The world crisis of terbinafine-resistant trichophyton indotineae until 2024: do we have enough knowledge?

IF 6 2区 生物学 Q1 MICROBIOLOGY
Ali Abdul Hussein S Al-Janabi
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Abstract

Dermatophytoses is a well-known name among dermatologists due to its high prevalence among various ages of humans. It is mainly caused by skin-infecting fungi called dermatophytes. From these dermatophytes, Trichophyton indotineae is a newly virulent species with high prevalence and multidrug properties. It was first described in the Indian subcontinent as a closely genetically related strain to Trichophyton interdigitale and Trichophyton mentagrophytes, and spread quickly worldwide. Terbinafine has been utilized for the treatment of dermatophytosis caused by T. indotineae owing to the development of resistance to azole in many of its strains. Wide use of terbinafine has also induced later the development of terbinafine-resistant strains of T. indotineae. Point mutations in the squalene epoxidase (SQLE) gene, which lead to single or multiple substitutions in amino acid positions in the encoded protein (SQLE), are the main reason for antifungal resistance in T. indotineae. This review aims to determine the background of terbinafine-resistant strains of T. indotineae and where they are currently located.

到2024年,特比萘芬耐药印度毛癣菌的世界危机:我们有足够的知识吗?
皮肤真菌病是皮肤科医生中众所周知的名字,因为它在不同年龄的人类中都有很高的患病率。它主要是由皮肤感染真菌引起的。在这些皮肤真菌中,印朵毛癣菌是一种具有高流行率和多药特性的新毒力种。它首先在印度次大陆被描述为与interdigitale Trichophyton和mentagrophytes Trichophyton有密切遗传关系的菌株,并迅速在世界范围内传播。特比萘芬已被用于治疗由T. inditineae引起的皮肤真菌病,因为它的许多菌株对唑产生耐药性。特比萘芬的广泛使用也导致了后来特比萘芬耐药菌株的发展。角鲨烯环氧化酶(SQLE)基因的点突变导致其编码蛋白(SQLE)的氨基酸位置发生单次或多次突变,是导致indodoineae抗真菌的主要原因。本综述旨在确定特比萘芬耐药菌株的背景和它们目前的位置。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Critical Reviews in Microbiology
Critical Reviews in Microbiology 生物-微生物学
CiteScore
14.70
自引率
0.00%
发文量
99
期刊介绍: Critical Reviews in Microbiology is an international, peer-reviewed journal that publishes comprehensive reviews covering all areas of microbiology relevant to humans and animals, including medical and veterinary microbiology, public health and environmental microbiology. These may include subjects related to microbial molecular biology, immunopathogenicity, physiology, biochemistry, structure, and epidemiology. Of particular interest are reviews covering clinical aspects of bacterial, virological, fungal and parasitic diseases. All reviews must be analytical, comprehensive, and balanced in nature. Editors welcome uninvited submissions, as well as suggested topics for reviews accompanied by an abstract.
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