Research progress on ultrasound in bacteria-mediated tumor treatment.

IF 6 2区 生物学 Q1 MICROBIOLOGY
Mingjie Li, Chenke Kuang, Zhili Guo, Meng Du, Zhiyi Chen
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引用次数: 0

Abstract

Bacteria-mediated tumor treatment (BMTT) has recently garnered significant attention as a promising avenue in tumor treatment. Despite the application of various strains in animal models and clinical trials, the effectiveness of BMTT has been hindered by its toxicity and inefficiency. In recent years, it has been explored that applying the biological effects of ultrasound could further improve the precision and effectiveness of BMTT. This review briefly introduces the challenges of BMTT and summarizes how the biological effects of ultrasound improve the efficacy and safety of BMTT in strategies involving genetic engineering, visualization and targeted delivery. The potential application and limitations of ultrasound in advancing BMTT controllable strategies are also discussed.

超声在细菌介导肿瘤治疗中的研究进展。
细菌介导的肿瘤治疗(BMTT)作为一种有前景的肿瘤治疗途径近年来引起了人们的广泛关注。尽管在动物模型和临床试验中应用了各种菌株,但BMTT的有效性一直受到其毒性和低效率的阻碍。近年来,人们一直在探索利用超声的生物学效应,进一步提高BMTT的精度和有效性。本文简要介绍了BMTT面临的挑战,总结了超声生物学效应如何在基因工程、可视化和靶向给药等方面提高BMTT的疗效和安全性。讨论了超声在推进BMTT可控策略方面的潜在应用和局限性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Critical Reviews in Microbiology
Critical Reviews in Microbiology 生物-微生物学
CiteScore
14.70
自引率
0.00%
发文量
99
期刊介绍: Critical Reviews in Microbiology is an international, peer-reviewed journal that publishes comprehensive reviews covering all areas of microbiology relevant to humans and animals, including medical and veterinary microbiology, public health and environmental microbiology. These may include subjects related to microbial molecular biology, immunopathogenicity, physiology, biochemistry, structure, and epidemiology. Of particular interest are reviews covering clinical aspects of bacterial, virological, fungal and parasitic diseases. All reviews must be analytical, comprehensive, and balanced in nature. Editors welcome uninvited submissions, as well as suggested topics for reviews accompanied by an abstract.
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