Communications Biology最新文献_第2页

Sepsis restructures the mitochondrial calcium uniporter complex in the lymphoid tissues of mice and humans. 脓毒症重组了小鼠和人类淋巴组织中的线粒体单转运钙复合体。

IF 5.2 1区生物学

Communications Biology Pub Date : 2025-07-23 DOI: 10.1038/s42003-025-08475-0

Xianghong Zhang, Jianguo Lin, Baobo Zou, Jack R Killinger, Andrew C Sayce, Thiagarajan Meyyappan, Zeyu Xiong, Melanie J Scott, Janet S Lee, Matthew R Rosengart

{"title":"Sepsis restructures the mitochondrial calcium uniporter complex in the lymphoid tissues of mice and humans.","authors":"Xianghong Zhang, Jianguo Lin, Baobo Zou, Jack R Killinger, Andrew C Sayce, Thiagarajan Meyyappan, Zeyu Xiong, Melanie J Scott, Janet S Lee, Matthew R Rosengart","doi":"10.1038/s42003-025-08475-0","DOIUrl":"https://doi.org/10.1038/s42003-025-08475-0","url":null,"abstract":"Survivors of sepsis suffer from an elevated risk of premature death that is not explained by a higher burden of chronic diseases prior to the infection. Nearly 1 out of 4 survivors have persistent elevations of inflammation biomarkers, such as interleukin (IL) 6. These observations suggest that sepsis imparts durable changes to organismal biology. Eukaryotic life depends upon ATP and calcium (Ca2+). During sepsis, mitochondrial dysfunction, a failure of Ca2+ homeostasis, and sustained elevations in cytosolic [Ca2+] occur. These insults may serve as sufficient pressure to select for cells uniquely able to adapt. In this study of murine and human sepsis survivors, we observe that sepsis induces in lymphoid tissues a restructuring of the mitochondrial calcium uniporter (MCU) complex: the critical channel mediating the electrophoretic uptake of Ca2+ into the mitochondrion. We show these changes persist after clinical resolution of sepsis and lead to alterations in mitochondrial Ca2+ regulation, Ca2+ signaling, oxidative metabolism, and sensitivity to programmed cell death pathways. These biochemical changes manifest as fundamental alterations in phenotype: i.e., heightened systemic IL-6 concentration. Inhibiting lysosomal pathways partially restores the MCU complex stoichiometry, mitochondrial Ca2+ homeostasis, and lymphoid tissue phenotype to a sepsis naïve state.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"8 1","pages":"1093"},"PeriodicalIF":5.2,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adipose-derived mesenchymal stromal/stem cells in type 1 diabetes treatment. 脂肪来源间充质基质/干细胞在1型糖尿病治疗中的应用

IF 5.2 1区生物学

Communications Biology Pub Date : 2025-07-23 DOI: 10.1038/s42003-025-08244-z

Vanshika Sood, Hannah Ricioli, George Chigozie Njoku, Rosita Primavera, Susana Dietrich, Avnesh S Thakor, Flemming Pociot, Reza Yarani

引用次数: 0

Analysis of histone modification interplay reveals two distinct domains in facultative heterochromatin in Pyricularia oryzae. 组蛋白修饰相互作用的分析揭示了稻瘟霉兼性异染色质的两个不同结构域。

IF 5.2 1区生物学

Communications Biology Pub Date : 2025-07-22 DOI: 10.1038/s42003-025-08473-2

Thach A Dang, Atsumi Morimoto, Natsuki Kobayashi, Kieu Pham, Ken-Ichi Ikeda, Hitoshi Nakayashiki

{"title":"Analysis of histone modification interplay reveals two distinct domains in facultative heterochromatin in Pyricularia oryzae.","authors":"Thach A Dang, Atsumi Morimoto, Natsuki Kobayashi, Kieu Pham, Ken-Ichi Ikeda, Hitoshi Nakayashiki","doi":"10.1038/s42003-025-08473-2","DOIUrl":"https://doi.org/10.1038/s42003-025-08473-2","url":null,"abstract":"Histone post-translational modifications (PTMs) interact in complex ways to regulate chromatin structure and gene expression. To investigate this interplay, we analyze ChIP-seq and RNA-seq data from knock-out mutants lacking enzymes responsible for H3K4me2/3, H3K9me3, or H3K27me3 in the phytopathogenic fungus Pyricularia oryzae. Loss of specific PTMs alters other PTMs and gene expression in a compartment-specific manner, with distinct effects across H3K4me2-rich euchromatin (EC), H3K27me3-rich facultative heterochromatin (fHC), H3K9me3-rich constitutive heterochromatin (cHC), and centromeres. We identify two distinct fHC subcompartments: K4-fHC, adjacent to EC, and K9-fHC, adjacent to cHC. Both contain poorly conserved genes, but K9-fHC harbors more transposable elements, while K4-fHC is more enriched for genes upregulated during infection, including effector-like genes. H3K27me3 levels in K4-fHC respond to changes in other PTMs, especially H3K9me3, and to environmental conditions. These findings suggest that K4-fHC functions as a reservoir of genes highly responsive to chromatin context and environmental cues.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"8 1","pages":"1086"},"PeriodicalIF":5.2,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144689110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond the nuclear border: single-cell analysis of in situ sequenced human brain tissue using cellular features. 超越核边界：利用细胞特征对原位测序的人类脑组织进行单细胞分析。

IF 5.2 1区生物学

Communications Biology Pub Date : 2025-07-22 DOI: 10.1038/s42003-025-08518-6

Janssen M Kotah, Thomas Rust, Hilmar R J van Weering, Janneke Bosma, Amber L Woudstra, Susanne M Kooistra, Bart J L Eggen

{"title":"Beyond the nuclear border: single-cell analysis of in situ sequenced human brain tissue using cellular features.","authors":"Janssen M Kotah, Thomas Rust, Hilmar R J van Weering, Janneke Bosma, Amber L Woudstra, Susanne M Kooistra, Bart J L Eggen","doi":"10.1038/s42003-025-08518-6","DOIUrl":"https://doi.org/10.1038/s42003-025-08518-6","url":null,"abstract":"Spatial transcriptomics has advanced our understanding of cellular heterogeneity at single-cell resolution. Here, we assess the suitability of in situ sequencing (ISS) for analyzing formalin-fixed, paraffin-embedded (FFPE) postmortem human brain tissue. A key challenge in ISS data analysis is optimizing transcript allocation while minimizing misallocation, particularly in the morphologically complex central nervous system (CNS). We compared geospatial methods using nuclear and expanded nuclear boundaries for segmentation and transcript allocation. While overall cell-type proportions remained comparable, transcript allocation methods affected specific cell types, including microglia, neurons, and neurovascular cells. To enhance specificity, we integrated fluorescent imaging data targeting 18S RNA and IBA1 protein to direct transcript allocation toward RNA-rich cells (e.g., neurons) and microglia, respectively. We demonstrate how this approach, paired with secondary allocation of transcripts outside imaging masks, improved both the number of microglia detected and the specificity of microglial transcripts assigned. Our method offers a flexible and efficient strategy for targeted transcript allocation based on cellular morphology, optimizing CNS cell segmentation in FFPE-preserved human brain tissue.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"8 1","pages":"1089"},"PeriodicalIF":5.2,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144689111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of neonatal kisspeptin in long-term social behavior in mammals. 新生儿kisspeptin在哺乳动物长期社会行为中的作用。

IF 5.2 1区生物学

Communications Biology Pub Date : 2025-07-22 DOI: 10.1038/s42003-025-08478-x

João R Neves, Miguel Castelo-Branco, Joana Gonçalves

{"title":"The role of neonatal kisspeptin in long-term social behavior in mammals.","authors":"João R Neves, Miguel Castelo-Branco, Joana Gonçalves","doi":"10.1038/s42003-025-08478-x","DOIUrl":"https://doi.org/10.1038/s42003-025-08478-x","url":null,"abstract":"Kisspeptins (Kiss) are key regulators of the hypothalamic-pituitary-gonadal axis, influencing testosterone surges essential for brain masculinization and behavioral development in mammals. This study explored the effects of transient neonatal Kiss blockade on long-term social behaviors in Wistar rats. Newborn rats of both sexes were injected with either a Kiss antagonist or vehicle during the postnatal testosterone surge, termed \"minipuberty\". In adolescence and adulthood, social behaviors, hypothalamic Kiss receptor levels, and serum levels of Gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH), testosterone, and follicle-stimulating hormone (FSH) were assessed. Results showed that neonatal Kiss modulates testosterone differently in males and females, influencing social communication and long-term social skills. Increased exploratory behavior was observed, with males exhibiting heightened sexual impulsiveness without anxiety changes. Altered hypothalamic-pituitary-gonadal hormone levels due to Kiss blockade may help explain some results. These findings highlight the critical role of neonatal Kiss in shaping lifelong social interactions and communication in a sex-dependent manner.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"8 1","pages":"1085"},"PeriodicalIF":5.2,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144689115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mapping the microstructure of human cerebral cortex in vivo with diffusion MRI. 磁共振扩散成像在体人脑皮层微结构的研究。

IF 5.2 1区生物学

Communications Biology Pub Date : 2025-07-22 DOI: 10.1038/s42003-025-08523-9

Amir Sadikov, Hannah L Choi, Jaclyn Xiao, Lanya T Cai, Pratik Mukherjee

{"title":"Mapping the microstructure of human cerebral cortex in vivo with diffusion MRI.","authors":"Amir Sadikov, Hannah L Choi, Jaclyn Xiao, Lanya T Cai, Pratik Mukherjee","doi":"10.1038/s42003-025-08523-9","DOIUrl":"https://doi.org/10.1038/s42003-025-08523-9","url":null,"abstract":"Despite advances in diffusion MRI, which have led to remarkable progress in mapping white matter of the living human brain, our understanding of cerebral cortical microstructure in vivo and its relationship to macrostructure, myeloarchitecture, cytoarchitecture, chemoarchitecture, metabolism, and function lag far behind. We present neuromaps of 21 microstructural metrics derived from diffusion tensor, diffusion kurtosis, mean apparent propagator, and neurite orientation dispersion and density imaging of the young adult cerebral cortex. These 21 metrics are explained by four composite factors that correspond to diffusion kurtosis (intracellular volume fraction/neurite density), isotropic diffusion (free water fraction), heterogenous diffusion (extracellular volume fraction) and diffusion anisotropy (neurite orientation dispersion). We demonstrate how cortical microstructure follows cytoarchitectural and laminar differentiation, aligns with the macroscale sensory-fugal and sensorimotor-association axes, and contributes to functional brain networks, neural oscillatory dynamics, neurotransmitter receptor/transporter distributions, and cognition and behavior.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"8 1","pages":"1088"},"PeriodicalIF":5.2,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144689113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Calcium dynamics in habenular astrocytes regulate active coping within behavioral transitions. 缰状星形胶质细胞中的钙动态调节行为转变中的主动应对。

IF 5.2 1区生物学

Communications Biology Pub Date : 2025-07-22 DOI: 10.1038/s42003-025-08535-5

Léo Michel, Denys Osypenko, Patricia Molina, Kadir A Mutlu, Salvatore Lecca, Chihiro Hisatsune, Katsuhiko Mikoshiba, Toko Kikuchi, Emre Yaksi, Andrea Volterra, Manuel Mameli

引用次数: 0

Astragalin promotes HSCs ferroptosis through NCOA4 mediated ferritinophagy to alleviate liver fibrosis in zebrafish and mice. 黄芪甲苷通过NCOA4介导的铁蛋白吞噬促进hsc铁凋亡，减轻斑马鱼和小鼠肝纤维化。

IF 5.2 1区生物学

Communications Biology Pub Date : 2025-07-21 DOI: 10.1038/s42003-025-08421-0

Yuhua Wang, Shanshan Kuang, Ke Li, Shuni Chen, Min Yang, Kaili Deng, Min Li, Shuwen Xie, Qing Chen, Jinjie Wen, Chuying Zhou, Weidong Cheng, Sha Huang, Zhiping Lv

{"title":"Astragalin promotes HSCs ferroptosis through NCOA4 mediated ferritinophagy to alleviate liver fibrosis in zebrafish and mice.","authors":"Yuhua Wang, Shanshan Kuang, Ke Li, Shuni Chen, Min Yang, Kaili Deng, Min Li, Shuwen Xie, Qing Chen, Jinjie Wen, Chuying Zhou, Weidong Cheng, Sha Huang, Zhiping Lv","doi":"10.1038/s42003-025-08421-0","DOIUrl":"10.1038/s42003-025-08421-0","url":null,"abstract":"Liver fibrosis is pathological progression of chronic liver disease. Recent research has focused on the activation of hepatic stellate cells (HSCs), highlighting their potential as targets for mitigating fibrosis. While herbal medicines and natural active ingredients have shown promising anti-fibrotic effects in clinical treatments, the impact of Astragalin (Ag) remains unexplored. In this study, we established in vivo and in vitro studies, employing fluorescence probe staining, transmission electron microscopy, and various analytical techniques. The results demonstrated Ag operates within a wide range of safe therapeutic doses in zebrafish and effectively alleviates liver fibrosis. Further experiments demonstrated that Ag induced HSCs ferroptosis via this pathway, leading to iron overload and ultimately alleviating liver fibrosis. In general, this study demonstrated that Ag promotes HSCs ferroptosis through NCOA4-mediated ferritinophagy, clarifying its mechanism in treating liver fibrosis and positioning Ag as a promising candidate for future clinical interventions.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"8 1","pages":"1081"},"PeriodicalIF":5.2,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12279947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of areal-level individualized homologous functional parcellations in youth. 青少年区域层面个体化同源功能分区的发展。

IF 5.2 1区生物学

Communications Biology Pub Date : 2025-07-21 DOI: 10.1038/s42003-025-08509-7

Jinlong Li, Yu Zhang, Xinyu Wu, Mufan Xue, Zhiming Wang, Shuo Lv, Ruoqi Yang, Wenjing Zhu, Xuesong Li, Tianyi Yan, Guoyuan Yang

{"title":"Development of areal-level individualized homologous functional parcellations in youth.","authors":"Jinlong Li, Yu Zhang, Xinyu Wu, Mufan Xue, Zhiming Wang, Shuo Lv, Ruoqi Yang, Wenjing Zhu, Xuesong Li, Tianyi Yan, Guoyuan Yang","doi":"10.1038/s42003-025-08509-7","DOIUrl":"10.1038/s42003-025-08509-7","url":null,"abstract":"Individualized functional brain networks from childhood to adolescence undergo varying patterns of maturation, associated with higher-order cognition outcomes. However, the developmental trajectory patterns based on homologous areal-level brain parcellations remain elusive. Here, we developed an individualized homologous functional parcellation technique (IHFP) to map brain functional development using resting-state functional magnetic resonance imaging data from the Lifespan Human Connectome Project in Development study (N = 591) aged 8-21 years. We delineate developmental trajectories based on areal-level homologous parcellations of resting-state functional connectivity. We found functional features during adolescence exhibit unique developmental trajectories, such as global mean functional connectivity with a widespread decrease across cerebral cortex. Then, we matched areal-level parcellations into large-scale networks and demonstrated that higher-order transmodal networks exhibited higher variability between developmental trajectories in areal-level parcels. We reveal that IHFPs possess a stronger capability for creating more homogeneous parcels in individuals, consequently showing a higher accuracy in predicting cognition behaviors. Together, these results establish the fine-grained areal-level functional homologous parcellations in adolescent development and will facilitate the understanding of human brain function more precisely.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"8 1","pages":"1083"},"PeriodicalIF":5.2,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12280106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Snow- and ice-ecosystem cleaning capability of the pucciniomycotinous yeast Phenoliferia psychrophenolica. puccininiomycotinous酵母Phenoliferia psychrophenolica的冰雪生态系统清洁能力。

IF 5.2 1区生物学

Communications Biology Pub Date : 2025-07-21 DOI: 10.1038/s42003-025-08506-w

Jade A Ezzedine, Pierre Guenzi-Tiberi, Gaëlle Villain, Riccardo Aiese Cigliano, Yacine Diagne, Enzo Franceschi, Elodie Drula, Jérôme Forêt, Jean-Gabriel Valay, Lenka Procházková, Daniel Remias, Nicolas Terrapon, Alberto Amato, Eric Maréchal

{"title":"Snow- and ice-ecosystem cleaning capability of the pucciniomycotinous yeast Phenoliferia psychrophenolica.","authors":"Jade A Ezzedine, Pierre Guenzi-Tiberi, Gaëlle Villain, Riccardo Aiese Cigliano, Yacine Diagne, Enzo Franceschi, Elodie Drula, Jérôme Forêt, Jean-Gabriel Valay, Lenka Procházková, Daniel Remias, Nicolas Terrapon, Alberto Amato, Eric Maréchal","doi":"10.1038/s42003-025-08506-w","DOIUrl":"10.1038/s42003-025-08506-w","url":null,"abstract":"Psychrophilic pucciniomycotinous yeasts inhabit snowfields and glacial ecosystems worldwide, yet their ecological role remains unclear. We isolated a clonal strain of Phenoliferia psychrophenolica (LCC-F-001-001) from an alpine red snowfield. Its 42-Mbp genome contains 11,523 genes, including 37 ice-binding protein genes, the highest number recorded in fungi, mainly acquired through horizontal transfers. This yeast tolerates freezing, grows optimally at 10 °C and forms pseudohyphae above 15 °C. Known to assimilate phenol and small metabolites, we found LCC-F-001-001 also hydrolyzes carotenoid and phenolic pigments from snow and glacier ice algae. LCC-F-001-001 genome encodes ~ 500 carbohydrate-active enzymes, ranking among the most catalytically versatile sequenced Microbotryomycetes, alongside a related permafrost species. P. psychrophenolica and related fungi are therefore key players in snow and ice ecosystems, capable of degrading organic molecules in snowfields and glaciers, likely during algal bloom declines, and connecting the carbon cycle between cryospheric environments and soils through their exceptional metabolic adaptability.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"8 1","pages":"1084"},"PeriodicalIF":5.2,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12279972/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0