Effect of selective and non-selective beta-adrenoreceptor blockade on calf blood flow in hypertensive patients.

D L Clement
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引用次数: 2

Abstract

1. Dose-response curves of isoprenaline were constructed in nine hypertensive patients before and after either propranolol or metoprolol. 2. The decrease of diastolic blood pressure and increase of heart rate with isoprenaline were significantly more inhibited by propranolol than by metoprolol. 3. The increase in calf blood flow with isoprenaline was significantly more depressed after propranolol than after metoprolol. 4. The results suggest that the response of the vessels in the limbs to sympathetic stimulation is much less affected after metoprolol than after propranolol.

选择性和非选择性β -肾上腺素受体阻断对高血压患者小腿血流的影响。
1. 对9例高血压患者应用心得安或美托洛尔前后异丙肾上腺素的剂量-反应曲线进行了分析。2. 心得安对异丙肾上腺素舒张压降低和心率升高的抑制作用明显强于美托洛尔。3.与美托洛尔相比,普萘洛尔对异丙肾上腺素对小牛血流的抑制作用更明显。4. 结果表明,美托洛尔对四肢血管交感神经刺激的影响比心得安小得多。
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