Critical Reviews in Microbiology最新文献_第4页

Methods to reduce environmental nontuberculous mycobacteria exposure: revisiting the recent literature. 减少环境中非结核分枝杆菌暴露的方法：回顾最近的文献。

IF 7 2区生物学

Critical Reviews in Microbiology Pub Date : 2026-08-01 Epub Date: 2026-01-04 DOI: 10.1080/1040841X.2025.2610213

Tiana N M Koch, Kelia K Siu, Joseph O Falkinham, Jennifer R Honda

{"title":"Methods to reduce environmental nontuberculous mycobacteria exposure: revisiting the recent literature.","authors":"Tiana N M Koch, Kelia K Siu, Joseph O Falkinham, Jennifer R Honda","doi":"10.1080/1040841X.2025.2610213","DOIUrl":"10.1080/1040841X.2025.2610213","url":null,"abstract":"The incidence and prevalence of nontuberculous mycobacterial (NTM) lung disease (LD) cases are rising, with diagnosis and treatment proving difficult. With the preponderance of viable NTM in both natural and engineered environments, the understood route of human infection is through environmental exposures. In an effort to decrease the occurrence of NTM LD, methods to reduce environmental NTM exposures are of great interest to people with infection and the clinical community. In 2013, coauthor Falkinham summarized methods known at the time to reduce exposure to LD-causing Mycobacterium avium. The objective of this current review was to perform an updated PubMed, Web of Science, and Google Scholar literature search spanning 2014-2025 for newly reported methods and newer studies that expand on known mitigation strategies. In total, 31 articles were found. Among these new reports that posed new or improved methods to reduce environmental NTM exposure, risk assessment remains limited underscoring the need for more research in this area. We propose a feasible solution may be to revisit the \"healthy home\" concept and to consider the engineered environmental microbiome interactions when designing future homes.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"631-645"},"PeriodicalIF":7.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145899296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microbial profiling through volatile organic compounds as a route toward rapid detection of bacterial infections. 通过挥发性有机化合物的微生物谱分析作为快速检测细菌感染的途径。

IF 7 2区生物学

Critical Reviews in Microbiology Pub Date : 2026-07-29 DOI: 10.1080/1040841X.2026.2707499

Susana P Costa, Adelaide Miranda, Pieter A A De Beule

{"title":"Microbial profiling through volatile organic compounds as a route toward rapid detection of bacterial infections.","authors":"Susana P Costa, Adelaide Miranda, Pieter A A De Beule","doi":"10.1080/1040841X.2026.2707499","DOIUrl":"https://doi.org/10.1080/1040841X.2026.2707499","url":null,"abstract":"Bacterial infections remain a critical global health challenge, particularly in clinical settings where antimicrobial resistance is rising. Rapid diagnostic tools are crucial for enabling timely therapeutic interventions and mitigating disease burden. Bacterial species produce distinct profiles of volatile organic compounds (VOCs) that serve as biochemical fingerprints, making VOC detection a promising noninvasive approach for rapid pathogen identification in clinical and environmental samples.This review provides a comprehensive overview of VOC profiles associated with ESKAPE-E pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter species, and Escherichia coli), integrating findings from controlled laboratory studies and clinically relevant patient-derived samples. Several VOCs consistently correlate with specific species, including isovaleric acid with S. aureus, indole with E. coli, and hydrogen cyanide with P. aeruginosa. Conversely, compounds such as dimethyl sulfide, dimethyl disulfide, ethanol, 2-phenylethanol, and 2-undecanone occur across multiple species, supporting pattern-based rather than single-marker diagnostic strategies.By synthesizing current evidence, we identify key knowledge gaps, including the limited characterization of certain pathogens and the need to advance VOC research toward clinically relevant, disease-oriented applications. We also discuss emerging analytical and sensing technologies that could enhance VOC detection and facilitate the integration of VOC-based diagnostics into routine clinical practice.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"1-20"},"PeriodicalIF":7.0,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148599989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intestinal microbiota and stress: how much do we know so far. 肠道微生物群和压力：到目前为止我们知道多少？

IF 7 2区生物学

Critical Reviews in Microbiology Pub Date : 2026-07-24 DOI: 10.1080/1040841X.2026.2706149

Noorulain Hyder, Muhammad Liaquat Raza

引用次数: 0

Mechanical determinants of bacterial collective behavior: from active turbulence to early biofilm organization. 细菌集体行为的机械决定因素：从主动湍流到早期生物膜组织。

IF 7 2区生物学

Critical Reviews in Microbiology Pub Date : 2026-07-11 DOI: 10.1080/1040841X.2026.2698959

Navinkumar Patil

{"title":"Mechanical determinants of bacterial collective behavior: from active turbulence to early biofilm organization.","authors":"Navinkumar Patil","doi":"10.1080/1040841X.2026.2698959","DOIUrl":"https://doi.org/10.1080/1040841X.2026.2698959","url":null,"abstract":"During early colonization, motile bacteria can shift from independent swimming to coordinated collective states shaped by environmental mechanics, with consequences for subsequent biofilm development and tolerance. This critical review integrates active matter physics with biofilm microbiology to evaluate a working model in which viscoelasticity, mechanotransduction, and geometric confinement form a synergistic triad of mechanical determinants that may bias communities toward tolerant states before matrix immobilization dominates. Community mechanics remains underexplored because established non-genetic mechanisms explain only part of the striking gap between planktonic killing and biofilm tolerance. Within this model, viscoelasticity of host fluids and nascent matrix, captured by an effective Deborah number, may extend hydrodynamic coupling between cells. Surface mechanotransduction can convert flagellar or pilus load into rapid cyclic di-GMP signaling, while geometric confinement in tissues and device lumens can restrict collective states available to bacteria. Together, these factors motivate testable links among viscoelasticity, bacterial density, and velocity correlation length. Current evidence derives mainly from simplified in vitro systems, and validation in three-dimensional polymicrobial clinical materials remains limited. The review highlights priorities and translational hypotheses, including motion phenotyping, rheology-modifying adjuvants, and geometry-based disruption as complements to antimicrobial therapy.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"1-19"},"PeriodicalIF":7.0,"publicationDate":"2026-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148419452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intelligent detection technologies for microbes and disease biomarkers. 微生物和疾病生物标志物的智能检测技术。

IF 7 2区生物学

Critical Reviews in Microbiology Pub Date : 2026-07-11 DOI: 10.1080/1040841X.2026.2701195

Shuang Liu, Yanhua Yang, Ye Pan, Juan Fan, Qinggang Xu, Peng Lü

{"title":"Intelligent detection technologies for microbes and disease biomarkers.","authors":"Shuang Liu, Yanhua Yang, Ye Pan, Juan Fan, Qinggang Xu, Peng Lü","doi":"10.1080/1040841X.2026.2701195","DOIUrl":"https://doi.org/10.1080/1040841X.2026.2701195","url":null,"abstract":"Microbial communities play a critical role in human health, and their metabolic activities are directly implicated in the pathogenesis and progression of various diseases. Conventional detection methods for microbes and biomarkers, however, are hampered by limitations including poor real-time performance, high invasiveness, low specificity, and limited capacity for multi-parameter parallel detection, which severely restrict their application in clinical and scientific research. In recent years, the deep integration of interdisciplinary fields such as synthetic biology, nanotechnology, optical imaging, and artificial intelligence has catalyzed the rapid development of intelligent detection technologies. These innovations provide novel solutions for achieving highly sensitive, noninvasive, real-time, and multi-modal detection of microbes and disease biomarkers. This review systematically summarizes the breakthroughs in these technologies for microbial visualization and disease biomarker tracking, with a focus on four core strategies: physical information-based sensing (e.g. photoacoustic imaging, acoustic reporter genes), specific probe labeling (fluorescent, isotopic, nanomaterial-based probes), genetically engineered biosensors, and bioluminescence imaging. Collectively, these approaches not only enable real-time in vivo monitoring of microbial dynamics but also hold substantial promise for biomarker detection. Finally, we discuss the pivotal challenges confronting their clinical translation, aiming to provide a valuable reference for advancing precision medicine, personalized health monitoring, and microbiome research.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"1-17"},"PeriodicalIF":7.0,"publicationDate":"2026-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148419462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mobilization of the ancient resistome from thawing permafrost. 从融化的永久冻土中动员古代抵抗体。

IF 7 2区生物学

Critical Reviews in Microbiology Pub Date : 2026-07-09 DOI: 10.1080/1040841X.2026.2698958

Maliha Rehman, Wasim Sajjad, Shichang Kang, Muhammad Rafiq, Yujiao Zhao

{"title":"Mobilization of the ancient resistome from thawing permafrost.","authors":"Maliha Rehman, Wasim Sajjad, Shichang Kang, Muhammad Rafiq, Yujiao Zhao","doi":"10.1080/1040841X.2026.2698958","DOIUrl":"https://doi.org/10.1080/1040841X.2026.2698958","url":null,"abstract":"Permafrost, ground frozen for at least two consecutive years, covers nearly one-quarter of the Northern Hemisphere and hosts diverse microbial communities. Climate-driven thaw is releasing preserved microorganisms and genetic material into contemporary ecosystems, where ancient genetic elements may be reintroduced into modern microbes and participate in gene exchange processes. Among these, antibiotic resistance genes (ARGs), which confer resistance to antibiotics, represent a critical yet underrecognized threat. Many originate from ancient microbial ecosystems shaped by natural antibiotic production and resistance, encode mechanisms not yet observed in clinical settings, and are associated with mobile genetic elements (MGEs) that facilitate horizontal gene transfer across microbial domains. Here, we synthesize evolutionary, molecular, and ecological perspectives on the preservation, release, and mobilization of permafrost-derived ARGs. We highlight mineral-DNA interactions that enhance the long-term stability of extracellular DNA containing ARGs and review the roles of MGEs in redistributing resistance determinants following thaw. We discuss conceptual models of rare cross-domain gene transfer and consider ecological and evolutionary implications under thawing conditions. ARG release from permafrost represents a neglected environmental factor that may contribute to antimicrobial resistance (AMR) dynamics and warrants investigation. Finally, identify key knowledge gaps and propose interdisciplinary frameworks for surveillance, risk assessment, and mitigation.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"1-21"},"PeriodicalIF":7.0,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148410567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elucidating the multifaceted antibacterial mechanisms of luteolin: insights, challenges, and prospects for clinical translation. 阐明木犀草素的多方面抗菌机制：见解、挑战和临床转化的前景。

IF 5.1 2区生物学

Critical Reviews in Microbiology Pub Date : 2026-05-01 Epub Date: 2025-11-24 DOI: 10.1080/1040841X.2025.2584072

Kushagra Khanna, Mogana Rajagopal, Pankaj Kumar, Ravishankar Ram Mani, K Oganeswary Kobi, Fariha Shagufta, Retno Wahyuningrum

{"title":"Elucidating the multifaceted antibacterial mechanisms of luteolin: insights, challenges, and prospects for clinical translation.","authors":"Kushagra Khanna, Mogana Rajagopal, Pankaj Kumar, Ravishankar Ram Mani, K Oganeswary Kobi, Fariha Shagufta, Retno Wahyuningrum","doi":"10.1080/1040841X.2025.2584072","DOIUrl":"10.1080/1040841X.2025.2584072","url":null,"abstract":"Novel antibacterial agents are critically needed in light of the constant menace posed by bacterial infections and subsequent emergence of antibiotic-resistant strains. Quality of life has been improved remarkably through antibiotics that have fought microbial pathogens. . Luteolin has shown effectiveness against both gram-positive and gram negative bacteria. Luteolin and its derivatives, as novel phytochemical antimicrobial agents, exhibit activity against both Gram-positive and Gram-negative bacteria . Luteolin target bacteria by disrupting their cell membranes, inhibiting nucleic acid synthesis, and interfering with key enzymes. It also blocks quorum sensing and biofilm formation, crucial for bacterial virulence and resistance. Luteolin, despite its therapeutic potential, has limited clinical use due to poor water solubility and low bioavailability, leading to reduced absorption and rapid metabolism in the body. To address these issues, researchers are exploring advanced formulations like nanoparticles and liposomes to improve its solubility and effectiveness. Recent formulation advancements aim to enhance luteolin's delivery and efficacy as an antibacterial agent. However, in-depth in vivo studies are essential to unlock its full therapeutic potential for clinical use. This review highlights luteolin's antibacterial capabilities, usage challenges, and recent progress, stressing the importance of further research to fully leverage its benefits.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"464-482"},"PeriodicalIF":5.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145586344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insight into the multifactorial effect of climate change on marine bacteria: resilience mechanisms and mitigation strategies. 深入了解气候变化对海洋细菌的多因素影响：复原机制和减缓战略。

IF 5.1 2区生物学

Critical Reviews in Microbiology Pub Date : 2026-05-01 Epub Date: 2025-11-24 DOI: 10.1080/1040841X.2025.2591753

Sonalin Rath, Sourav Kumar Panda, Surajit Das

{"title":"Insight into the multifactorial effect of climate change on marine bacteria: resilience mechanisms and mitigation strategies.","authors":"Sonalin Rath, Sourav Kumar Panda, Surajit Das","doi":"10.1080/1040841X.2025.2591753","DOIUrl":"10.1080/1040841X.2025.2591753","url":null,"abstract":"Industrialization marked a significant turning point that impacted the global climate at an unprecedented scale. Oceans, covering 71% of the surface of Earth, play a pivotal role in regulating climate change factors, serving as essential components of planetary processes. In these oceanic ecosystems, marine bacteria are intricately involved in regulating various biogeochemical cycles that are crucial to climate regulation and ecosystem functioning. However, the ongoing climatic changes pose significant challenges to marine bacteria and their associated processes. In the Anthropocene epoch, the interaction between anthropogenic pollutants and climatic stressors further amplifies their impact on marine bacteria across diverse ecological niches and their resilience mechanisms. It delves into the interactive effects of anthropogenic pollutants with climatic stressors on bacteria, particularly emphasizing on organic pollutants, heavy metals, and microplastics. The review entails the impact and resilience mechanisms of marine bacteria in response to climatic stressors. The current trajectory of climatic changes highlights the urgent need for concerted global action to mitigate greenhouse gas emissions and adapt to the inevitable impacts of climate change. In this context, various strategies employing marine bacteria in mitigating climate change for a sustainable future have also been discussed.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"518-553"},"PeriodicalIF":5.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145586350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The therapeutic potential of phage-based antifungal treatment: strategies, mechanisms, and prospects. 基于噬菌体的抗真菌治疗的治疗潜力：策略、机制和前景。

IF 5.1 2区生物学

Critical Reviews in Microbiology Pub Date : 2026-05-01 Epub Date: 2025-10-15 DOI: 10.1080/1040841X.2025.2572805

Haowen Xiao, Jiayue Xie, Zhiping Luo, Xiaomin Yu, Jumei Zeng, Yuqing Li

{"title":"The therapeutic potential of phage-based antifungal treatment: strategies, mechanisms, and prospects.","authors":"Haowen Xiao, Jiayue Xie, Zhiping Luo, Xiaomin Yu, Jumei Zeng, Yuqing Li","doi":"10.1080/1040841X.2025.2572805","DOIUrl":"10.1080/1040841X.2025.2572805","url":null,"abstract":"Human fungal infections are increasingly being recognized as a significant global health threat. The burden of fungal diseases is escalating, primarily due to the rising number of at-risk individuals, compounded by the limited availability of antifungal therapies that are both effective and minimally toxic. Phages, viruses that specifically infect and kill bacteria, have long been investigated for their therapeutic potential. However, despite their success in bacteriology, the applications of phages in antifungal therapy are under active research. Particularly, phages could be used to treat fungal infections by engineering them to express fungal antigens on their surfaces, and this would trigger specific immune responses, such as activating Th1 and Th17 responses or inducing the production of neutralizing antibodies. Phages could also be combined with photodynamic inactivation (PDI) or antimicrobials to enhance treatment efficiency. Meanwhile, phages can exert direct antifungal effects by depleting iron, a crucial nutrient for fungal growth. This paper provides a comprehensive review of the phage-based antifungal treatment.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"433-451"},"PeriodicalIF":5.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145291416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chitin and its derivatives as potential candidates to reduce intestinal colonization of Crohn's disease-associated adherent and invasive E. coli. 几丁质及其衍生物作为减少克罗恩病相关粘附性和侵袭性大肠杆菌肠道定植的潜在候选者。

IF 7 2区生物学

Critical Reviews in Microbiology Pub Date : 2026-05-01 Epub Date: 2026-01-09 DOI: 10.1080/1040841X.2025.2605544

Margot Fargeas, Devon Kavanaugh, Anthony Buisson

{"title":"Chitin and its derivatives as potential candidates to reduce intestinal colonization of Crohn's disease-associated adherent and invasive E. coli.","authors":"Margot Fargeas, Devon Kavanaugh, Anthony Buisson","doi":"10.1080/1040841X.2025.2605544","DOIUrl":"10.1080/1040841X.2025.2605544","url":null,"abstract":"Crohn's disease (CD) is a chronic inflammatory bowel disease becoming a major issue for healthcare systems in most parts of the world. While the causes of the disease are still not fully understood, the role of the microbiota has been widely demonstrated including the colonization by a particular pathovar of Escherichia coli, defined as adherent and invasive E. coli (AIEC), able to adhere to, and invade the intestinal epithelium, as well as to survive within macrophages. As the involvement of AIEC within CD pathophysiology is highly suspected, developing new strategies to limit AIEC colonization is a promising area of research. In this context, chitin and its derivatives, such as chitosan and chito-oligosaccharides (COS), possessing immunomodulatory and antimicrobial properties, could be promising candidates. This review provides a structural overview of chitin and its derivatives and summarizes the existing literature in the context of the potential beneficial effects of chitinous elements in CD and CD-like models, their capability to restrict AIEC colonization via multiple mechanisms, such as of reducing AIEC growth, countering biofilm formation, blocking bacterial adhesion, or stimulating the innate immune response. Lastly, we will explore strategies based on chitin-supplemented diet as therapeutic strategy in patients with CD.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"599-610"},"PeriodicalIF":7.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145942755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0