Clinical science and molecular medicine. Supplement最新文献_第9页

Effects of indomethacin alone and during diuretic or beta-adrenoreceptor-blockade therapy on blood pressure and the renin system in essential hypertension. 单用吲哚美辛及利尿剂或肾上腺素受体阻断治疗对高血压患者血压和肾素系统的影响。

Clinical science and molecular medicine. Supplement Pub Date : 1978-12-01 DOI: 10.1042/cs055203s

J A Lopez-Ovejero, M A Weber, J I Drayer, J E Sealey, J H Laragh

{"title":"Effects of indomethacin alone and during diuretic or beta-adrenoreceptor-blockade therapy on blood pressure and the renin system in essential hypertension.","authors":"J A Lopez-Ovejero, M A Weber, J I Drayer, J E Sealey, J H Laragh","doi":"10.1042/cs055203s","DOIUrl":"https://doi.org/10.1042/cs055203s","url":null,"abstract":"1. Indomethacin was administered alone or in addition to either diuretic or propranolol therapy to three groups of patients with essential hypertension on a free sodium diet. 2. Indomethacin administration reduced renin secretion by about 30% in untreated uncomplicated hypertensive patients and by about 75% in those whose renin secretion had either been stimulated or suppressed by maintained diuretic or beta-adrenoreceptor-blockade therapy. 3. Indomethacin administration produced no net effect on blood pressure in untreated patients with uncomplicated hypertension but it blunted or reversed the antihypertensive effect of either diuretic or propranolol therapy. 4. Salt and water retention may be an important factor in the blood pressure-raising effect of indomethacin during diuretic or propranolol therapy: In addition, prostaglandin synthesis may be important in counteracting increased alpha-adrenergic tone, which may limit the blood pressure-lowering effect of beta-adrenoreceptor-blockade. 5. Because of these interactions and their pressor potential indomethacin should be used with caution when combined with either diuretics or beta-adrenoreceptor blockers.","PeriodicalId":10672,"journal":{"name":"Clinical science and molecular medicine. Supplement","volume":"4 ","pages":"203s-205s"},"PeriodicalIF":0.0,"publicationDate":"1978-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs055203s","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11496266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 86

Hypoxanthine--guanine phosphoribosyltransferase activity in blood and skeletal muscles of normal and dystrophic mice. 正常和营养不良小鼠血液和骨骼肌中的次黄嘌呤-鸟嘌呤磷酸核糖基转移酶活性。

Clinical science and molecular medicine. Supplement Pub Date : 1978-12-01 DOI: 10.1042/cs0550573

J S Neerunjun, J Allsop, V Dubowitz

{"title":"Hypoxanthine--guanine phosphoribosyltransferase activity in blood and skeletal muscles of normal and dystrophic mice.","authors":"J S Neerunjun, J Allsop, V Dubowitz","doi":"10.1042/cs0550573","DOIUrl":"https://doi.org/10.1042/cs0550573","url":null,"abstract":"1. Hypoxanthine--guanine phosphoribosyltransferase (HGPRT) activity was measured in erythrocyte haemolysates and quadriceps muscle extracts of normal and dystrophic 129 ReJ and C57 BL/6J mice with [8(-14)C]hypoxanthine as substrate and 5-phosphorylribose 1-pyrophosphate as a ribose 5-phosphate donor. [8(-14)C]Inosine monophosphate formed was separated by high-voltage electrophoresis and radioactivity was measured by liquid-scintillation counting. 2. In erythrocyte haemolysates, HGPRT activity was similar in normal and dystrophic C57 BL/6J mice but was significantly higher in dystrophic than in normal 129 ReJ mice. Elevated enzyme activity was observed only in mice that were clinically severely affected. 3. In muscle homogenates, HGPRT activity was significantly higher in dystrophic than in normal animals of both 129 ReJ and C57 BL/6J mice. Enzyme activity was not related to the severity of the disease. 4. It is suggested that changes in erythrocytes are secondary to the dystrophic process and that elevated HGPRT activity in skeletal muscle may be related to abnormal energy metabolism, possibly via the pentose monophosphate shunt.","PeriodicalId":10672,"journal":{"name":"Clinical science and molecular medicine. Supplement","volume":"55 6","pages":"573-6"},"PeriodicalIF":0.0,"publicationDate":"1978-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs0550573","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11497983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Activation of inactive plasma renin: evidence that both cryoactivation and acid-activation work by liberating a neutral serine protease from endogenous inhibitors. 无活性血浆肾素的活化:证据表明冷冻活化和酸活化都是通过从内源性抑制剂中释放中性丝氨酸蛋白酶而起作用的。

Clinical science and molecular medicine. Supplement Pub Date : 1978-12-01 DOI: 10.1042/cs055135s

S A Atlas, J H Laragh, J E Sealey

引用次数: 21

A renal carcinoma secreting inactive renin. 一种分泌无活性肾素的肾癌。

Clinical science and molecular medicine. Supplement Pub Date : 1978-12-01 DOI: 10.1042/cs055159s

B Leckie, J J Brown, R Fraser, K Kyle, A F Lever, J J Morton, J I Robertson

引用次数: 32

Pseudohypertension in the elderly. 老年人假性高血压。

Clinical science and molecular medicine. Supplement Pub Date : 1978-12-01 DOI: 10.1042/cs055399s

J D Spence, W J Sibbald, R D Cape

引用次数: 75

Noradrenaline secretion by the human kidney. 人体肾脏分泌的去甲肾上腺素。

Clinical science and molecular medicine. Supplement Pub Date : 1978-12-01 DOI: 10.1042/cs055085s

P W de Leeuw, H E Falke, R Punt, W H Birkenhäger

引用次数: 16

Treatment of mild hypertension. 治疗轻度高血压。

Clinical science and molecular medicine. Supplement Pub Date : 1978-12-01 DOI: 10.1042/cs055305s

T Morgan, W Adam, A Gillies, S Carney

引用次数: 9

Different secretion patterns of active and inactive renin in man. 人体内有活性和无活性肾素的不同分泌模式。

Clinical science and molecular medicine. Supplement Pub Date : 1978-12-01 DOI: 10.1042/cs055143s

A M Kappelgaard, J Giese, H Ibsen, M D Nielsen, A Rabøl

{"title":"Different secretion patterns of active and inactive renin in man.","authors":"A M Kappelgaard, J Giese, H Ibsen, M D Nielsen, A Rabøl","doi":"10.1042/cs055143s","DOIUrl":"https://doi.org/10.1042/cs055143s","url":null,"abstract":"1. In plasma samples from normal subjects and patients with untreated essential hypertension, the concentration of inactive renin (as measured after acidification) was on average 4-5 times higher than the concentration of active renin (as measured without acidification).2. Plasma angiotensin II concentration was correlated to active renin but not to inactive renin. 3. A hyperacute stimulation induced by infusion of saralasin resulted in a marked rise of active renin, whereas inactive renin remained unchanged. 4. An acute stimulation induced by frusemide and ambulation led to a considerable rise in active renin and a slight, but significant, rise of inactive renin. 5. Stimulation with oral thiazide over 5 days induced a seven-fold rise of active renin, with a doubling of inactive renin. Thiazide treatment for 3 months led to a four-fold rise of active renin and a three-fold rise of inactive renin. 6. There was no difference between the concentrations of inactive renin in systemic plasma, ipsilateral and contralateral renal venous plasma in 12 patients with renovascular hypertension, neither before nor after infusion of saralasin with the associated fall in blood pressure. 7. We conclude that the time constants pertinent to secretion or release of active and inactive renin in man are of different orders of magnitude.","PeriodicalId":10672,"journal":{"name":"Clinical science and molecular medicine. Supplement","volume":"4 ","pages":"143s-146s"},"PeriodicalIF":0.0,"publicationDate":"1978-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs055143s","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11496644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 34

A survey of salivary kallikrein and amylase in a population of schoolgirls, throughout the menstrual cycle. 在整个月经周期中，一群女学生唾液钾化酶和淀粉酶的调查。

Clinical science and molecular medicine. Supplement Pub Date : 1978-12-01 DOI: 10.1042/cs0550561

K D Bhoola, R W Matthews, F Roberts

引用次数: 22

Sodium and renin in the hypertension of early renal disease. 钠和肾素在早期肾病高血压中的作用。

Clinical science and molecular medicine. Supplement Pub Date : 1978-12-01 DOI: 10.1042/cs055301s

S F Wong, M I Mitchell, V Robson, R Wilkinson

引用次数: 9