{"title":"Plasma noradrenaline, age and blood pressure: a population study.","authors":"D H Jones, C A Hamilton, J L Reid","doi":"10.1042/cs055073s","DOIUrl":"https://doi.org/10.1042/cs055073s","url":null,"abstract":"<p><p>1. Mean supine plasma noradrenaline was lower in 12 male laboratory staff (0.24 +/- 0.02 microgram/l) than similarly normotensive out-patients (0.44 +/- 0.07 microgram/l). 2. In 164 non-medical hospital staff, plasma noradrenaline increased with age in white males only. 3. Plasma noradrenaline was significantly higher in women than men. 4. There was no relationship between supine blood pressure and plasma noradrenaline in normotensive or hypertensive subjects.</p>","PeriodicalId":10672,"journal":{"name":"Clinical science and molecular medicine. Supplement","volume":"4 ","pages":"73s-75s"},"PeriodicalIF":0.0,"publicationDate":"1978-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs055073s","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11495626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Relation of plasma noradrenaline to blood pressure, age, sex and sodium balance in patients with stable essential hypertension and in normotensive subjects.","authors":"H M Brecht, W Schoeppe","doi":"10.1042/cs055081s","DOIUrl":"https://doi.org/10.1042/cs055081s","url":null,"abstract":"<p><p>1. Plasma noradrenaline was measured in 125 patients with stable essential hypertension (WHO I-II) and in 107 normotensive control subjects lying and standing. 2. In normotensive subjects and in patients with essential hypertension no sex-related differences of plasma noradrenaline were found between age-matched groups. 3. Plasma noradrenaline was not related to sodium balance indexed by urinary sodium/creatinine ratio. 4. In patients with essential hypertension plasma noradrenaline increases with age. 5. Mean plasma noradrenaline concentrations are significantly higher in patients with essential hypertension compared with age-matched normotensive subjects both lying and standing. 6. In patients with essential hypertension diastolic blood pressure and heart rate correlated significantly with supine plasma noradrenaline concentrations.</p>","PeriodicalId":10672,"journal":{"name":"Clinical science and molecular medicine. Supplement","volume":"4 ","pages":"81s-83s"},"PeriodicalIF":0.0,"publicationDate":"1978-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs055081s","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11495628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C E Grim, M H Weinberger, D P Henry, F C Luft, N S Fineberg
{"title":"Biochemical correlates of the increase in blood pressure with age.","authors":"C E Grim, M H Weinberger, D P Henry, F C Luft, N S Fineberg","doi":"10.1042/cs055377s","DOIUrl":"https://doi.org/10.1042/cs055377s","url":null,"abstract":"<p><p>1. Blood pressure, plasma renin activity, plasma aldosterone, urinary noradrenaline during sleep (UNA-S) and several estimates of sodium intake were determined in 379 normotensive subjects (age 13--70) to investigate the relationship of these variables to blood pressure. 2. Blood pressure was correlated with age, weight, plasma renin activity UNA-S, and estimates of sodium intake. There variables were frequently intercorrelated. 3. Multiple-correlation analysis revealed that after removal of the effects of age, blood pressure was related to weight, plasma renin activity, UNA-S and estimates of sodium intake. 4. However, multiple-regression analysis failed to demonstrate an effect of plasma renin activity, UNA-S, or estimates of sodium intake on blood pressure when the effects of age, weight, race and sex were removed. 5. Careful matching of subjects by age, weight, race and sex in studies of blood pressure and biochemical factors in normal subjects is crucial to proper interpretation of such data.</p>","PeriodicalId":10672,"journal":{"name":"Clinical science and molecular medicine. Supplement","volume":"4 ","pages":"377s-379s"},"PeriodicalIF":0.0,"publicationDate":"1978-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs055377s","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11495798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M W Millar Craig, S Mann, V Balasubramanian, E B Raftery
{"title":"Blood pressure circadian rhythm in essential hypertension.","authors":"M W Millar Craig, S Mann, V Balasubramanian, E B Raftery","doi":"10.1042/cs055391s","DOIUrl":"https://doi.org/10.1042/cs055391s","url":null,"abstract":"<p><p>1. Both systolic and diastolic blood pressure show a well defined circadian variation in ambulatory hypertensive subjects. 2. Blood pressure is highest in the mid-morning (10.00 hours) and lowest during sleep at 03.00 hours. 3. Treatment with oxprenolol (taken during the day) reduces daytime blood pressure but is less effective during the night and early morning.</p>","PeriodicalId":10672,"journal":{"name":"Clinical science and molecular medicine. Supplement","volume":"4 ","pages":"391s-393s"},"PeriodicalIF":0.0,"publicationDate":"1978-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs055391s","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11495802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R Fagard, A Amery, T Reybrouck, P Lijnen, L Billiet
{"title":"Effects of labetalol on systemic and pulmonary haemodynamics at rest and during exercise in hypertensive patients.","authors":"R Fagard, A Amery, T Reybrouck, P Lijnen, L Billiet","doi":"10.1042/cs055279s","DOIUrl":"https://doi.org/10.1042/cs055279s","url":null,"abstract":"<p><p>1. Labetalol was administered to 18 hypertensive patients for an average duration of 2.44 weeks, with an average final daily dose of 1.65 g. 2. Labetalol decreased resting heart rate by 16% and maximal exercise heart rate by 21%; the phenylephrine-induced rise of systolic brachial artery pressure was reduced by 36%. 3. During labetalol brachial artery pressure was lowered by 29/15 mmHg in the recumbent position, by 41/23 mmHg at rest sitting, and by 53/23 mmHg at maximal exercise; total peripheral resistance was not significantly affected at rest recumbent, but was reduced at sitting and at exercise; cardiac output decreased in all conditions. 4. Labetalol reduced mean pulmonary artery and capillary wedge pressures only in the sitting position. Pulmonary vascular resistance remained unchanged. 5. The drug produced significant decreases of plasma renin activity and of plasma aldosterone concentration.</p>","PeriodicalId":10672,"journal":{"name":"Clinical science and molecular medicine. Supplement","volume":"4 ","pages":"279s-281s"},"PeriodicalIF":0.0,"publicationDate":"1978-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs055279s","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11496169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of selective and non-selective beta-adrenoreceptor blockade on calf blood flow in hypertensive patients.","authors":"D L Clement","doi":"10.1042/cs055287s","DOIUrl":"https://doi.org/10.1042/cs055287s","url":null,"abstract":"<p><p>1. Dose-response curves of isoprenaline were constructed in nine hypertensive patients before and after either propranolol or metoprolol. 2. The decrease of diastolic blood pressure and increase of heart rate with isoprenaline were significantly more inhibited by propranolol than by metoprolol. 3. The increase in calf blood flow with isoprenaline was significantly more depressed after propranolol than after metoprolol. 4. The results suggest that the response of the vessels in the limbs to sympathetic stimulation is much less affected after metoprolol than after propranolol.</p>","PeriodicalId":10672,"journal":{"name":"Clinical science and molecular medicine. Supplement","volume":"4 ","pages":"287s-290s"},"PeriodicalIF":0.0,"publicationDate":"1978-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs055287s","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11496170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
W Simon, K Schaz, U Ganten, G Stock, K H Schlör, D Ganten
{"title":"Effects of enkephalins on arterial blood pressure are reduced by propranolol.","authors":"W Simon, K Schaz, U Ganten, G Stock, K H Schlör, D Ganten","doi":"10.1042/cs055237s","DOIUrl":"https://doi.org/10.1042/cs055237s","url":null,"abstract":"<p><p>1. The cardiovascular effects of enkephalins have been tested in normotensive Wistar-Kyoto rats. Methionine-enkephalin and leucine-enkephalin increased blood pressure and heart rate after infusion into the brain ventricles. 2. After intravenous injection, blood pressure was increased by methionine-enkephalin and leucine-enkephalin, but heart rate was increased by methionine-enkephalin only. 3. Propranolol treatment reduced the increases in blood pressure following intraventricular methionine-enkephalin and leucine-enkephalin, while only the methionine-enkephalin-induced increases in heart rate were reduced by propranolol. 4. Heart rate and blood pressure responses after intravenous administration of methionine-enkephalins and leucine-enkephalin were not affected by propranolol. 5. Since opioid peptides occur in the blood and in regions of the brain involved in blood pressure regulation, the demonstrated cardiovascular effects to intraventricular and intravenous enkephalins support a role of these peptides in central and peripheral mechanisms of blood pressure control.</p>","PeriodicalId":10672,"journal":{"name":"Clinical science and molecular medicine. Supplement","volume":"4 ","pages":"237s-241s"},"PeriodicalIF":0.0,"publicationDate":"1978-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs055237s","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11496275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hypertension and brain catecholamine distribution in the Hebrew University Sabra, H and N rats.","authors":"N Zamir, Y Gutman, D Ben-Ishay","doi":"10.1042/cs055105s","DOIUrl":"https://doi.org/10.1042/cs055105s","url":null,"abstract":"<p><p>1. The concentration of catecholamines was measured in several brain areas of the Hewbrew University Sabra rat (SB rat), and in two substrains selected for their respective sensitivity (H) or immunity (N) to hypertension. 2. Hypertension was induced in SB rats by DOCA-salt, renal artery constriction and NaCl 1.7% drinking. The noradrenaline content was consistently elevated in the medulla oblongata of hypertension animals. In other brain areas the rise in noradrenaline varied in the different types of hypertension. 3. Administration of DOCA-salt to H and N rats, while causing marked hypertension in the former, had no effect on noradrenaline in either strain. 4. Untreated, normotensive N rats had in the medulla oblongata, significantly higher concentrations of noradrenaline than did H rats. 5. Differences in brain noradrenaline may explain the inherited susceptibility or resistance to hypertension in H and N rats.</p>","PeriodicalId":10672,"journal":{"name":"Clinical science and molecular medicine. Supplement","volume":"4 ","pages":"105s-107s"},"PeriodicalIF":0.0,"publicationDate":"1978-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs055105s","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11496639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K Poulsen, A H Nielsen, S Lykkegaard, C Malling, J Krøll, J Jensenius
{"title":"Is high-molecular-weight-renin binding of renin to the protease inhibitors and lipoproteins?","authors":"K Poulsen, A H Nielsen, S Lykkegaard, C Malling, J Krøll, J Jensenius","doi":"10.1042/cs055125s","DOIUrl":"https://doi.org/10.1042/cs055125s","url":null,"abstract":"<p><p>1. Two high-molecular-weight forms of renin (molecular weights 800 000 and 70 000) are present in mouse plasma. 2. The 800 000 form could be activated and converted into the fully active 40 000 form, by acid or limited proteolysis. The 70 000 form was activated without change in molecular weight. 3. In addition to its enzymic activity, renin was measured by a direct radioimmunoassay, which revealed that the current acid treatment of plasma did not activate all the renin present. 4. Renin is stored as fully active 40 000 renin, with a specific enzymic reactivity of 0.4 times 10(-3) GU ng(-1), in the submaxillary gland of mice. 5. Pure 125I-labelled 40 000 submaxillary renin did not bind to plasma proteins. However, by changing the tertiary structure of renin, it was bound to some of the plasma protease inhibitors; alpha2-macroglobulin, inter-alpha-trypsin inhibitor and alpha2-antithrombin. It was also bound to alpha1- and beta1-lipoprotein, albumin and an unidentified plasma protein. No binding was seen to more than 50 other studied plasma proteins.</p>","PeriodicalId":10672,"journal":{"name":"Clinical science and molecular medicine. Supplement","volume":"4 ","pages":"125s-128s"},"PeriodicalIF":0.0,"publicationDate":"1978-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs055125s","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11496642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}