Critical Reviews in Microbiology最新文献_第2页

New strains, new threats: the rise of atypical non-typhoidal Salmonella serovars and what it means for global health. 新的菌株，新的威胁：非典型非伤寒沙门氏菌血清型的兴起及其对全球卫生的意义。

IF 7 2区生物学

Critical Reviews in Microbiology Pub Date : 2026-09-01 Epub Date: 2026-06-01 DOI: 10.1080/1040841X.2026.2668055

Amy Campbell, Archie Harber, Séamus Fanning, Helina Marshall

{"title":"New strains, new threats: the rise of atypical non-typhoidal Salmonella serovars and what it means for global health.","authors":"Amy Campbell, Archie Harber, Séamus Fanning, Helina Marshall","doi":"10.1080/1040841X.2026.2668055","DOIUrl":"10.1080/1040841X.2026.2668055","url":null,"abstract":"Salmonella is one of the most common causes of foodborne illness worldwide. These infections, in turn, exert an impact on both industry and healthcare settings. Salmonella is the agent that causes salmonellosis, a gastroenteric infection. Outbreaks of salmonellosis commonly arise from the consumption of contaminated foods of animal origin, and on occasion, from exotic and companion animals. The genus consists of more than 2,600 serovars, with Salmonella Typhimurium and Salmonella Enteritidis being the most commonly isolated serovars which cause non-typhoidal infection in susceptible humans. Moreover, factors such as global trade, government policy and globalization have led to an increased emergence of atypical salmonellae. Current limited literature suggests that these emerging atypical Salmonella serovars pose a unique threat to human health due to their novel host adaptations, antimicrobial resistance profiles, epidemiology and infection sources. Thus, this paper aims to provide a short overview of the current knowledge of the taxonomy of selected atypical serovars as well as their epidemiology, virulence factors and the impact they pose on the One Health paradigm. The aim of this being to highlight the ever-increasing importance of focusing research upon these variant serovars due to their changing incidence and diverse attributes.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"874-891"},"PeriodicalIF":7.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148136746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tripartite warfare: decoding the cell-virus-virophage arms race. 三方战争：破解细胞-病毒-噬菌体军备竞赛。

IF 7 2区生物学

Critical Reviews in Microbiology Pub Date : 2026-09-01 Epub Date: 2026-05-23 DOI: 10.1080/1040841X.2026.2675950

Ting Chu, Yongjie Wang

引用次数: 0

Recent advances in omics-driven research of photosynthetic microorganisms in green biotechnology. 绿色生物技术中光合微生物组学驱动研究进展。

IF 7 2区生物学

Critical Reviews in Microbiology Pub Date : 2026-09-01 Epub Date: 2026-04-20 DOI: 10.1080/1040841X.2026.2655676

Boris Sorokin, Evgeniy Gusev, Zorigto Namsaraev, Anton Buzdin, Alina Osmakova, Denis Kuzmin

{"title":"Recent advances in omics-driven research of photosynthetic microorganisms in green biotechnology.","authors":"Boris Sorokin, Evgeniy Gusev, Zorigto Namsaraev, Anton Buzdin, Alina Osmakova, Denis Kuzmin","doi":"10.1080/1040841X.2026.2655676","DOIUrl":"10.1080/1040841X.2026.2655676","url":null,"abstract":"Microalgae and cyanobacteria have attracted significant interest from green biotechnology and the bioeconomy due to their numerous beneficial qualities: extremely high growth rate compared to vascular plants; independence from arable land or clean water; ability to produce a variety of industrially important bioproducts, such as biofuels, food and feed additives, and substances for the cosmetics and pharmaceutical industries. They also offer the possibility of combining bioproduction with industrial carbon dioxide capture and wastewater utilization. One of the main limitations to the widespread use microalgae is the economic feasibility of their cultivation. Consequently, researchers in the field are primarily concerned with the identification of novel high-productive strains and the augmentation of biomass and/or target metabolite yield. Omics technologies are the key to unlocking the biotechnological potential of photosynthetic microorganisms, enabling significant acceleration in the identification of novel, efficient strains and providing valuable insights into the microbial metabolism. The present review focuses on the latest advances in the field of omics-driven research of photosynthetic microorganisms and provides a comprehensive outlook of practical instruments, such as open-access omics databases and stoichiometric metabolic models, that can improve the efficiency of biotechnological research pipelines to achieve breakthroughs in the industrial application of microalgae and cyanobacteria.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"816-849"},"PeriodicalIF":7.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147721913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-Candida albicans natural products: convergent technologies revolutionizing discovery from bioactivity assessment to targeted mechanisms. 抗白色念珠菌天然产物：聚合技术从生物活性评估到靶向机制的革命性发现。

IF 7 2区生物学

Critical Reviews in Microbiology Pub Date : 2026-09-01 Epub Date: 2026-05-13 DOI: 10.1080/1040841X.2026.2655675

Di Zhang, Xiaoxing Liu, Xueqin Zhao, Zixin Yan, Weichen Wang, Guifu Dai

引用次数: 0

Bacterial kinase in ESKAPE pathogen: regulators of virulence and novel therapeutic targets. ESKAPE病原体中的细菌激酶：毒力调节剂和新的治疗靶点。

IF 7 2区生物学

Critical Reviews in Microbiology Pub Date : 2026-09-01 Epub Date: 2026-04-18 DOI: 10.1080/1040841X.2026.2655678

Saroj Sharma, Vishvanath Tiwari

{"title":"Bacterial kinase in ESKAPE pathogen: regulators of virulence and novel therapeutic targets.","authors":"Saroj Sharma, Vishvanath Tiwari","doi":"10.1080/1040841X.2026.2655678","DOIUrl":"10.1080/1040841X.2026.2655678","url":null,"abstract":"Bacterial protein kinases regulate fundamental processes like cell division and transcription, hence controlling various metabolic pathways. They share a common evolutionary origin with eukarya and archaea. Kinases promote the virulence of pathogenic bacteria and are also involved in the host-pathogen interactions leading to the manipulation of host defence systems for the establishment of infections. Bacterial protein kinases regulate various metabolic processes, including pathogenesis, virulence, upregulation of efflux pumps to discard antibiotics, synthesis of capsular polysaccharides, and pathogenesis. Bacterial kinases offer a new aspect of monitoring and managing the infections caused by bacterial pathogens. As kinases are essential proteins of the bacterial system, there are lesser chances of mutation in them. Hence, therapeutics targeting the pathogenic bacterial kinases would have significant value. This review deals with the functions and structural aspects of bacterial protein kinases, and the different types of kinase inhibitors that have been experimentally validated to control infections. They represent promising therapeutic target, as they will minimize the risk of gaining new types of resistance and offer a high probability of success, given their role as master regulators of the fundamental processes of the bacterial system.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"850-863"},"PeriodicalIF":7.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147716351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Environmental regulation of pathogenicity islands by nucleoid-associated proteins in bacteria. 细菌中核相关蛋白对致病性岛的环境调控。

IF 7 2区生物学

Critical Reviews in Microbiology Pub Date : 2026-09-01 Epub Date: 2026-06-16 DOI: 10.1080/1040841X.2026.2688089

Harsh V Purohit, Joydeep Chakraborty

{"title":"Environmental regulation of pathogenicity islands by nucleoid-associated proteins in bacteria.","authors":"Harsh V Purohit, Joydeep Chakraborty","doi":"10.1080/1040841X.2026.2688089","DOIUrl":"10.1080/1040841X.2026.2688089","url":null,"abstract":"Pathogenicity islands (PAIs) are horizontally acquired genomic regions that encode virulence factors essential for bacterial pathogenicity. Their expression must be precisely regulated to avoid detrimental fitness costs outside the host and to ensure timely activation during infection. This review explores how environmental cues such as temperature, osmolarity, pH, and nutrient availability regulate PAI gene expression via nucleoid-associated proteins (NAPs). Molecular mechanisms by which key NAPs, including H-NS, Fis, IHF, and HU, modulate PAI activity in response to environmental changes are examined. H-NS functions as a central xenogeneic silencer by repressing AT-rich PAI genes under non-host conditions through oligomerization and DNA bridging. Its activity is modulated by environmental inputs and post-translational modifications. In contrast, Fis promotes virulence gene expression during early exponential growth. IHF and HU serve as architectural DNA-bending proteins that facilitate transcriptional activation by altering local DNA topology or counteracting H-NS repression. These proteins integrate environmental signals with chromosomal structure to fine-tune PAI expression. A cohesive model is proposed in which NAPs act as environmental interpreters of the genome, linking chromatin architecture with adaptive virulence gene regulation. Understanding these mechanisms provides valuable insight into bacterial pathogenesis and potential targets for antimicrobial intervention.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"910-925"},"PeriodicalIF":7.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148257582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bat-rodent-human interfaces in the Americas: a synthesis of zoonotic pathways. 美洲的蝙蝠-啮齿动物-人类界面：人畜共患病途径的综合。

IF 7 2区生物学

Critical Reviews in Microbiology Pub Date : 2026-08-31 DOI: 10.1080/1040841X.2026.2719579

Céline Arnathau, Andres Garchitorena, Benjamin Roche, Montserrat-Elemi García-Hernández, Ana Laura Vigueras-Galván, Angel Rodriguez-Moreno, Carlos N Ibarra-Cerdeña, Heliot Zarza, Erika N Hernández Villegas, Stéphanie Jacquet, Florian Liégeois, Pierre Becquart, Andrea Chaves, Raina K Plowright, Jan Felix Drexler, Rosa Elena Sarmiento Silva, Audrey Arnal

{"title":"Bat-rodent-human interfaces in the Americas: a synthesis of zoonotic pathways.","authors":"Céline Arnathau, Andres Garchitorena, Benjamin Roche, Montserrat-Elemi García-Hernández, Ana Laura Vigueras-Galván, Angel Rodriguez-Moreno, Carlos N Ibarra-Cerdeña, Heliot Zarza, Erika N Hernández Villegas, Stéphanie Jacquet, Florian Liégeois, Pierre Becquart, Andrea Chaves, Raina K Plowright, Jan Felix Drexler, Rosa Elena Sarmiento Silva, Audrey Arnal","doi":"10.1080/1040841X.2026.2719579","DOIUrl":"https://doi.org/10.1080/1040841X.2026.2719579","url":null,"abstract":"Emerging zoonoses often arise at wildlife-human interfaces, yet prevention efforts still treat wildlife reservoirs in isolation. This review synthesizes evidence on RNA viruses detected in bats and rodents across the Americas and examines the ecological interfaces underlying bat-rodent-human transmission. Rather than an exhaustive inventory, we adopt an interface-based perspective on cross-species transmission. We focus on astroviruses, coronaviruses, hantaviruses, and lyssaviruses-groups combining high genetic diversity, broad host ranges, and documented or suspected zoonotic potential. We describe interfaces created by land-use change, urbanization, shared food and water resources, co-roosting in human-made structures, environmental contamination (guano- and urine-borne aerosols), and seasonality of shedding. Key gaps include geographic sampling biases, limited infectivity data, and scarce integration of host movement, contact ecology, and human practices. Prevention priorities include longitudinal surveillance along rural-urban gradients, genomic tracking of cross-species transmission, experimental work on commensal rodents that may bridge bats and humans, and co-designed community interventions. Given the region's exceptional biodiversity and rapid socio-ecological change, the Americas represent a hotspot where bat-rodent-human viral interactions may increase spillover risk. Recognizing and monitoring this overlooked interface can sharpen early warning and inform cost-effective prevention.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"1-21"},"PeriodicalIF":7.0,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148863849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional effects of microbial metabolites in dental caries. 微生物代谢物对龋病的功能影响。

IF 7 2区生物学

Critical Reviews in Microbiology Pub Date : 2026-08-24 DOI: 10.1080/1040841X.2026.2719588

Munire Aili, Shuxing Yu, Xinyue Wang, Dingwei Ye, Yuwen Fang, Yumeng Wu, Yuyin Long, Shiya Wang, Jing Zou, Qizhao Ma

{"title":"Functional effects of microbial metabolites in dental caries.","authors":"Munire Aili, Shuxing Yu, Xinyue Wang, Dingwei Ye, Yuwen Fang, Yumeng Wu, Yuyin Long, Shiya Wang, Jing Zou, Qizhao Ma","doi":"10.1080/1040841X.2026.2719588","DOIUrl":"https://doi.org/10.1080/1040841X.2026.2719588","url":null,"abstract":"Dental caries is a multifactorial disease primarily driven by the metabolic activity of microorganisms within oral biofilms. The carious process begins when fermentable carbohydrates are metabolized by microbes, leading to the production of organic acids that lower the local pH and demineralize tooth enamel. While carbohydrates are important substrates for microbial metabolism, proteins and lipids also influence microbial activity and contribute to caries development. Recent advances in microbiology and metabolomics have highlighted the role of microbial metabolites in shaping the oral microbiome and influencing caries progression. Primary metabolites such as lactate and acetate play key roles in biofilm acidification and enamel demineralization, while secondary metabolites including antimicrobial peptides (AMPs), bacteriocins, polyketides (PKs), and non-ribosomal peptides (NRPs) mediate microbial competition and regulate biofilm stability. This review explores the mechanisms by which these metabolites influence microbial competition and biofilm dynamics and discusses their potential applications in the prevention and treatment of dental caries. By understanding the interplay between microbial metabolism and oral health, new therapeutic strategies that leverage microbial metabolites, such as targeted antimicrobial agents, biofilm modulators, and metabolic interventions, hold promise for revolutionizing caries management and improving oral health outcomes.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"1-17"},"PeriodicalIF":7.0,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148808250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxidative stress responses in human fungal pathogens: a review of molecular mechanisms. 人类真菌病原体的氧化应激反应：分子机制综述。

IF 7 2区生物学

Critical Reviews in Microbiology Pub Date : 2026-08-11 DOI: 10.1080/1040841X.2026.2706136

Marcos D Pereira, Luiza D R Costa, Larissa M M Mattos, Daniele C Pires, Fernanda L Fonseca, André L S Santos, Cristiano J Riger

{"title":"Oxidative stress responses in human fungal pathogens: a review of molecular mechanisms.","authors":"Marcos D Pereira, Luiza D R Costa, Larissa M M Mattos, Daniele C Pires, Fernanda L Fonseca, André L S Santos, Cristiano J Riger","doi":"10.1080/1040841X.2026.2706136","DOIUrl":"https://doi.org/10.1080/1040841X.2026.2706136","url":null,"abstract":"Fungal infections represent a major global health challenge due to their high morbidity and mortality and calling for innovative therapeutic approaches. Effective redox regulation is essential for fungal pathogens to maintain viability and virulence within the oxidative environment of the host. Key components of the fungal antioxidant network include superoxide dismutases, catalases, glutathione- and thioredoxin-dependent systems, and enzymes involved in trehalose metabolism. In pathogens such as Candida albicans and Cryptococcus neoformans, disruption of specific antioxidant factors increases susceptibility to oxidative stress and markedly reduces virulence. Moreover, redox-sensing transcription factors such as Yap1, Cap1, and CnYap1 play central roles in modulating antioxidant response during host interaction and antifungal exposure. Cap1 is critical for oxidative stress tolerance and immune evasion in C. albicans, whereas CnYap1 is required for resistance to oxidative stress and fluconazole in C. neoformans. In addition, antifungals such as amphotericin B increase ROS load, demanding efficient antioxidant responses from fungal cells. Collectively, these findings highlight oxidative stress response pathways as a promising therapeutic target for invasive fungal infections. Targeting key elements of redox sensing and detoxification pathways, such as transcriptional regulators and antioxidant enzymes, could increase antifungal activity, compromise fungal resistance mechanisms, and ultimately improve clinical outcomes.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"1-24"},"PeriodicalIF":7.0,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148705584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antimicrobial resistance in Ecuador, 2000-2024: a systematic review within a One Health framework. 厄瓜多尔2000-2024年抗微生物药物耐药性：同一健康框架下的系统回顾。

IF 7 2区生物学

Critical Reviews in Microbiology Pub Date : 2026-08-10 DOI: 10.1080/1040841X.2026.2709521

Carlos Bastidas-Caldes, Fernanda Hernández-Alomía, Francisco Bolaños, Emily Cisneros-Vásquez, Daniel Romero-Alvarez

{"title":"Antimicrobial resistance in Ecuador, 2000-2024: a systematic review within a One Health framework.","authors":"Carlos Bastidas-Caldes, Fernanda Hernández-Alomía, Francisco Bolaños, Emily Cisneros-Vásquez, Daniel Romero-Alvarez","doi":"10.1080/1040841X.2026.2709521","DOIUrl":"https://doi.org/10.1080/1040841X.2026.2709521","url":null,"abstract":"Antimicrobial resistance (AMR) is a major global public health threat, particularly in low- and middle-income countries. In Ecuador, AMR research has expanded during the last two decades, but evidence remains fragmented and largely restricted to the human health sector. We systematically reviewed studies reporting laboratory-confirmed bacterial resistance in Ecuador between 2000 and 2024, including evidence from human, animal, food, and environmental sources. Eighty studies met the inclusion criteria. Most were hospital-based and conducted in urban areas, with limited evidence from rural, Amazonian, and insular regions. Gram-negative bacteria accounted for the greatest resistance burden, particularly Escherichia coli (56.6%), Klebsiella pneumoniae, Salmonella spp. (22.3%), the Acinetobacter baumannii complex, and Pseudomonas aeruginosa, together with resistant Staphylococcus aureus and Mycobacterium tuberculosis. Resistance to beta-lactams and fluoroquinolones predominated, whereas carbapenem resistance was especially notable among WHO priority pathogens. Evidence from animal, food, and environmental sectors was scarce and heterogeneous, and molecular characterization was inconsistently reported. These findings highlight important surveillance gaps beyond hospital settings and underscore the need for integrated multisectoral surveillance to strengthen public health policy, antimicrobial stewardship, and AMR prevention in Ecuador.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"1-20"},"PeriodicalIF":7.0,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148700979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0