Communications Biology最新文献_第2页

Uncovering critical transitions and molecule mechanisms in disease progressions using Gaussian graphical optimal transport.

IF 5.2 1区生物学

Communications Biology Pub Date : 2025-04-06 DOI: 10.1038/s42003-025-07995-z

Wenbo Hua, Ruixia Cui, Heran Yang, Jingyao Zhang, Chang Liu, Jian Sun

{"title":"Uncovering critical transitions and molecule mechanisms in disease progressions using Gaussian graphical optimal transport.","authors":"Wenbo Hua, Ruixia Cui, Heran Yang, Jingyao Zhang, Chang Liu, Jian Sun","doi":"10.1038/s42003-025-07995-z","DOIUrl":"10.1038/s42003-025-07995-z","url":null,"abstract":"Understanding disease progression is crucial for detecting critical transitions and finding trigger molecules, facilitating early diagnosis interventions. However, the high dimensionality of data and the lack of aligned samples across disease stages have posed challenges in addressing these tasks. We present a computational framework, Gaussian Graphical Optimal Transport (GGOT), for analyzing disease progressions. The proposed GGOT uses Gaussian graphical models, incorporating protein interaction networks, to characterize the data distributions at different disease stages. Then we use population-level optimal transport to calculate the Wasserstein distances and transport between stages, enabling us to detect critical transitions. By analyzing the per-molecule transport distance, we quantify the importance of each molecule and identify trigger molecules. Moreover, GGOT predicts the occurrence of critical transitions in unseen samples and visualizes the disease progression process. We apply GGOT to the simulation dataset and six disease datasets with varying disease progression rates to substantiate its effectiveness. Compared to existing methods, our proposed GGOT exhibits superior performance in detecting critical transitions.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"8 1","pages":"575"},"PeriodicalIF":5.2,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11973219/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GRASPs link Reelin to the Golgi during neocortical development to control neuronal migration and dendritogenesis. 在新皮层发育过程中，GRASPs 将 Reelin 与高尔基体连接起来，以控制神经元迁移和树突形成。

IF 5.2 1区生物学

Communications Biology Pub Date : 2025-04-06 DOI: 10.1038/s42003-025-08014-x

Elisa Calvo-Jiménez, Kirsten Stam, Angélique Jossi, Yves Jossin

{"title":"GRASPs link Reelin to the Golgi during neocortical development to control neuronal migration and dendritogenesis.","authors":"Elisa Calvo-Jiménez, Kirsten Stam, Angélique Jossi, Yves Jossin","doi":"10.1038/s42003-025-08014-x","DOIUrl":"10.1038/s42003-025-08014-x","url":null,"abstract":"Reelin serves as a crucial regulator of brain organogenesis, playing a significant role in neuronal positioning and dendritogenesis. At subcellular level, it influences the translocation and remodeling of the Golgi apparatus. Despite its importance, the mechanisms by which Reelin governs the Golgi during neuronal migration and dendrite formation remain largely unknown. This study reveals that Reelin promotes de novo translation of Golgi Re-Assembly Stacking Proteins (GRASPs), which are essential for the functions of Reelin on cortical neurons. Downregulation of GRASPs in migrating excitatory neurons of the embryonic neocortex leads to disoriented cells during the multipolar phase of migration and an aberrant leading process length during locomotion. Postnatally, it results in mislocalized neurons displaying a disorganized Golgi structure and an improperly oriented, underdeveloped apical dendrite. Our findings position GRASPs and their role in Golgi morphology modulation as novel contributors to the Reelin-mediated processes during embryonic development of the mammalian neocortex.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"8 1","pages":"572"},"PeriodicalIF":5.2,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11972360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatially informed graph transformers for spatially resolved transcriptomics.

IF 5.2 1区生物学

Communications Biology Pub Date : 2025-04-06 DOI: 10.1038/s42003-025-08015-w

Xinyu Bao, Xiaosheng Bai, Xiaoping Liu, Qianqian Shi, Chuanchao Zhang

{"title":"Spatially informed graph transformers for spatially resolved transcriptomics.","authors":"Xinyu Bao, Xiaosheng Bai, Xiaoping Liu, Qianqian Shi, Chuanchao Zhang","doi":"10.1038/s42003-025-08015-w","DOIUrl":"10.1038/s42003-025-08015-w","url":null,"abstract":"Spatially resolved transcriptomics (SRT) has emerged as a powerful technique for mapping gene expression landscapes within spatial contexts. However, significant challenges persist in effectively integrating gene expression with spatial information to elucidate the heterogeneity of biological tissues. Here, we present a Spatially informed Graph Transformers framework, SpaGT, which leverages both node and edge channels to model spatially aware graph representation for denoising gene expression and identifying spatial domains. Unlike conventional graph neural networks, which rely on static, localized convolutional aggregation, SpaGT employs a structure-reinforced self-attention mechanism that iteratively evolves topological structural information and transcriptional signal representation. By replacing graph convolution with global self-attention, SpaGT enables the integration of both global and spatially localized information, thereby improving the detection of fine-grained spatial domains. We demonstrate that SpaGT achieves superior performance in identifying spatial domains and denoising gene expression data across diverse platforms and species. Furthermore, SpaGT facilitates the discovery of spatially variable genes with significant prognostic potential in cancer tissues. These findings establish SpaGT as a powerful tool for unraveling the complexities of biological tissues.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"8 1","pages":"574"},"PeriodicalIF":5.2,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11972348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trans-ethnic GWAS meta-analysis of idiopathic spermatogenic failure highlights the immune-mediated nature of Sertoli cell-only syndrome.

IF 5.2 1区生物学

Communications Biology Pub Date : 2025-04-05 DOI: 10.1038/s42003-025-08001-2

Sara González-Muñoz, Yichen Long, Andrea Guzmán-Jiménez, Miriam Cerván-Martín, Inmaculada Higueras-Serrano, José A Castilla, Ana Clavero, Nicolás Garrido, Saturnino Luján, Xiaoyu Yang, Xuejiang Guo, Jiayin Liu, Lluís Bassas, Susana Seixas, João Gonçalves, Alexandra M Lopes, Sara Larriba, Lara Bossini-Castillo, Rogelio J Palomino-Morales, Cheng Wang, Zhibin Hu, F David Carmona

{"title":"Trans-ethnic GWAS meta-analysis of idiopathic spermatogenic failure highlights the immune-mediated nature of Sertoli cell-only syndrome.","authors":"Sara González-Muñoz, Yichen Long, Andrea Guzmán-Jiménez, Miriam Cerván-Martín, Inmaculada Higueras-Serrano, José A Castilla, Ana Clavero, Nicolás Garrido, Saturnino Luján, Xiaoyu Yang, Xuejiang Guo, Jiayin Liu, Lluís Bassas, Susana Seixas, João Gonçalves, Alexandra M Lopes, Sara Larriba, Lara Bossini-Castillo, Rogelio J Palomino-Morales, Cheng Wang, Zhibin Hu, F David Carmona","doi":"10.1038/s42003-025-08001-2","DOIUrl":"10.1038/s42003-025-08001-2","url":null,"abstract":"Non-obstructive azoospermia, a severe form of male infertility caused by spermatogenic failure (SPGF), has a largely unknown genetic basis across ancestries. To our knowledge, this is the first trans-ethnic meta-analysis of genome-wide association studies on SPGF, involving 2255 men with idiopathic SPGF and 3608 controls from European and Asian populations. Using logistic regression and inverse variance methods, we identify two significant genetic associations with Sertoli cell-only (SCO) syndrome, the most extreme SPGF phenotype. The G allele of rs34915133, in the major histocompatibility complex class II region, significantly increases SCO risk (P = 5.25E-10, OR = 1.57), supporting a potential immune-related cause. Additionally, the rs10842262 variant in the SOX5 gene region is also a genetic marker of SCO (P = 5.29E-09, OR = 0.72), highlighting the key role of this gene in the male reproductive function. Our findings reveal shared genetic factors in male infertility across ancestries and provide insights into the molecular mechanisms underlying SCO.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"8 1","pages":"571"},"PeriodicalIF":5.2,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11972312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Network-informed analysis of a multivariate trait-space reveals optimal trait selection.

IF 5.2 1区生物学

Communications Biology Pub Date : 2025-04-05 DOI: 10.1038/s42003-025-07940-0

Quan Pan, Marijn Bauters, Marc Peaucelle, David Ellsworth, Jens Kattge, Hans Verbeeck

{"title":"Network-informed analysis of a multivariate trait-space reveals optimal trait selection.","authors":"Quan Pan, Marijn Bauters, Marc Peaucelle, David Ellsworth, Jens Kattge, Hans Verbeeck","doi":"10.1038/s42003-025-07940-0","DOIUrl":"10.1038/s42003-025-07940-0","url":null,"abstract":"Trait-based analyses have shown great potential to advance our understanding of terrestrial ecosystem processes and functions. However, challenges remain in adequately synthesising a multidimensional and covarying trait space. Reducing the number of studied traits while identifying the most informative ones is increasingly recognized as a priority in functional ecology. Here, we develop a trait reduction procedure based on network analysis of a global dataset comprising 27 traits in three steps. We first construct all possible reduced networks and identify optimal reduced networks that capture the structure of the full 27-trait network. Then we apply the constraints on trait consistency to identified optimal reduced networks and establish consistent network series across ecoregions. We find the best performing networks that capture the three main dimensions of the full network (hydrological safety, leaf economic strategy, and plant reproduction and competition) and the global variance of network metrics. Finally, we find a parsimonious representation of trait covariation strategies is achieved by a 10-trait network which preserves 60% of all the original information while costing only 20.1% of the full suite of traits. Our results show the network reduction approach can improve our understanding on the main plant strategies and facilitate the future trait-based research.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"8 1","pages":"569"},"PeriodicalIF":5.2,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11972376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TransBind allows precise detection of DNA-binding proteins and residues using language models and deep learning. TransBind 可利用语言模型和深度学习技术精确检测 DNA 结合蛋白和残基。

IF 5.2 1区生物学

Communications Biology Pub Date : 2025-04-05 DOI: 10.1038/s42003-025-07534-w

Md Toki Tahmid, A K M Mehedi Hasan, Md Shamsuzzoha Bayzid

{"title":"TransBind allows precise detection of DNA-binding proteins and residues using language models and deep learning.","authors":"Md Toki Tahmid, A K M Mehedi Hasan, Md Shamsuzzoha Bayzid","doi":"10.1038/s42003-025-07534-w","DOIUrl":"10.1038/s42003-025-07534-w","url":null,"abstract":"Identifying DNA-binding proteins and their binding residues is critical for understanding diverse biological processes, but conventional experimental approaches are slow and costly. Existing machine learning methods, while faster, often lack accuracy and struggle with data imbalance, relying heavily on evolutionary profiles like PSSMs and HMMs derived from multiple sequence alignments (MSAs). These dependencies make them unsuitable for orphan proteins or those that evolve rapidly. To address these challenges, we introduce TransBind, an alignment-free deep learning framework that predicts DNA-binding proteins and residues directly from a single primary sequence, eliminating the need for MSAs. By leveraging features from pre-trained protein language models, TransBind effectively handles the issue of data imbalance and achieves superior performance. Extensive evaluations using diverse experimental datasets and case studies demonstrate that TransBind significantly outperforms state-of-the-art methods in terms of both accuracy and computational efficiency. TransBind is available as a web server at https://trans-bind-web-server-frontend.vercel.app/ .","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"8 1","pages":"568"},"PeriodicalIF":5.2,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11971327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single-cell transcriptional responses of T cells during microsporidia infection.

IF 5.2 1区生物学

Communications Biology Pub Date : 2025-04-05 DOI: 10.1038/s42003-025-07990-4

Yunlin Tang, Lu Cao, Jiangyan Jin, Tangxin Li, Yebo Chen, Yishan Lu, Tian Li, Louis M Weiss, Guoqing Pan, Jialing Bao, Zeyang Zhou

{"title":"Single-cell transcriptional responses of T cells during microsporidia infection.","authors":"Yunlin Tang, Lu Cao, Jiangyan Jin, Tangxin Li, Yebo Chen, Yishan Lu, Tian Li, Louis M Weiss, Guoqing Pan, Jialing Bao, Zeyang Zhou","doi":"10.1038/s42003-025-07990-4","DOIUrl":"10.1038/s42003-025-07990-4","url":null,"abstract":"T cells have been reported to play critical roles in preventing of microsporidia dissemination. However, there roles and functions of each subset remain unclear. Here in the study, we performed a thorough analysis of murine splenic T-cell response analysis via single-cell RNA sequencing during microsporidia E. cuniculi infection. We demonstrated that Type I T helper (Th1) cells, T follicular helper (Tfh) cells, effector CD8 + T cells and proliferating CD8 + T cells were activated and expanded after infection. Activated Th1 cells and Tfh cells presented significantly upregulated gene expression of Ifng and Il21, respectively. A subcluster of Th1 cells with high Csf1 expression was detected after infection. Subsets of activated CD8 + T cells were markedly enriched with high expression of cytotoxic-function related genes such as Gzma and Gzmb, whereas some active CD8 T cells were enriched with proliferation-function related genes Mki67 and Stmn1. Other subsets of T cells including NK T cells, Myb+ T cells, γδ T cells and Cxcr6+ T cells, were also analyzed in this study yet no expansion was observed. In summary, our findings provide in-depth and comprehensive insights into T-cell responses during microsporidia infection, which will be valuable for further investigations.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"8 1","pages":"567"},"PeriodicalIF":5.2,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11971339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Direct comparisons of neural activity during placebo analgesia and nocebo hyperalgesia between humans and rats.

IF 5.2 1区生物学

Communications Biology Pub Date : 2025-04-05 DOI: 10.1038/s42003-025-07993-1

Damien C Boorman, Lewis S Crawford, Luke A Henderson, Kevin A Keay

{"title":"Direct comparisons of neural activity during placebo analgesia and nocebo hyperalgesia between humans and rats.","authors":"Damien C Boorman, Lewis S Crawford, Luke A Henderson, Kevin A Keay","doi":"10.1038/s42003-025-07993-1","DOIUrl":"10.1038/s42003-025-07993-1","url":null,"abstract":"Placebo analgesia and nocebo hyperalgesia can profoundly alter pain perception, offering critical implications for pain management. While animal models are increasingly used to explore the underlying mechanisms of these phenomena, it remains unclear whether animals experience placebo and nocebo effects in a manner comparable to humans or whether the associated neurobiological pathways are conserved across species. In this study, we introduce a novel framework for comparing brain activity between humans and rodents during placebo analgesia and nocebo hyperalgesia. Using c-Fos immunohistochemistry in rats and fMRI in humans, we examined neural activity in 70 pain-related brain regions, identifying both conserved and species-specific connectivity changes. Functional connectivity analysis, refined by pruning connections based on known anatomical pathways, revealed significant overlap in key regions, including the amygdala, anterior cingulate cortex, and nucleus accumbens, highlighting conserved circuits driving placebo and nocebo responses. This cross-species methodology offers a powerful new approach for investigating the neurobiology of pain modulation, bridging the gap between animal models and human studies. Identifying these common connections validates the use of animal models and enables preclinical researchers to focus on circuits that are conserved across species, ensuring greater translational relevance when developing new and effective treatments for pain conditions.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"8 1","pages":"570"},"PeriodicalIF":5.2,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11972415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A bovine pulmosphere model and multiomics reveal early host response signature in tuberculosis.

IF 5.2 1区生物学

Communications Biology Pub Date : 2025-04-04 DOI: 10.1038/s42003-025-07883-6

Vinay Bhaskar, Rishi Kumar, Manas Ranjan Praharaj, Sripratyusha Gandham, Hemanta Kumar Maity, Uttam Sarkar, Bappaditya Dey

{"title":"A bovine pulmosphere model and multiomics reveal early host response signature in tuberculosis.","authors":"Vinay Bhaskar, Rishi Kumar, Manas Ranjan Praharaj, Sripratyusha Gandham, Hemanta Kumar Maity, Uttam Sarkar, Bappaditya Dey","doi":"10.1038/s42003-025-07883-6","DOIUrl":"10.1038/s42003-025-07883-6","url":null,"abstract":"Early interactions between tubercle bacilli and lung cells are critical in tuberculosis (TB) pathogenesis. Conventional two-dimensional cell cultures fail to replicate the multicellular complexity of lungs. We introduce a three-dimensional pulmosphere model for Mycobacterium tuberculosis infection in bovine systems, demonstrating through comprehensive transcriptome and proteome analyses that these multicellular spheroids closely mimic lung cell diversity, interactions, and extracellular matrix (ECM) composition. Cell viability, hypoxia, and reactive oxygen species assessments over three weeks confirm the model's suitability. To establish infection, we employed M. bovis BCG-an attenuated vaccine strain, and M. tuberculosis H37Rv-a laboratory adapted human clinical strain that is attenuated for cattle infection compared to M. bovis. Both infection upregulated key host pathways; however, M. tuberculosis induced distinct responses, including enhanced ECM receptors expression, neutrophil chemotaxis, interferon signaling, and RIG-1 signaling. A six genes/protein signature- IRF1, CCL5, CXCL8, CXCL10, SERPINE1, and CFB -emerges as an early host response marker to M. tuberculosis infection. Infection with virulent M. bovis and M. orygis revealed a shared upregulated gene signature across Mycobacterium tuberculosis complex species, but with pathogen-specific variations. This study presents a robust ex vivo bovine pulmosphere TB model with implications in biomarkers discovery, high-throughput drug screening, and TB control strategies.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"8 1","pages":"559"},"PeriodicalIF":5.2,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11971429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

G0S2 modulates normal vitreous-induced proliferation in endothelial cells. G0S2 可调节正常玻璃体诱导的内皮细胞增殖。

IF 5.2 1区生物学

Communications Biology Pub Date : 2025-04-04 DOI: 10.1038/s42003-025-07955-7

Yiwei Yin, Li Pu, Xi Yang, Ying Zhu, Fang Chen, Chenkun Wu, Hetian Lei, Wenyi Wu

{"title":"G0S2 modulates normal vitreous-induced proliferation in endothelial cells.","authors":"Yiwei Yin, Li Pu, Xi Yang, Ying Zhu, Fang Chen, Chenkun Wu, Hetian Lei, Wenyi Wu","doi":"10.1038/s42003-025-07955-7","DOIUrl":"10.1038/s42003-025-07955-7","url":null,"abstract":"Abnormal blood vessel growth in the eye is a leading cause of vision loss globally, particularly in diseases like diabetic retinopathy where the vitreous plays a crucial but poorly understood role in disease progression. While we know the vitreous can stimulate blood vessel growth, the specific molecular mechanisms remain unclear. Here we show that a protein called G0S2 (G0/G1 switch gene 2) serves as a key regulator of blood vessel growth in response to normal vitreous. Through comprehensive gene analysis, we discovered that G0S2 levels increase significantly when blood vessel cells are exposed to normal vitreous. The importance of G0S2 is highlighted by our finding that uveal melanoma patients with higher G0S2 levels had poorer survival rates. When we removed G0S2 from blood vessel cells, they no longer responded to vitreous stimulation, confirming its critical role. Notably, we identified an existing drug that can target G0S2, potentially offering a new therapeutic approach. This discovery of G0S2's role and its potential therapeutic targeting opens new avenues for treating eye diseases characterized by abnormal blood vessel growth, while also providing a valuable biomarker for predicting disease progression in eye cancer patients.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"8 1","pages":"560"},"PeriodicalIF":5.2,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11971441/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0