Communications Biology最新文献

BUB signaling in cancer and molecular insights into targeted therapies. 癌症中的BUB信号和靶向治疗的分子见解。

IF 5.8 1区生物学

Communications Biology Pub Date : 2026-10-16 DOI: 10.1038/s42003-026-10976-5

Bhavika Baweja, Chainsee Saini, Prerna Vats, Rashi Soni, Kritika Jangir, Prachi Patidar, Ashok Kumar, Rajeev Nema

引用次数: 0

Towards a unified biology of vertebrate number sense. 朝向脊椎动物数目感觉的统一生物学。

IF 5.8 1区生物学

Communications Biology Pub Date : 2026-10-15 DOI: 10.1038/s42003-026-11146-3

Mirko Zanon, Andrea Messina, Brian Butterworth, Giorgio Vallortigara, Caroline H Brennan, Jose Vicente Torres-Pérez, Maria Elena Miletto-Petrazzini

引用次数: 0

Selective inhibition of IL-6 trans-signalling reveals distinct mechanisms of human classic and trans-signalling receptor-complex formation. 选择性抑制IL-6反式信号传导揭示了人类经典和反式信号传导受体复合物形成的不同机制。

IF 5.8 1区生物学

Communications Biology Pub Date : 2026-10-14 DOI: 10.1038/s42003-026-11014-0

Emelie Rieneck, Jan René Haak, Kamal Asgarov, Jean-René Pallandre, Nicole Wundrack, Julia Ettich, Niloufarsadat Miri, Doreen M Floss, Jürgen Scheller, Christoph Garbers, Andy Clark, John Wijdenes, Fred Schaper, Anna Dittrich

{"title":"Selective inhibition of IL-6 trans-signalling reveals distinct mechanisms of human classic and trans-signalling receptor-complex formation.","authors":"Emelie Rieneck, Jan René Haak, Kamal Asgarov, Jean-René Pallandre, Nicole Wundrack, Julia Ettich, Niloufarsadat Miri, Doreen M Floss, Jürgen Scheller, Christoph Garbers, Andy Clark, John Wijdenes, Fred Schaper, Anna Dittrich","doi":"10.1038/s42003-026-11014-0","DOIUrl":"10.1038/s42003-026-11014-0","url":null,"abstract":"The cytokine interleukin-6 orchestrates inflammation through two distinct pathways of receptor activation: anti-inflammatory classic signalling via membrane-bound interleukin-6 receptor and pro-inflammatory trans-signalling via soluble interleukin-6 receptor. Current interleukin-6-targeted therapies block both pathways, thereby disrupting essential homeostatic functions initiated by classic signalling. We here show a high-affinity, human-specific antibody that selectively inhibits interleukin-6 trans-signalling. This antibody maintains classic signalling-induced expression of hepatic acute phase genes while completely blocking trans-signalling-induced activation of endothelial cells. By targeting the domain D2 of membrane-bound and soluble human interleukin-6 receptor, the antibody selectively prevents formation of the trans-signalling receptor complex without interfering with ligand binding. This selective blockade demonstrates that human interleukin-6 classic and trans-signalling proceed through distinct receptor assemblies. Our findings describe mechanistic insight into interleukin-6 receptor assembly and provide a strategy to suppress inflammatory interleukin-6 activity while preserving regenerative and anti-inflammatory signalling, thus offering both conceptual and potential therapeutic advances in the targeted modulation of cytokine signalling networks.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"9 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13669321/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

KCNQ1 disruption alters human neuronal development through mitochondrial and insulin signalling pathways. KCNQ1的破坏通过线粒体和胰岛素信号通路改变人类神经元的发育。

IF 5.8 1区生物学

Communications Biology Pub Date : 2026-10-13 DOI: 10.1038/s42003-026-11111-0

Dorothea Schall, Baran E Güler, Siamand Alibrahim, Mahmudul Hasan, Naeem Ahmad, Joanna Widomska, Claudio Acuna, Mairéad Sullivan, Ralph Röth, Chang Liu, Linda Blaier, Katalin Vincze, Karin Burau, Simone Macri, Daniela Mauceri, Marcin Luzarowski, Ágota Apáti, János M Réthelyi, Geert Poelmans, Gudrun A Rappold, Barbara Franke, Jeffrey C Glennon, Simone Berkel

{"title":"KCNQ1 disruption alters human neuronal development through mitochondrial and insulin signalling pathways.","authors":"Dorothea Schall, Baran E Güler, Siamand Alibrahim, Mahmudul Hasan, Naeem Ahmad, Joanna Widomska, Claudio Acuna, Mairéad Sullivan, Ralph Röth, Chang Liu, Linda Blaier, Katalin Vincze, Karin Burau, Simone Macri, Daniela Mauceri, Marcin Luzarowski, Ágota Apáti, János M Réthelyi, Geert Poelmans, Gudrun A Rappold, Barbara Franke, Jeffrey C Glennon, Simone Berkel","doi":"10.1038/s42003-026-11111-0","DOIUrl":"10.1038/s42003-026-11111-0","url":null,"abstract":"KCNQ1 encodes a voltage-gated potassium channel implicated in peripheral and neurological disorders, but its role in human neurodevelopment remains unclear. We generated KCNQ1 knockout (KO) human induced pluripotent stem cells and differentiated them into neural stem cells (NSCs) and cortical neurons. KCNQ1-deficient NSCs show impaired neurite outgrowth, linked to reduced cell adhesion and disrupted neural cell adhesion molecule signalling, a phenotype reproduced by pharmacological KCNQ1 inhibition. Multi-omics and follow-up analyses reveal mitochondrial dysfunction, including reduced mitochondrial copy number and ATP synthase expression. KO cells also show impaired insulin signalling, with diminished insulin receptor gene expression and altered RAS-MAPK and PI3K-AKT pathways. In differentiated neuronal cultures, KCNQ1 loss decreases synaptic activity and maintains an immature transcriptional profile. Together, these findings identify a role for KCNQ1 in regulating cell adhesion, mitochondrial function, insulin signalling, and neuronal maturation, expanding our understanding of processes that may contribute to neurological manifestations associated with KCNQ1-related disorders.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"9 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13661531/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Divergent processing strategies for auditory sequence recognition in humans and zebra finches (Taeniopygia guttata). 人类和斑胸草雀听觉序列识别的不同处理策略。

IF 5.8 1区生物学

Communications Biology Pub Date : 2026-10-13 DOI: 10.1038/s42003-026-11035-9

Zhi-Yuan Ning, Jiaxin Li, Carel Ten Cate, Henkjan Honing

{"title":"Divergent processing strategies for auditory sequence recognition in humans and zebra finches (Taeniopygia guttata).","authors":"Zhi-Yuan Ning, Jiaxin Li, Carel Ten Cate, Henkjan Honing","doi":"10.1038/s42003-026-11035-9","DOIUrl":"10.1038/s42003-026-11035-9","url":null,"abstract":"Deriving sequential information from complex sounds is a challenge for auditory systems, yet it remains unclear whether humans and nonhuman species integrate multidimensional cues or prioritize a single dimension when processing multidimensional input. We investigated how humans and zebra finches (Taeniopygia guttata) process concurrent acoustic cues using an identical behavioural paradigm with complex-tone sequences. By presenting probe stimuli that selectively preserved or disrupted either pitch or formant trajectory, we quantified these processing strategies. We show that zebra finches employ an additive integration strategy, treating pitch and formant trajectories as complementary components of a unified auditory pattern. In contrast, humans exhibit a dominant reliance on pitch. Experience further modulates this bias, with trained human listeners recruiting secondary cues to preserve learned relational structure when pitch is unreliable. These findings imply a cross-species divergence in auditory representation, suggesting that auditory processing is shaped by an interplay of species-specific priorities and experience-dependent functional substitution.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"9 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13661893/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DNMT1 function in cortical PV interneurons modulates cortical network activity, mood disorder‑related behavior, and perineuronal nets. DNMT1在皮质PV中间神经元中的功能调节皮质网络活动、情绪障碍相关行为和神经周围网络。

IF 5.8 1区生物学

Communications Biology Pub Date : 2026-10-08 DOI: 10.1038/s42003-026-11079-x

Jenice Linde, Can Bora Yildiz, Katharina Vöhringer, Gerion Nabbefeld, Severin Graff, Daniel Pensold, Julia Reichard, Marie Hermanns, Laura Koch, Magdalena Sophie Müller, Ayushi Tanwar, Christoph Weber-Hamacher, Ivan G Costa Filho, Thomas Stiehl, Marc Spehr, Björn Kampa, Anja Urbach, Simon Musall, Geraldine Zimmer-Bensch

{"title":"DNMT1 function in cortical PV interneurons modulates cortical network activity, mood disorder‑related behavior, and perineuronal nets.","authors":"Jenice Linde, Can Bora Yildiz, Katharina Vöhringer, Gerion Nabbefeld, Severin Graff, Daniel Pensold, Julia Reichard, Marie Hermanns, Laura Koch, Magdalena Sophie Müller, Ayushi Tanwar, Christoph Weber-Hamacher, Ivan G Costa Filho, Thomas Stiehl, Marc Spehr, Björn Kampa, Anja Urbach, Simon Musall, Geraldine Zimmer-Bensch","doi":"10.1038/s42003-026-11079-x","DOIUrl":"10.1038/s42003-026-11079-x","url":null,"abstract":"Parvalbuminergic (PV) interneurons are central to cortical network stability and psychiatric vulnerability. Here, we identify DNA methyltransferase 1 (DNMT1) as a key epigenetic regulator linking PV interneuron function to glial and extracellular matrix remodeling. Conditional PV-specific Dnmt1 deletion, combined with single-nucleus RNA-seq (snRNA-seq), snATAC-seq, in vivo electrophysiology, histology, and behavioral analyses, revealed that DNMT1 loss increases PV spiking but reduces inhibitory efficacy, driving network desynchronization and depression- and anxiety-like behavior in mice. These physiological changes were accompanied by non-cell-autonomous transcriptional and chromatin alterations, affecting perineuronal net (PNN) organization and neuron-glia communication. Cell-cell communication analyses predicted reorganized perisomatic signaling, and compartmental modeling of oligodendrocyte lineage dynamics further revealed impaired formation of PNN-supporting perineuronal oligodendrocytes, consistent with a tissue-level reduction in PNN integrity. Together, our findings demonstrate that DNMT1 maintains inhibitory circuit stability through PV interneuron function, secondarily shaping glial states and extracellular scaffolds to support cortical network synchronization and affective behavior.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"9 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13650159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149135321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Global patterns are key to understanding macroevolution. 全局模式是理解宏观进化的关键。

IF 5.8 1区生物学

Communications Biology Pub Date : 2026-10-08 DOI: 10.1038/s42003-026-11118-7

Zhen Guo, Wolfgang Kiessling

引用次数: 0

In situ enhancement of coral larval settlement using acoustic enrichment, engineered habitats and living materials. 利用声富集、工程生境和生物材料原位增强珊瑚幼虫的定居。

IF 5.8 1区生物学

Communications Biology Pub Date : 2026-10-08 DOI: 10.1038/s42003-026-10932-3

Aaron Thode, Natalie Levy, Océane Boulais, Samapti Kundu, Marnie Freckelton, Daniel Schar, Michael Hadfield, Jessica Reichert, Hendrikje Jorissen, Netanel Kramer, Joshua Levy, Kira Hughes, Joshua Madin, Daniel Wangpraseurt

{"title":"In situ enhancement of coral larval settlement using acoustic enrichment, engineered habitats and living materials.","authors":"Aaron Thode, Natalie Levy, Océane Boulais, Samapti Kundu, Marnie Freckelton, Daniel Schar, Michael Hadfield, Jessica Reichert, Hendrikje Jorissen, Netanel Kramer, Joshua Levy, Kira Hughes, Joshua Madin, Daniel Wangpraseurt","doi":"10.1038/s42003-026-10932-3","DOIUrl":"10.1038/s42003-026-10932-3","url":null,"abstract":"Worldwide reef ecosystem degradation is inspiring efforts to enhance in-situ coral larvae settlement onto degraded or artificial reefs. Here we simultaneously test three approaches for enhancing settlement over two weeks in Kāne'ohe Bay, O'ahu, Hawai'i. Nineteen artificial structures, mimicking natural reef mesoscale roughness, were deployed along two transect lines at distances between 1 and 42 m from an \"acoustic enrichment\" underwater speaker broadcasting healthy reef sound. Twelve additional cinder blocks supporting micro-habitat structures designed to attenuate flow were also deployed at various distances. Some micro-habitats were coated with a living bacteria reef ink (Brink) to further induce larval settlement. Statistical regressions identify Brink presence, structure type, and speaker distance to 20 m as significant factors in predicting coral larval settlement density, but conclusions about acoustic enrichment efficacy are tentative. The cumulative effects of acoustic enrichment, living microbial materials, and custom-designed habitats on enhancing in-situ larval settlement justify further scaled-up reef restoration trials.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"9 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13650121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149135261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The bacteriophage transcription factor Gp53 suppresses cell division and regulates Pseudomonas aeruginosa physiology. 噬菌体转录因子Gp53抑制细胞分裂，调控铜绿假单胞菌生理。

IF 5.8 1区生物学

Communications Biology Pub Date : 2026-10-08 DOI: 10.1038/s42003-026-11031-z

Ying Li, Xiaomin Li, Gukui Chen, Lixin Yuan, Hailong Zhong, Min Hui, Yongfeng Sun, Yufei Han, Shuqin Zhou, Shiwei Wang, Weina Kong

{"title":"The bacteriophage transcription factor Gp53 suppresses cell division and regulates Pseudomonas aeruginosa physiology.","authors":"Ying Li, Xiaomin Li, Gukui Chen, Lixin Yuan, Hailong Zhong, Min Hui, Yongfeng Sun, Yufei Han, Shuqin Zhou, Shiwei Wang, Weina Kong","doi":"10.1038/s42003-026-11031-z","DOIUrl":"10.1038/s42003-026-11031-z","url":null,"abstract":"Pseudomonas aeruginosa is a highly drug-resistant pathogen that poses a major challenge to clinical treatment. Bacteriophages encode diverse regulatory proteins that can alter host cellular processes during infection. Here we show that the ΦPA1019-encoded transcription factor Gp53 regulates bacterial physiology by targeting key host pathways. Gp53 expression reduces bacterial growth, motility, and biofilm formation, and causes filamentous cell morphology. Transcriptomic analysis reveals that Gp53 alters the expression of 3,342 genes, including genes involved in cell division and virulence-associated processes. DNA-binding assays demonstrate that Gp53 directly represses promoters of key host genes, including ftsZ, fleQ, pslA, and amrZ. Gp53-mediated repression of ftsZ disrupts Z-ring formation and inhibits cell division, while ftsZ expression restores these defects. Structural and mutational analyses identify residues important for Gp53-DNA interaction. Together, these findings reveal a phage-encoded mechanism that coordinately interferes with bacterial cell division and virulence-associated pathways, providing mechanistic insights into host transcriptional regulation during phage infection and expanding our understanding of phage-host interactions.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"9 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13650114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149135339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DNA-based monitoring uncovers contrasting salinity-driven diversity patterns of bacterial and protist plankton in the Baltic Sea area. 基于dna的监测揭示了波罗的海地区细菌和原生浮游生物的不同盐度驱动的多样性模式。

IF 5.8 1区生物学

Communications Biology Pub Date : 2026-10-07 DOI: 10.1038/s42003-026-10977-4

Krzysztof T Jurdzinski, Meike Ac Latz, Anders Torstensson, Sonia Brugel, Mikael Hedblom, Yue O O Hu, Markus Lindh, Agneta Andersson, Bengt Karlson, Anders F Andersson

{"title":"DNA-based monitoring uncovers contrasting salinity-driven diversity patterns of bacterial and protist plankton in the Baltic Sea area.","authors":"Krzysztof T Jurdzinski, Meike Ac Latz, Anders Torstensson, Sonia Brugel, Mikael Hedblom, Yue O O Hu, Markus Lindh, Agneta Andersson, Bengt Karlson, Anders F Andersson","doi":"10.1038/s42003-026-10977-4","DOIUrl":"10.1038/s42003-026-10977-4","url":null,"abstract":"Salinity has been identified as a primary factor structuring community composition in global diversity assessments of free-living bacteria in non-extreme environments. It remains unknown whether the same is true for protists. Moreover, changes in alpha diversity of both bacteria and protists across the brackish salinity gradient remain elusive. Here, we analyzed protist and bacterial diversity using DNA metabarcoding across 398 surface water samples synchronized with national monitoring of the Baltic Sea and the Kattegat-Skagerrak. We show that salinity, unlike other environmental factors, had a stronger effect on bacterial than on protist community composition. Likewise, protist taxonomic units tended to have broader salinity niches than bacterial ones. In contrast, protist but not bacterial alpha diversity (richness) increased with salinity. Bacterial alpha diversity was similar across salinities despite drastic changes in community composition, as marine-associated taxa steadily replaced freshwater-associated ones. Conversely, marine-associated protists dominated across most of the salinity gradient, with fewer taxonomic units adapted to lower salinities. Overall, the diversity of protists but not bacteria followed patterns consistent with local adaptation as observed in other groups of organisms. Ultimately, the observed patterns form a baseline for environmental monitoring and suggest unexplored differences between bacterial and protist eco-evolutionary dynamics.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"9 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13646260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0