Effects of labetalol on systemic and pulmonary haemodynamics at rest and during exercise in hypertensive patients.

R Fagard, A Amery, T Reybrouck, P Lijnen, L Billiet
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引用次数: 3

Abstract

1. Labetalol was administered to 18 hypertensive patients for an average duration of 2.44 weeks, with an average final daily dose of 1.65 g. 2. Labetalol decreased resting heart rate by 16% and maximal exercise heart rate by 21%; the phenylephrine-induced rise of systolic brachial artery pressure was reduced by 36%. 3. During labetalol brachial artery pressure was lowered by 29/15 mmHg in the recumbent position, by 41/23 mmHg at rest sitting, and by 53/23 mmHg at maximal exercise; total peripheral resistance was not significantly affected at rest recumbent, but was reduced at sitting and at exercise; cardiac output decreased in all conditions. 4. Labetalol reduced mean pulmonary artery and capillary wedge pressures only in the sitting position. Pulmonary vascular resistance remained unchanged. 5. The drug produced significant decreases of plasma renin activity and of plasma aldosterone concentration.

拉贝他洛尔对高血压患者静息和运动时全身和肺血流动力学的影响。
1. 18例高血压患者给予拉贝他洛尔,平均持续时间2.44周,平均每日终剂量1.65 g。拉贝他洛尔使静息心率降低16%,最大运动心率降低21%;苯肾上腺素引起的肱动脉收缩压升高降低了36%。3.使用拉贝他洛尔时,平卧位肱动脉压降低29/15 mmHg,静坐时降低41/23 mmHg,最大运动时降低53/23 mmHg;总外周阻力在休息时平卧时没有明显影响,但在坐着和运动时有所降低;心输出量在所有情况下均下降。4. 拉贝他洛尔仅在坐位时降低平均肺动脉和毛细血管楔压。肺血管阻力保持不变。5. 该药显著降低血浆肾素活性和血浆醛固酮浓度。
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