Communications Biology最新文献_第2页

Mutational signature analyses in multi-child families reveal sources of age-related increases in human germline mutations. 多子女家庭的突变特征分析揭示了与年龄相关的人类种系突变增加的来源。

IF 5.2 1区生物学

Communications Biology Pub Date : 2024-11-06 DOI: 10.1038/s42003-024-07140-2

Habiballah Shojaeisaadi, Andrew Schoenrock, Matthew J Meier, Andrew Williams, Jill M Norris, Nicholette D Palmer, Carole L Yauk, Francesco Marchetti

{"title":"Mutational signature analyses in multi-child families reveal sources of age-related increases in human germline mutations.","authors":"Habiballah Shojaeisaadi, Andrew Schoenrock, Matthew J Meier, Andrew Williams, Jill M Norris, Nicholette D Palmer, Carole L Yauk, Francesco Marchetti","doi":"10.1038/s42003-024-07140-2","DOIUrl":"10.1038/s42003-024-07140-2","url":null,"abstract":"<p><p>Whole-genome sequencing studies of parent-offspring trios have provided valuable insights into the potential impact of de novo mutations (DNMs) on human health and disease. However, the molecular mechanisms that drive DNMs are unclear. Studies with multi-child families can provide important insight into the causes of inter-family variability in DNM rates but they are highly limited. We characterized 2479 de novo single nucleotide variants (SNVs) in 13 multi-child families of Mexican-American ethnicity. We observed a strong paternal age effect on validated de novo SNVs with extensive inter-family variability in the yearly rate of increase. Children of older fathers showed more C > T transitions at CpG sites than children from younger fathers. Validated SNVs were examined against one cancer (COSMIC) and two non-cancer (human germline and CRISPR-Cas 9 knockout of human DNA repair genes) mutational signature databases. These analyses suggest that inaccurate DNA mismatch repair during repair initiation and excision processes, along with DNA damage and replication errors, are major sources of human germline de novo SNVs. Our findings provide important information for understanding the potential sources of human germline de novo SNVs and the critical role of DNA mismatch repair in their genesis.</p>","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":null,"pages":null},"PeriodicalIF":5.2,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11541588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retinol binding protein 4 restricts PCV2 replication via selective autophagy degradation of viral ORF1 protein 视黄醇结合蛋白 4 通过选择性自噬降解病毒 ORF1 蛋白限制 PCV2 复制

IF 5.2 1区生物学

Communications Biology Pub Date : 2024-11-05 DOI: 10.1038/s42003-024-07052-1

Qingbing Han, Hejiao Zhao, Meng Chen, Wenshuo Xue, Jun Li, Lei Sun, Yingli Shang

{"title":"Retinol binding protein 4 restricts PCV2 replication via selective autophagy degradation of viral ORF1 protein","authors":"Qingbing Han, Hejiao Zhao, Meng Chen, Wenshuo Xue, Jun Li, Lei Sun, Yingli Shang","doi":"10.1038/s42003-024-07052-1","DOIUrl":"10.1038/s42003-024-07052-1","url":null,"abstract":"Autophagy is a highly conserved degradative process that has been linked to various functions, including defending host cells against pathogens. Although the involvement of autophagy in porcine circovirus 2 (PCV2) infection has become apparent, it remains unclear whether selective autophagy plays a critical role in PCV2 restriction. Here we show that retinol-binding protein 4 (RBP4), an adipokine for retinol carrier, initiates the autophagic degradation of PCV2 ORF1 protein. PCV2 infection increases RBP4 protein levels through MAPK-eIF4E axis in living cells. Ectopic expression of RBP4 or recombinant RBP4 treatment promotes the degradation of ORF1 protein. Mechanistically, RBP4 activates TRAF6 to induce K63-linked ubiquitination of ORF1, leading to SQSTM1/p62-mediated selective autophagy for degradation. Consequently, RBP4 deficiency increases viral loads and exacerbates the pathogenicity of PCV2 in vivo. Collectively, these results identify RBP4 as a key host restriction factor of PCV2 and reveal a previously undescribed antiviral mechanism against PCV2 in infected cells. Retinol binding protein 4 activates TRAF6 to induce K63-linked ubiquitination and degradation of PCV2 ORF1 protein through SQSTM1/p62-mediated selective autophagy to restrict PCV2 replication.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":null,"pages":null},"PeriodicalIF":5.2,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s42003-024-07052-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142579795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting GPR39 in structure-based drug discovery reduces Ang II-induced hypertension 在基于结构的药物研发中以 GPR39 为靶点，降低血管紧张素 II 诱导的高血压

IF 5.2 1区生物学

Communications Biology Pub Date : 2024-11-05 DOI: 10.1038/s42003-024-07132-2

Dongxu Hua, Wanlin Huang, Qiyang Xie, Wenna Xu, Lu Tang, Mingwei Liu, Xiaoguang Wu, Qiaodong Zhang, Xu Cao, Peng Li, Yanhui Sheng

{"title":"Targeting GPR39 in structure-based drug discovery reduces Ang II-induced hypertension","authors":"Dongxu Hua, Wanlin Huang, Qiyang Xie, Wenna Xu, Lu Tang, Mingwei Liu, Xiaoguang Wu, Qiaodong Zhang, Xu Cao, Peng Li, Yanhui Sheng","doi":"10.1038/s42003-024-07132-2","DOIUrl":"10.1038/s42003-024-07132-2","url":null,"abstract":"The endothelium-dependent vascular injury, a primary pathological feature of angiotensin II (Ang II)-induced hypertension. This study aimed to explore the role and underlying mechanisms of G protein-coupled receptor 39 (GPR39) in the pathogenesis of Ang II-induced hypertension. For in vivo studies, GPR39 knockout (KO) mice (C57BL/6 J, male) were generated and administered Ang II for 4 weeks. GPR39 expression was upregulated in the aorta of hypertensive patients and mice. The ablation of GPR39 mitigated vascular fibrosis, augmented endothelium-dependent vasodilation, and inhibited endothelial inflammation, oxidative stress, and apoptosis in mice. Additionally, GPR39 KO decreased NOD-like receptor protein 3 (Nlrp3) gene expression in Ang II-stimulated endothelial cells. Notably, Nlrp3 activation counteracted the therapeutic benefits of GPR39 KO. We identified the potential ligand of GPR39 using structure-based high throughput virtual screening (HTVS) and validated its antihypertensive function in vitro and in vivo. The small molecule ligand Z1780628919 of GPR39 can also reduce Ang II-induced hypertension and improve vascular function. GPR39 KO and the small molecule ligand Z1780628919 potentially downregulates Nlrp3, thereby mitigating vascular fibrosis, endothelial inflammation, oxidative stress, and apoptosis. This effect contributes to the alleviation of Ang II-induced hypertension and the rectification of vascular dysfunctions. These findings suggest new avenues for therapeutic intervention. Knocking out GPR39 or using its small molecule inhibitors can alleviate vascular fibrosis, endothelial inflammation, oxidative stress, and apoptosis by downregulating Nlrp3. This effect helps alleviate Ang II-induced hypertension in mice.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":null,"pages":null},"PeriodicalIF":5.2,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s42003-024-07132-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142579814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of data resolution on dynamic causal inference in multiscale ecological networks 数据分辨率对多尺度生态网络动态因果推理的影响

IF 5.2 1区生物学

Communications Biology Pub Date : 2024-11-05 DOI: 10.1038/s42003-024-07054-z

Erik Saberski, Tom Lorimer, Delia Carpenter, Ethan Deyle, Ewa Merz, Joseph Park, Gerald M. Pao, George Sugihara

{"title":"The impact of data resolution on dynamic causal inference in multiscale ecological networks","authors":"Erik Saberski, Tom Lorimer, Delia Carpenter, Ethan Deyle, Ewa Merz, Joseph Park, Gerald M. Pao, George Sugihara","doi":"10.1038/s42003-024-07054-z","DOIUrl":"10.1038/s42003-024-07054-z","url":null,"abstract":"While it is commonly accepted that ecosystem dynamics are nonlinear, what is often not acknowledged is that nonlinearity implies scale-dependence. With the increasing availability of high-resolution ecological time series, there is a growing need to understand how scale and resolution in the data affect the construction and interpretation of causal networks—specifically, networks mapping how changes in one variable drive changes in others as part of a shared dynamic system (“dynamic causation”). We use Convergent Cross Mapping (CCM), a method specifically designed to measure dynamic causation, to study the effects of varying temporal and taxonomic/functional resolution in data when constructing ecological causal networks. As the system is viewed at different scales relationships will appear and disappear. The relationship between data resolution and interaction presence is not random: the temporal scale at which a relationship is uncovered identifies a biologically relevant scale that drives changes in population abundance. Further, causal relationships between taxonomic aggregates (low-resolution) are shown to be influenced by the number of interactions between their component species (high-resolution). Because no single level of resolution captures all the causal links in a system, a more complete understanding requires multiple levels when constructing causal networks. This paper examines how data resolution affects dynamic causal inference in ecological networks. Using Convergent Cross Mapping (CCM), we show that different temporal and taxonomic scales reveal varying causal links, important for ecosystem management.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":null,"pages":null},"PeriodicalIF":5.2,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s42003-024-07054-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142579793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Knowledge-based inductive bias and domain adaptation for cell type annotation 细胞类型注释中基于知识的归纳偏差和领域适应性

IF 5.2 1区生物学

Communications Biology Pub Date : 2024-11-05 DOI: 10.1038/s42003-024-07171-9

Zhenchao Tang, Guanxing Chen, Shouzhi Chen, Haohuai He, Linlin You, Calvin Yu-Chian Chen

{"title":"Knowledge-based inductive bias and domain adaptation for cell type annotation","authors":"Zhenchao Tang, Guanxing Chen, Shouzhi Chen, Haohuai He, Linlin You, Calvin Yu-Chian Chen","doi":"10.1038/s42003-024-07171-9","DOIUrl":"10.1038/s42003-024-07171-9","url":null,"abstract":"Measurement techniques often result in domain gaps among batches of cellular data from a specific modality. The effectiveness of cross-batch annotation methods is influenced by inductive bias, which refers to a set of assumptions that describe the behavior of model predictions. Different annotation methods possess distinct inductive biases, leading to varying degrees of generalizability and interpretability. Given that certain cell types exhibit unique functional patterns, we hypothesize that the inductive biases of cell annotation methods should align with these biological patterns to produce meaningful predictions. In this study, we propose KIDA, Knowledge-based Inductive bias and Domain Adaptation. The knowledge-based inductive bias constrains the prediction rules learned from the reference dataset, composed of multiple batches, to functional patterns relevant to biology, thereby enhancing the generalization of the model to unseen batches. Since the query dataset also contains gaps from multiple batches, KIDA’s domain adaptation employs pseudo labels for self-knowledge distillation, effectively narrowing the distribution gap between model predictions and the query dataset. Benchmark experiments demonstrate that KIDA is capable of achieving accurate cross-batch cell type annotation. Knowledge-based inductive bias and domain adaptation can enhance the cell type annotation accuracy of deep learning models.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":null,"pages":null},"PeriodicalIF":5.2,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s42003-024-07171-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142579790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trait responses, nonconsumptive effects, and the physiological basis of Helicoverpa armigera to bat predation risk Helicoverpa armigera 对蝙蝠捕食风险的性状反应、非消耗效应和生理基础

IF 5.2 1区生物学

Communications Biology Pub Date : 2024-11-05 DOI: 10.1038/s42003-024-07166-6

Yingying Liu, Yang Geng, Man Si, Dan Zhu, Zhenglanyi Huang, Hanli Yin, Hao Zeng, Jiang Feng, Tinglei Jiang

{"title":"Trait responses, nonconsumptive effects, and the physiological basis of Helicoverpa armigera to bat predation risk","authors":"Yingying Liu, Yang Geng, Man Si, Dan Zhu, Zhenglanyi Huang, Hanli Yin, Hao Zeng, Jiang Feng, Tinglei Jiang","doi":"10.1038/s42003-024-07166-6","DOIUrl":"10.1038/s42003-024-07166-6","url":null,"abstract":"Predation reduces the population density of prey, affecting its fitness and population dynamics. Few studies have connected trait changes with fitness consequences in prey and the molecular basis and metabolic mechanisms of such changes in bat-insect systems. This study focuses on the responses of Helicoverpa armigera to different predation risks, focusing on echolocating bats and their calls. Substantial modifications were observed in the nocturnal and diurnal activities of H. armigera under predation risk, with enhanced evasion behaviors. Accelerated development and decreased fitness were observed under predation risks. Transcriptomic and metabolomic analyses indicated that exposure to bats induced the upregulation of amino acid metabolism- and antioxidant pathway-related genes, reflecting shifts in resource utilization in response to oxidative stress. Exposure to bat predation risks enhanced the activity of DNA damage repair pathways and suppressed energy metabolism, contributing to the observed trait changes and fitness decreases. The current results underscore the complex adaptive strategies that prey species evolve in response to predation risk, enhancing our understanding of the predator–prey dynamic and offering valuable insights for innovative and ecologically informed pest management strategies. Helicoverpa armigera shows adaptive trait changes under bat predation risk, with increased evasion, accelerated development, and fitness decreases. Molecular analyses reveal shifts in metabolism and stress response pathways linked to these changes.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":null,"pages":null},"PeriodicalIF":5.2,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s42003-024-07166-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142579807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Three-dimensional localization and tracking of chromosomal loci throughout the Escherichia coli cell cycle. 大肠杆菌细胞周期中染色体位点的三维定位和追踪。

IF 5.2 1区生物学

Communications Biology Pub Date : 2024-11-05 DOI: 10.1038/s42003-024-07155-9

Praneeth Karempudi, Konrad Gras, Elias Amselem, Spartak Zikrin, Dvir Schirman, Johan Elf

引用次数: 0

STUB1 suppresses paclitaxel resistance in ovarian cancer through mediating HOXB3 ubiquitination to inhibit PARK7 expression STUB1 通过介导 HOXB3 泛素化来抑制 PARK7 的表达，从而抑制卵巢癌的紫杉醇耐药性

IF 5.2 1区生物学

Communications Biology Pub Date : 2024-11-05 DOI: 10.1038/s42003-024-07127-z

Laigang Zhao, HanLin Yang, Yuanmei Wang, Shuang Yang, Qisi Jiang, Jun Tan, Xing Zhao, Dan Zi

{"title":"STUB1 suppresses paclitaxel resistance in ovarian cancer through mediating HOXB3 ubiquitination to inhibit PARK7 expression","authors":"Laigang Zhao, HanLin Yang, Yuanmei Wang, Shuang Yang, Qisi Jiang, Jun Tan, Xing Zhao, Dan Zi","doi":"10.1038/s42003-024-07127-z","DOIUrl":"10.1038/s42003-024-07127-z","url":null,"abstract":"Paclitaxel (PTX) is a first-line drug for ovarian cancer (OC) treatment. However, the regulatory mechanism of STUB1 on ferroptosis and PTX resistance in OC remains unclear. Genes and proteins levels were evaluated by RT-qPCR, western blot and IHC. Cell viability and proliferation were measured by CCK-8 and clone formation. The changes of mitochondrial morphology were observed under a transmission electron microscope (TEM). Reactive oxygen species (ROS), iron, malondialdehyde (MDA) and glutathione (GSH) were measured using suitable kits. The interactions among STUB1, HOXB3 and PARK7 were validated using Co-IP, and dual luciferase reporter assay. Our study found that STUB1 was decreased and PARK7 was increased in tumor tissue, especially from chemotherapy resistant ovarian cancer tissue and resistant OC cells. STUB1 overexpression or PARK7 silencing suppressed cell growth and promoted ferroptosis in PTX-resistant OC cells, which was reversed by HOXB3 overexpression. Mechanistically, STUB1 mediated ubiquitination of HOXB3 to inhibit HOXB3 expression, and HOXB3 promoted the transcription of PARK7 by binding to the promoter region of PARK7. Furthermore, STUB1 overexpression or PARK7 silencing suppressed tumor formation in nude mice. In short, STUB1 promoted ferroptosis through regulating HOXB3/PARK7 axis, thereby suppressing chemotherapy resistance in OC. STUB1 mediates the degradation of HOXB3 through ubiquitin, and the decrease of HOXB3 inhibits the level of PARK7, thereby promoting ferroptosis in drug-resistant ovarian cancer cells.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":null,"pages":null},"PeriodicalIF":5.2,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s42003-024-07127-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142579825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The evolutionary landscape of prokaryotic chromosome/plasmid balance 原核生物染色体/质粒平衡的进化图景。

IF 5.2 1区生物学

Communications Biology Pub Date : 2024-11-04 DOI: 10.1038/s42003-024-07167-5

Wenzhi Xue, Juken Hong, Teng Wang

{"title":"The evolutionary landscape of prokaryotic chromosome/plasmid balance","authors":"Wenzhi Xue, Juken Hong, Teng Wang","doi":"10.1038/s42003-024-07167-5","DOIUrl":"10.1038/s42003-024-07167-5","url":null,"abstract":"The balance between chromosomal and plasmid DNAs determines the genomic plasticity of prokaryotes. Natural selections, acting on the level of organisms or plasmids, shape the abundances of plasmid DNAs in prokaryotic genomes. Despite the importance of plasmids in health and engineering, there have been rare systematic attempts to quantitatively model and predict the determinants underlying the strength of different selection forces. Here, we develop a metabolic flux model that describes the intracellular resource competition between chromosomal and plasmid-encoded reactions. By coarse graining, this model predicts a landscape of natural selections on chromosome/plasmid balance, which is featured by the tradeoff between phenotypic and non-phenotypic selection pressures. This landscape is further validated by the observed pattern of plasmid distributions in the vast collection of prokaryotic genomes retrieved from the NCBI database. Our results establish a universal paradigm to understand the prokaryotic chromosome/plasmid interplay and provide insights into the evolutionary origin of plasmid diversity. An intracellular resource competition model sheds light on the evolutionary forces that govern the balance between chromosomal and plasmid DNAs in prokaryotic genomes.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":null,"pages":null},"PeriodicalIF":5.2,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s42003-024-07167-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142574991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Complexity and weak integration promote the diversity of reef fish oral jaws 复杂性和弱整合性促进了珊瑚礁鱼类口颌的多样性。

IF 5.2 1区生物学

Communications Biology Pub Date : 2024-11-04 DOI: 10.1038/s42003-024-07148-8

M. D. Burns, D. R. Satterfield, N. Peoples, H. Chan, A. J. Barley, M. L. Yuan, A. S. Roberts-Hugghis, K. T. Russell, M. Hess, S. L. Williamson, K. A. Corn, M. Mihalitsis, D. K. Wainwright, P. C. Wainwright

{"title":"Complexity and weak integration promote the diversity of reef fish oral jaws","authors":"M. D. Burns, D. R. Satterfield, N. Peoples, H. Chan, A. J. Barley, M. L. Yuan, A. S. Roberts-Hugghis, K. T. Russell, M. Hess, S. L. Williamson, K. A. Corn, M. Mihalitsis, D. K. Wainwright, P. C. Wainwright","doi":"10.1038/s42003-024-07148-8","DOIUrl":"10.1038/s42003-024-07148-8","url":null,"abstract":"Major trade-offs often manifest as axes of diversity in organismal functional systems. Overarching trade-offs may result in high trait integration and restrict the trajectory of diversification to be along a single axis. Here, we explore the diversification of the feeding mechanism in coral reef fishes to establish the role of trade-offs and complexity in a spectacular ecological radiation. We show that the primary axis of variation in the measured musculo-skeletal traits is aligned with a trade-off between mobility and force transmission, spanning species that capture prey with suction and those that bite attached prey. We found weak or no covariation between about half the traits, reflecting deviations from the trade-off axis. The dramatic trophic range found among reef fishes occurs along the primary trade-off axis, with numerous departures that use a mosaic of trait combinations to adapt the feeding mechanism to diverse challenges. We suggest that morphological evolution both along and independent of a major axis of variation is a widespread mechanism of diversification in complex systems where a global trade-off shapes major patterns of diversity. Significant additional diversity emerges as systems use weak integration and complexity to assemble functional units with many trait combinations that meet varying ecological demands. The diversity of coral reef fishes’ feeding apparatus aligns with the trade-off between mobility and force transmission, but weak trait covariation and complexity allow jaw traits to evolve independently to adapt to diverse ecological challenges.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":null,"pages":null},"PeriodicalIF":5.2,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s42003-024-07148-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142575538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0