Communications Biology最新文献

Sex-specific fear acquisition following early life stress is linked to amygdala and hippocampal purine and glutamate metabolism.

IF 5.2 1区生物学

Communications Biology Pub Date : 2024-12-20 DOI: 10.1038/s42003-024-07396-8

Joeri Bordes, Thomas Bajaj, Lucas Miranda, Lotte van Doeselaar, Lea Maria Brix, Sowmya Narayan, Huanqing Yang, Shiladitya Mitra, Veronika Kovarova, Margherita Springer, Karin Kleigrewe, Bertram Müller-Myhsok, Nils C Gassen, Mathias V Schmidt

{"title":"Sex-specific fear acquisition following early life stress is linked to amygdala and hippocampal purine and glutamate metabolism.","authors":"Joeri Bordes, Thomas Bajaj, Lucas Miranda, Lotte van Doeselaar, Lea Maria Brix, Sowmya Narayan, Huanqing Yang, Shiladitya Mitra, Veronika Kovarova, Margherita Springer, Karin Kleigrewe, Bertram Müller-Myhsok, Nils C Gassen, Mathias V Schmidt","doi":"10.1038/s42003-024-07396-8","DOIUrl":"10.1038/s42003-024-07396-8","url":null,"abstract":"Early life stress (ELS) can negatively impact health, increasing the risk of stress-related disorders, such as post-traumatic stress disorder (PTSD). Importantly, PTSD disproportionately affects women, emphasizing the critical need to explore how sex differences influence the genetic and metabolic neurobiological pathways underlying trauma-related behaviors. This study uses the limited bedding and nesting (LBN) paradigm to model ELS and investigate its sex-specific effects on fear memory formation. Employing innovative unsupervised behavioral classification, the current study reveals distinct behavioral patterns associated with fear acquisition and retrieval in male and female mice following ELS. Females exposed to LBN display heightened active fear responses, contrasting with males. Furthermore, the study examined the crucial link between behavioral regulation and cellular metabolism in key brain regions involved in fear and stress processing. Sex-specific and stress-dependent alterations were observed in purine, pyrimidine, and glutamate metabolism within the basolateral amygdala, the dorsal hippocampus, and the ventral hippocampus. These findings provide crucial insights into the complex interplay between metabolic pathways, the neurobiological underpinnings of fear memory, and stress responses. Importantly, they emphasize the significance of considering sex-specific metabolic alterations when investigating stress-related disorders, opening potential avenues for the development of targeted interventions.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"7 1","pages":"1684"},"PeriodicalIF":5.2,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142863603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ThirdPeak is a flexible tool designed for the robust analysis of two- and three-dimensional tracking data.

IF 5.2 1区生物学

Communications Biology Pub Date : 2024-12-20 DOI: 10.1038/s42003-024-07378-w

Thomas Müller, Elisabeth Meiser, Markus Engstler

引用次数: 0

Multi-omics analysis reveals the evolution, function, and regulatory mechanisms of SPF pheromones in Anurans.

IF 5.2 1区生物学

Communications Biology Pub Date : 2024-12-20 DOI: 10.1038/s42003-024-07388-8

Puyang Zheng, Yunyun Lv, Yuzhou Gong, Gang Wang, Bin Wang, Xiuqin Lin, Xun Liao, Jianghong Ran, JiaTang Li, Feng Xie

{"title":"Multi-omics analysis reveals the evolution, function, and regulatory mechanisms of SPF pheromones in Anurans.","authors":"Puyang Zheng, Yunyun Lv, Yuzhou Gong, Gang Wang, Bin Wang, Xiuqin Lin, Xun Liao, Jianghong Ran, JiaTang Li, Feng Xie","doi":"10.1038/s42003-024-07388-8","DOIUrl":"10.1038/s42003-024-07388-8","url":null,"abstract":"Pheromones play a pivotal role in chemical communication across various taxa, with protein-based pheromones being particularly significant in amphibian courtship and reproduction. In this study, we investigate the Emei music frog (Nidirana daunchina), which utilizes both acoustic and chemical signals for communication. Base on a de novo assembled genome of a male Emei music frog, we identify substantial expansion in four pheromone-related gene families associated with chemical communication. Notably, six members of the two-domain three-finger protein (2D-TFP) family, belonging to the sodefrin precursor-like factor (SPF) pheromone system, exhibited high and specific expression in the male post-axillary glands during the breeding season. Structural and evolutionary analyses confirm the presence of the SPF system across amphibians, classifiable into four distinct classes (two within urodeles and two within anurans). We propose a complete regulatory network governing SPF secretion via the hypothalamic-pituitary-testicular-breeding gland axis, and suggest testosterone synthesis as the pivotal pathway. Behavioral experiments further reveal a previously unknown female-attractant role of SPF in anurans. Overall, these findings not only highlight the underestimated diversity and function of pheromones in anurans, but also provide important insights into the evolution of protein-based pheromones in vertebrates.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"7 1","pages":"1682"},"PeriodicalIF":5.2,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142863595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Flexibility of intrinsic neural timescales during distinct behavioral states.

IF 5.2 1区生物学

Communications Biology Pub Date : 2024-12-19 DOI: 10.1038/s42003-024-07349-1

Yasir Çatal, Kaan Keskin, Angelika Wolman, Philipp Klar, David Smith, Georg Northoff

{"title":"Flexibility of intrinsic neural timescales during distinct behavioral states.","authors":"Yasir Çatal, Kaan Keskin, Angelika Wolman, Philipp Klar, David Smith, Georg Northoff","doi":"10.1038/s42003-024-07349-1","DOIUrl":"https://doi.org/10.1038/s42003-024-07349-1","url":null,"abstract":"Recent neuroimaging studies demonstrate a heterogeneity of timescales prevalent in the brain's ongoing spontaneous activity, labeled intrinsic neural timescales (INT). At the same time, neural timescales also reflect stimulus- or task-related activity. The relationship of the INT during the brain's spontaneous activity with their involvement in task states including behavior remains unclear. To address this question, we combined calcium imaging data of spontaneously behaving mice and human electroencephalography (EEG) during rest and task states with computational modeling. We obtained four primary findings: (i) the distinct behavioral states can be accurately predicted from INT, (ii) INT become longer during behavioral states compared to rest, (iii) INT change from rest to task is correlated negatively with the variability of INT during rest, (iv) neural mass modeling shows a key role of recurrent connections in mediating the rest-task change of INT. Extending current findings, our results show the dynamic nature of the brain's INT in reflecting continuous behavior through their flexible rest-task modulation possibly mediated by recurrent connections.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"7 1","pages":"1667"},"PeriodicalIF":5.2,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142863567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Repeat and haplotype aware error correction in nanopore sequencing reads with DeChat.

IF 5.2 1区生物学

Communications Biology Pub Date : 2024-12-19 DOI: 10.1038/s42003-024-07376-y

Yuansheng Liu, Yichen Li, Enlian Chen, Jialu Xu, Wenhai Zhang, Xiangxiang Zeng, Xiao Luo

引用次数: 0

Single cell transcriptomics reveals the cellular heterogeneity of keloids and the mechanism of their aggressiveness.

IF 5.2 1区生物学

Communications Biology Pub Date : 2024-12-19 DOI: 10.1038/s42003-024-07311-1

Xinwei Cheng, Zhen Gao, Shengzhou Shan, Haoyu Shen, Hongkun Zheng, Lu Jin, Qingfeng Li, Jia Zhou

{"title":"Single cell transcriptomics reveals the cellular heterogeneity of keloids and the mechanism of their aggressiveness.","authors":"Xinwei Cheng, Zhen Gao, Shengzhou Shan, Haoyu Shen, Hongkun Zheng, Lu Jin, Qingfeng Li, Jia Zhou","doi":"10.1038/s42003-024-07311-1","DOIUrl":"https://doi.org/10.1038/s42003-024-07311-1","url":null,"abstract":"Keloid is a dermatofibrotic disease known for its aggressive nature and characterized by pathological scarring, which often leads to disfigurement and frequent recurrences. Effective therapies for keloids are still limited, presumably due to the inadequate comprehension of their aggressive mechanisms. In our study, we examined the unique scenario where both keloid and non-aggressive pathological scar originate from the same patient, providing a rare opportunity to explore the aggressive mechanisms of keloids through single-cell RNA sequencing. We found that the dominant fibroblast subgroup in keloids is mechanoresponsive group, which showed enhanced mechanotransduction and migration. This mechanoresponsive fibroblast subgroup is likely to be the key cell population and confer aggressive growth of keloids. The results also indicate that the endothelial cells and keratinocytes in keloid involve in endothelial-mesenchymal and epithelial-mesenchymal transitions. This study demonstrated the mechanoresponsive fibroblasts and multiple cellular mesenchymal processes could pave the way for further investigations into the keloid aggressiveness.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"7 1","pages":"1647"},"PeriodicalIF":5.2,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142863604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chilling- and dark-regulated photoprotection in Miscanthus, an economically important C₄ grass.

IF 5.2 1区生物学

Communications Biology Pub Date : 2024-12-19 DOI: 10.1038/s42003-024-07320-0

Jared Haupt, Katarzyna Glowacka

{"title":"Chilling- and dark-regulated photoprotection in Miscanthus, an economically important C4 grass.","authors":"Jared Haupt, Katarzyna Glowacka","doi":"10.1038/s42003-024-07320-0","DOIUrl":"https://doi.org/10.1038/s42003-024-07320-0","url":null,"abstract":"Tolerance of chilling dictates the geographical distribution, establishment, and productivity of C4 crops. Chilling reduces enzyme rate, limiting the sink for the absorbed light energy leading to the need for quick energy dissipation via non-photochemical quenching (NPQ). Here, we characterize NPQ upon chilling in three Miscanthus accessions representing diverse chilling tolerance in C4 grasses. High chilling tolerant accessions accumulate substantial amounts of zeaxanthin during chilling nights in both field and growth chamber settings. Chilling-induced zeaxanthin accumulation in the dark enhances rate of NPQ induction by 66% in the following morning. Based on our data, the emerging ways for the unique regulation of NPQ include post-translational regulation of violaxanthin de-epoxidase (VDE), VDE cofactor accessibility, and absence of transcriptional upregulation of zeaxanthin conversion back to violaxanthin. In the future, more studies will be required to obtain further evidence for these ways contributions to the chilling-dark regulation of NPQ. Engineering dark accumulation of zeaxanthin will help improve crop chilling tolerance and promote sustainable production by allowing early spring planting to maximize the use of early-season soil moisture. Driving the engineered trait by chilling inducible promoter would ensure the minimization of a trade-off between photoprotection and photosynthesis efficiency.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"7 1","pages":"1660"},"PeriodicalIF":5.2,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142863458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EZH2 elicits CD8⁺ T-cell desert in esophageal squamous cell carcinoma via suppressing CXCL9 and dendritic cells.

IF 5.2 1区生物学

Communications Biology Pub Date : 2024-12-19 DOI: 10.1038/s42003-024-07341-9

Chun-Yan Zhu, Tian-Tian Zhai, Meng Su, Hong-Chao Pan, Qian Tang, Bao-Hua Huang, Xin-Rui Chi, Nuo Li, Ling-Hui Xie, Si-Qi Qiu, Feng Pan, Guo-Wei Huang

{"title":"EZH2 elicits CD8+ T-cell desert in esophageal squamous cell carcinoma via suppressing CXCL9 and dendritic cells.","authors":"Chun-Yan Zhu, Tian-Tian Zhai, Meng Su, Hong-Chao Pan, Qian Tang, Bao-Hua Huang, Xin-Rui Chi, Nuo Li, Ling-Hui Xie, Si-Qi Qiu, Feng Pan, Guo-Wei Huang","doi":"10.1038/s42003-024-07341-9","DOIUrl":"https://doi.org/10.1038/s42003-024-07341-9","url":null,"abstract":"CD8+ T cell spatial distribution in the context of tumor microenvironment (TME) dictates the immunophenotypes of tumors, comprised of immune-infiltrated, immune-excluded and immune-desert, discriminating \"hot\" from \"cold\" tumors. The infiltration of cytotoxic CD8+ T cells is associated with favorable therapeutic response. Hitherto, the immunophenotypes of esophageal squamous cell carcinoma (ESCC) have not yet been comprehensively delineated. Herein, we comprehensively characterized the immunophenotypes of ESCC and identified a subset of ESCC, which was defined as cold tumor and characterized with CD8+ T cell-desert TME. However, the mechanism underlying the defect of CD8+ T cells in TME is still pending. Herein, we uncovered that tumor cell-intrinsic EZH2 with high expression was associated with the immunophenotype of immune-desert tumors. Targeted tumor cell-intrinsic EZH2 rewired the transcriptional activation of CXCL9 mediated by NF-κB and concomitantly reinvigorated DC maturation differentiation via inducing the reduction of VEGFC secretion, thereby enhancing the infiltration of cytotoxic CD8+ T cells into TME and inhibiting tumor immune evasion. Our findings identify EZH2 as a potential therapeutic target and point to avenues for targeted therapy applied to patients with ESCC characterized by CD8+ T cell-desert tumors.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"7 1","pages":"1645"},"PeriodicalIF":5.2,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142863558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of KCNE6, a new member of the KCNE family of potassium channel auxiliary subunits.

IF 5.2 1区生物学

Communications Biology Pub Date : 2024-12-19 DOI: 10.1038/s42003-024-07352-6

Go Kasuya, Buntaro Zempo, Yasuhiro Yamamoto, Kaei Ryu, Fumihito Ono, Koichi Nakajo

{"title":"Identification of KCNE6, a new member of the KCNE family of potassium channel auxiliary subunits.","authors":"Go Kasuya, Buntaro Zempo, Yasuhiro Yamamoto, Kaei Ryu, Fumihito Ono, Koichi Nakajo","doi":"10.1038/s42003-024-07352-6","DOIUrl":"https://doi.org/10.1038/s42003-024-07352-6","url":null,"abstract":"The KCNE family (KCNE1-5) is a group of single transmembrane auxiliary subunits for the voltage-gated K+ channel KCNQ1. The KCNQ1-KCNE complexes are crucial for numerous physiological processes including ventricular repolarization and K+ recycling in epithelial cells. We identified a new member of the KCNE family, \"KCNE6\", from zebrafish. We found that KCNE6 is expressed in the zebrafish heart and is involved in cardiac excitability. When co-expressed with KCNQ1, KCNE6 produces a slowly activating current like the slow delayed-rectifier K+ current (IKs) induced by KCNE1, despite the fact that the KCNE6 amino acid sequence has the highest similarity to that of KCNE3, which forms a constitutively open channel with KCNQ1. The kcne6 nucleotide sequences exist throughout vertebrates, including humans, although only the KCNE6 proteins of lower vertebrates, up to marsupials, can modulate KCNQ1, and it has become a pseudogene in eutherians. Our findings will facilitate a better understanding of how the KCNE family has evolved to modulate KCNQ1.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"7 1","pages":"1662"},"PeriodicalIF":5.2,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142863590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Auditory brainstem responses as a biomarker for cognition.

IF 5.2 1区生物学

Communications Biology Pub Date : 2024-12-19 DOI: 10.1038/s42003-024-07346-4

Yasmeen Hamza, Ye Yang, Janie Vu, Antoinette Abdelmalek, Mobina Malekifar, Carol A Barnes, Fan-Gang Zeng

{"title":"Auditory brainstem responses as a biomarker for cognition.","authors":"Yasmeen Hamza, Ye Yang, Janie Vu, Antoinette Abdelmalek, Mobina Malekifar, Carol A Barnes, Fan-Gang Zeng","doi":"10.1038/s42003-024-07346-4","DOIUrl":"https://doi.org/10.1038/s42003-024-07346-4","url":null,"abstract":"A non-invasive, accessible and effective biomarker is critical to the diagnosis, monitoring and treatment of age-related cognitive decline. Recent work has suggested a strong association between auditory brainstem responses (ABR) and cognitive function in aging macaques. Here we show in 118 human participants (66 females; age range=18-92 years; hearing loss = -5 to 70 dB HL) that cognition is associated with both age and hearing level, but this triad relationship is mainly driven by the age factor. After adjusting for age, cognition is still significantly associated with both the ABR wave V amplitude (B, 0.110, 95% CI, 0.018- 0.202; p = 0.020) and latency (B, -0.101, 95% CI, -0.186- -0.016; p = 0.021). Importantly, this age-adjusted ABR-cognition association is primarily driven by older individuals and language-dependent cognitive functions. We also perform the area under the curve (AUC) of the receiver-operating-characteristic analysis and find that the ABR wave V amplitude is best for detecting good cognitive performers (AUC = 0.96) whereas the wave V latency is best for detecting poor ones (AUC = 0.86). The present result not only confirms the previous animal work in humans but also shows the clinical potential of using auditory brainstem responses to improve diagnosis and treatment of age-related cognitive decline.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"7 1","pages":"1653"},"PeriodicalIF":5.2,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142863359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0