Critical Reviews in Microbiology最新文献_第5页

Current and novel therapies for management of Acinetobacter baumannii-associated pneumonia. 治疗鲍曼不动杆菌相关肺炎的现有疗法和新型疗法。

IF 6 2区生物学

Critical Reviews in Microbiology Pub Date : 2024-07-01 DOI: 10.1080/1040841X.2024.2369948

Aye Mya Sithu Shein, Parichart Hongsing, O'Rorke Kevin Smith, Phatthranit Phattharapornjaroen, Kazuhiko Miyanaga, Longzhu Cui, Hitoshi Ishikawa, Mohan Amarasiri, Peter N Monk, Anthony Kicic, Tanittha Chatsuwan, Daniel Pletzer, Paul G Higgins, Shuichi Abe, Dhammika Leshan Wannigama

{"title":"Current and novel therapies for management of Acinetobacter baumannii-associated pneumonia.","authors":"Aye Mya Sithu Shein, Parichart Hongsing, O'Rorke Kevin Smith, Phatthranit Phattharapornjaroen, Kazuhiko Miyanaga, Longzhu Cui, Hitoshi Ishikawa, Mohan Amarasiri, Peter N Monk, Anthony Kicic, Tanittha Chatsuwan, Daniel Pletzer, Paul G Higgins, Shuichi Abe, Dhammika Leshan Wannigama","doi":"10.1080/1040841X.2024.2369948","DOIUrl":"https://doi.org/10.1080/1040841X.2024.2369948","url":null,"abstract":"Acinetobacter baumannii is a common pathogen associated with hospital-acquired pneumonia showing increased resistance to carbapenem and colistin antibiotics nowadays. Infections with A. baumannii cause high patient fatalities due to their capability to evade current antimicrobial therapies, emphasizing the urgency of developing viable therapeutics to treat A. baumannii-associated pneumonia. In this review, we explore current and novel therapeutic options for overcoming therapeutic failure when dealing with A. baumannii-associated pneumonia. Among them, antibiotic combination therapy administering several drugs simultaneously or alternately, is one promising approach for optimizing therapeutic success. However, it has been associated with inconsistent and inconclusive therapeutic outcomes across different studies. Therefore, it is critical to undertake additional clinical trials to ascertain the clinical effectiveness of different antibiotic combinations. We also discuss the prospective roles of novel antimicrobial therapies including antimicrobial peptides, bacteriophage-based therapy, repurposed drugs, naturally-occurring compounds, nanoparticle-based therapy, anti-virulence strategies, immunotherapy, photodynamic and sonodynamic therapy, for utilizing them as additional alternative therapy while tackling A. baumannii-associated pneumonia. Importantly, these innovative therapies further require pharmacokinetic and pharmacodynamic evaluation for safety, stability, immunogenicity, toxicity, and tolerability before they can be clinically approved as an alternative rescue therapy for A. baumannii-associated pulmonary infections.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":null,"pages":null},"PeriodicalIF":6.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141466773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fusarium and Neocosmospora: fungal priority pathogens in laboratory diagnosis. 镰刀菌和新孢子菌：实验室诊断中的真菌重点病原体。

IF 6 2区生物学

Critical Reviews in Microbiology Pub Date : 2024-07-01 DOI: 10.1080/1040841X.2024.2369693

Valeri Sáenz, Andrés Felipe Lizcano Salas, Josepa Gené, Adriana Marcela Celis Ramírez

引用次数: 0

Host and bacterial lipid metabolism during tuberculosis infections: possibilities to synergise host- and bacteria-directed therapies. 结核病感染期间宿主和细菌的脂质代谢：协同宿主和细菌导向疗法的可能性。

IF 6 2区生物学

Critical Reviews in Microbiology Pub Date : 2024-06-25 DOI: 10.1080/1040841X.2024.2370979

Teun van der Klugt, Robin H G A van den Biggelaar, Anno Saris

{"title":"Host and bacterial lipid metabolism during tuberculosis infections: possibilities to synergise host- and bacteria-directed therapies.","authors":"Teun van der Klugt, Robin H G A van den Biggelaar, Anno Saris","doi":"10.1080/1040841X.2024.2370979","DOIUrl":"10.1080/1040841X.2024.2370979","url":null,"abstract":"Mycobacterium tuberculosis (Mtb) is the causative pathogen of tuberculosis, the most lethal infectious disease resulting in 1.3 million deaths annually. Treatments against Mtb are increasingly impaired by the growing prevalence of antimicrobial drug resistance, which necessitates the development of new antibiotics or alternative therapeutic approaches. Upon infecting host cells, predominantly macrophages, Mtb becomes critically dependent on lipids as a source of nutrients. Additionally, Mtb produces numerous lipid-based virulence factors that contribute to the pathogen's ability to interfere with the host's immune responses and to create a lipid rich environment for itself. As lipids, lipid metabolism and manipulating host lipid metabolism play an important role for the virulence of Mtb, this review provides a state-of-the-art overview of mycobacterial lipid metabolism and concomitant role of host metabolism and host-pathogen interaction therein. While doing so, we will emphasize unexploited bacteria-directed and host-directed drug targets, and highlight potential synergistic drug combinations that hold promise for the development of new therapeutic interventions.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":null,"pages":null},"PeriodicalIF":6.0,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141445849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Roles of alcohol dehydrogenase 1 in the biological activities of Candida albicans. 醇脱氢酶 1 在白色念珠菌生物活性中的作用。

IF 6 2区生物学

Critical Reviews in Microbiology Pub Date : 2024-06-25 DOI: 10.1080/1040841X.2024.2371510

Ziqi Wang, Qi Zhang, Haoying Zhang, Yuanyuan Lu

{"title":"Roles of alcohol dehydrogenase 1 in the biological activities of Candida albicans.","authors":"Ziqi Wang, Qi Zhang, Haoying Zhang, Yuanyuan Lu","doi":"10.1080/1040841X.2024.2371510","DOIUrl":"https://doi.org/10.1080/1040841X.2024.2371510","url":null,"abstract":"Candida albicans stands as the foremost prevalent human commensal pathogen and a significant contributor to nosocomial fungal infections. In the metabolism of C. albicans, alcohol dehydrogenase 1 (Adh1) is one of the important enzymes that converts acetaldehyde produced by pyruvate decarboxylation into ethanol at the end of glycolysis. Leveraging the foundational processes of alcoholic fermentation, Adh1 plays an active role in multiple biological phenomena, including biofilm formation, interactions between different species, the development of drug resistance, and the potential initiation of gastrointestinal cancer. Additionally, Adh1 within C. albicans has demonstrated associations with regulating the cell cycle, stress responses, and various intracellular states. Furthermore, Adh1 is extracellularly localized on the cell wall surface, where it plays roles in processes such as tissue invasion and host immune responses. Drawing from an analysis of ADH1 gene structure, expression patterns, and fundamental functions, this review elucidates the intricate connections between Adh1 and various biological processes within C. albicans, underscoring its potential implications for the prevention, diagnosis, and treatment of candidiasis.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":null,"pages":null},"PeriodicalIF":6.0,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141445850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic basis of antibiotic resistance in bovine mastitis and its possible implications for human and ecological health. 牛乳腺炎抗生素耐药性的遗传基础及其对人类和生态健康的可能影响。

IF 6 2区生物学

Critical Reviews in Microbiology Pub Date : 2024-06-25 DOI: 10.1080/1040841X.2024.2369140

Wendy Johana Velasco Garcia, Nilton Araripe Dos Santos Neto, Thuanny Borba Rios, Mariana Rocha Maximiano, Camila Maurmann de Souza, Octávio Luiz Franco

{"title":"Genetic basis of antibiotic resistance in bovine mastitis and its possible implications for human and ecological health.","authors":"Wendy Johana Velasco Garcia, Nilton Araripe Dos Santos Neto, Thuanny Borba Rios, Mariana Rocha Maximiano, Camila Maurmann de Souza, Octávio Luiz Franco","doi":"10.1080/1040841X.2024.2369140","DOIUrl":"https://doi.org/10.1080/1040841X.2024.2369140","url":null,"abstract":"Bovine mastitis is a mammary gland inflammation that can occur due to infectious pathogens, Staphylococcus aureus and Escherichia coli, which are, respectively, the most prevalent Gram-positive and Gram-negative bacteria associated with this disease. Currently, antibiotic treatment has become more complicated due to the presence of resistant pathogens. This review, therefore, aims to identify the most common resistance genes reported for these strains in the last four years. During the review, it was noted that blaZ, blaSHV, blaTEM, and blaampC are the most reported genes for S. aureus and E. coli, associated with drug inactivation, mainly β-lactamases. They are characterized by generating bacterial resistance to β-lactam antibiotics, the most common treatment in animal and human bacterial treatments (penicillins and cephalosporins, among others). Genes associated with efflux systems were also present in the two strains and included norA, tetA, tetC, and tetK, which generate resistance to macrolide and tetracycline antibiotics. Additionally, the effects of spreading resistance between animals and humans through direct contact (such as consumption of contaminated milk) or indirect contact (through environmental contamination) has been deeply discussed, emphasizing the importance of having adequate sanitation and antibiotic control and administration protocols.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":null,"pages":null},"PeriodicalIF":6.0,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141449893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapid diagnosis and precision treatment of Helicobacter pylori infection in clinical settings. 在临床环境中快速诊断和精确治疗幽门螺旋杆菌感染。

IF 6 2区生物学

Critical Reviews in Microbiology Pub Date : 2024-06-24 DOI: 10.1080/1040841X.2024.2364194

Zeeshan Umar, Jia-Wei Tang, Barry J Marshall, Alfred Chin Yen Tay, Liang Wang

{"title":"Rapid diagnosis and precision treatment of Helicobacter pylori infection in clinical settings.","authors":"Zeeshan Umar, Jia-Wei Tang, Barry J Marshall, Alfred Chin Yen Tay, Liang Wang","doi":"10.1080/1040841X.2024.2364194","DOIUrl":"https://doi.org/10.1080/1040841X.2024.2364194","url":null,"abstract":"Helicobacter pylori is a gram-negative bacterium that colonizes the stomach of approximately half of the worldwide population, with higher prevalence in densely populated areas like Asia, the Caribbean, Latin America, and Africa. H. pylori infections range from asymptomatic cases to potentially fatal diseases, including peptic ulcers, chronic gastritis, and stomach adenocarcinoma. The management of these conditions has become more difficult due to the rising prevalence of drug-resistant H. pylori infections, which ultimately lead to gastric cancer and mucosa-associated lymphoid tissue (MALT) lymphoma. In 1994, the International Agency for Research on Cancer (IARC) categorized H. pylori as a Group I carcinogen, contributing to approximately 780,000 cancer cases annually. Antibiotic resistance against drugs used to treat H. pylori infections ranges between 15% and 50% worldwide, with Asian countries having exceptionally high rates. This review systematically examines the impacts of H. pylori infection, the increasing prevalence of antibiotic resistance, and the urgent need for accurate diagnosis and precision treatment. The present status of precision treatment strategies and prospective approaches for eradicating infections caused by antibiotic-resistant H. pylori will also be evaluated.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":null,"pages":null},"PeriodicalIF":6.0,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141442264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identifying the panorama of potential pandemic pathogens and their key characteristics: a systematic scoping review. 确定潜在大流行病病原体的全貌及其主要特征：系统性范围审查。

IF 6 2区生物学

Critical Reviews in Microbiology Pub Date : 2024-06-20 DOI: 10.1080/1040841X.2024.2360407

Yara Khachab, Antoine Saab, Christo El Morr, Yahya El-Lahib, Elie Salem Sokhn

{"title":"Identifying the panorama of potential pandemic pathogens and their key characteristics: a systematic scoping review.","authors":"Yara Khachab, Antoine Saab, Christo El Morr, Yahya El-Lahib, Elie Salem Sokhn","doi":"10.1080/1040841X.2024.2360407","DOIUrl":"https://doi.org/10.1080/1040841X.2024.2360407","url":null,"abstract":"The globe has recently seen several terrifying pandemics and outbreaks, underlining the ongoing danger presented by infectious microorganisms. This literature review aims to explore the wide range of infections that have the potential to lead to pandemics in the present and the future and pave the way to the conception of epidemic early warning systems. A systematic review was carried out to identify and compile data on infectious agents known to cause pandemics and those that pose future concerns. One hundred and fifteen articles were included in the review. They provided insights on 25 pathogens that could start or contribute to creating pandemic situations. Diagnostic procedures, clinical symptoms, and infection transmission routes were analyzed for each of these pathogens. Each infectious agent's potential is discussed, shedding light on the crucial aspects that render them potential threats to the future. This literature review provides insights for policymakers, healthcare professionals, and researchers in their quest to identify potential pandemic pathogens, and in their efforts to enhance pandemic preparedness through building early warning systems for continuous epidemiological monitoring.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":null,"pages":null},"PeriodicalIF":6.0,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141431632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ureaplasma infections: update on epidemiology, antimicrobial resistance, and pathogenesis. 解脲脲原体感染：流行病学、抗菌药耐药性和致病机理的最新进展。

IF 6.5 2区生物学

Critical Reviews in Microbiology Pub Date : 2024-05-24 DOI: 10.1080/1040841X.2024.2349556

Wenwen Liu, Ting Yang, Yingying Kong, Xinyou Xie, Zhi Ruan

{"title":"Ureaplasma infections: update on epidemiology, antimicrobial resistance, and pathogenesis.","authors":"Wenwen Liu, Ting Yang, Yingying Kong, Xinyou Xie, Zhi Ruan","doi":"10.1080/1040841X.2024.2349556","DOIUrl":"https://doi.org/10.1080/1040841X.2024.2349556","url":null,"abstract":"Human Ureaplasma species are being increasingly recognized as opportunistic pathogens in human genitourinary tract infections, infertility, adverse pregnancy, neonatal morbidities, and other adult invasive infections. Although some general reviews have focused on the detection and clinical manifestations of Ureaplasma spp., the molecular epidemiology, antimicrobial resistance, and pathogenesis of Ureaplasma spp. have not been adequately explained. The purpose of this review is to offer valuable insights into the current understanding and future research perspectives of the molecular epidemiology, antimicrobial resistance, and pathogenesis of human Ureaplasma infections. This review summarizes the conventional culture and detection methods and the latest molecular identification technologies for Ureaplasma spp. We also reviewed the global prevalence and mechanisms of antibiotic resistance for Ureaplasma spp. Aside from regular antibiotics, novel antibiotics with outstanding in vitro antimicrobial activity against Ureaplasma spp. are described. Furthermore, we discussed the pathogenic mechanisms of Ureaplasma spp., including adhesion, proinflammatory effects, cytotoxicity, and immune escape effects, from the perspectives of pathology, related molecules, and genetics.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":null,"pages":null},"PeriodicalIF":6.5,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141093023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sensitive delivery systems and novel encapsulation technologies for live biotherapeutic products and probiotics. 用于活生物治疗产品和益生菌的敏感输送系统和新型封装技术。

IF 6 2区生物学

Critical Reviews in Microbiology Pub Date : 2024-05-01 Epub Date: 2023-04-19 DOI: 10.1080/1040841X.2023.2202237

Shuang Li, Yi-Xuan Zhang

{"title":"Sensitive delivery systems and novel encapsulation technologies for live biotherapeutic products and probiotics.","authors":"Shuang Li, Yi-Xuan Zhang","doi":"10.1080/1040841X.2023.2202237","DOIUrl":"10.1080/1040841X.2023.2202237","url":null,"abstract":"Live biotherapeutic product (LBP), a type of biological product, holds promise for the prevention or treatment of metabolic disease and pathogenic infection. Probiotics are live microorganisms that improve the intestinal microbial balance and beneficially affect the health of the host when ingested in sufficient numbers. These biological products possess the advantages of inhibition of pathogens, degradation of toxins, and modulation of immunity. The application of LBP and probiotic delivery systems has attracted great interest to researchers. The initial used technologies for LBP and probiotic encapsulation are traditional capsules and microcapsules. However, the stability and targeted delivery capability require further improved. The specific sensitive materials can greatly improve the delivery efficiency of LBPs and probiotics. The specific sensitive delivery systems show advantages over traditional ones due to their better properties of biocompatibility, biodegradability, innocuousness, and stability. Moreover, some new technologies, including layer-by-layer encapsulation, polyelectrolyte complexation, and electrohydrodynamic technology, show great potential in LBP and probiotic delivery. In this review, novel delivery systems and new technologies of LBPs and probiotics were presented, and the challenges and prospects were explored in specific sensitive materials for LBP and probiotic delivery.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":null,"pages":null},"PeriodicalIF":6.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9737906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-Term effects of COVID-19: a review of current perspectives and mechanistic insights. COVID-19 的长期效应：当前观点和机理见解综述。

IF 6 2区生物学

Critical Reviews in Microbiology Pub Date : 2024-05-01 Epub Date: 2023-04-19 DOI: 10.1080/1040841X.2023.2190405

Christian Lenz, Mary P E Slack, Kimberly M Shea, Ralf René Reinert, Bülent N Taysi, David L Swerdlow

{"title":"Long-Term effects of COVID-19: a review of current perspectives and mechanistic insights.","authors":"Christian Lenz, Mary P E Slack, Kimberly M Shea, Ralf René Reinert, Bülent N Taysi, David L Swerdlow","doi":"10.1080/1040841X.2023.2190405","DOIUrl":"10.1080/1040841X.2023.2190405","url":null,"abstract":"Although SARS-CoV-2, responsible for COVID-19, is primarily a respiratory infection, a broad spectrum of cardiac, pulmonary, neurologic, and metabolic complications can occur. More than 50 long-term symptoms of COVID-19 have been described, and as many as 80% of patients may develop ≥1 long-term symptom. To summarize current perspectives of long-term sequelae of COVID-19, we conducted a PubMed search describing the long-term cardiovascular, pulmonary, gastrointestinal, and neurologic effects post-SARS-CoV-2 infection and mechanistic insights and risk factors for the above-mentioned sequelae. Emerging risk factors of long-term sequelae include older age (≥65 years), female sex, Black or Asian race, Hispanic ethnicity, and presence of comorbidities. There is an urgent need to better understand ongoing effects of COVID-19. Prospective studies evaluating long-term effects of COVID-19 in all body systems and patient groups will facilitate appropriate management and assess burden of care. Clinicians should ensure patients are followed up and managed appropriately, especially those in at-risk groups. Healthcare systems worldwide need to develop approaches to follow-up and support patients recovering from COVID-19. Surveillance programs can enhance prevention and treatment efforts for those most vulnerable.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":null,"pages":null},"PeriodicalIF":6.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9440741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0