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Antihypertensive activity of metyrosine in spontaneously hypertensive rats and its enhancement by carbidopa. 甲基酪氨酸对自发性高血压大鼠的降压活性及卡比多巴对其的增强作用。
Clinical science and molecular medicine. Supplement Pub Date : 1978-12-01 DOI: 10.1042/cs055255s
A Scriabine, C T Ludden, C S Sweet, C C Porter, E H Ulm, C A Stone, C J Watkins, R J Wurtman, B L Cronin
{"title":"Antihypertensive activity of metyrosine in spontaneously hypertensive rats and its enhancement by carbidopa.","authors":"A Scriabine, C T Ludden, C S Sweet, C C Porter, E H Ulm, C A Stone, C J Watkins, R J Wurtman, B L Cronin","doi":"10.1042/cs055255s","DOIUrl":"https://doi.org/10.1042/cs055255s","url":null,"abstract":"","PeriodicalId":10672,"journal":{"name":"Clinical science and molecular medicine. Supplement","volume":"4 ","pages":"255s-257s"},"PeriodicalIF":0.0,"publicationDate":"1978-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs055255s","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11496165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Role of persistent vascular renin after bilateral nephrectomy in Goldblatt-two kidney hypertension. 双侧肾切除术后持续性血管肾素在goldblatt - 2型肾高血压中的作用。
Clinical science and molecular medicine. Supplement Pub Date : 1978-12-01 DOI: 10.1042/cs055023s
H Thurston, B C Hurst, R F Bing, J D Swales
{"title":"Role of persistent vascular renin after bilateral nephrectomy in Goldblatt-two kidney hypertension.","authors":"H Thurston,&nbsp;B C Hurst,&nbsp;R F Bing,&nbsp;J D Swales","doi":"10.1042/cs055023s","DOIUrl":"https://doi.org/10.1042/cs055023s","url":null,"abstract":"<p><p>1. Aorta homogenate contains renin-like activity which on incubation generates angiotensin I over a wide pH range. 2. Rat aortic renin measured at an incubation pH of 6.5 rose and fell in parallel to plasma renin with salt depletion and salt-loading respectively. Renin little relationship with plasma renin. 3. Aortic renin (pH 6.5) was elevated in Goldblatt-two kidney hypertension and slowly fell for 24h after bilateral nephrectomy whereas the fall in plasma renin was complete by the first hour. Aortic renin (pH 5.3) was also high, but did not fall after bilateral nephrectomy. 4. Aortic renin (pH 6.5) is probably derived from plasma renin whereas renin measured at pH 5.3 is probably a tissue renin. 5. The prolonged half-life of aortic renin (pH 6.5) explains the observation that the renin-angiotensin system appears to be active in maintaining blood pressure for several hours after bilateral nephrectomy whereas the decline in plasma renin is rapid and does not continue significantly beyond 1 h.</p>","PeriodicalId":10672,"journal":{"name":"Clinical science and molecular medicine. Supplement","volume":"4 ","pages":"23s-26s"},"PeriodicalIF":0.0,"publicationDate":"1978-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs055023s","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11496273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Address on the occasion of the presentation of the Merck Sharp and Dohme International Award to Professor Jens Bing and his associates and the Franz Volhard Award to Professor Bjorn Folkow. 在向Jens Bing教授及其同事颁发默克夏普和Dohme国际奖以及向Bjorn Folkow教授颁发Franz Volhard奖之际发表讲话。
Clinical science and molecular medicine. Supplement Pub Date : 1978-12-01 DOI: 10.1042/cs055001s
J I Robertson
{"title":"Address on the occasion of the presentation of the Merck Sharp and Dohme International Award to Professor Jens Bing and his associates and the Franz Volhard Award to Professor Bjorn Folkow.","authors":"J I Robertson","doi":"10.1042/cs055001s","DOIUrl":"https://doi.org/10.1042/cs055001s","url":null,"abstract":"","PeriodicalId":10672,"journal":{"name":"Clinical science and molecular medicine. Supplement","volume":"4 ","pages":"1s-2s"},"PeriodicalIF":0.0,"publicationDate":"1978-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs055001s","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11496638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nomenclature of the renin-angiotensin system. 肾素-血管紧张素系统的命名。
Clinical science and molecular medicine. Supplement Pub Date : 1978-12-01
{"title":"Nomenclature of the renin-angiotensin system.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":10672,"journal":{"name":"Clinical science and molecular medicine. Supplement","volume":"4 ","pages":"113s-116s"},"PeriodicalIF":0.0,"publicationDate":"1978-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11496640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of prostaglandins in the pathogenesis of hypertension. 前列腺素在高血压发病中的作用。
Clinical science and molecular medicine. Supplement Pub Date : 1978-12-01 DOI: 10.1042/cs055207s
C M Markov
{"title":"The role of prostaglandins in the pathogenesis of hypertension.","authors":"C M Markov","doi":"10.1042/cs055207s","DOIUrl":"https://doi.org/10.1042/cs055207s","url":null,"abstract":"<p><p>1. Biosynthesis of PGE2 from [14C]arachidonic acid has been found to be lower and PGF2alpha higher in the renal medulla of spontaneously hypertensive (SH) rats than in normal Wistar (NW) rats. 2. Biosynthesis of prostacyclin (PGF1alpha) from [14C]arachidonic acid was decreased in lungs, aorta and heart of SH rats. 3. Metabolism of [3H]PGF1alpha was decreased in renal cortex and lungs and PGE2 increased in SH rats in comparison with NW rats. Thus the lungs of SH rats let more PGF and less PGE enter the systemic circulation. 4. Emotional stress decreased the metabolism of [3H]PGF1alpha in lungs of SH and NW rats, the effect being less in SH rats.</p>","PeriodicalId":10672,"journal":{"name":"Clinical science and molecular medicine. Supplement","volume":"4 ","pages":"207s-210s"},"PeriodicalIF":0.0,"publicationDate":"1978-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs055207s","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11575146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
The interaction between prazosin and clonidine. 哌唑嗪与可乐定的相互作用。
Clinical science and molecular medicine. Supplement Pub Date : 1978-12-01 DOI: 10.1042/cs055259s
P A van Zwieten, E Lam, P B Timmermans
{"title":"The interaction between prazosin and clonidine.","authors":"P A van Zwieten,&nbsp;E Lam,&nbsp;P B Timmermans","doi":"10.1042/cs055259s","DOIUrl":"https://doi.org/10.1042/cs055259s","url":null,"abstract":"<p><p>1. The interaction between prazosin and clonidine was studied in anaesthetized rats, pithed rats and in anaesthetized cats. 2. Prazosin diminished the clonidine-induced hypotensive effect in anaesthetized rats, probably via an antagonism at the level of central alpha-adrenoreceptors. 3. In pithed rats, stimulation of the Nervi accelerantes caused tachycardia, which was diminished considerably by clonidine. The antagonism by clonidine was partly reversed by prazosin, suggesting that prazosin possesses a certain degree of presynaptic activity apart from its predominant effect at the postsynaptic alpha-receptor. Piperoxan was more active than prazosin. 4. The central hypotensive effect of clonidine, injected into the left vertebral artery of cats was significantly reduced by prazosin, administered before clonidine via the same route. Intravenously injected prazosin did not diminish the central hypotensive effect of clonidine. The antagonism is, therefore, caused by a central mechanism. 5. The combined application of clonidine and prazosin in antihypertensive treatment is probably not only irrational but ought to be discouraged in view of the interaction between the drugs, which leads to a reduced antihypertensive potency of clonidine.</p>","PeriodicalId":10672,"journal":{"name":"Clinical science and molecular medicine. Supplement","volume":"4 ","pages":"259s-261s"},"PeriodicalIF":0.0,"publicationDate":"1978-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs055259s","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11254597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
beta-Adrenoreceptor-blocking agents and lipid metabolism. 肾上腺素受体阻滞剂与脂质代谢。
Clinical science and molecular medicine. Supplement Pub Date : 1978-12-01 DOI: 10.1042/cs055323s
J D England, A S Hua, J Shaw
{"title":"beta-Adrenoreceptor-blocking agents and lipid metabolism.","authors":"J D England,&nbsp;A S Hua,&nbsp;J Shaw","doi":"10.1042/cs055323s","DOIUrl":"https://doi.org/10.1042/cs055323s","url":null,"abstract":"<p><p>1. Chlorothiazide twice a day plus atenolol, metoprolol, pindolol and propranolol in single daily doses administered to patients with essential hypertension achieved effective control of blood pressure. 2. Each beta-adrenoreceptor-blocking drug was associated with small, but significant, increases in plasma triglyceride concentrations and suppression of fasting immuno-reactive glucagon concentrations.</p>","PeriodicalId":10672,"journal":{"name":"Clinical science and molecular medicine. Supplement","volume":"4 ","pages":"323s-324s"},"PeriodicalIF":0.0,"publicationDate":"1978-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs055323s","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11255433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Tonin--angiotensin II system in hypertension. 高血压中的张力-血管紧张素II系统。
Clinical science and molecular medicine. Supplement Pub Date : 1978-12-01
R Boucher, R Garcia, J Gutkowska, S Demassieux, J Genest
{"title":"Tonin--angiotensin II system in hypertension.","authors":"R Boucher,&nbsp;R Garcia,&nbsp;J Gutkowska,&nbsp;S Demassieux,&nbsp;J Genest","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>1. A single intravenous administration of rabbit tonin antiserum into one-kidney one-clip hypertensive rats restored blood pressure to normal in seven out of ten animals. There was little change in blood pressure in two-kidney one-clip hypertensive, uninephrectomized or sham-operated rats. 2. Infusion of tonin in control rats did not modify arterial blood pressure. However, in indomethacin salt-treated rats a marked increase in arterial blood pressure was observed under tonin infusion. 3. Plasma tonin activity was significantly increased in human essential and renovascular hypertension. 4. These findings strongly suggest that tonin is important in the maintenance of high blood pressure. However, other factors (possibly prostaglandins and sodium) have to be modified in order to activate the tonin--angiotensin II system.</p>","PeriodicalId":10672,"journal":{"name":"Clinical science and molecular medicine. Supplement","volume":"4 ","pages":"183s-186s"},"PeriodicalIF":0.0,"publicationDate":"1978-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11431059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Steroidogenic and pressor activity of angiotensin analogues in the rat. 血管紧张素类似物在大鼠体内的类固醇生成和升压活性。
Clinical science and molecular medicine. Supplement Pub Date : 1978-12-01 DOI: 10.1042/cs055175s
P A Khairallah, M C Khosla, F M Bumpus, J F Tait, S A Tait
{"title":"Steroidogenic and pressor activity of angiotensin analogues in the rat.","authors":"P A Khairallah,&nbsp;M C Khosla,&nbsp;F M Bumpus,&nbsp;J F Tait,&nbsp;S A Tait","doi":"10.1042/cs055175s","DOIUrl":"https://doi.org/10.1042/cs055175s","url":null,"abstract":"<p><p>1. A classical 6 point assay in vitro for measuring aldosterone stimulating activity has been developed. 2. The steroidogenic potency of Ile5-angiotensin II was 62% of that given by Val5-angiotensin II. Ile5-angiotensin III (Des-Asp1-Ile5-angiotensin II) was likewise 50% as active as Val5-angiotensin III (Des-Asp1-Val5-angiotensin II). Similar results were obtained in the pressor and myotropic assays. 3. Ile5-angiotensin III and Val5-angiotensin III had only 7% and 16% respectively of the steroidogenic activity of Val5-angiotensin II. 4. Sar1-Ile5-angiotensin II was 2.3 times as potent as Val5-angiotensin II in aldosterone-stimulating activity. The corresponding activities of Me2-Gly1-angiotensin II, Pro1-angiotensin II and Pro31-angiotensin II were 71%, 15% and 3% of Val5-angiotensin II respectively.</p>","PeriodicalId":10672,"journal":{"name":"Clinical science and molecular medicine. Supplement","volume":"4 ","pages":"175s-177s"},"PeriodicalIF":0.0,"publicationDate":"1978-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs055175s","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11495154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Effects of prostaglandin E2 and prostaglandin F2alpha upon urinary kallikrein excretion in rats. 前列腺素E2和前列腺素f2α对大鼠尿钾激肽排泄的影响。
Clinical science and molecular medicine. Supplement Pub Date : 1978-12-01
H R Croxatto, R Arriagada, M Rojas, J Roblero, R Rosas
{"title":"Effects of prostaglandin E2 and prostaglandin F2alpha upon urinary kallikrein excretion in rats.","authors":"H R Croxatto,&nbsp;R Arriagada,&nbsp;M Rojas,&nbsp;J Roblero,&nbsp;R Rosas","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>1. In normally hydrated rats prostaglandin F2alpha (PGF2alpha) in doses of 5 microgram/100 g body weight given subcutaneously every 2 h (three times) induced a significant increase in urinary kallikrein activity, and in sodium, potassium and water excretion for 8 h after the first injection. In moderately hyperhydrated rats loaded 2.5% of body wt. with 0.5% NaCl solution, PGF2alpha produced similar changes in kallikrein activity and electrolyte excretion. 2. In normally hydrated rats prostaglandin E2 (PGE2) in the same conditions and doses as in 1 had no effect on kallikrein activity, showing a tendency to decrease potassium and water excretion. 3. PGE2 in doses of 5, 12.5 and 25 microgram/100 g body wt. in overhydrated rats given 2.5% and 0.5% NaCl and 5% of tap water/100 g body wt. 1 h later, significantly increased kallikrein activity in the urine collected for 120 min after the injections. A significant decrease in potassium and water excretion was observed with the highest dose. 4. PGF2alpha, had no effect on kallikrein activity in overhydrated rats, but an increase in sodium and a decrease in potassium excretion was seen at the highest dose. 5. The different actions of PGE2 and PGF2alpha may be part of a regulatory mechanism associated with the kallikrein-kinin system which contributes maintainance of extracellular fluid homeostasis.</p>","PeriodicalId":10672,"journal":{"name":"Clinical science and molecular medicine. Supplement","volume":"4 ","pages":"187s-189s"},"PeriodicalIF":0.0,"publicationDate":"1978-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11495156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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