Critical Reviews in Microbiology最新文献_第6页

Antimicrobial peptides as promising antibiotic adjuvants to combat drug-resistant pathogens. 抗菌肽作为抗生素佐剂，有望对抗耐药性病原体。

IF 6 2区生物学

Critical Reviews in Microbiology Pub Date : 2024-05-01 Epub Date: 2023-03-08 DOI: 10.1080/1040841X.2023.2186215

Chen Chen, Jingru Shi, Dejuan Wang, Pan Kong, Zhiqiang Wang, Yuan Liu

{"title":"Antimicrobial peptides as promising antibiotic adjuvants to combat drug-resistant pathogens.","authors":"Chen Chen, Jingru Shi, Dejuan Wang, Pan Kong, Zhiqiang Wang, Yuan Liu","doi":"10.1080/1040841X.2023.2186215","DOIUrl":"10.1080/1040841X.2023.2186215","url":null,"abstract":"The widespread antimicrobial resistance (AMR) calls for the development of new antimicrobial strategies. Antibiotic adjuvant rescues antibiotic activity and increases the life span of the antibiotics, representing a more productive, timely, and cost-effective strategy in fighting drug-resistant pathogens. Antimicrobial peptides (AMPs) from synthetic and natural sources are considered new-generation antibacterial agents. Besides their direct antimicrobial activity, growing evidence shows that some AMPs effectively enhance the activity of conventional antibiotics. The combinations of AMPs and antibiotics display an improved therapeutic effect on antibiotic-resistant bacterial infections and minimize the emergence of resistance. In this review, we discuss the value of AMPs in the age of resistance, including modes of action, limiting evolutionary resistance, and their designing strategies. We summarise the recent advances in combining AMPs and antibiotics against antibiotic-resistant pathogens, as well as their synergistic mechanisms. Lastly, we highlight the challenges and opportunities associated with the use of AMPs as potential antibiotic adjuvants. This will shed new light on the deployment of synergistic combinations to address the AMR crisis.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":null,"pages":null},"PeriodicalIF":6.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9075998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineered probiotics as live biotherapeutics for diagnosis and treatment of human diseases. 将工程益生菌作为诊断和治疗人类疾病的活生物疗法。

IF 6 2区生物学

Critical Reviews in Microbiology Pub Date : 2024-05-01 Epub Date: 2023-03-22 DOI: 10.1080/1040841X.2023.2190392

Jiao Meng, Shufan Liu, Xin Wu

{"title":"Engineered probiotics as live biotherapeutics for diagnosis and treatment of human diseases.","authors":"Jiao Meng, Shufan Liu, Xin Wu","doi":"10.1080/1040841X.2023.2190392","DOIUrl":"10.1080/1040841X.2023.2190392","url":null,"abstract":"The use of probiotics to regulate the intestinal microbiota to prevent and treat a large number of disorders and diseases has been an international research hotspot. Although conventional probiotics have a certain regulatory role in nutrient metabolism, inhibiting pathogens, inducing immune regulation, and maintaining intestinal epithelial barrier function, they are unable to treat certain diseases. In recent years, aided by the continuous development of synthetic biology, engineering probiotics with desired characteristics and functionalities to benefit human health has made significant progress. In this article, we summarise the mechanism of action of conventional probiotics and their limitations and highlight the latest developments in the design and construction of probiotics as living diagnostics and therapeutics for the detection and treatment of a series of diseases, including pathogen infections, cancer, intestinal inflammation, metabolic disorders, vaccine delivery, cognitive health, and fatty liver. Besides we discuss the concerns regarding engineered probiotics and corresponding countermeasures and outline the desired features in the future development of engineered live biotherapeutics.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":null,"pages":null},"PeriodicalIF":6.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9164115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibiotic resistance in the microbiota of periodontitis patients: an update of current findings. 牙周炎患者微生物群的抗生素耐药性：最新研究结果。

IF 6 2区生物学

Critical Reviews in Microbiology Pub Date : 2024-05-01 Epub Date: 2023-05-04 DOI: 10.1080/1040841X.2023.2197481

Ethan Ng, John Rong Hao Tay, Sean Kuan Boey, Marja L Laine, Sašo Ivanovski, Chaminda Jayampath Seneviratne

{"title":"Antibiotic resistance in the microbiota of periodontitis patients: an update of current findings.","authors":"Ethan Ng, John Rong Hao Tay, Sean Kuan Boey, Marja L Laine, Sašo Ivanovski, Chaminda Jayampath Seneviratne","doi":"10.1080/1040841X.2023.2197481","DOIUrl":"10.1080/1040841X.2023.2197481","url":null,"abstract":"Systemic antibiotics are an effective adjunct in the treatment of periodontitis, but their judicious use is necessary as antimicrobial resistance is a growing global concern. This review aims to explore the current understanding and insight related to antibiotic resistance in the subgingival microbiota of periodontitis patients. A search of MEDLINE (PubMed) was carried out from 1 January 2012 to 25 November 2021 for studies related to antibiotic resistance in periodontitis patients. Of the 90 articles identified, 12 studies were selected for inclusion. A significant incidence of antibiotic resistant isolates was reported for Porphyromonas gingivalis, Prevotella intermedia, Prevotella denticola, Prevotella melaninogenica, Fusobacterium nucleatum, Tanerella forsythia, Aggretibacter actinomycetemcomitans, Streptococcus constellatus, Streptococcus intermedius, and Parvimonas micra, but resistance to specific antibiotics did not reach above 10% of isolates in most studies except for amoxicillin resistance in Aggretibacter actinomycetemcomitans. The highest frequency of resistance across all bacterial species was for amoxicillin, clindamycin, and metronidazole. However, resistance patterns were widely variable across geographical locations, and the high heterogeneity between antibiotic-resistant isolates across studies precludes any clinical recommendations from this study. Although antibiotic resistance has yet to reach critical levels in periodontitis patients, an emphasis on antibiotic stewardship interventions such as point-of-care diagnostics and education for key stakeholders is needed to curb a growing problem.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":null,"pages":null},"PeriodicalIF":6.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9774791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring halophilic environments as a source of new antibiotics. 探索嗜卤环境作为新抗生素来源的可能性。

IF 6 2区生物学

Critical Reviews in Microbiology Pub Date : 2024-05-01 Epub Date: 2023-04-20 DOI: 10.1080/1040841X.2023.2197491

Thomas P Thompson, Brendan F Gilmore

{"title":"Exploring halophilic environments as a source of new antibiotics.","authors":"Thomas P Thompson, Brendan F Gilmore","doi":"10.1080/1040841X.2023.2197491","DOIUrl":"10.1080/1040841X.2023.2197491","url":null,"abstract":"Microbial natural products from microbes in extreme environments, including haloarchaea, and halophilic bacteria, possess a huge capacity to produce novel antibiotics. Additionally, enhanced isolation techniques and improved tools for genomic mining have expanded the efficiencies in the antibiotic discovery process. This review article provides a detailed overview of known antimicrobial compounds produced by halophiles from all three domains of life. We summarize that while halophilic bacteria, in particular actinomycetes, contribute the vast majority of these compounds the importance of understudied halophiles from other domains of life requires additional consideration. Finally, we conclude by discussing upcoming technologies- enhanced isolation and metagenomic screening, as tools that will be required to overcome the barriers to antimicrobial drug discovery. This review highlights the potential of these microbes from extreme environments, and their importance to the wider scientific community, with the hope of provoking discussion and collaborations within halophile biodiscovery. Importantly, we emphasize the importance of bioprospecting from communities of lesser-studied halophilic and halotolerant microorganisms as sources of novel therapeutically relevant chemical diversity to combat the high rediscovery rates. The complexity of halophiles will necessitate a multitude of scientific disciplines to unravel their potential and therefore this review reflects these research communities.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":null,"pages":null},"PeriodicalIF":6.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9390485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of single and mixed biofilms in Clostridioides difficile infection and strategies for prevention and inhibition. 艰难梭菌感染中单一生物膜和混合生物膜的作用以及预防和抑制策略。

IF 6 2区生物学

Critical Reviews in Microbiology Pub Date : 2024-05-01 Epub Date: 2023-03-20 DOI: 10.1080/1040841X.2023.2189950

Saiwei Zhong, Jingpeng Yang, He Huang

{"title":"The role of single and mixed biofilms in Clostridioides difficile infection and strategies for prevention and inhibition.","authors":"Saiwei Zhong, Jingpeng Yang, He Huang","doi":"10.1080/1040841X.2023.2189950","DOIUrl":"10.1080/1040841X.2023.2189950","url":null,"abstract":"Clostridioides difficile infection (CDI) is a serious disease with a high recurrence rate. The single and mixed biofilms formed by C. difficile in the gut contribute to the formation of recurrent CDI (rCDI). In parallel, other gut microbes influence the formation and development of C. difficile biofilms, also known as symbiotic biofilms. Interactions between members within the symbiotic biofilm are associated with the worsening or alleviation of CDI. These interactions include effects on C. difficile adhesion and chemotaxis, modulation of LuxS/AI-2 quorum sensing (QS) system activity, promotion of cross-feeding by microbial metabolites, and regulation of intestinal bile acid and pyruvate levels. In the process of C. difficile biofilms control, inhibition of C. difficile initial biofilm formation and killing of C. difficile vegetative cells and spores are the main targets of action. The role of symbiotic biofilms in CDI suggested that targeting interventions of C. difficile-promoting gut microbes could indirectly inhibit the formation of C. difficile mixed biofilms and improved the ultimate therapeutic effect. In summary, this review outlines the mechanisms of C. difficile biofilm formation and summarises the treatment strategies for such single and mixed biofilms, aiming to provide new ideas for the prevention and treatment of CDI.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":null,"pages":null},"PeriodicalIF":6.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9194139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The development and application of the Environmental Relative Moldiness Index (ERMI). 环境相对霉度指数（ERMI）的开发和应用。

IF 6.5 2区生物学

Critical Reviews in Microbiology Pub Date : 2024-04-23 DOI: 10.1080/1040841X.2024.2344112

S.J. Vesper

{"title":"The development and application of the Environmental Relative Moldiness Index (ERMI).","authors":"S.J. Vesper","doi":"10.1080/1040841X.2024.2344112","DOIUrl":"https://doi.org/10.1080/1040841X.2024.2344112","url":null,"abstract":"The prevalence of asthma in the United States (U.S.) has doubled since 1970, coinciding with the increased use of gypsum-drywall in home construction. Mold growth is promoted when gypsum-drywall gets wet. Since asthma is linked to mold exposures, accurate quantification of mold contamination in homes is critical. Therefore, qPCR assays were created and then used to quantify 36 common molds in dust collected in representative U.S. homes during the first American Health Homes Survey (AHHS). The concentrations of the 36 molds, i.e. 26 water-damage molds (Group 1) and 10 outside molds (Group 2), were used in the formulation of a home's Environmental Relative Moldiness Index (ERMI) value. The ERMI values for each of the AHHS homes were assembled from lowest to highest to create the ERMI scale, which ranges from -10 to 20. Subsequent epidemiological studies consistently demonstrated that higher ERMI values were linked to asthma development, reduced lung capacity or occupant asthma. Reducing mold exposures by remediation or with HEPA filtration resulted in a reduced prevalence of asthma and improvements in respiratory health. The ERMI scale has also been successfully applied in evaluating mold concentrations in schools and large buildings and appears to have applications outside the U.S.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":null,"pages":null},"PeriodicalIF":6.5,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140666875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The link between obesity and the gut microbiota and immune system in early-life. 肥胖与生命早期肠道微生物群和免疫系统之间的联系。

IF 6.5 2区生物学

Critical Reviews in Microbiology Pub Date : 2024-04-23 DOI: 10.1080/1040841X.2024.2342427

Maria Inês Magalhães, M. Azevedo, F. Castro, Maria J. Oliveira, Ângela M Costa, Benedita Sampaio Maia

引用次数: 0

Dynamics of antibiotic resistance genes in plasmids and bacteriophages. 质粒和噬菌体中抗生素抗性基因的动态变化。

IF 6.5 2区生物学

Critical Reviews in Microbiology Pub Date : 2024-04-23 DOI: 10.1080/1040841X.2024.2339262

S. Gomathinayagam, Gothandam Kodiveri Muthukaliannan

{"title":"Dynamics of antibiotic resistance genes in plasmids and bacteriophages.","authors":"S. Gomathinayagam, Gothandam Kodiveri Muthukaliannan","doi":"10.1080/1040841X.2024.2339262","DOIUrl":"https://doi.org/10.1080/1040841X.2024.2339262","url":null,"abstract":"This brief review explores the intricate interplay between bacteriophages and plasmids in the context of antibiotic resistance gene (ARG) dissemination. Originating from studies in the late 1950s, the review traces the evolution of knowledge regarding extrachromosomal factors facilitating horizontal gene transfer and adaptation in bacteria. Analyzing the gene repertoires of plasmids and bacteriophages, the study highlights their contributions to bacterial evolution and adaptation. While plasmids encode essential and accessory genes influencing host characteristics, bacteriophages carry auxiliary metabolic genes (AMGs) that augment host metabolism. The debate on phages carrying ARGs is explored through a critical evaluation of various studies, revealing contrasting findings from researchers. Additionally, the review addresses the interplay between prophages and plasmids, underlining their similarities and divergences. Based on the available literature evidence, we conclude that plasmids generally encode ARGs while bacteriophages typically do not contain ARGs. But extra-chromosomaly present prophages with plasmid characteristics can encode and disseminate ARGs.","PeriodicalId":10736,"journal":{"name":"Critical Reviews in Microbiology","volume":null,"pages":null},"PeriodicalIF":6.5,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140671664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of Epstein-Barr virus in autoimmune and autoinflammatory diseases Epstein-Barr 病毒在自身免疫性疾病和自身炎症性疾病中的作用

IF 6.5 2区生物学

Critical Reviews in Microbiology Pub Date : 2024-04-18 DOI: 10.1080/1040841x.2024.2344114

Abdul Hamid Borghol, Elio R. Bitar, Aya Hanna, Georges Naim, Elias A. Rahal

引用次数: 0

Addressing low-density malaria infections in India and other endemic part of the world—the opportune time? 应对印度和世界其他疟疾流行地区的低密度疟疾感染--时机是否成熟？

IF 6.5 2区生物学

Critical Reviews in Microbiology Pub Date : 2024-04-17 DOI: 10.1080/1040841x.2024.2339267

Loick P. Kojom Foko, Amit Moun, Vineeta Singh

引用次数: 0