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A fully automated framework for acoustic identification and localization of terrestrial wildlife at scale. 陆地野生动物声学识别与定位的全自动化框架。
IF 5.1 1区 生物学
Communications Biology Pub Date : 2026-05-09 DOI: 10.1038/s42003-026-09949-5
Louis Freeland-Haynes, Sam Lapp, Chapin Czarnecki, Lauren Chronister, Joe Begley, Alex Rogers, Peter Prince, Andy Hill, Justin Kitzes
{"title":"A fully automated framework for acoustic identification and localization of terrestrial wildlife at scale.","authors":"Louis Freeland-Haynes, Sam Lapp, Chapin Czarnecki, Lauren Chronister, Joe Begley, Alex Rogers, Peter Prince, Andy Hill, Justin Kitzes","doi":"10.1038/s42003-026-09949-5","DOIUrl":"https://doi.org/10.1038/s42003-026-09949-5","url":null,"abstract":"<p><p>Autonomous acoustic recorders are increasingly important tools for monitoring sound-producing taxa. Coupled with advances in machine learning, they enable greater sampling effort and larger spatial and temporal scales than in-person surveys. With synchronized recorders, acoustic localization enables collection of fine-grained spatial data on animals' positions. Spatial data has important applications in abundance estimation, territory delineation, studies of movement and microhabitat use. Applications of acoustic localization have however been limited in scale, due to the technical and cost challenges of hardware and effort-intensive analysis steps.. We present a fully automated framework for identification and acoustic localization of terrestrial wildlife. Using low-cost GPS-Audiomoth recorders, we provide an open source software pipeline for detection, time-delay estimation, localization, error rejection and resolution of multiple simultaneous sound-sources. We achieve high spatial accuracy on a loudspeaker test, where 99% of broadcast calls localized were accurate to within 5 m. We demonstrate its utility for surveying birds at large spatial scales with a localization array of over 60 recorders at a forested site. Using a CNNfor automated detection, our localization framework produces spatial patterns of species observations similar to those found by in-person spot mapping surveys. Our framework enables applications of acoustic localization at large scales.</p>","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147863633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gene regulatory networks orchestrating oocyte fate bifurcation in primordial follicles revealed by single-cell transcriptomics. 单细胞转录组学揭示了原始卵泡中协调卵母细胞命运分叉的基因调控网络。
IF 5.1 1区 生物学
Communications Biology Pub Date : 2026-05-09 DOI: 10.1038/s42003-026-10235-7
Hanwen Zhang, Xingsi He, Qiuzhen Chen, Min Su, Huanyu Yan, Xiao Zeng, Shicai Fan, Xi Wang
{"title":"Gene regulatory networks orchestrating oocyte fate bifurcation in primordial follicles revealed by single-cell transcriptomics.","authors":"Hanwen Zhang, Xingsi He, Qiuzhen Chen, Min Su, Huanyu Yan, Xiao Zeng, Shicai Fan, Xi Wang","doi":"10.1038/s42003-026-10235-7","DOIUrl":"https://doi.org/10.1038/s42003-026-10235-7","url":null,"abstract":"<p><p>The first wave of primordial follicle activation occurs around postnatal day 2.5 (P2.5), with the remaining follicles entering a dormant state to ensure a continuous supply of fertilizable oocytes. However, the molecular characterization and underlying mechanisms of this critical fate commitment remain poorly understood. Here, we employ SMART-seq2 to profile transcriptional dynamics in individual perinatal female C57BL/6 mouse germ cells across three developmental stages: cyst stage at embryonic day 17.5 (E17.5), primordial-follicle stage at P2.5, and primary-follicle stage at P6.5. Unsupervised clustering and trajectory inference reveal divergent transcriptional programs within P2.5 primordial oocytes, indicative of a bifurcating process in which pre-determined oocytes commit towards either dormant or activated states. Activated oocytes exhibit upregulation of genes linked to PI3K-Akt/mTORC1 signaling, extracellular matrix (ECM) disassembly, and oocyte maturation, whereas marker genes of dormant oocytes are enriched in oxidative stress response and DNA repair pathways. Transcriptional regulatory network reconstruction based on SCENIC inference identifies key transcription factors (e.g., BHLHE41, TCF3/12) orchestrating the fate bifurcation. Notably, dormant oocytes form a stable transcriptional state distinct from the continuous activation and development trajectory. Our findings provide a comprehensive landscape of gene expression and regulatory networks that orchestrate fate determination in P2.5 primordial-follicle oocytes.</p>","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147863654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biogeography and community stability of leaf endophytic diazotrophs in mangrove Kandelia obovata. 红树叶内生重氮营养菌的生物地理及群落稳定性。
IF 5.1 1区 生物学
Communications Biology Pub Date : 2026-05-09 DOI: 10.1038/s42003-026-10168-1
Qinghua Hou, Rajapakshalage Thashikala Nethmini, Feng Qi, Lianghao Pan, Xiaofang Shi, Laizhen Huang, Qing He, Qingxiang Chen, Xiaolei Li, Gonglingxia Jiang, Dong Ke, Nan Li
{"title":"Biogeography and community stability of leaf endophytic diazotrophs in mangrove Kandelia obovata.","authors":"Qinghua Hou, Rajapakshalage Thashikala Nethmini, Feng Qi, Lianghao Pan, Xiaofang Shi, Laizhen Huang, Qing He, Qingxiang Chen, Xiaolei Li, Gonglingxia Jiang, Dong Ke, Nan Li","doi":"10.1038/s42003-026-10168-1","DOIUrl":"https://doi.org/10.1038/s42003-026-10168-1","url":null,"abstract":"<p><p>The leaf endosphere hosts diazotrophs vital for plant health and ecosystem resilience in saline environments. However, the geographic pattern and stability of the diazotrophic community in coastal salt marshes ecosystems are poorly understood. In this study, we examine the biogeographic distribution, assembly processes and community stability of leaf endophytic diazotrophs in the mangrove species Kandelia obovata across multiple regions in China. Our findings reveal that Rhizobiales are the most abundant in the diazotrophic communities. Community assembly is largely governed by stochastic processes, with dispersal limitations playing a dominant role. Soil nutrients emerge as the dominant factor influencing diazotroph composition, surpassing climatic variables and host traits. Notably, soil total sulfur (TS) serves as a key environmental factor shaping the diazotrophic community structure, with low TS environments supporting more stable microbial networks. These findings reveal ecological drivers and adaption strategies of endophytic diazotrophic communities in mangrove ecosystems, emphasizing the influence of nutrients dynamics in leaf endophytic microbial assembly under environmental changes.</p>","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147863664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regions of low gene expression promote maintenance and adaptation of horizontally acquired genes in yeasts. 低基因表达区促进酵母水平获得基因的维持和适应。
IF 5.1 1区 生物学
Communications Biology Pub Date : 2026-05-09 DOI: 10.1038/s42003-026-10153-8
Patrícia H Brito, Victoria Gil, Ana Pontes, Margarida Silva, Carla Gonçalves, Paula Gonçalves
{"title":"Regions of low gene expression promote maintenance and adaptation of horizontally acquired genes in yeasts.","authors":"Patrícia H Brito, Victoria Gil, Ana Pontes, Margarida Silva, Carla Gonçalves, Paula Gonçalves","doi":"10.1038/s42003-026-10153-8","DOIUrl":"https://doi.org/10.1038/s42003-026-10153-8","url":null,"abstract":"<p><p>We showed previously that yeasts in Starmerella and Wickerhamiella genera (W/S clade) exhibit numbers of horizontal gene transfer (HGT) events much larger than found in any other yeast species, with bacteria and other fungi (Pezizomycotina) as donors. Here we shed light on HGT in the W/S clade by carrying out the characterization of xenologous genes present in three species harboring together close to 600 xenologous genes. Metabolic genes were strongly overrepresented and either introduced functions new to yeasts or restored functions that were likely absent in the W/S clade ancestor. RNA-sequencing revealed lower global levels of expression of xenologous vs native yeast genes in two species. This difference is associated with the preferential accumulation of xenologous genes in large, AT-enriched chromosome terminal regions, dubbed \"End\" domains, characterized by overall lower gene expression. In one species, \"End\" domains were shown to be more permissive for protein diversification, but only for xenologous genes. We posit that \"End\" domains may generate favorable conditions for the adaptation and retention of xenologous genes, helping explain the exceptional numbers of HGT events in the W/S clade.</p>","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structural insights into the assembly and function of Retron Ec78 PtuAB. 对Retron Ec78 PtuAB组装和功能的结构见解。
IF 5.1 1区 生物学
Communications Biology Pub Date : 2026-05-09 DOI: 10.1038/s42003-026-10199-8
Leyuan Duan, Lu Chen, Qian Hu, Xiao Li, Shanshan Li, Kaiming Zhang, Qingguo Gong
{"title":"Structural insights into the assembly and function of Retron Ec78 PtuAB.","authors":"Leyuan Duan, Lu Chen, Qian Hu, Xiao Li, Shanshan Li, Kaiming Zhang, Qingguo Gong","doi":"10.1038/s42003-026-10199-8","DOIUrl":"https://doi.org/10.1038/s42003-026-10199-8","url":null,"abstract":"<p><p>The Retron system is a crucial prokaryotic anti-phage defense mechanism, composed of a noncoding RNA, reverse transcriptase, and effector proteins, which synthesizes multicopy single-stranded DNA to trigger immune responses. While Retron Ec86's anti-phage mechanism has been elucidated, other Retron types remain poorly understood. Here, we investigate Retron Ec78, a Type I-A system encoding effector proteins PtuA (ATPase) and PtuB (HNH nuclease). Structural analysis reveals that PtuA hexameric complex putatively bound to PtuB, with ATP playing a key role in hexamer assembly. Beyond its known role in abortive infection via tRNA degradation, we demonstrate that the PtuAB complex also exhibits DNA-cleaving activity. These findings provide novel insights into the assembly and dual functionality of the Retron Ec78 system, advancing our understanding of prokaryotic immune mechanisms against phage infection.</p>","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147863692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Complexity of PEDF multifunctional signaling in retinal development and diseases. PEDF多功能信号在视网膜发育和疾病中的复杂性。
IF 5.1 1区 生物学
Communications Biology Pub Date : 2026-05-09 DOI: 10.1038/s42003-026-10175-2
Zihao Yu, Mingliang Zhang, Changjie Ren, Xiaomin Zhang, Colin J Barnstable, Joyce Tombran-Tink, Xiaorong Li
{"title":"Complexity of PEDF multifunctional signaling in retinal development and diseases.","authors":"Zihao Yu, Mingliang Zhang, Changjie Ren, Xiaomin Zhang, Colin J Barnstable, Joyce Tombran-Tink, Xiaorong Li","doi":"10.1038/s42003-026-10175-2","DOIUrl":"https://doi.org/10.1038/s42003-026-10175-2","url":null,"abstract":"<p><p>PEDF has neuroprotective, anti-inflammatory, anti-oxidative stress, and anti-angiogenic actions, but its multifunctional mechanisms remain unclear. We map the developmental distribution of the PEDF receptors LR, LRP6, and ATGL in naïve and Pedf<sup>-/-</sup> retinas, and define receptor-specific signaling using siRNA and pharmacological inhibition. These receptors are broadly expressed in retinoblasts and acquire cell-type-specific patterns during retinal maturation via PEDF-independent mechanisms. LR and LRP6 also colocalize at the outer limiting membrane (OLM). Functionally, PEDF activates AKT, STAT3, ERK, and p38 and suppresses β-catenin in both HUVEC and ARPE-19 cells, while mTOR activation remains receptor-independent. LR and LRP6 couple PEDF to STAT3 and β-catenin in HUVECs, whereas in ARPE-19 cells LR links PEDF to AKT/STAT3/ERK and LRP6 to AKT/β-catenin. ATGL inhibition abolishes PEDF-induced AKT/STAT3/ERK/p38 signaling in both cell types. A 17-mer PEDF mimetic (Ppx) recapitulates these effects. These findings help define a framework for PEDF pleiotropy and highlight the OLM as a therapeutic interface.</p>","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting CCR1-mediated macrophage phenotypic switching to alleviate bladder pain and urinary dysfunction in interstitial cystitis. 靶向ccr1介导的巨噬细胞表型转换减轻间质性膀胱炎患者膀胱疼痛和尿功能障碍。
IF 5.1 1区 生物学
Communications Biology Pub Date : 2026-05-09 DOI: 10.1038/s42003-026-10232-w
Ruixiang Luo, Wenshuang Li, Bolong Liu, Junlong Huang, Honglu Ding, Chi Zhang, Xiaoyang Li, Ziqiao Wang, Zheng Liu, Xiangfu Zhou, Jialiang Chen
{"title":"Targeting CCR1-mediated macrophage phenotypic switching to alleviate bladder pain and urinary dysfunction in interstitial cystitis.","authors":"Ruixiang Luo, Wenshuang Li, Bolong Liu, Junlong Huang, Honglu Ding, Chi Zhang, Xiaoyang Li, Ziqiao Wang, Zheng Liu, Xiangfu Zhou, Jialiang Chen","doi":"10.1038/s42003-026-10232-w","DOIUrl":"https://doi.org/10.1038/s42003-026-10232-w","url":null,"abstract":"<p><p>Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic inflammatory condition with limited treatments. Although macrophages are implicated in its pathogenesis, the mechanisms driving their phenotypic switching remain unclear. This study identifies CCR1's role in IC/BPS and evaluates CCR1 inhibition as a therapeutic strategy. Integrated bulk and single-cell RNA sequencing reveal enrichment of pro-inflammatory CCR1⁺ macrophages in bladder tissue from patients with IC/BPS. In a lipopolysaccharide-induced rat model, pharmacological inhibition of CCR1 suppresses M1 polarization, promotes M2 polarization, and improves pain thresholds, urinary symptoms as well as bladder inflammation. Mechanistically, CCR1 knockdown enhances FOXO1 phosphorylation and degradation, reduces its nuclear translocation, and activates PPARγ signaling to promote M2 polarization. Analysis of clinical samples shows increased CCL7 levels in bladder tissue and urine, with urinary levels correlating with symptom severity. These findings identify CCR1 as a candidate target for further therapeutic evaluation in IC/BPS.</p>","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Proximity and current alignment drive fertilisation success in a broadcast-spawning coral (Acropora cf. hyacinthus). 靠近和电流对齐驱动了广播产卵珊瑚(Acropora cf. hyacinthus)的受精成功。
IF 5.1 1区 生物学
Communications Biology Pub Date : 2026-05-09 DOI: 10.1038/s42003-026-10055-9
Gerard F Ricardo, Christopher Doropoulos, Adriana Humanes, Liam Lachs, Helios M Martinez, Greta Sartori, Taison Ka Tai Chang, Apple Pui Yi Chui, Elvis Long Ching Wong, Jamie R Stevens, Iva Popovic, James R Guest, Elizabeth Buccheri, David Idip, Peter J Mumby
{"title":"Proximity and current alignment drive fertilisation success in a broadcast-spawning coral (Acropora cf. hyacinthus).","authors":"Gerard F Ricardo, Christopher Doropoulos, Adriana Humanes, Liam Lachs, Helios M Martinez, Greta Sartori, Taison Ka Tai Chang, Apple Pui Yi Chui, Elvis Long Ching Wong, Jamie R Stevens, Iva Popovic, James R Guest, Elizabeth Buccheri, David Idip, Peter J Mumby","doi":"10.1038/s42003-026-10055-9","DOIUrl":"https://doi.org/10.1038/s42003-026-10055-9","url":null,"abstract":"<p><p>As populations decline under climate change and other stressors, survivors become increasingly isolated. Allee effects in such fragmented populations may arise during reproduction, particularly for sessile organisms such as corals, reducing fertilisation potential and increasing the probability of recruitment failure. However, the critical distances between corals needed to maintain viable populations remains uncertain. We experimentally investigated fertilisation patterns in the broadcast spawning coral Acropora cf. hyacinthus using a manipulated patch, spacing colonies at increasing distances downstream from a central spawning aggregation. Field samples showed a steep decline in fertilisation with increasing intercolonial distance and genetic paternity analysis indicated most parents were located within 3 m of each other. Colony position relative to the current direction also influenced fertilisation success, with 81% of sequenced progeny sired by upstream colonies. Simulations projecting natural population distributions onto a virtual grid, incorporating experimental results, indicated that populations remained well-mixed at typical adult densities. Yet at reduced densities approaching 0.01 colonies m<sup>-2</sup>, reproductive isolation and patchy breeding units emerged. These findings demonstrate that colony isolation substantially impairs reproductive connectivity, with additional influence from the spatial arrangement of colonies. Conservation strategies should prioritise maintaining colony density and spatial connectivity to support viable coral populations on degraded reefs.</p>","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147863626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cryo-EM structures of human ABCB7 reveal the molecular basis of mitochondrial matrix heme export. 人ABCB7的低温电镜结构揭示了线粒体基质血红素输出的分子基础。
IF 5.1 1区 生物学
Communications Biology Pub Date : 2026-05-09 DOI: 10.1038/s42003-026-10223-x
Seulgi Ju, Seung Hun Choi, Hyeon You Lee, Mi Sun Jin
{"title":"Cryo-EM structures of human ABCB7 reveal the molecular basis of mitochondrial matrix heme export.","authors":"Seulgi Ju, Seung Hun Choi, Hyeon You Lee, Mi Sun Jin","doi":"10.1038/s42003-026-10223-x","DOIUrl":"https://doi.org/10.1038/s42003-026-10223-x","url":null,"abstract":"<p><p>ATP-binding cassette transporter subfamily B member 7 (ABCB7) is a mitochondrial ATP-driven pump essential for cytosolic iron-sulfur (Fe-S) cluster biogenesis and cellular iron homeostasis. Mutations in ABCB7 are linked to X-linked sideroblastic anemia with ataxia (XLSA/A). Here, we demonstrate that the ATPase activity of ABCB7 is stimulated by iron and cobalt protoporphyrin IX (hemin and CoPP) in the presence of glutathione (GSH), highlighting an additional role for ABCB7 as a metalloporphyrin exporter. Using single-particle cryo-electron microscopy, we determine the structures of human ABCB7 in multiple functional states at resolutions of up to 2.3 Å. Our structures reveal a putative substrate-binding cavity that accommodates two stacked CoPP molecules conjugated by two GSH cysteine thiols. The conserved residue F426 controls substrate entrapment and release as a molecular gate. We further show that at high substrate concentrations excess CoPP easily partitions into the lipid bilayer, where the hydrophobic environment stabilizes the porphyrin macrocycle and limits the aggregation or redox reactivity that is prone to occur with free porphyrins in aqueous solution. Finally, our structure analyses rationalize the pathogenic effect of the E433K mutation associated with XLSA/A disease.</p>","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High-fat diet feeding induces organ-specific vascular remodeling with distinct temporal dynamics in male mice. 高脂肪饮食喂养诱导雄性小鼠器官特异性血管重构,具有明显的时间动力学。
IF 5.1 1区 生物学
Communications Biology Pub Date : 2026-05-09 DOI: 10.1038/s42003-026-10092-4
Emmi Pakarinen, Satu Paavonsalo, Madeleine H Lackman, Yelin Subashi, Hanna M Ruddock, Sinem Karaman
{"title":"High-fat diet feeding induces organ-specific vascular remodeling with distinct temporal dynamics in male mice.","authors":"Emmi Pakarinen, Satu Paavonsalo, Madeleine H Lackman, Yelin Subashi, Hanna M Ruddock, Sinem Karaman","doi":"10.1038/s42003-026-10092-4","DOIUrl":"https://doi.org/10.1038/s42003-026-10092-4","url":null,"abstract":"<p><p>Obesity-induced changes in adipose vasculature are well documented, but systematic analyses in other tissues have not been as extensive. Here, we analyze the vessel-covered area and endothelial cell (EC) numbers in seven non-adipose organs (liver, heart, intestine, kidney, lung, ear skin, retina) in male mice after short-term high-fat diet (HFD) feeding (5 days or 5 weeks), long-term HFD feeding (10 weeks), and weight loss (5 weeks of HFD followed by 5 weeks of chow feeding). We show HFD-induced morphological changes in the liver, heart, kidney, and intestinal vasculatures, and a negative correlation between body weight and vessel density in most of the analyzed tissues. Interestingly, changes in vessel area do not always reflect alterations in EC numbers. Additionally, both the intestine and ear skin show preserved vessel perfusion in response to obesity. This study provides a comprehensive analysis of how different HFD feeding durations affect organotypic vasculature and reports that HFD feeding induces organ-specific vascular remodeling with distinct temporal dynamics in mice.</p>","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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