, has also been reported in CoNS species. It is mediated by the mecA gene within the staphylococcal cassette chromosome (SCCmec). SCCmec typing, primarily using PCR-based methods, has been employed as a molecular epidemiological tool. However, the introduction of whole genome sequencing (WGS) and next-generation sequencing (NGS) has enabled the identification and verification of new SCCmec types. This review describes the current distribution of SCCmec types, subtypes, and variants among CoNS species, including S. epidermidis, S. haemolyticus, and S. capitis. The literature review focuses on recent research articles from the past decade that discuss new combinations of SCCmec in coagulase-negative Staphylococcus. The high genetic diversity and gaps in CoNS SCCmec annotation rules underscore the need for an efficient typing system. Typing SCCmec cassettes in CoNS strains is crucial to continuously updating databases and developing a unified classification system.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":null,"pages":null},"PeriodicalIF":6.5,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50161020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in the applications of Bacteriophages and phage products against food-contaminating bacteria. 噬菌体及其制品对抗食品污染细菌的应用进展。

IF 6.5 2区生物学

Critical Reviews in Microbiology Pub Date : 2023-10-20 DOI: 10.1080/1040841X.2023.2271098

Suja E, Sathyanarayana N Gummadi

{"title":"Advances in the applications of Bacteriophages and phage products against food-contaminating bacteria.","authors":"Suja E, Sathyanarayana N Gummadi","doi":"10.1080/1040841X.2023.2271098","DOIUrl":"https://doi.org/10.1080/1040841X.2023.2271098","url":null,"abstract":"Food-contaminating bacteria pose a threat to food safety and the economy by causing foodborne illnesses and spoilage. Bacteriophages, a group of viruses that infect only bacteria, have the potential to control bacteria throughout the \"farm-to-fork continuum\". Phage application offers several advantages, including targeted action against specific bacterial strains and minimal impact on the natural microflora of food. This review covers multiple aspects of bacteriophages applications in the food industry, including their use as biocontrol and biopreservation agents to fight over 20 different genera of food-contaminating bacteria, reduce cross-contamination and the risk of foodborne diseases, and also to prolong shelf life and preserve freshness. The review also highlights the benefits of using bacteriophages in bioprocesses to selectively inhibit undesirable bacteria, such as substrate competitors and toxin producers, which is particularly valuable in complex microbial bioprocesses where physical or chemical methods become inadequate. Furthermore, the review briefly discusses other uses of bacteriophages in the food industry, such as sanitizing food processing environments and detecting specific bacteria in food products. The review also explores strategies to enhance the effectiveness of phages, such as employing multi-phage cocktails, encapsulated phages, phage products, and synergistic hurdle approaches by combining them with antimicrobials.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":null,"pages":null},"PeriodicalIF":6.5,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49675291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bile acid and its bidirectional interactions with gut microbiota: a review. 胆汁酸及其与肠道微生物群的双向相互作用：综述。

IF 6.5 2区生物学

Critical Reviews in Microbiology Pub Date : 2023-09-27 DOI: 10.1080/1040841X.2023.2262020

Shuqi He, Lanxin Li, Yingning Yao, Jinhan Su, Suzhen Lei, Yi Zhang, Hongliang Zeng

{"title":"Bile acid and its bidirectional interactions with gut microbiota: a review.","authors":"Shuqi He, Lanxin Li, Yingning Yao, Jinhan Su, Suzhen Lei, Yi Zhang, Hongliang Zeng","doi":"10.1080/1040841X.2023.2262020","DOIUrl":"10.1080/1040841X.2023.2262020","url":null,"abstract":"Bile acids (BAs) are an important metabolite produced by cholesterol catabolism. It serves important roles in glucose and lipid metabolism and host-microbe interaction. Recent research has shown that different gut-microbiota can secrete different metabolic-enzymes to mediate the deconjugation, dehydroxylation and epimerization of BAs. In addition, microbes mediate BAs transformation and exert physiological functions in metabolic diseases may have a potentially close relationship with diet. Therefore, elaborating the pathways by which gut microbes mediate the transformation of BAs through enzymatic reactions involved are principal to understand the mechanism of effects between dietary patterns, gut microbes and BAs, and to provide theoretical knowledge for the development of functional foods to regulate metabolic diseases. In the present review, we summarized works on the physiological function of BAs, as well as the classification and composition of BAs in different animal models and its organs. In addition, we mainly focus on the bidirectional interactions of gut microbes with BAs transformation, and discuss the effects of diet on microbial transformation of BAs. Finally, we raised the question of further in-depth investigation of the food-gut microbial-BAs relationship, which might contribute to the improvement of metabolic diseases through dietary interventions in the future.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":null,"pages":null},"PeriodicalIF":6.5,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41135174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0