Clinical science and molecular medicine. Supplement最新文献_第10页

Renal release of active and inactive renin in essential and renovascular hypertension. 原发性和肾血管性高血压患者肾素的活性和非活性释放。

Clinical science and molecular medicine. Supplement Pub Date : 1978-12-01 DOI: 10.1042/cs055129s

F H Derkx, R P Verhoeven, G J Wenting, A J Man in 't Veld, M A Schalekamp

{"title":"Renal release of active and inactive renin in essential and renovascular hypertension.","authors":"F H Derkx, R P Verhoeven, G J Wenting, A J Man in 't Veld, M A Schalekamp","doi":"10.1042/cs055129s","DOIUrl":"https://doi.org/10.1042/cs055129s","url":null,"abstract":"1. Active and acid-activable inactive renin were measured in renal venous and arterial plasma of 18 patients with essential hypertension (EHT) and 19 patients with renovascular hypertension (RVHT). In seven patients with EHT and in 11 patients with RVHT measurements were made before and 25-35 min after an intravenous injection of 300 mg of diazoxide. 2. Under basal conditions the renal vein to artery ratios for active and inactive renin in EHT ranged from 0.71 to 1.96 and from 0.68 to 1.44 respectively. In 14 patients with RVHT the renal vein to artery ratio for active renin on the affected side was above the range found in EHT and in six of them the renal vein to artery ratio for inactive renin was also elevated. 3. The diazoxide-induced release of active renin from kidneys, which had a stenotic artery but were not seriously contracted, was associated with a fall of the renal vein to artery ratio for inactive renin to a value below 1.00. 4. The results indicate that changes in the release of active and inactive renin do not always run in parallel. The findings are compatible with the hypothesis that circulating inactive renin can be activated in the kidney.","PeriodicalId":10672,"journal":{"name":"Clinical science and molecular medicine. Supplement","volume":"4 ","pages":"129s-132s"},"PeriodicalIF":0.0,"publicationDate":"1978-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs055129s","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11254594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Endogenous prostaglandin synthesis inhibitor in the renal cortex. Effects on production of prostacyclin by renal blood vessels. 肾皮质内源性前列腺素合成抑制剂。肾血管对前列环素生成的影响。

Clinical science and molecular medicine. Supplement Pub Date : 1978-12-01 DOI: 10.1042/cs055199s

N A Terragno, A Terragno, J A Early, M A Roberts, J C McGiff

{"title":"Endogenous prostaglandin synthesis inhibitor in the renal cortex. Effects on production of prostacyclin by renal blood vessels.","authors":"N A Terragno, A Terragno, J A Early, M A Roberts, J C McGiff","doi":"10.1042/cs055199s","DOIUrl":"https://doi.org/10.1042/cs055199s","url":null,"abstract":"1. The capacity of various tissues of the porcine kidney to convert [1-14C]arachidonic acid into radiolabelled prostaglandins was studied. 2. Only after removal from the cortical matrix, were renal blood vessels able to convert arachidonic acid into prostaglandins (primarily prostacyclin). In contrast, convoluted tubules showed a low capacity to metabolize arachidonic acid. 3. The failure to demonstrate prostaglandin synthesis by renal cortical slices is related to the presence of an inhibitor of cyclo-oxygenase. Thus the addition of renal cortical incubate to isolated vascular tissues and ram seminal vesicles inhibited their ability to synthesize prostaglandins. 4. Slices of renal medulla metabolized arachidonic acid primarily to prostaglandin F2alpha; lesser amounts of prostaglandin E2 and prostacyclin were generated. 5. The large capacity of the renal vasculature to generate prostacyclin is consistent with an important role for this prostaglandin in regulation of renin release and renal haemodynamics.","PeriodicalId":10672,"journal":{"name":"Clinical science and molecular medicine. Supplement","volume":"4 ","pages":"199s-202s"},"PeriodicalIF":0.0,"publicationDate":"1978-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs055199s","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11323889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 58

Nervous system and hypertension. 神经系统和高血压。

Clinical science and molecular medicine. Supplement Pub Date : 1978-12-01 DOI: 10.1042/cs055045s

J P Chalmers

引用次数: 72

Improvement in foetal growth with treatment of maternal hypertension in pregnancy. 妊娠期孕妇高血压治疗对胎儿生长的改善。

Clinical science and molecular medicine. Supplement Pub Date : 1978-12-01 DOI: 10.1042/cs055359s

E D Gallery, D M Saunders, S N Hunyor, A Z Györy

引用次数: 11

Effect of prazosin on blood pressure and plasma renin activity in man. 哌唑嗪对人血压及血浆肾素活性的影响。

Clinical science and molecular medicine. Supplement Pub Date : 1978-12-01 DOI: 10.1042/cs055337s

J Rosenthal, H Jaeger, I Arlart

{"title":"Effect of prazosin on blood pressure and plasma renin activity in man.","authors":"J Rosenthal, H Jaeger, I Arlart","doi":"10.1042/cs055337s","DOIUrl":"https://doi.org/10.1042/cs055337s","url":null,"abstract":"1. The effects of oral administration of 4.5 mg of prazosin/day on blood pressure and on plasma renin activity were assessed in patients with essential hypertension and in healthy normotensive volunteer subjects. 2. Mean blood pressure in the hypertensive group fell significantly within 2 weeks of treatment, whereas heart rate was little affected. None of the parameters measured in the normotensive subjects during treatment with prazosin revealed significant changes. 3. Sub-classification of the hypertensive patients into low-, normal- and high-renin categories revealed significant decreases of renin in all six patients with high renin- and in four out of 12 patients with normal renin- but not in the two patients with low renin-essential hypertension. 4. The results indicate the prazosin exerts its hypotensive action and suppresses plasma renin activity particularly in patients with high renin-essential hypertension. These may be considered to have increased sympathetic drive. 5. Conceivably, the blood pressure-lowering effect of prazosin is affected by peripheral vasodilatation and also by a decreased venous return to the heart.","PeriodicalId":10672,"journal":{"name":"Clinical science and molecular medicine. Supplement","volume":"4 ","pages":"337s-339s"},"PeriodicalIF":0.0,"publicationDate":"1978-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs055337s","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11496019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuronal and vascular reactivity in isolated perfused kidneys during the development of spontaneous hypertension. 自发性高血压发生过程中离体灌注肾的神经元和血管反应性。

Clinical science and molecular medicine. Supplement Pub Date : 1978-12-01 DOI: 10.1042/cs055233s

M G Collis, P M Vanhoutte

{"title":"Neuronal and vascular reactivity in isolated perfused kidneys during the development of spontaneous hypertension.","authors":"M G Collis, P M Vanhoutte","doi":"10.1042/cs055233s","DOIUrl":"https://doi.org/10.1042/cs055233s","url":null,"abstract":"1. Vascular reactivity was studied in Tyrode solution perfused kidneys from young (7 weeks) and mature (4-6 months) spontaneously hypertensive rats (SH rats). 2. The response to nerve stimulation was greater in the kidneys from young SH rats than in those from young control rats, both in control solution and after inhibition of the disposition of noradrenaline; both groups exhibited the same sensitivity to noradrenaline, angiotensin II and barium chloride. 3. The response to nerve stimulation was normal in kidneys from mature SH rats, but responses to noradrenaline, angiotensin II and barium chloride were greater than the control. 4. Cocaine potentiated the response to nerve stimulation more in the kidneys from mature SH rats than in those from the control rats. 5. The results suggest that renal sympathetic nerves release more noradrenaline than normal in the young SH rats, which could be an important factor in causing hypertension. 6. In the established phase of spontaneous hypertension the vascular reactivity to exogenous agonists is increased, probably as a consequence of high blood pressure; the more efficient neuronal uptake causes normalization of the response to sympathetic nerve stimulation.","PeriodicalId":10672,"journal":{"name":"Clinical science and molecular medicine. Supplement","volume":"4 ","pages":"233s-235s"},"PeriodicalIF":0.0,"publicationDate":"1978-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs055233s","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11496274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Renin secretion by the human kidney. 人肾脏分泌的肾素。

Clinical science and molecular medicine. Supplement Pub Date : 1978-12-01 DOI: 10.1042/cs055147s

W H Birkenhäger, P W De Leeuw, H E Falke, G A Van Soest

引用次数: 9

An endogenous protease activating plasma inactive renin. 激活血浆无活性肾素的内源性蛋白酶。

Clinical science and molecular medicine. Supplement Pub Date : 1978-12-01 DOI: 10.1042/cs055133s

B J Leckie

引用次数: 11

Sympathetic and parasympathetic components of reflex cardiostimulation during vasodilator treatment of hypertension. 血管扩张剂治疗高血压期间反射性心脏刺激的交感和副交感成分。

Clinical science and molecular medicine. Supplement Pub Date : 1978-12-01 DOI: 10.1042/cs055329s

A J Man in 't Veld, G J Wenting, R P Verhoeven, M A Schalekamp

{"title":"Sympathetic and parasympathetic components of reflex cardiostimulation during vasodilator treatment of hypertension.","authors":"A J Man in 't Veld, G J Wenting, R P Verhoeven, M A Schalekamp","doi":"10.1042/cs055329s","DOIUrl":"https://doi.org/10.1042/cs055329s","url":null,"abstract":"1. Haemodynamic responses to diazoxide (300 mg intravenously) were studied in 15 hypertensive patients before and after chronic beta-adrenoreceptor blockade by 320 mg of propranolol daily. After diazoxide alone, mean arterial pressure and total peripheral resistance were lowered by 24 +/- 3 and 35 +/- 5% (mean +/- SEM) respectively. Cardiac output and heart rate rose by 25 +/- 9 and 21 +/- 3%. During beta-adrenoreceptor blockade, the percentage changes of mean arterial pressure, heart rate, cardiac output and total peripheral resistance after vasodilatation were not significantly different from those after diazoxide alone. 2. Atropine, 0.04 mg/kg body weight, was given to 12 hypertensive patients chronically treated with beta-adrenoreceptor blockade, before acute vasodilatation by diazoxide. Diazoxide caused no increase in heart rate after combined beta-adrenoreceptor and parasympathetic blockade. However, cardiac output rose by 14 +/- 5%. 3. We conclude that withdrawal of parasympathetic tone is an important determinant of circulatory homeostasis after acute vasodilatation during beta-adrenoreceptor blockade.","PeriodicalId":10672,"journal":{"name":"Clinical science and molecular medicine. Supplement","volume":"4 ","pages":"329s-332s"},"PeriodicalIF":0.0,"publicationDate":"1978-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs055329s","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11255434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Soluble pepstatins: a new approach to blockade in vivo of the renin-angiotensin system. 可溶性胃抑素:一种阻断肾素-血管紧张素系统的新方法。

Clinical science and molecular medicine. Supplement Pub Date : 1978-12-01

G Evin, J Gardes, C Kreft, B Castro, P Corvol, J Menard

引用次数: 0