Communications Biology最新文献_第3页

Author Correction: The cellular correlates and adolescent reorganisation of cortical myelination networks in the common marmoset. 作者更正：普通狨猴皮层髓鞘网络的细胞相关性和青春期重组。

IF 5.8 1区生物学

Communications Biology Pub Date : 2026-10-05 DOI: 10.1038/s42003-026-11090-2

E D Hutchings, S J Sawiak, R L Smith, R A I Bethlehem, A C Roberts, E T Bullmore

引用次数: 0

Biotope-dependent resistance to reactive oxygen species, antibiotic tolerance, and virulence of Staphylococcus aureus. 生物群落对活性氧的依赖抗性，抗生素耐受性和金黄色葡萄球菌的毒力。

IF 5.8 1区生物学

Communications Biology Pub Date : 2026-10-01 DOI: 10.1038/s42003-026-10771-2

Vincent Léguillier, Karine Gloux, Majd Khalife, Rochelle D'Mello, Zoran Minic, Milica Sentic, Marta Catto, Marisa Manzano, Christine Péchoux, Sandrine Truchet, Philippe Gaudu, Christina Nielsen-Leroux, Brahim Heddi, Alexandra Gruss, Jasmina Vidic

{"title":"Biotope-dependent resistance to reactive oxygen species, antibiotic tolerance, and virulence of Staphylococcus aureus.","authors":"Vincent Léguillier, Karine Gloux, Majd Khalife, Rochelle D'Mello, Zoran Minic, Milica Sentic, Marta Catto, Marisa Manzano, Christine Péchoux, Sandrine Truchet, Philippe Gaudu, Christina Nielsen-Leroux, Brahim Heddi, Alexandra Gruss, Jasmina Vidic","doi":"10.1038/s42003-026-10771-2","DOIUrl":"https://doi.org/10.1038/s42003-026-10771-2","url":null,"abstract":"The human and livestock pathogen Staphylococcus aureus poses a major clinical challenge due to antibiotic treatment failure. Its resilience is mainly attributed to antibiotic resistance and tolerance mechanisms related to persistence. Here we investigate how two infection-relevant conditions, milk and serum, shape S. aureus pathogenic properties and capacity to withstand environmental stresses. Milk- versus serum-grown bacteria show gross differences in envelope physical properties, membrane fatty acid composition and rigidity, and pigment production, and display distinct proteomic profiles. Compared to growth in serum, S. aureus grown in milk exhibits extreme resistance to ROS damage, marked antimicrobial tolerance, and accelerated killing in a larval infection model. High level S. aureus pigmentation in whole milk is stimulated by milk lipids, and is responsible for high ROS resistance. The remarkable robustness of S. aureus in a milk biotope may signal the need to adjust antibiotic regimens when treating mastitis infections in humans and livestock.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"9 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13631261/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149105237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-omics insight into cardiac myofibril remodeling in post-prandial Burmese pythons. 缅甸蟒蛇餐后心肌肌原纤维重塑的多组学研究。

IF 5.8 1区生物学

Communications Biology Pub Date : 2026-09-30 DOI: 10.1038/s42003-026-11007-z

Thomas G Martin, Lorena Suarez-Artiles, Kathleen C Woulfe, Elise G Melhedegaard, Yuxiao Tan, Dakota R Hunt, Bruce E Kirkpatrick, Lia Nguyen, Joseph Lee, Isabella Laskey, Kristi S Anseth, Julien Ochala, Michael Gotthardt, Philipp Mertins, Leslie A Leinwand

{"title":"Multi-omics insight into cardiac myofibril remodeling in post-prandial Burmese pythons.","authors":"Thomas G Martin, Lorena Suarez-Artiles, Kathleen C Woulfe, Elise G Melhedegaard, Yuxiao Tan, Dakota R Hunt, Bruce E Kirkpatrick, Lia Nguyen, Joseph Lee, Isabella Laskey, Kristi S Anseth, Julien Ochala, Michael Gotthardt, Philipp Mertins, Leslie A Leinwand","doi":"10.1038/s42003-026-11007-z","DOIUrl":"10.1038/s42003-026-11007-z","url":null,"abstract":"Burmese pythons exhibit cardiac remodeling in response to increased metabolic rate during digestion. Here, we performed single-myofibril mechanics measurements and myosin biochemical assays to evaluate the impact of feeding on the cardiomyocyte sarcomere in two experimental paradigms: normal feeding (one meal per month) and frequent feeding (eight meals per month). Myofibril tension and rate of relaxation increased during digestion in both paradigms, while frequent feeding was further associated with slower myofibril activation. To gain potential mechanistic insight, we performed multi-omics analyses. RNA sequencing identified increased relative concentration of some sarcomeric mRNAs during digestion; however, proteomics suggested a delay in sarcomere protein synthesis at the peak of remodeling, as the relative abundance of most sarcomere proteins declined. Analysis of post-translational modifications identified hundreds of sites on sarcomere proteins, including on the tension-regulating proteins titin and myosin. Our results detail the molecular underpinnings of cardiac remodeling in digesting Burmese pythons and suggest the mechanism for rapidly increasing myofibril function is a post-translational program.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"9 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13676620/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149215127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decomposing population differences in type 2 diabetes through a high-resolution GWAS of ~600,000 individuals with East Asian ancestry. 通过对60万东亚血统个体的高分辨率GWAS分析2型糖尿病人群差异

IF 5.8 1区生物学

Communications Biology Pub Date : 2026-09-30 DOI: 10.1038/s42003-026-10791-y

Kohei Saito, Hsing-Fang Lu, Tatsuhide Inoue, Takeshi Usui, Toshihiro Shirai, Tatsuo Ogawa, Rieko Kosugi, Chika Kyo, Keiko Hikino, Yun Li, Momoko Horikoshi, Hiroshi Itoh, Kaori Hayashi, Toshio Shimada, Koichi Ozaki, Issei Tanaka, Wen-Ling Liao, Yen-Ting Chang, Ting-Yuan Liu, Fuu-Jen Tsai, Chikashi Terao

{"title":"Decomposing population differences in type 2 diabetes through a high-resolution GWAS of ~600,000 individuals with East Asian ancestry.","authors":"Kohei Saito, Hsing-Fang Lu, Tatsuhide Inoue, Takeshi Usui, Toshihiro Shirai, Tatsuo Ogawa, Rieko Kosugi, Chika Kyo, Keiko Hikino, Yun Li, Momoko Horikoshi, Hiroshi Itoh, Kaori Hayashi, Toshio Shimada, Koichi Ozaki, Issei Tanaka, Wen-Ling Liao, Yen-Ting Chang, Ting-Yuan Liu, Fuu-Jen Tsai, Chikashi Terao","doi":"10.1038/s42003-026-10791-y","DOIUrl":"https://doi.org/10.1038/s42003-026-10791-y","url":null,"abstract":"Type 2 diabetes (T2D) is a highly heterogeneous metabolic trait, with a higher prevalence in East Asians. Despite extensive genetic studies focusing mainly on Europeans, how genetic risk for T2D is distributed across biological pathways in East Asians in comparison with Europeans remains incompletely understood. Here, we show results from what is, to our knowledge, the largest genome-wide association study in East Asians, including 596,778 individuals, with a direct comparison to a European study of comparable sample size. We identified 196 loci, including three previously unreported loci. Subsequent multi-ancestry fine-mapping resolved 521 independent causal signals with high precision, revealing that 74% are shared while the remainder are strictly ancestry-specific. Beyond this shared architecture, we observed population differences in regulatory and pathway-level contributions, particularly involving pancreatic regulation and lipid- or adipose-related pathways. Furthermore, constructing a polygenic risk score using the cross-ancestry meta-analysis yielded the most robust predictive performance (AUC = 0.788). These findings clarify how T2D genetic risk is organized across populations, demonstrating that while multi-ancestry integration maximizes clinical predictive power, well-powered single-ancestry studies remain indispensable for uncovering population-specific biological mechanisms.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"9 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13627662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149105219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The thermodynamic state map of biomolecular condensates. 生物分子凝聚物的热力学状态图。

IF 5.8 1区生物学

Communications Biology Pub Date : 2026-09-29 DOI: 10.1038/s42003-026-11056-4

Yaoyao Hou, Lingyun Jing, Kan Sun, Yufeng Chang, Jingyue Zhao, Xin Li, Jinrong Min, Liang Wang

{"title":"The thermodynamic state map of biomolecular condensates.","authors":"Yaoyao Hou, Lingyun Jing, Kan Sun, Yufeng Chang, Jingyue Zhao, Xin Li, Jinrong Min, Liang Wang","doi":"10.1038/s42003-026-11056-4","DOIUrl":"10.1038/s42003-026-11056-4","url":null,"abstract":"Biomolecular condensates spatiotemporally regulate cellular biochemistry through liquid-liquid phase separation. In this Perspective, we refine the Condensate Code as a testable thermodynamic state map that integrates continuous cellular inputs, intrinsic molecular grammar and boundary conditions to govern measurable material states. Building on stickers-and-spacers and related grammar frameworks, we highlight a continuum from electrostatic coacervates to viscoelastic networks. We define active anti-grammar as an operational umbrella for localized repulsive or hydration-promoting effects that can counterbalance excessive cohesion when embedded in, modified within or recruited to dense phases. This view predicts measurable changes in partitioning, FRAP recovery, viscosity, aging and fibril-nucleation kinetics. Disruption of the code can drive pathogenic liquid-to-solid transitions and spatial uncoupling with organelle mechanotoxicity. We therefore conceptualize physical therapeutics as programmable macromolecular modulators that test whether localized anti-cohesive effects can remodel pathological material states while monitoring targeting, partitioning, oligomeric intermediates and safety.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"9 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13623880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149079864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cryo-EM structures of CENP-A nucleosomes isolated from human cells. 从人细胞分离的CENP-A核小体的低温电镜结构。

IF 5.8 1区生物学

Communications Biology Pub Date : 2026-09-29 DOI: 10.1038/s42003-026-10946-x

Eisho Tanida, Suguru Hatazawa, Takumi Oishi, Yuki Kobayashi, Mitsuo Ogasawara, Marta A Jaskiewicz, Akihito Harada, Takeru Fujii, Yasuyuki Ohkawa, Yoshimasa Takizawa, Hitoshi Kurumizaka

{"title":"Cryo-EM structures of CENP-A nucleosomes isolated from human cells.","authors":"Eisho Tanida, Suguru Hatazawa, Takumi Oishi, Yuki Kobayashi, Mitsuo Ogasawara, Marta A Jaskiewicz, Akihito Harada, Takeru Fujii, Yasuyuki Ohkawa, Yoshimasa Takizawa, Hitoshi Kurumizaka","doi":"10.1038/s42003-026-10946-x","DOIUrl":"10.1038/s42003-026-10946-x","url":null,"abstract":"Centromeres ensure accurate chromosome segregation, and their identity is specified epigenetically by the histone H3 variant CENP-A. Although the structures of reconstituted CENP-A nucleosomes have provided important insights, how this epigenetic mark is structurally organized within native chromatin remains incompletely understood. Here, we combine cryogenic electron microscopy with chromatin immunoprecipitation (ChIP-CryoEM) to determine the structures of human CENP-A nucleosomes isolated directly from cells without crosslinking or stabilizing agents. We resolved two distinct cellular CENP-A nucleosome structures: a homotypic CENP-A nucleosome and a heterotypic CENP-A/H3 nucleosome, which have been proposed to represent centromeric and ectopic nucleosomes, respectively. Both cellular CENP-A nucleosomes assemble as histone octamers and wrap DNA in a left-handed superhelix, supporting an octameric model proposed for native CENP-A chromatin. In addition, the hallmark CENP-A-specific structural features previously characterized in vitro, including the shortened CENP-A N-terminal α-helix and the distinctive RG loop, are preserved in cellular CENP-A nucleosomes. These findings define the structural organization of CENP-A nucleosomes in cellular chromatin.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"9 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13623831/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149079840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Culture and gene expression profiling of Schwann cells from human sural nerve. 人腓肠神经雪旺细胞的培养及基因表达谱分析。

IF 5.8 1区生物学

Communications Biology Pub Date : 2026-09-28 DOI: 10.1038/s42003-026-11023-z

Patricia García-Fernández, Thorsten Bischler, Annemarie Sodmann, Julia Grüner, Maximilian Koch, Eva Meller, Tom Gräfenhan, Robert Blum, Nurcan Üçeyler, Claudia Sommer

{"title":"Culture and gene expression profiling of Schwann cells from human sural nerve.","authors":"Patricia García-Fernández, Thorsten Bischler, Annemarie Sodmann, Julia Grüner, Maximilian Koch, Eva Meller, Tom Gräfenhan, Robert Blum, Nurcan Üçeyler, Claudia Sommer","doi":"10.1038/s42003-026-11023-z","DOIUrl":"https://doi.org/10.1038/s42003-026-11023-z","url":null,"abstract":"Polyneuropathies (PNP) are diseases of the peripheral nervous system (PNS) whose pathophysiology remains poorly understood. Schwann cells (SC) are the principle glial cells in the PNS, and their dysfunction can lead to demyelination and secondary axonal degeneration, causing or exacerbating PNP. The study of SC can thus shed light on the molecular and cellular mechanisms involved in PNP. Protocols have been developed to isolate and culture human and animal SC from large amounts of starting material. The isolation of human SC from patients, where only small biosamples are available, remains a challenge. In this study, we present a protocol to culture human SC from ~4-mm diagnostic sural nerve biopsies and a comprehensive transcriptome analysis to characterize their phenotype. Our protocol allows the reproducible establishment of cultures containing proliferative human Schwann cells that can be stored, expanded, and used as tools for diagnostic applications.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"9 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13627658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149105258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recurrent deletions and regulatory disruption of the Y chromosome in cancer. 癌症中Y染色体的反复缺失和调控中断。

IF 5.8 1区生物学

Communications Biology Pub Date : 2026-09-28 DOI: 10.1038/s42003-026-10875-9

Trini Nguyen, Aditi Kuchi, Hongyu Liu, Nicholas Tatonetti, Dan Theodorescu

{"title":"Recurrent deletions and regulatory disruption of the Y chromosome in cancer.","authors":"Trini Nguyen, Aditi Kuchi, Hongyu Liu, Nicholas Tatonetti, Dan Theodorescu","doi":"10.1038/s42003-026-10875-9","DOIUrl":"10.1038/s42003-026-10875-9","url":null,"abstract":"Somatic loss of the Y chromosome (LOY) is the most frequent acquired genomic alteration in aging males and occurs across multiple cancer types. While common, its functional role in tumorigenesis is only beginning to emerge. Most studies treat LOY as a binary event, ignoring partial deletions that may selectively remove gene-rich euchromatic regions. To address this, we used high-coverage whole-genome sequencing, large-scale transcriptomics, and eQTL to map male cancer cell lines, eliminating confounding non-malignant cells. We reveal a region-specific LOY landscape with recurrent euchromatic deletions affecting protein-coding genes and non-coding elements. Losses were quantified using a new Y EroSion (YES) Score, which is associated with transcriptional differences and clinical outcome patterns suggestive of functional relevance. Retained Y-linked loci remain transcriptionally active, enriched for proliferation, immune signaling, and stress adaptation functions. These findings position LOY as a structured genomic event with regulatory and clinical implications, motivating validation in primary tumor cohorts.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"9 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13619554/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149073775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Arthritis models for studying chikungunya virus joint inflammation. 研究基孔肯雅病毒关节炎症的关节炎模型。

IF 5.8 1区生物学

Communications Biology Pub Date : 2026-09-28 DOI: 10.1038/s42003-026-10559-4

Ivan J H Sam, Laurent Rénia, Louisa L Y Chan, Lisa F P Ng

引用次数: 0

Unexpected functional role of the transactivation domain for nuclear import of STAT5. 核导入STAT5的transactivation域的意外功能作用。

IF 5.8 1区生物学

Communications Biology Pub Date : 2026-09-26 DOI: 10.1038/s42003-026-10898-2

Sabrina Ernst, Merith Borgen-Möller, Andrea Küster, Henning Schurse, Gerhard Müller-Newen

{"title":"Unexpected functional role of the transactivation domain for nuclear import of STAT5.","authors":"Sabrina Ernst, Merith Borgen-Möller, Andrea Küster, Henning Schurse, Gerhard Müller-Newen","doi":"10.1038/s42003-026-10898-2","DOIUrl":"10.1038/s42003-026-10898-2","url":null,"abstract":"Signal transducer and activator of transcription 5 (STAT5) is a key transcriptional regulator acting downstream of hematopoietic cytokines and hormones, such as erythropoietin (Epo), thrombopoietin or prolactin. STAT5-mediated gene regulation involves tyrosine phosphorylation at cytokine receptors and subsequent nuclear import. We studied STAT5 nucleocytoplasmic shuttling via live-cell imaging of fluorescent mutants in STAT5-/- HeLa EpoR cells. Unexpectedly, STAT5 mutants lacking the transactivation domain (TAD) were retained in the cytoplasm following Epo stimulation. Building upon this, we identified a 12-amino-acid stretch in the TAD sufficient to restore nuclear translocation. Further analysis revealed two residues within this 12‑amino‑acid stretch, D754 and D758, to be essential for nuclear import of phosphorylated full-length STAT5. Importantly, a single intact TAD in the STAT5 dimer is sufficient for nuclear import. Our findings reveal a unique role of the TAD in STAT5 nuclear trafficking distinct from other STATs, providing new mechanistic insight and potential targets for therapeutic intervention in STAT5-driven disease such as myeloproliferative neoplasms and leukemia.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"9 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13615974/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149058883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0