Clinical science and molecular medicine. Supplement最新文献

Acid-activated renin responses to hydrochlorothiazide, propranol and indomethacin. 酸激活肾素对氢氯噻嗪、心得安和吲哚美辛的反应。

Clinical science and molecular medicine. Supplement Pub Date : 1978-12-01 DOI: 10.1042/cs055151s

J K McKenzie, E Reisin

{"title":"Acid-activated renin responses to hydrochlorothiazide, propranol and indomethacin.","authors":"J K McKenzie, E Reisin","doi":"10.1042/cs055151s","DOIUrl":"https://doi.org/10.1042/cs055151s","url":null,"abstract":"1. Six essential hypertensive patients (five with low renin) were treated in successive weeks with placebo; hydrochlorothiazide 100 mg (382 micromol)/day; hydrochlorothiazide and 50 mmol of sodium/day diet; hydrochlorothiazide, 50 mmol of sodium diet and propranolol 160 mg (544 micromol)/day; and hydrochlorothiazide, 50 mmol of sodium and indomethacin 100 mg (287 micromol)/day. 2. Although blood pressure remained unchanged and serum potassium fell on diuretic with or without low salt, there was a marked increase of active renin and a lesser increase of inactive renin, resulting in an increased proportion of active to total renin. 3. Propranolol decreased both active and inactive renin, but not significantly. 4. Indomethacin produced a marked suppression of active renin, a smaller reduction in inactive renin, and a reduction of the ratio of active to total renin almost to placebo values. 5. Blood pressure rose to control values on indomethacin despite the fall in renin whereas it fell with propranolol with little change in renin. 6. Serum aldosterone rose with stimulation but remained elevated despite effective renin suppression with indomethacin and continuing reduced serum potassium concentration.","PeriodicalId":10672,"journal":{"name":"Clinical science and molecular medicine. Supplement","volume":"4 ","pages":"151s-153s"},"PeriodicalIF":0.0,"publicationDate":"1978-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs055151s","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11495150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

The compliance of the resistance vessels in skeletal muscle of hypertensive patients. 高血压患者骨骼肌阻力血管的顺应性。

Clinical science and molecular medicine. Supplement Pub Date : 1978-12-01 DOI: 10.1042/cs055037s

O J Hartling, T L Svendsen, P E Nielsen, J Trap-Jensen

引用次数: 1

Muscle-nerve sympathetic activity in man. Relationship to blood pressure in resting normo- and hyper-tensive subjects. 人的肌肉神经交感神经活动。静息正常和高血压受试者与血压的关系。

Clinical science and molecular medicine. Supplement Pub Date : 1978-12-01 DOI: 10.1042/cs055387s

G Sundlöf, B G Wallin

引用次数: 23

Relationship between the hypotensive and renin-stimulating actions of diuretic therapy in hypertensive patients. 高血压患者利尿剂降压与刺激肾素作用的关系。

Clinical science and molecular medicine. Supplement Pub Date : 1978-12-01 DOI: 10.1042/cs055307s

G Leonetti, L Terzoli, C Sala, C Bianchini, L Sernesi, A Zanchetti

{"title":"Relationship between the hypotensive and renin-stimulating actions of diuretic therapy in hypertensive patients.","authors":"G Leonetti, L Terzoli, C Sala, C Bianchini, L Sernesi, A Zanchetti","doi":"10.1042/cs055307s","DOIUrl":"https://doi.org/10.1042/cs055307s","url":null,"abstract":"1. The pressor role of renin stimulated by chronic diuretic therapy has been assessed in 31 patients with essential hypertension by infusing the angiotensin II antagonist, saralasin, immediately before and at the end of 2 weeks' treatment with the diuretic, chlorthalidone. 2. Under diuretic therapy the change in blood pressure caused by saralasin was found to be correlated to plasma renin activity values, in such a way that small pressor responses were again observed in patients whose renin was mildly stimulated by the diuretic, whereas a marked depressor response occurred in patients whose renin was markedly increased. 3. On the other hand, the hypotensive effect of chlorthalidone was correlated to values of plasma renin activity under diuretic therapy in an opposite direction: indeed little or no decrease and sometimes an increase in blood pressure were observed in patients with marked renin activation by diuretic therapy. 4. It is concluded that stimulation of renin release by chronic diuretic therapy can be considered a factor limiting the hypotensive activity of diuretic drugs.","PeriodicalId":10672,"journal":{"name":"Clinical science and molecular medicine. Supplement","volume":"4 ","pages":"307s-309s"},"PeriodicalIF":0.0,"publicationDate":"1978-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs055307s","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11496013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 33

Raised serum lipid concentrations during diuretic treatment of hypertension: a study of predictive indexes. 利尿剂治疗高血压期间血脂浓度升高:预测指标的研究。

Clinical science and molecular medicine. Supplement Pub Date : 1978-12-01 DOI: 10.1042/cs055311s

R P Ames, P Hill

引用次数: 42

Renin--angiotensin system in mild essential hypertension. The functional significance of angiotensin II in untreated and thiazide-treated hypertensive patients. 肾素-血管紧张素系统在轻度原发性高血压中的作用。血管紧张素II在未治疗和噻嗪类药物治疗高血压患者中的功能意义。

Clinical science and molecular medicine. Supplement Pub Date : 1978-12-01 DOI: 10.1042/cs055319s

H Ibsen, A Leth, H Hollnagel, A M Kappelgaard, M D Nielsen, J Giese

引用次数: 11

Central nervous system pressor responses in rats susceptible and resistant to sodium chloride hypertension. 氯化钠高血压易感和抵抗大鼠中枢神经系统升压反应。

Clinical science and molecular medicine. Supplement Pub Date : 1978-12-01 DOI: 10.1042/cs055225s

T Ikeda, L Tobian, J Iwai, P Goossens

引用次数: 46

Purification of human renal renin. 人肾肾素的纯化。

Clinical science and molecular medicine. Supplement Pub Date : 1978-12-01 DOI: 10.1042/cs055117s

E E Slater, R C Cohn, V J Dzau, E Haber

引用次数: 19

Cryoactivation of plasma renin. 血浆肾素的冷冻活化。

Clinical science and molecular medicine. Supplement Pub Date : 1978-12-01 DOI: 10.1042/cs055139s

A Hara, M Matsunaga, J Yamamoto, K Morimoto, H Nagai, K Kanatsu, C H Pak, K Ogino, C Kawai

{"title":"Cryoactivation of plasma renin.","authors":"A Hara, M Matsunaga, J Yamamoto, K Morimoto, H Nagai, K Kanatsu, C H Pak, K Ogino, C Kawai","doi":"10.1042/cs055139s","DOIUrl":"https://doi.org/10.1042/cs055139s","url":null,"abstract":"1. The mechanism of increased renin activity after human plasma had been kept at -5 degrees C for 4 days (cryoactivation) was investigated. 2. The increase in renin activity of human plasma by cryoactivation was closely correlated to the increase obtained by incubation with trypsin (r = 0.88, P less than 0.001, n = 10). 3. An inhibitor of thiol enzyme, N-ethylmaleimide did not inhibit cryoactivation. 4. Soyabean trypsin inhibitor and di-isopropylflurophosphate (DFP) inhibited cryoactivation, suggesting that the cryoactivation may be due to the action of a trypsin-like serine enzyme. 5. In an experiment in the rat haemorrhagic shock caused parallel and cryoactivated plasma, the renin activity being about two times higher in the latter. No significant differences were found in the concentrations of renin and renin substrate between the non-cryoactivated and cryoactivated plasma samples. 6. The results may indicate that a destruction of an inhibitor of the renin-renin substrate reaction is responsible for the increase of renin activity after exposure of rat plasma to low temperature. A trypsin-like enzyme in plasma might have destroyed the inhibitor during this procedure.","PeriodicalId":10672,"journal":{"name":"Clinical science and molecular medicine. Supplement","volume":"4 ","pages":"139s-141s"},"PeriodicalIF":0.0,"publicationDate":"1978-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs055139s","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11496643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

The kinetics of plasma noradrenaline in normal and hypertensive subjects. 正常人和高血压患者血浆去甲肾上腺素的动力学。

Clinical science and molecular medicine. Supplement Pub Date : 1978-12-01 DOI: 10.1042/cs055089s

S Ghione, C Palombo, M Pellegrini, E Fommei, A Pilo, L Donato

引用次数: 31