Critical Reviews in Microbiology最新文献_第2页

Emerging strategies to target virulence in Pseudomonas aeruginosa respiratory infections. 针对铜绿假单胞菌呼吸道感染毒力的新策略。

IF 6 2区生物学

Critical Reviews in Microbiology Pub Date : 2024-11-01 Epub Date: 2023-11-24 DOI: 10.1080/1040841X.2023.2285995

Tegan M Hibbert, Marvin Whiteley, Stephen A Renshaw, Daniel R Neill, Joanne L Fothergill

{"title":"Emerging strategies to target virulence in Pseudomonas aeruginosa respiratory infections.","authors":"Tegan M Hibbert, Marvin Whiteley, Stephen A Renshaw, Daniel R Neill, Joanne L Fothergill","doi":"10.1080/1040841X.2023.2285995","DOIUrl":"10.1080/1040841X.2023.2285995","url":null,"abstract":"Pseudomonas aeruginosa is an opportunistic pathogen that is responsible for infections in people living with chronic respiratory conditions, such as cystic fibrosis (CF) and non-CF bronchiectasis (NCFB). Traditionally, in people with chronic respiratory disorders, P. aeruginosa infection has been managed with a combination of inhaled and intravenous antibiotic therapies. However, due in part to the prolonged use of antibiotics in these people, the emergence of multi-drug resistant P. aeruginosa strains is a growing concern. The development of anti-virulence therapeutics may provide a new means of treating P. aeruginosa lung infections whilst also combatting the AMR crisis, as these agents are presumed to exert reduced pressure for the emergence of drug resistance as compared to antibiotics. However, the pipeline for developing anti-virulence therapeutics is poorly defined, and it is currently unclear as to whether in vivo and in vitro models effectively replicate the complex pulmonary environment sufficiently to enable development and testing of such therapies for future clinical use. Here, we discuss potential targets for P. aeruginosa anti-virulence therapeutics and the effectiveness of the current models used to study them. Focus is given to the difficulty of replicating the virulence gene expression patterns of P. aeruginosa in the CF and NCFB lung under laboratory conditions and to the challenges this poses for anti-virulence therapeutic development.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"1037-1052"},"PeriodicalIF":6.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138298543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Review on computer-assisted biosynthetic capacities elucidation to assess metabolic interactions and communication within microbial communities. 综述计算机辅助生物合成能力阐释，以评估微生物群落内的代谢相互作用和交流。

IF 6 2区生物学

Critical Reviews in Microbiology Pub Date : 2024-11-01 Epub Date: 2024-01-25 DOI: 10.1080/1040841X.2024.2306465

Mahnoor Zulfiqar, Vinay Singh, Christoph Steinbeck, Maria Sorokina

{"title":"Review on computer-assisted biosynthetic capacities elucidation to assess metabolic interactions and communication within microbial communities.","authors":"Mahnoor Zulfiqar, Vinay Singh, Christoph Steinbeck, Maria Sorokina","doi":"10.1080/1040841X.2024.2306465","DOIUrl":"10.1080/1040841X.2024.2306465","url":null,"abstract":"Microbial communities thrive through interactions and communication, which are challenging to study as most microorganisms are not cultivable. To address this challenge, researchers focus on the extracellular space where communication events occur. Exometabolomics and interactome analysis provide insights into the molecules involved in communication and the dynamics of their interactions. Advances in sequencing technologies and computational methods enable the reconstruction of taxonomic and functional profiles of microbial communities using high-throughput multi-omics data. Network-based approaches, including community flux balance analysis, aim to model molecular interactions within and between communities. Despite these advances, challenges remain in computer-assisted biosynthetic capacities elucidation, requiring continued innovation and collaboration among diverse scientists. This review provides insights into the current state and future directions of computer-assisted biosynthetic capacities elucidation in studying microbial communities.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"1053-1092"},"PeriodicalIF":6.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139545419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mycobacteroides abscessus ability to interact with the host mucosal cells plays an important role in pathogenesis of the infection. 脓肿分枝杆菌与宿主粘膜细胞相互作用的能力在感染的发病机制中起着重要作用。

IF 6 2区生物学

Critical Reviews in Microbiology Pub Date : 2024-10-25 DOI: 10.1080/1040841X.2024.2418130

Amy Leestemaker-Palmer, Luiz E Bermudez

{"title":"Mycobacteroides abscessus ability to interact with the host mucosal cells plays an important role in pathogenesis of the infection.","authors":"Amy Leestemaker-Palmer, Luiz E Bermudez","doi":"10.1080/1040841X.2024.2418130","DOIUrl":"https://doi.org/10.1080/1040841X.2024.2418130","url":null,"abstract":"Non-tuberculous mycobacteria (NTM) are opportunistic pathogens ubiquitous in the environment. Mycobacteroides abscessus is a relatively new pathogen associated with underlying lung chronic pathologies, accounting for most of the pulmonary infections linked to the rapidly growing mycobacteria group. This includes chronic obstructive pulmonary disease, bronchiectasis, or cystic fibrosis. Patient outcomes from M. abscessus infections are poor due to complicated treatments and other factors. Intrinsic drug resistance plays an important role. The M. abscessus toolbox of resistance is varied leading to complex strategies for treatment. Mechanisms include waxy cell walls, drug export mechanisms, and acquired resistance. Many studies have also shown the impact of extracellular DNA found in the biofilm matrix during early infection and its possible advantage in pathogenicity. In this review, we discuss the current knowledge of early infection focusing on biofilm formation, an environmental strategy, and which treatments prevent its formation improving current antibiotic treatment outcomes in preliminary studies.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"1-13"},"PeriodicalIF":6.0,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142496512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-fungal peptides: an emerging category with enthralling therapeutic prospects in the treatment of candidiasis. 抗真菌肽：在治疗念珠菌病方面具有令人着迷的治疗前景的新兴类别。

IF 6 2区生物学

Critical Reviews in Microbiology Pub Date : 2024-10-23 DOI: 10.1080/1040841X.2024.2418125

Jyoti Sankar Prusty, Ashwini Kumar, Awanish Kumar

{"title":"Anti-fungal peptides: an emerging category with enthralling therapeutic prospects in the treatment of candidiasis.","authors":"Jyoti Sankar Prusty, Ashwini Kumar, Awanish Kumar","doi":"10.1080/1040841X.2024.2418125","DOIUrl":"https://doi.org/10.1080/1040841X.2024.2418125","url":null,"abstract":"Candida infections, particularly invasive candidiasis, pose a serious global health threat. Candida albicans is the most prevalent species causing candidiasis, and resistance to key antifungal drugs, such as azoles, echinocandins, polyenes, and fluoropyrimidines, has emerged. This growing multidrug resistance (MDR) complicates treatment options, highlighting the need for novel therapeutic approaches. Antifungal peptides (AFPs) are gaining recognition for their potential as new antifungal agents due to their diverse structures and functions. These natural or recombinant peptides can effectively target fungal virulence and viability, making them promising candidates for future antifungal development. This review examines infections caused by Candida species, the limitations of current antifungal treatments, and the therapeutic potential of AFPs. It emphasizes the importance of identifying novel AFP targets and their production for advancing treatment strategies. By discussing the therapeutic development of AFPs, the review aims to draw researchers' attention to this promising field. The integration of knowledge about AFPs could pave the way for novel antifungal agents with broad-spectrum activity, reduced toxicity, targeted action, and mechanisms that limit resistance in pathogenic fungi, offering significant advancements in antifungal therapeutics.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"1-37"},"PeriodicalIF":6.0,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142496522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the antibiotic resistance of Listeria monocytogenes in food environments - a review. 探索食品环境中李斯特菌的抗生素耐药性--综述。

IF 6 2区生物学

Critical Reviews in Microbiology Pub Date : 2024-10-15 DOI: 10.1080/1040841X.2024.2412007

Cristina Díaz-Martínez, Araceli Bolívar, Birce Mercanoglu Taban, Nazlı Kanca, Fernando Pérez-Rodríguez

{"title":"Exploring the antibiotic resistance of Listeria monocytogenes in food environments - a review.","authors":"Cristina Díaz-Martínez, Araceli Bolívar, Birce Mercanoglu Taban, Nazlı Kanca, Fernando Pérez-Rodríguez","doi":"10.1080/1040841X.2024.2412007","DOIUrl":"https://doi.org/10.1080/1040841X.2024.2412007","url":null,"abstract":"Listeria monocytogenes, a resilient bacterium in diverse food conditions, such as refrigeration, reduced water activity and low pH, poses a significant threat to the food industry and public health. In recent years, it has been documented an increase in the antibiotic resistance of zoonotic pathogens, including L. monocytogenes. This review provides new insight into the molecular mechanisms involved in both intrinsic and acquired antibiotic resistance of L. monocytogenes with an emphasis on the effect of different environmental and food-related factors. It also explores the relationship of these resistance mechanisms with virulence factors. An analysis of literature data (2009-2021) was conducted to investigate statistically and graphically potential associations between specific antibiotic resistance patterns in the pathogen and food categories using an unbiased variance analysis. The results evidenced that food type had an influence on the antibiotic resistance profiles of L. monocytogenes, with meat and vegetables being the food categories exhibiting the most prevalent profiles. The frequent detection of resistance to ampicillin, penicillin, and tetracycline (non-intrinsic resistances) indicates that specific processing conditions along the food chain may induce them. Many questions remain about the impact of food chain factors (e.g. thermal treatments, cold chain, preservatives, etc.) and food type (low pH, reduced water activity, etc.) on the antibiotic resistance patterns of the pathogen, particularly concerning food-related sources, the resistance mechanisms involved (e.g. cross-protection, horizontal gene transfer, etc.), and the evolutionary processes of antibiotic-resistant microbial populations. Metagenomics, in addition to other -omics technologies (metabolomics and transcriptomics), allows a better understanding of the processes involved in the acquisition of resistance.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"1-24"},"PeriodicalIF":6.0,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The battle within: how Pseudomonas aeruginosa uses host-pathogen interactions to infect the human lung. 内部斗争：铜绿假单胞菌如何利用宿主与病原体之间的相互作用感染人类肺部。

IF 6 2区生物学

Critical Reviews in Microbiology Pub Date : 2024-10-09 DOI: 10.1080/1040841X.2024.2407378

Carmen Mesas Vaz, Alba Guembe Mülberger, Marc Torrent Burgas

{"title":"The battle within: how Pseudomonas aeruginosa uses host-pathogen interactions to infect the human lung.","authors":"Carmen Mesas Vaz, Alba Guembe Mülberger, Marc Torrent Burgas","doi":"10.1080/1040841X.2024.2407378","DOIUrl":"https://doi.org/10.1080/1040841X.2024.2407378","url":null,"abstract":"Pseudomonas aeruginosa is a versatile Gram-negative pathogen known for its ability to invade the respiratory tract, particularly in cystic fibrosis patients. This review provides a comprehensive analysis of the multifaceted strategies for colonization, virulence, and immune evasion used by P. aeruginosa to infect the host. We explore the extensive protein arsenal of P. aeruginosa, including adhesins, exotoxins, secreted proteases, and type III and VI secretion effectors, detailing their roles in the infective process. We also address the unique challenge of treating diverse lung conditions that provide a natural niche for P. aeruginosa on the airway surface, with a particular focus in cystic fibrosis. The review also discusses the current limitations in treatment options due to antibiotic resistance and highlights promising future approaches that target host-pathogen protein-protein interactions. These approaches include the development of new antimicrobials, anti-attachment therapies, and quorum-sensing inhibition molecules. In summary, this review aims to provide a holistic understanding of the pathogenesis of P. aeruginosa in the respiratory system, offering insights into the underlying molecular mechanisms and potential therapeutic interventions.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"1-36"},"PeriodicalIF":6.0,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142388725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antimicrobial and antibiofilm properties of procyanidins: potential for clinical and biotechnological applications. 原花青素的抗菌和抗生物膜特性：临床和生物技术应用潜力。

IF 6 2区生物学

Critical Reviews in Microbiology Pub Date : 2024-09-20 DOI: 10.1080/1040841X.2024.2404509

Mariana M G Mattos, Sérgio Antunes Filho, Gabriel R Martins, Lara Souza Venturi, Vinícius Benjamim Canetti, Fabienne Antunes Ferreira, Debora Foguel, Ayla Sant'Ana da Silva

{"title":"Antimicrobial and antibiofilm properties of procyanidins: potential for clinical and biotechnological applications.","authors":"Mariana M G Mattos, Sérgio Antunes Filho, Gabriel R Martins, Lara Souza Venturi, Vinícius Benjamim Canetti, Fabienne Antunes Ferreira, Debora Foguel, Ayla Sant'Ana da Silva","doi":"10.1080/1040841X.2024.2404509","DOIUrl":"https://doi.org/10.1080/1040841X.2024.2404509","url":null,"abstract":"Procyanidins (PCs) have emerged as agents with potential antimicrobial and antibiofilm activities, although their mechanisms of action and structure-activity relationships remain poorly understood. This review assessed the potential mechanisms of action and applications of these compounds to explore these aspects. Studies on the antimicrobial properties of PCs suggest that they are involved in osmotic imbalance, DNA interactions and metabolic disruption. Although less studied, their antibiofilm activities include antiadhesive effects and the modulation of mobility and quorum sensing. However, most research has used uncharacterized plant extracts for in vitro assays, limiting the understanding of the structure-activity relationships of PCs and their in vivo mechanisms. Clinical trials on the antimicrobial and antibiofilm properties of PCs have not clarified these issues due to nonstandardized methodologies, inadequate chemical characterization, and the limited number of studies, preventing a consensus and evaluation of the in vivo effects. Additionally, patent analysis revealed that technological developments in the antimicrobial and antibiofilm uses of PCs are concentrated in health care and dental care, but new biotechnological uses are emerging. Therefore, while PCs are promising antimicrobial and antibiofilm compounds, further research into their chemical structures and mechanisms of action is crucial for evidence-based applications in biotechnology and health care.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"1-24"},"PeriodicalIF":6.0,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Precise pathogen quantification by CRISPR-Cas: a sweet but tough nut to crack. 利用 CRISPR-Cas 对病原体进行精确定量：甜蜜但难以攻克的难题。

IF 6.5 2区生物学

Critical Reviews in Microbiology Pub Date : 2024-09-17 DOI: 10.1080/1040841x.2024.2404041

Zhihao Yao,Wanglu Li,Kaiyu He,Hongmei Wang,Yan Xu,Xiahong Xu,Qun Wu,Liu Wang

{"title":"Precise pathogen quantification by CRISPR-Cas: a sweet but tough nut to crack.","authors":"Zhihao Yao,Wanglu Li,Kaiyu He,Hongmei Wang,Yan Xu,Xiahong Xu,Qun Wu,Liu Wang","doi":"10.1080/1040841x.2024.2404041","DOIUrl":"https://doi.org/10.1080/1040841x.2024.2404041","url":null,"abstract":"Pathogen detection is increasingly applied in medical diagnosis, food processing and safety, and environmental monitoring. Rapid, sensitive, and accurate pathogen quantification is the most critical prerequisite for assessing protocols and preventing risks. Among various methods evolved, those based on clustered regularly interspaced short palindromic repeats (CRISPR)-associated proteins (Cas) have been developed as important pathogen detection strategies due to their distinct advantages of rapid target recognition, programmability, ultra-specificity, and potential for scalability of point-of-care testing (POCT). However, arguments and concerns on the quantitative capability of CRISPR-based strategies are ongoing. Herein, we systematically overview CRISPR-based pathogen quantification strategies according to the principles, properties, and application scenarios. Notably, we review future challenges and perspectives to address the of precise pathogen quantification by CRISPR-Cas. We hope the insights presented in this review will benefit development of CRISPR-based pathogen detection methods.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":"12 1","pages":"1-19"},"PeriodicalIF":6.5,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142254854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Male-specific bacteriophages and their potential on combating the spreading of T4SS-bearing antimicrobial resistance plasmids. 雄性特异性噬菌体及其在阻止携带 T4SS 的抗菌性质粒传播方面的潜力。

IF 6.5 2区生物学

Critical Reviews in Microbiology Pub Date : 2024-09-10 DOI: 10.1080/1040841x.2024.2400150

Jun Li,Pilar García,Xing Ji,Ran Wang,Tao He

引用次数: 0

Pseudomonas aeruginosa: metabolic allies and adversaries in the world of polymicrobial infections. 铜绿假单胞菌：多微生物感染世界中的代谢盟友和对手。

IF 6 2区生物学

Critical Reviews in Microbiology Pub Date : 2024-09-03 DOI: 10.1080/1040841X.2024.2397359

Chandni Sachdeva, Kapaettu Satyamoorthy, Thokur Sreepathy Murali

引用次数: 0