Critical Reviews in Microbiology最新文献_第5页

Mycobacterium avium biofilms: mechanism of production, composition, and its role in pathogenesis and drug resistance. 禽分枝杆菌生物膜：产生机制、组成及其在发病和耐药中的作用。

IF 7 2区生物学

Critical Reviews in Microbiology Pub Date : 2026-05-01 Epub Date: 2025-10-31 DOI: 10.1080/1040841X.2025.2580269

William R McManus, Katie Mulvey, Jeffrey S Schorey

{"title":"Mycobacterium avium biofilms: mechanism of production, composition, and its role in pathogenesis and drug resistance.","authors":"William R McManus, Katie Mulvey, Jeffrey S Schorey","doi":"10.1080/1040841X.2025.2580269","DOIUrl":"10.1080/1040841X.2025.2580269","url":null,"abstract":"The genus Mycobacterium contains over 180 species, and new species are added frequently. Among these are several obligate pathogens, namely Mycobacterium leprae and the species of the Mycobacterium tuberculosis complex; however, the vast majority are environmental bacteria that occupy numerous habitats and are collectively referred to as nontuberculous mycobacteria (NTM). Most NTM are harmless to humans, but the ability of some species to cause infections in people has been increasingly recognized over the past several decades. Mycobacterium avium subs. hominissuis has emerged as one of the most common opportunistic pathogens, usually causing pulmonary infections in susceptible people following environmental exposure. Mycobacterium avium's ability to form biofilms is key to its survival in environments that place it in close proximity to susceptible populations. Their capacity to form biofilms in vivo may also be an important aspect of their pathogenesis and known antibiotic resistance. In this review, we discuss the pathogenesis of this important mycobacterial species, what we know of its ability to form biofilms in vitro and in vivo, and gaps in our knowledge of these processes. We also discuss how we may leverage our understanding of molecules involved in biofilm formation and biofilm matrix composition to develop new therapeutics targeting biofilm formation.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"452-463"},"PeriodicalIF":7.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13265058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145421218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanobiotics to tackle efflux-mediated resistance in bacterial pathogens. 纳米生物制剂用于解决细菌病原体外排介导的耐药性。

IF 5.1 2区生物学

Critical Reviews in Microbiology Pub Date : 2026-05-01 Epub Date: 2025-12-03 DOI: 10.1080/1040841X.2025.2597220

Barani Devi Thillai, Sudarshan Kini, Vijaya Kumar Deekshit

{"title":"Nanobiotics to tackle efflux-mediated resistance in bacterial pathogens.","authors":"Barani Devi Thillai, Sudarshan Kini, Vijaya Kumar Deekshit","doi":"10.1080/1040841X.2025.2597220","DOIUrl":"10.1080/1040841X.2025.2597220","url":null,"abstract":"Efflux-mediated resistance is a critical mechanism by which bacterial pathogens evade antibiotic treatment, posing significant challenges to effective infection management. As the first line of defence mechanism in bacteria, efflux pumps actively expel antibiotics, contributing to multidrug resistance. Recent advances in nanotechnology offer promising solutions, with nanobiotics emerging as a novel approach to combating efflux-mediated resistance. Nanobiotics are engineered nanoscale materials with antibacterial properties. They can be designed to inhibit efflux pump function, enhance drug accumulation, and disrupt bacterial cell membranes, thereby overcoming traditional resistance mechanisms. Nanobiotics can easily fuze with the bacterial cell wall and facilitate the release of antibiotics into the cytoplasm. This review provides an overview of efflux-mediated resistance mechanisms, highlights recent nanotechnology developments to design and formulate nanobiotics, and examines their potential to inhibit efflux pumps in multidrug-resistant bacterial strains. By targeting efflux systems, nanobiotics offer a potent and innovative approach to restoring the efficacy of conventional antibiotics and advancing the treatment of multidrug-resistant bacterial infections.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"554-576"},"PeriodicalIF":5.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145667691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolomics in influenza viral infection: insights into host-virus interactions and potential biomarkers of severe outcomes. 流感病毒感染的代谢组学：对宿主-病毒相互作用和严重后果的潜在生物标志物的见解

IF 5.1 2区生物学

Critical Reviews in Microbiology Pub Date : 2026-05-01 Epub Date: 2026-01-04 DOI: 10.1080/1040841X.2025.2601028

Chen Liu, Qingyun Ma, Yong Yang, Rong Rong

{"title":"Metabolomics in influenza viral infection: insights into host-virus interactions and potential biomarkers of severe outcomes.","authors":"Chen Liu, Qingyun Ma, Yong Yang, Rong Rong","doi":"10.1080/1040841X.2025.2601028","DOIUrl":"10.1080/1040841X.2025.2601028","url":null,"abstract":"Influenza viruses are highly contagious respiratory pathogens that cause seasonal outbreaks, leading to millions of infections and a significant number of deaths worldwide. To support rapid replication and transmission, influenza viruses hijack the host's metabolic pathways, including those involved in carbohydrate, amino acid, and lipid metabolism. Through this metabolic reprogramming, the virus leverages the host's metabolic resources to produce viral components and create specialized compartments necessary for replication and dissemination. In response, host cells activate a range of metabolic defense mechanisms to detect and counteract the virus-induced metabolic changes, resulting in a dynamic interplay that profoundly impacts the outcome of the infection. Advances in metabolomics have provided valuable insights into these complex host-virus interactions, identifying key metabolic biomarkers with potential for early diagnosis, real-time disease monitoring, and therapeutic response evaluation, especially in the early detection and management of severe influenza infections. In the future, these metabolic biomarkers could drive the development of new strategies for influenza prevention and treatment, providing a scientific foundation for precision medicine.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"577-598"},"PeriodicalIF":5.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145899323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Revisiting the antimicrobial potential of metalloporphyrins: from food to pharma. 重新审视金属卟啉的抗菌潜力：从食品到制药。

IF 5.1 2区生物学

Critical Reviews in Microbiology Pub Date : 2026-05-01 Epub Date: 2025-11-07 DOI: 10.1080/1040841X.2025.2584078

Igori Balta, Marta Žogota, Nicolae Corcionivoschi, Irina Chiorescu, Oleksandr Dobrovolnyi, Stefan Batrina, Ioan Pet, Aurelia Coroian, Andrejs Sitovs, Lavinia Ștef, Valentyn Mohylyuk

{"title":"Revisiting the antimicrobial potential of metalloporphyrins: from food to pharma.","authors":"Igori Balta, Marta Žogota, Nicolae Corcionivoschi, Irina Chiorescu, Oleksandr Dobrovolnyi, Stefan Batrina, Ioan Pet, Aurelia Coroian, Andrejs Sitovs, Lavinia Ștef, Valentyn Mohylyuk","doi":"10.1080/1040841X.2025.2584078","DOIUrl":"10.1080/1040841X.2025.2584078","url":null,"abstract":"Porphyrins, their derivatives, and metal ion complexes - particularly copper-substituted forms such as Cu-Chl, Cu-Chln, and Na-Cu-Chln - are increasingly recognized for their broad-spectrum antimicrobial properties. However, in the context of terminological and trivial confusions in food chemistry and pharmaceuticals, data on the chemical properties and biological activity of porphyrins remains fragmented and lacks comprehensive systematization. This review adopts a cross-disciplinary mapping approach to clarify the chemical structures, nomenclature, antimicrobial properties, and the presented mechanistic insights of porphyrins and their derivatives, highlighting their significance in both the food and pharmaceutical industries. As a result of the mapping systematization, porphyrins have been remarked as current and potential antimicrobial agents, with a specific emphasis on the compounds such as Cu-Chl, Cu-Chln, and Na-Cu-Chln. Copper complexation has been shown to enhance biological activity while maintaining low toxicity profiles. Emphasis is placed on Cu-Chl, Cu-Chln, and Na-Cu-Chln, which demonstrate promising properties and applications in nutraceuticals and therapeutics. Their bactericidal properties, which resulted in combating antibiotic-resistant infection-causative pathogens, are particularly interesting, especially in the era of addressing global challenges such as antibiotic resistance. This conceptual review remarks on the critical gaps in current knowledge and accentuates the need for systematic studies to optimize the clinical and industrial applications of porphyrins.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"500-517"},"PeriodicalIF":5.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145457992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How force drives pathogenicity: mechanoregulation of Streptococcus mutans adhesion to collagen. 力如何驱动致病性：变形链球菌黏附于胶原蛋白的机械调节。

IF 5.1 2区生物学

Critical Reviews in Microbiology Pub Date : 2026-05-01 Epub Date: 2025-11-12 DOI: 10.1080/1040841X.2025.2584074

Carla Inostroza, Pablo Berríos, Ivana Orellana, Jaime Andrés Rivas-Pardo, Sebastian Aguayo

{"title":"How force drives pathogenicity: mechanoregulation of Streptococcus mutans adhesion to collagen.","authors":"Carla Inostroza, Pablo Berríos, Ivana Orellana, Jaime Andrés Rivas-Pardo, Sebastian Aguayo","doi":"10.1080/1040841X.2025.2584074","DOIUrl":"10.1080/1040841X.2025.2584074","url":null,"abstract":"Streptococcus mutans is a caries-associated bacterium with the ability to adhere to the surface of oral tissues and promote biofilm formation. For this purpose, S. mutans expresses a range of specialized surface adhesins, among which collagen-binding proteins (CBPs) have demonstrated an important function regarding attachment to dentin, bacterial coaggregation, and extracellular matrix invasion. Understanding the mechanobiological behavior of CBPs, particularly their interaction with collagens during the process of bacterial adhesion, is crucial for developing novel strategies to prevent biofilm formation in oral and remote tissues. Therefore, this review summarizes recent evidence regarding the main mechanical properties of the relevant S. mutans CBPs SpaP, WapA, Cnm, and Cbm, and how their mechanobiological and adhesive characteristics play an important role in their virulence toward the host. Particularly, we will focus on how state-of-the-art interdisciplinary approaches such as atomic force microscopy (AFM)-based single-molecule force spectroscopy (SMFS) and single-cell force spectroscopy (SCFS) have been employed to characterize S. mutans and CBP attachment to collagen substrates and mechanical behavior in real-time and under physiological conditions. Altogether, the potential use of AFM SMFS and SCFS to explore novel anti-biofilm molecules against S. mutans remains an exciting possibility for the development of caries-preventive treatments in the future.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"483-499"},"PeriodicalIF":5.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145494930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Host-inspired anti-virulence strategies against membrane-targeting bacterial toxins: modification and mimicry. 宿主启发抗膜靶向细菌毒素的毒力策略：修饰和模仿。

IF 5.1 2区生物学

Critical Reviews in Microbiology Pub Date : 2026-05-01 Epub Date: 2025-12-25 DOI: 10.1080/1040841X.2025.2605546

O'Rorke K Smith, Lyn M Wise, Jeremy Simcock, Dhammika Leshan Wannigama, Eduard B Babiychuk, Daniel Pletzer

{"title":"Host-inspired anti-virulence strategies against membrane-targeting bacterial toxins: modification and mimicry.","authors":"O'Rorke K Smith, Lyn M Wise, Jeremy Simcock, Dhammika Leshan Wannigama, Eduard B Babiychuk, Daniel Pletzer","doi":"10.1080/1040841X.2025.2605546","DOIUrl":"10.1080/1040841X.2025.2605546","url":null,"abstract":"Pore-forming toxins (PFTs) are essential virulence factors produced by many bacterial pathogens, enabling tissue invasion, nutrient acquisition, and immune evasion. Neutralizing these toxins offers a promising therapeutic avenue to mitigate infection symptoms and slow disease progression. Recent research highlights the potential of host-inspired strategies targeting toxin-membrane interactions. Statins and oxysterols disrupt intracellular cholesterol synthesis and trafficking to reduce its abundance in cell membranes, mimicking natural cellular defenses against PFTs. Aminosterols alter membrane properties to hinder toxin binding and pore formation. Nanoparticle-based decoys, such as artificial liposomes composed of the lipids cholesterol and sphingomyelin or recycled cell membranes, act as toxin traps, sequestering PFTs to protect host tissues. These nanoparticles demonstrate broad-spectrum efficacy across many bacterial species and offer additional functions, such as scavenging inflammatory cytokines. This review evaluates the clinical potential of these emerging treatment strategies and discusses the advantages of leveraging host factors to mitigate bacterial virulence rather than directly targeting toxins. Such host-inspired approaches represent a novel and complementary addition to the arsenal against antibiotic-resistant bacterial pathogens.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"611-629"},"PeriodicalIF":5.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145827070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding the ambiguity behind Enterococcus as a probiotic ally or a pathogenic adversary. 理解肠球菌作为益生菌盟友或致病对手背后的模糊性。

IF 5.1 2区生物学

Critical Reviews in Microbiology Pub Date : 2026-03-01 Epub Date: 2025-09-18 DOI: 10.1080/1040841X.2025.2562926

Arxel G Elnar, Geun-Bae Kim

{"title":"Understanding the ambiguity behind Enterococcus as a probiotic ally or a pathogenic adversary.","authors":"Arxel G Elnar, Geun-Bae Kim","doi":"10.1080/1040841X.2025.2562926","DOIUrl":"10.1080/1040841X.2025.2562926","url":null,"abstract":"The genus Enterococcus has been extensively investigated, emphasizing either its potential as a probiotic in fermented foods or its opportunistic pathogenic nature, particularly in hospital settings. This review focuses on the defining characteristics of enterococci species to better understand their dual nature, with the goal of establishing a universal method to safely and effectively characterize probiotic enterococci. Despite harboring genes for potentially harmful enzymes and metabolites, enterococci have traditionally been used to improve the flavor profiles of artisanal dairy products. Additionally, certain strains produce antimicrobial compounds, particularly bacteriocins, which help control the microbial composition of food products. These bacteriocins have been extensively explored as alternatives to antibiotics, driven by the rapid increase in antimicrobial resistance across several bacterial species. However, enterococcal isolates of nosocomial origin are harmful. Recent studies have clarified the divergent lineages that resulted in the emergence of pathogenic and nosocomial strains, thus improving the selection process for determining whether an isolate can be utilized as a probiotic. The insights gathered in this review have important implications for developing regulations on and optimizing the use of enterococci.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"350-376"},"PeriodicalIF":5.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond tellurite: the multifunctional roles of genes annotated as tellurium resistance determinants in bacteria. 超越碲：在细菌中作为碲抗性决定因素的基因的多功能作用。

IF 5.1 2区生物学

Critical Reviews in Microbiology Pub Date : 2026-03-01 Epub Date: 2025-09-10 DOI: 10.1080/1040841X.2025.2555936

Linda Darwiche, Jennifer L Goff

{"title":"Beyond tellurite: the multifunctional roles of genes annotated as tellurium resistance determinants in bacteria.","authors":"Linda Darwiche, Jennifer L Goff","doi":"10.1080/1040841X.2025.2555936","DOIUrl":"10.1080/1040841X.2025.2555936","url":null,"abstract":"The metalloid tellurium (Te) is toxic to bacteria; however, the element is also extremely rare. Thus, most bacteria will never encounter Te in their environment. Nonetheless significant research has been performed on bacterial Te resistance because of the medical applications of the element. The so-called \"tellurium resistance (TeR) genes\" were first described on plasmids isolated from clinically relevant Enterobacteriaceae. With time, it has become apparent that, given the rarity of Te on the planet, these genes may have functions beyond tellurium resistance. Nonetheless, the description of these genes as \"tellurium resistance genes\" has persisted. In this review, we first examine the history and discovery of the TeR genes. We then performed an analysis of 184,000 high-quality, prokaryotic (meta)genomes, which revealed that terZABCDF, telA, and tehAB are relatively common in genome annotations and that they are frequently described as \"tellurium resistance genes\". We synthesized the literature to describe the functions of these ubiquitous genes beyond tellurium resistance. These genes have functions in diverse cellular processes including phage resistance, antibiotic resistance, virulence, oxidative stress resistance, cell cycle regulation, metal resistance, and metalation of exoenzymes. Considering this analysis, we propose that it is time to appreciate the multifunctional nature of the \"tellurium resistance genes\".","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"262-282"},"PeriodicalIF":5.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current and emerging therapies for fungal biofilms and systemic infections. 目前和新兴的治疗真菌生物膜和全身性感染。

IF 7 2区生物学

Critical Reviews in Microbiology Pub Date : 2026-03-01 Epub Date: 2025-10-10 DOI: 10.1080/1040841X.2025.2570185

Yehia Elgammal, Rafael I Garcia Martinez, Adrian Requejo, Luis R Martinez

引用次数: 0

Under the lens: using Raman spectroscopy as a unique system in biofilm analyses. 镜头下：利用拉曼光谱作为生物膜分析的独特系统。

IF 5.1 2区生物学

Critical Reviews in Microbiology Pub Date : 2026-03-01 Epub Date: 2025-09-06 DOI: 10.1080/1040841X.2025.2555937

Zainab Bilal, William Tipping, Jason L Brown, Karen Faulds

{"title":"Under the lens: using Raman spectroscopy as a unique system in biofilm analyses.","authors":"Zainab Bilal, William Tipping, Jason L Brown, Karen Faulds","doi":"10.1080/1040841X.2025.2555937","DOIUrl":"10.1080/1040841X.2025.2555937","url":null,"abstract":"Biofilms are microbial communities that adhere to surfaces and each other, encapsulated in a protective extracellular matrix. These structures enhance resistance to antimicrobials, contributing to 65-80% of human infections. The transition from free-living cells to structured biofilms involves a myriad of molecular and structural adaptations. Raman spectroscopy is an analytical technique that has recently been adapted for biofilm analysis. The ability to operate without interference from water makes Raman spectroscopy a valuable tool for in situ characterization of biofilms, including direct analysis from clinical samples. The technique also offers the advantage of imaging speed and the capacity to generate extensive chemical and molecular data from samples, whilst also being non-destructive. However, Raman spectroscopy is often limited by its low sensitivity, particularly when applied to microbial analysis. This limitation has been addressed with the advent of surface-enhanced Raman spectroscopy and stimulated Raman scattering microscopy. When used in combination with traditional methods, these Raman technologies can be incredibly useful for understanding the mechanisms underlying biofilm development, antimicrobial susceptibility testing, and detection and discrimination of microorganisms. In this critical review, the application of Raman spectroscopy and its derivatives as a tool for biofilm characterization is discussed along with its associated advantages and challenges.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":" ","pages":"283-301"},"PeriodicalIF":5.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145005980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0