Clinical science and molecular medicine. Supplement最新文献_第2页

Implications of prostacyclin generation for modulation of vascular tone. 前列环素对血管张力调节的影响。

Clinical science and molecular medicine. Supplement Pub Date : 1978-12-01 DOI: 10.1042/cs055195s

G J Dusting, S Moncada, K M Mullane, J R Vane

引用次数: 19

Enhanced hypothalamic noradrenaline biosynthesis in Goldblatt I renovascular hypertension. Goldblatt型肾血管性高血压患者下丘脑去甲肾上腺素生物合成增强。

Clinical science and molecular medicine. Supplement Pub Date : 1978-12-01 DOI: 10.1042/cs055109s

V Dequattro, I Eide, M R Myers, K Eide, R Kolloch, H Whigham

引用次数: 15

Definitive evidence for renin in rat brain by affinity chromatographic separation from protease. 蛋白酶亲和层析分离肾素在大鼠脑中的明确证据。

Clinical science and molecular medicine. Supplement Pub Date : 1978-12-01 DOI: 10.1042/cs055121s

T Inagami, H Yokosawa, S Hirose

引用次数: 29

The effect of established beta-adrenoreceptor-blocking therapy on the release of cytosolic and lysosomal enzymes after acute myocardial infarction in man. 已建立的β -肾上腺素受体阻断治疗对急性心肌梗死后胞质酶和溶酶体酶释放的影响。

Clinical science and molecular medicine. Supplement Pub Date : 1978-12-01 DOI: 10.1042/cs0550549

E Welman, K M Fox, A P Selwyn, B J Carroll

{"title":"The effect of established beta-adrenoreceptor-blocking therapy on the release of cytosolic and lysosomal enzymes after acute myocardial infarction in man.","authors":"E Welman, K M Fox, A P Selwyn, B J Carroll","doi":"10.1042/cs0550549","DOIUrl":"https://doi.org/10.1042/cs0550549","url":null,"abstract":"1. Serial venous blood samples were obtained from 45 patients with acute myocardial infarction. Ten of these patients were receiving beta-adreno-receptor-blocking drugs at the time of onset of chest pain and continued on these drugs during their stay in the coronary care unit. The activities of creatine kinase and its MB-isoenzyme (CK-MB) were assayed in the plasma. A lysosomal enzyme, beta-N-acetylglucosaminidase, was also assayed. 2. In the 35 untreated patients it was found that creatine kinase activity was maximal at a mean time of 21.3 +/- 1.3 h after the onset of chest pain, whereas in the patients receiving beta-adrenoreceptor-blocking drugs peak activity of the enzyme occurred at 24.4 +/- 0.7 h. 3. Peak CK-MB acitivity was also delayed from 18.1 +/- 1.6 h in the control group to 22.4 +/- 1.2 h in the treated patients. 4. The lysosomal enzyme showed a similar pattern of changes to that of CK-MB. Maximum activity in plasma occurred at 18.0 +/- 1.0 h after the onset of chest pain in the control group of patients. In the treated patients peak lysosomal enzyme activity was not found until 24.2 +/- 1.2 h. 5. These alterations in the time-course of plasma enzyme changes after acute myocardial infarction are consistent with the suggestion that beta-receptor antagonists may delay tissue damage during myocardial ischaemia.","PeriodicalId":10672,"journal":{"name":"Clinical science and molecular medicine. Supplement","volume":"55 6","pages":"549-53"},"PeriodicalIF":0.0,"publicationDate":"1978-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs0550549","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11255663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

The absence of 24,25-dihydroxycholecalciferol in anephric patients. 肾衰患者缺乏24,25-二羟基胆骨化醇。

Clinical science and molecular medicine. Supplement Pub Date : 1978-12-01 DOI: 10.1042/cs0550541

C M Taylor, E B Mawer, J E Wallace, J St John, M Cochran, R G Russell, J A Kanis

引用次数: 47

Plasma noradrenaline and the pressor action of exogenous noradrenaline in normotensive subjects and patients with essential hypertension. 血浆去甲肾上腺素和外源性去甲肾上腺素在正常血压和原发性高血压患者中的降压作用。

Clinical science and molecular medicine. Supplement Pub Date : 1978-12-01 DOI: 10.1042/cs055061s

T Philipp, A Distler, U Cordes, H P Wolff

引用次数: 12

Are racial differences in essential hypertension due to different pathogenetic mechanisms? 原发性高血压的种族差异是由不同的发病机制引起的吗?

Clinical science and molecular medicine. Supplement Pub Date : 1978-12-01 DOI: 10.1042/cs055383s

P S Sever, W S Peart, T W Meade, I B Davies, D Gordon, R D Tunbridge

{"title":"Are racial differences in essential hypertension due to different pathogenetic mechanisms?","authors":"P S Sever, W S Peart, T W Meade, I B Davies, D Gordon, R D Tunbridge","doi":"10.1042/cs055383s","DOIUrl":"https://doi.org/10.1042/cs055383s","url":null,"abstract":"1. Plasma noradrenaline concentration and plasma renin activity were measured in a control, British, urban population (n = 115) in which blacks were matched for age and sex with whites. 2. Similar measurements were made in subjects with essential hypertension (77 white and 23 black), and 48 healthy normotensive white civil servants. 3. In controls blood pressure was significantly higher in blacks; it correlated with age in both races and with pulse rate in blacks. There were no significant racial differences in plasma noradrenaline which was positively correlated with age in both blacks and whites. Mean plasma renin activity was 55% lower in blacks, and this difference was not related to urinary sodium excretion. 4. In hypertensive subjects plasma noradrenaline positively correlated with age in blacks. This relationship was not found in whites in whom 20% of young hypertensive subjects (less than 45 years) had significantly raised plasma noradrenaline. Plasma renin activity was again significantly lower in blacks. In white hypertensives plasma noradrenaline and renin activity were significantly correlated. 5. There may be racial differences in the pathogenesis of essential hypertension.","PeriodicalId":10672,"journal":{"name":"Clinical science and molecular medicine. Supplement","volume":"4 ","pages":"383s-386s"},"PeriodicalIF":0.0,"publicationDate":"1978-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs055383s","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11495800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Increased ratio between serum beta- and alpha-lipoproteins during diuretic therapy: an adverse effect? 利尿剂治疗期间血清β -脂蛋白和α -脂蛋白比值升高:不良反应?

Clinical science and molecular medicine. Supplement Pub Date : 1978-12-01 DOI: 10.1042/cs055325s

Z Glück, G Baumgartner, P Weidmann, E Peheim, C Bachmann, R Mordasini, J Flammer, G Keusch

引用次数: 52

Side-effects of antihypertensive treatment: a placebo-controlled study. 抗高血压治疗的副作用:一项安慰剂对照研究。

Clinical science and molecular medicine. Supplement Pub Date : 1978-12-01 DOI: 10.1042/cs055341s

G E Bauer, J Baker, S N Hunyor, P Marshall

引用次数: 50

Redistribution of regional blood flow after administration of saralasin in salt-depleted dogs. 给药后局部血流的重新分布在盐枯竭的狗。

Clinical science and molecular medicine. Supplement Pub Date : 1978-12-01 DOI: 10.1042/cs055243s

C S Liang, H Gavras, H R Brunner

引用次数: 3