Communications Biology最新文献_第2页

The bacteriophage transcription factor Gp53 suppresses cell division and regulates Pseudomonas aeruginosa physiology. 噬菌体转录因子Gp53抑制细胞分裂，调控铜绿假单胞菌生理。

IF 5.8 1区生物学

Communications Biology Pub Date : 2026-10-08 DOI: 10.1038/s42003-026-11031-z

Ying Li, Xiaomin Li, Gukui Chen, Lixin Yuan, Hailong Zhong, Min Hui, Yongfeng Sun, Yufei Han, Shuqin Zhou, Shiwei Wang, Weina Kong

{"title":"The bacteriophage transcription factor Gp53 suppresses cell division and regulates Pseudomonas aeruginosa physiology.","authors":"Ying Li, Xiaomin Li, Gukui Chen, Lixin Yuan, Hailong Zhong, Min Hui, Yongfeng Sun, Yufei Han, Shuqin Zhou, Shiwei Wang, Weina Kong","doi":"10.1038/s42003-026-11031-z","DOIUrl":"10.1038/s42003-026-11031-z","url":null,"abstract":"Pseudomonas aeruginosa is a highly drug-resistant pathogen that poses a major challenge to clinical treatment. Bacteriophages encode diverse regulatory proteins that can alter host cellular processes during infection. Here we show that the ΦPA1019-encoded transcription factor Gp53 regulates bacterial physiology by targeting key host pathways. Gp53 expression reduces bacterial growth, motility, and biofilm formation, and causes filamentous cell morphology. Transcriptomic analysis reveals that Gp53 alters the expression of 3,342 genes, including genes involved in cell division and virulence-associated processes. DNA-binding assays demonstrate that Gp53 directly represses promoters of key host genes, including ftsZ, fleQ, pslA, and amrZ. Gp53-mediated repression of ftsZ disrupts Z-ring formation and inhibits cell division, while ftsZ expression restores these defects. Structural and mutational analyses identify residues important for Gp53-DNA interaction. Together, these findings reveal a phage-encoded mechanism that coordinately interferes with bacterial cell division and virulence-associated pathways, providing mechanistic insights into host transcriptional regulation during phage infection and expanding our understanding of phage-host interactions.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"9 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13650114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149135339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DNA-based monitoring uncovers contrasting salinity-driven diversity patterns of bacterial and protist plankton in the Baltic Sea area. 基于dna的监测揭示了波罗的海地区细菌和原生浮游生物的不同盐度驱动的多样性模式。

IF 5.8 1区生物学

Communications Biology Pub Date : 2026-10-07 DOI: 10.1038/s42003-026-10977-4

Krzysztof T Jurdzinski, Meike Ac Latz, Anders Torstensson, Sonia Brugel, Mikael Hedblom, Yue O O Hu, Markus Lindh, Agneta Andersson, Bengt Karlson, Anders F Andersson

{"title":"DNA-based monitoring uncovers contrasting salinity-driven diversity patterns of bacterial and protist plankton in the Baltic Sea area.","authors":"Krzysztof T Jurdzinski, Meike Ac Latz, Anders Torstensson, Sonia Brugel, Mikael Hedblom, Yue O O Hu, Markus Lindh, Agneta Andersson, Bengt Karlson, Anders F Andersson","doi":"10.1038/s42003-026-10977-4","DOIUrl":"10.1038/s42003-026-10977-4","url":null,"abstract":"Salinity has been identified as a primary factor structuring community composition in global diversity assessments of free-living bacteria in non-extreme environments. It remains unknown whether the same is true for protists. Moreover, changes in alpha diversity of both bacteria and protists across the brackish salinity gradient remain elusive. Here, we analyzed protist and bacterial diversity using DNA metabarcoding across 398 surface water samples synchronized with national monitoring of the Baltic Sea and the Kattegat-Skagerrak. We show that salinity, unlike other environmental factors, had a stronger effect on bacterial than on protist community composition. Likewise, protist taxonomic units tended to have broader salinity niches than bacterial ones. In contrast, protist but not bacterial alpha diversity (richness) increased with salinity. Bacterial alpha diversity was similar across salinities despite drastic changes in community composition, as marine-associated taxa steadily replaced freshwater-associated ones. Conversely, marine-associated protists dominated across most of the salinity gradient, with fewer taxonomic units adapted to lower salinities. Overall, the diversity of protists but not bacteria followed patterns consistent with local adaptation as observed in other groups of organisms. Ultimately, the observed patterns form a baseline for environmental monitoring and suggest unexplored differences between bacterial and protist eco-evolutionary dynamics.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"9 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13646260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Target-dependent routing of sensory information in the olfactory system. 嗅觉系统中感官信息的目标依赖路径。

IF 5.8 1区生物学

Communications Biology Pub Date : 2026-10-07 DOI: 10.1038/s42003-026-11071-5

Kim Le-Jahns, Siran Sireci, Jan Mayland, Franziska Richter, Pablo Chamero, Martin K Schwarz, Daniela Brunert, Markus Rothermel

{"title":"Target-dependent routing of sensory information in the olfactory system.","authors":"Kim Le-Jahns, Siran Sireci, Jan Mayland, Franziska Richter, Pablo Chamero, Martin K Schwarz, Daniela Brunert, Markus Rothermel","doi":"10.1038/s42003-026-11071-5","DOIUrl":"10.1038/s42003-026-11071-5","url":null,"abstract":"Parallel processing, the ability to split the information content of sensory stimuli and handle them simultaneously, is essential for sensory perception in many systems. Mitral (MCs) and tufted cells (TCs) in the olfactory bulb (OB), with their separate but overlapping projection areas, provide an ideal anatomical basis for parallel processing. Whether they convey different information to distinct areas of the olfactory cortex remains unclear. Here, we separated mouse OB output neurons by innervation area using retrograde tracing from the anterior olfactory nucleus (AON) or the anterior piriform cortex (APC). In vivo 2-photon calcium imaging in the OB revealed projection area-dependent differences, with APC-projecting neurons coding more strongly for odor concentration and more selectively for odor identity. This separation became more pronounced when differentially traced populations were split by cell type, with APC TCs displaying the strongest concentration-dependent changes in response and AON TCs showing very promiscuous odor tuning. Purely cell-type-derived properties did not explain the projection target-dependent differences in odor representation, as both mitral and tufted cells showed similar changes, and SVM classifier analysis demonstrated that classification by projection target outperformed classification by cell type. Our data suggests a prominent projection-defined separation of sensory information in the OB.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"9 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13646270/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adult hippocampal neurogenesis shapes ideomotor action control in mice. 成年海马神经发生影响小鼠的意识运动动作控制。

IF 5.8 1区生物学

Communications Biology Pub Date : 2026-10-07 DOI: 10.1038/s42003-026-11112-z

Warsha Barde, Gerd Kempermann, Christian Beste

{"title":"Adult hippocampal neurogenesis shapes ideomotor action control in mice.","authors":"Warsha Barde, Gerd Kempermann, Christian Beste","doi":"10.1038/s42003-026-11112-z","DOIUrl":"10.1038/s42003-026-11112-z","url":null,"abstract":"Humans select and learn goal-directed actions through the anticipation of their outcomes. While this ideomotor principle is well established in humans, its biological instantiation and relevance for organizing naturalistic behavior remain unclear, including its neurobiological substrates such as hippocampal plasticity. Here, we leverage high-resolution, continuous behavioral tracking in mice across a month-long series of automated learning tasks to test whether ideomotor principles generalize to naturalistic behavior and how they relate to adult hippocampal neurogenesis. Mice lived in a shared enriched environment and engaged in self-initiated learning tasks, allowing us to quantify how action-outcome associations are formed, maintained, and updated. Despite identical genetic background and environment, animals showed stable individual differences in how these associations were organized. These differences correlated with levels of adult hippocampal neurogenesis: higher neurogenesis was associated with broader, more variable exploration and greater flexibility in updating action-outcome relations, whereas lower neurogenesis was linked to more rigid behavior. Together, these findings link ideomotor theory to a cellular plasticity mechanism supporting flexible action control.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"9 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13645787/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LSD reconfigures cortical dynamics through faster brain rhythms and increased fractal dimension. LSD通过更快的大脑节奏和增加的分形维数来重新配置皮质动力学。

IF 5.8 1区生物学

Communications Biology Pub Date : 2026-10-07 DOI: 10.1038/s42003-026-10629-7

Venkatesh Subramani, Timothy Nest, Annalisa Pascarella, Jérémy Brunel, Yorguin José Mantilla Ramos, Yann Harel, Suresh Muthukumaraswamy, Robin Carhart-Harris, Giulia Lioi, Nicolas Farrugia, Karim Jerbi

{"title":"LSD reconfigures cortical dynamics through faster brain rhythms and increased fractal dimension.","authors":"Venkatesh Subramani, Timothy Nest, Annalisa Pascarella, Jérémy Brunel, Yorguin José Mantilla Ramos, Yann Harel, Suresh Muthukumaraswamy, Robin Carhart-Harris, Giulia Lioi, Nicolas Farrugia, Karim Jerbi","doi":"10.1038/s42003-026-10629-7","DOIUrl":"10.1038/s42003-026-10629-7","url":null,"abstract":"Lysergic acid diethylamide (LSD) profoundly alters conscious experience, yet the electrophysiological mechanisms by which it reshapes neural dynamics remain incompletely understood. A hallmark of psychedelic states is widespread cortical desynchronization, typically inferred from reductions in spectral power, but whether such effects reflect genuine weakening of neural oscillations or are confounded by shifts in oscillatory peak frequencies remains unresolved. We combine source-resolved magnetoencephalography (MEG), spectral parameterization, temporal complexity metrics, and interpretable machine learning in an LSD versus placebo design, with and without music. We show that LSD induces robust, spatially structured increases in alpha and beta peak frequencies alongside genuine attenuation of oscillatory power, with partly dissociable cortical patterns. Beyond rhythmic activity, LSD is associated with flattening of the aperiodic 1/f spectral slope and increased neural signal fractality and complexity, preferentially affecting sensory, language, emotion, and imagery-related networks while sparing motor cortex. Machine-learning analyses identify peak-frequency shifts, aperiodic parameters, and complexity measures as key discriminators of the psychedelic state. Music does not robustly amplify these neural signatures and instead shows a trend toward attenuation. These findings provide an electrophysiological account of how LSD reorganizes large-scale human brain dynamics and highlight features that may differentiate its neural signature from other psychedelics.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"9 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13646281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diversity drives disease by Candida auris. 多样性驱动着金黄色念珠菌的疾病。

IF 5.8 1区生物学

Communications Biology Pub Date : 2026-10-07 DOI: 10.1038/s42003-026-11113-y

Ananya Dash, Christopher N LaRock

引用次数: 0

ESR1 mutations are associated with enhanced MTORC1 signaling in a context-dependent manner. ESR1突变以上下文依赖的方式与MTORC1信号增强相关。

IF 5.8 1区生物学

Communications Biology Pub Date : 2026-10-07 DOI: 10.1038/s42003-026-11096-w

Tommaso De Marchi, Magdalena Kuras, Lazaro Hiram Betancourt, Sven Kjellström, Jeanette Valcich, Johan Vallon-Christersson, Christian Brueffer, Lao H Saal, Johan Malmström, Emma Niméus

{"title":"ESR1 mutations are associated with enhanced MTORC1 signaling in a context-dependent manner.","authors":"Tommaso De Marchi, Magdalena Kuras, Lazaro Hiram Betancourt, Sven Kjellström, Jeanette Valcich, Johan Vallon-Christersson, Christian Brueffer, Lao H Saal, Johan Malmström, Emma Niméus","doi":"10.1038/s42003-026-11096-w","DOIUrl":"10.1038/s42003-026-11096-w","url":null,"abstract":"ESR1 mutations are a driver of endocrine therapy resistance in breast cancer, however their impact on protein signaling pathways and clinical outcomes remains poorly understood. We analyzed the transcriptomic, proteomic, and phosphoproteomic landscape of tumors harboring ESR1 mutations. Here we show that ESR1 mutated cancers exhibit a higher mutational burden associated with increased cell proliferation, and display enhanced activation of the mTOR pathway via MTORC1, suggesting an ER-driven amplification of existing oncogenic mechanisms. Analysis of an independent proteomic dataset from breast cancer cell lines further supported a convergence between MTORC1 and ER signaling programs. Integrative multi-omic data analysis incorporating features related to tumor grade, MTORC1 signaling, and ESR1 mutations, enabled the development of a predictive signature that distinguishes patients with ESR1 mutation and identified those at high risk of recurrence. This study provides insights into the mechanisms underlying tumor aggressiveness and poor clinical outcome modulated by ESR1 mutations and highlights the potential of proteogenomic approaches to identify signaling pathways and molecular signatures.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"9 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13645737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Championing neurodiversity and human potential: an interview with Lawrence Fung. 倡导神经多样性和人类潜能：劳伦斯·冯访谈。

IF 5.8 1区生物学

Communications Biology Pub Date : 2026-10-06 DOI: 10.1038/s42003-026-11052-8

引用次数: 0

Cancer-derived lactic acid as a potential upstream contributor to tumor hypoxia. 肿瘤来源的乳酸作为肿瘤缺氧的潜在上游贡献者。

IF 5.8 1区生物学

Communications Biology Pub Date : 2026-10-06 DOI: 10.1038/s42003-026-11151-6

Ning Kang, Yuzhuo Wang

{"title":"Cancer-derived lactic acid as a potential upstream contributor to tumor hypoxia.","authors":"Ning Kang, Yuzhuo Wang","doi":"10.1038/s42003-026-11151-6","DOIUrl":"10.1038/s42003-026-11151-6","url":null,"abstract":"Hypoxia contributes to tumor progression, abnormal blood vessel formation, immune suppression, and therapeutic resistance. Although hypoxia is traditionally viewed as the primary driver of glycolysis, intrinsic oncogenic signaling, mitochondrial dysfunction, and epigenetic reprogramming also stimulate glycolysis independently of oxygen limitation, leading to substantial lactic acid accumulation under oxygenated conditions. Beyond its classic role in metabolism, lactic acid is a bioactive molecule that shapes tumor physiology by influencing immune responses, driving vascular remodeling, and mediating metabolic interactions among tumor and stromal populations. In this Perspective, we propose that cancer-derived lactic acid may contribute to the development and persistence of hypoxic tumor regions and sustain hypoxia-associated signaling. This framework positions lactic acid not only as a consequence of hypoxia but also as a potential upstream driver, forming a self-reinforcing glycolysis-lactic acid-hypoxia feedback loop that can be therapeutically disrupted by targeting lactic acid production or transport.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"9 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13642263/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149105216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An ALLO-1-associated network links mitochondrial quality control to functional recovery in structurally compromised muscle. alo -1相关网络将线粒体质量控制与结构受损肌肉的功能恢复联系起来。

IF 5.8 1区生物学

Communications Biology Pub Date : 2026-10-06 DOI: 10.1038/s42003-026-11093-z

Anwesha Sarkar, Lilla Biriczová, Natalia A Szulc, Pankaj Thapa, Remigiusz Serwa, Wojciech Pokrzywa

{"title":"An ALLO-1-associated network links mitochondrial quality control to functional recovery in structurally compromised muscle.","authors":"Anwesha Sarkar, Lilla Biriczová, Natalia A Szulc, Pankaj Thapa, Remigiusz Serwa, Wojciech Pokrzywa","doi":"10.1038/s42003-026-11093-z","DOIUrl":"10.1038/s42003-026-11093-z","url":null,"abstract":"Muscle function can recover before damaged contractile structures are fully repaired, but the mechanisms enabling this recovery remain poorly understood. Using a temperature-sensitive Caenorhabditis elegans model of UNC-45 dysfunction, in which impaired myosin chaperoning triggers muscle proteotoxic stress and reversible paralysis, we show that coordinated movement recovers while sarcomere disorganisation persists. Quantitative proteomics identified ALLO-1, a selective-autophagy receptor previously characterised for paternal organelle clearance during embryogenesis, as induced during recovery from UNC-45dependent muscle stress. Functional and proteomic analyses revealed an ALLO-1-associated regulatory network comprising IKKE-1, SIP-1, DIM-1 and CAR-1 that modulates mitochondrial stress responses and muscle recovery. Loss of ALLO-1 or its associated factors altered mitochondrial homoeostasis and delayed functional recovery, whereas muscle-specific ALLO-1a restoration improved recovery, preserved mitochondrial network integrity, and modulated mitochondrial turnover despite reduced respiratory capacity. These findings identify ALLO-1 as a regulator of mitochondrial stress adaptation that enables functional recovery before completing structural repair.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"9 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13669348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0