Communications Biology最新文献_第4页

Coral-associated denitrification is seasonally variable and species-specific. 珊瑚相关的反硝化是随季节变化和物种特异性的。

IF 5.8 1区生物学

Communications Biology Pub Date : 2026-09-26 DOI: 10.1038/s42003-026-11026-w

Claudia E L Hill, Arjen Tilstra, Yusuf C El-Khaled, Neus Garcias-Bonet, Vivian A Bonacker, Andres Novoa-Lamprea, Walter A Rich, Malte Ostendarp, Michael D Fox, Susana Carvalho, Raquel S Peixoto, Christian Wild

{"title":"Coral-associated denitrification is seasonally variable and species-specific.","authors":"Claudia E L Hill, Arjen Tilstra, Yusuf C El-Khaled, Neus Garcias-Bonet, Vivian A Bonacker, Andres Novoa-Lamprea, Walter A Rich, Malte Ostendarp, Michael D Fox, Susana Carvalho, Raquel S Peixoto, Christian Wild","doi":"10.1038/s42003-026-11026-w","DOIUrl":"10.1038/s42003-026-11026-w","url":null,"abstract":"Nitrogen (N) plays a critical role in coral growth, but maintaining an N-limited state is essential for coral-algal symbiosis stability. Coral-associated denitrifiers may help regulate excess N, though denitrification in corals remains poorly quantified. To better understand species-specific and environmental effects on the denitrification pathway, we investigated year-long denitrification dynamics in four Red Sea corals, using acetylene inhibition assays alongside physiological and environmental measurements. All species exhibited measurable denitrification activity, ranging from 0 - 0.8 nmol N cm-2 h-1 for Stylophora pistillata and Acropora sp., 0 - 0.4 nmol N cm-2 h-1 for Millepora dichotoma, and 0 - 2.0 nmol N cm-2 h- 1 for Dendrophylliidae indet. Denitrification displayed seasonal patterns, with higher rates in the spring/summer compared to autumn/winter, and we identified temperature, dissolved organic carbon (DOC) and nitrate availability as key environmental drivers. Lastly, we observed up to fivefold higher denitrification rates in the fully heterotrophic azooxanthellate coral Dendrophylliidae indet, than among mixotrophic species harbouring Symbiodiniaceae. Our findings indicate that denitrifiers use both photosynthetically derived and environmental carbon (C), with DOC central in maintaining tight coupling of C and N cycling in coral holobionts. Additionally, denitrification is modulated by environmental conditions, highlighting its vulnerability to environmental change.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"9 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13615964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149058888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clathrin adaptors drive phase separation in endocytosis and trafficking. 网格蛋白接头驱动内吞和运输过程中的相分离。

IF 5.8 1区生物学

Communications Biology Pub Date : 2026-09-26 DOI: 10.1038/s42003-026-11043-9

George Draper-Barr, Janina Schiller, Katharina Veith, Stephan Niebling, David Ruiz-Carrillo, Ziqiang Huang, Christian Tischer, Roland Thuenauer, Lucas A Defelipe, Maria García-Alai

{"title":"Clathrin adaptors drive phase separation in endocytosis and trafficking.","authors":"George Draper-Barr, Janina Schiller, Katharina Veith, Stephan Niebling, David Ruiz-Carrillo, Ziqiang Huang, Christian Tischer, Roland Thuenauer, Lucas A Defelipe, Maria García-Alai","doi":"10.1038/s42003-026-11043-9","DOIUrl":"10.1038/s42003-026-11043-9","url":null,"abstract":"Liquid-liquid phase separation (LLPS) underlies the formation of biomolecular condensates that organize processes, including endocytosis and membrane trafficking. Although LLPS has been implicated in clathrin-mediated pathways, the contribution of adaptor proteins to condensate formation and function remains unclear. Here we show that two yeast adaptors, Ent5 and Sla2, undergo LLPS in vitro and this property correlates with their roles in membrane trafficking and condensate recruitment in vivo. Ent5 condensation is driven by a dynamic helix within its disordered region that acts as a molecular \"sticker\". Deletion of this 249-287 helix disrupts membrane-associated condensation and leads to altered coating dynamics in vivo, with Ent5-dependent transport events becoming delayed. In contrast, Sla2 behaves as a driver and as a client of LLPS, with its coiled-coil (CC) region mediating condensation. Together, these findings reveal that endocytic adaptors can promote condensate formation through distinct structural features, coupling clathrin binding and membrane association through phase separation.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"9 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13615978/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149058961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cyclic thermal stress during pupation triggers irreversible carry-over effects in a key pollinator. 化蛹过程中的循环热应力触发了一种关键传粉媒介的不可逆携带效应。

IF 5.8 1区生物学

Communications Biology Pub Date : 2026-09-25 DOI: 10.1038/s42003-026-10940-3

Maximilian M Mandlinger, Christoph Kurze

引用次数: 0

Expanded proinflammatory CD4 T cells expressing toll like receptor 4 in trauma associated acute lung injury. 创伤相关急性肺损伤中表达toll样受体4的促炎CD4 T细胞扩增

IF 5.8 1区生物学

Communications Biology Pub Date : 2026-09-25 DOI: 10.1038/s42003-026-10995-2

Priyanka Hastak, Christopher R Andersen, Phoebe Crammond, Zong-Hong Zhang, Chansavath Phetsouphanh, David van Bockel, Calum Walsh, Louise M Judd, Timothy P Stinear, Aayushma Lohani, Swosti Shrestha, Raymond Louie, Frances Bass, Anthony Delaney, Naomi Hammond, Balasubramanian Venkatesh, Simon Finfer, Nicodemus Tedla, Anthony D Kelleher, Sarah C Sasson

{"title":"Expanded proinflammatory CD4 T cells expressing toll like receptor 4 in trauma associated acute lung injury.","authors":"Priyanka Hastak, Christopher R Andersen, Phoebe Crammond, Zong-Hong Zhang, Chansavath Phetsouphanh, David van Bockel, Calum Walsh, Louise M Judd, Timothy P Stinear, Aayushma Lohani, Swosti Shrestha, Raymond Louie, Frances Bass, Anthony Delaney, Naomi Hammond, Balasubramanian Venkatesh, Simon Finfer, Nicodemus Tedla, Anthony D Kelleher, Sarah C Sasson","doi":"10.1038/s42003-026-10995-2","DOIUrl":"10.1038/s42003-026-10995-2","url":null,"abstract":"Acute lung injury (ALI) is characterised by hypoxia and inflammation that derives from diverse aetiologies. Delineating the molecular pathogeneses may identify treatable subgroups and inform clinical trials. Using a multi-omics approach, we analysed trauma-associated ALI (n = 9), COVID-19 ALI (n = 11), ICU controls (n = 13) using scRNA-seq, serum cytokine profiling, and bronchoalveolar lavage (BAL) microbiome analysis. We identified a population of activated CD4+ T cells expressing Toll-like receptor 4 (TLR4) and downstream NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome complex, predominantly in trauma-associated ALI (23% of CD45+ Cells) compared to COVID-19 ALI (14%) and ICU controls (15%). Serum IL-1RA and IL-6 were upregulated in trauma ALI, along with TLR4-binding ligand hyaluronan. TLR4 expression on CD4+ T cells was confirmed by spectral cytometry. Lung microbiome analysis revealed distinct diversity in trauma-associated ALI compared to COVID-19 ALI. These findings highlight TLR4-mediated inflammation in trauma-associated ALI and suggest potential precision medicine approaches for ALI management.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"9 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13649737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149135299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Actin conformation dynamics precede force generation in cytotoxic T lymphocytes. 在细胞毒性T淋巴细胞中，肌动蛋白构象动力学先于力的产生。

IF 5.8 1区生物学

Communications Biology Pub Date : 2026-09-25 DOI: 10.1038/s42003-026-11011-3

Adam M Rochussen, Aybaran O Kebabci, Alex K Winkel, Kristian Franze, Daniel A Fletcher, Gillian M Griffiths, Anna H Lippert

{"title":"Actin conformation dynamics precede force generation in cytotoxic T lymphocytes.","authors":"Adam M Rochussen, Aybaran O Kebabci, Alex K Winkel, Kristian Franze, Daniel A Fletcher, Gillian M Griffiths, Anna H Lippert","doi":"10.1038/s42003-026-11011-3","DOIUrl":"10.1038/s42003-026-11011-3","url":null,"abstract":"Cytotoxic T lymphocytes (CTLs) are cells of the adaptive immune system that are able to recognise and kill cancerous or virally infected target cells. The biochemical basis of CTL-mediated killing has been examined in great detail. Recent work has underscored the importance of physical forces in T cell function too, but how CTLs sense and exert force during migration and killing is not fully understood. Here, by expressing actin conformation probes based on the CH domain of utrophin, we directly visualize regions of altered F-actin conformation in primary CTLs during migration and killing. By combining these probes with traction force microscopy, we correlate external force with the internal cytoskeleton. We show that actin conformation is regulated upstream of force production, and that force exertion at the cytotoxic immune synapse temporally follows actin conformation dynamics. Our work offers insight into the relationship between cellular force production and F-actin conformation in important primary immune cells.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"9 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13614940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149058933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fermented protein foods as modulators of the gut-muscle axis: mechanisms, evidence, and future directions. 发酵蛋白食品作为肠肌轴的调节剂：机制、证据和未来方向。

IF 5.8 1区生物学

Communications Biology Pub Date : 2026-09-25 DOI: 10.1038/s42003-026-10941-2

Dominic N Farsi, Paul D Cotter, Orla O'Sullivan

{"title":"Fermented protein foods as modulators of the gut-muscle axis: mechanisms, evidence, and future directions.","authors":"Dominic N Farsi, Paul D Cotter, Orla O'Sullivan","doi":"10.1038/s42003-026-10941-2","DOIUrl":"10.1038/s42003-026-10941-2","url":null,"abstract":"Skeletal muscle has a profound influence on metabolic health, functional capacity and resilience across the lifespan. Beyond dietary protein and physical activity, the gut microbiome may have the capacity to impact skeletal muscle mass and function through the bidirectional network termed the gut-muscle axis (GMA). Fermented protein foods (FPFs) are protein rich matrices transformed by microbial activity that integrate modified protein structures, bioactive peptides, and live microorganisms, or components thereof, which could modulate skeletal muscle physiology. Here, we review mechanistic, preclinical and human evidence concerning the potential of FPFs to influence skeletal muscle health through GMA modulation. Although emerging human studies suggest favourable effects on metabolic regulation, inflammatory pathways and gut microbial ecology, direct evidence that FPFs impact muscle protein synthesis, muscle mass or function remains limited. Furthermore, the literature is characterised by considerable heterogeneity in interventions and outcome measures. Studies integrating comprehensive microbiome characterisation, multi-omics approaches and direct skeletal muscle phenotyping are needed to determine whether FPFs confer advantages over conventional protein foods or more established microbiome targeted strategies such as probiotic supplementation. Such studies will be essential to elucidate their role in targeted nutritional strategies for ageing, metabolic disease, muscle atrophy, and physical performance.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"9 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13612462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149036870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two coinfecting archaeal viruses provide insights into virus-virus interactions. 两种合并的古细菌病毒提供了对病毒-病毒相互作用的见解。

IF 5.8 1区生物学

Communications Biology Pub Date : 2026-09-24 DOI: 10.1038/s42003-026-11061-7

Lauren Queiss, Coraline Mercier, Tomas Alarcón-Schumacher, Grace D'Angelo, Federico Agustin Vignale, Judith M Klatt, Manuel Liebeke, Manuel Contreras, María Eugenia Farías, Susanne Erdmann

{"title":"Two coinfecting archaeal viruses provide insights into virus-virus interactions.","authors":"Lauren Queiss, Coraline Mercier, Tomas Alarcón-Schumacher, Grace D'Angelo, Federico Agustin Vignale, Judith M Klatt, Manuel Liebeke, Manuel Contreras, María Eugenia Farías, Susanne Erdmann","doi":"10.1038/s42003-026-11061-7","DOIUrl":"10.1038/s42003-026-11061-7","url":null,"abstract":"Virus-virus interactions can profoundly shape viral ecology and evolution, yet they remain poorly understood, particularly in haloarchaea. Upon characterization of a spindle-shaped virus, Tebenquiche spindle-shaped virus 1 (Tebi-SV1), isolated from Halorubrum strain TLS-6, we detected the presence of a second virus, Tebenquiche pleomorphic virus 1 (Tebi-PV1), that coinfects host cells. Gene sharing network analysis revealed several genomes related to Tebi-SV1 in public databases, most of which also co-occur with pleolipoviruses in their host genomes. Attempts to separate the two viruses were unsuccessful, suggesting a symbiotic relationship between Tebi-SV1 and Tebi-PV1. We discovered that virus abundances may be regulated through a shared operator sequence allowing Tebi-PV1 to keep Tebi-SV1 copy numbers low without excluding Tebi-SV1 from the host genome. Additionally, Tebi-PV1 encodes and expresses a type-4-pilin, that likely plays a role in regulating the interactions between the host and the viruses. Our findings highlight the complexity of virus-virus interactions and that resident viruses are important regulators of virus-host interactions.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"9 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13612827/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149036876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How mitochondrial heterogeneity fuels a dynamic organelle ecosystem. 线粒体异质性如何推动一个动态的细胞器生态系统。

IF 5.8 1区生物学

Communications Biology Pub Date : 2026-09-24 DOI: 10.1038/s42003-026-11029-7

Pierre-Jean Desmaison, Giulia Bertolin

引用次数: 0

A human cell-free translation screen identifies the NT-2 mycotoxin as a ribosomal inhibitor that binds the peptidyl transferase center. 人类无细胞翻译筛选鉴定NT-2真菌毒素作为结合肽基转移酶中心的核糖体抑制剂。

IF 5.8 1区生物学

Communications Biology Pub Date : 2026-09-23 DOI: 10.1038/s42003-026-10743-6

Nino Schwaller, Dominic Andenmatten, Jonas Luginbühl, Julius Rabl, Helena Baur, Marc Chambon, Jonathan Vesin, Gerardo Turcatti, Evangelos D Karousis

{"title":"A human cell-free translation screen identifies the NT-2 mycotoxin as a ribosomal inhibitor that binds the peptidyl transferase center.","authors":"Nino Schwaller, Dominic Andenmatten, Jonas Luginbühl, Julius Rabl, Helena Baur, Marc Chambon, Jonathan Vesin, Gerardo Turcatti, Evangelos D Karousis","doi":"10.1038/s42003-026-10743-6","DOIUrl":"10.1038/s42003-026-10743-6","url":null,"abstract":"Translation inhibitors are invaluable for probing ribosome function and therapeutic applications, but systematic discovery in human systems is limited by the lack of scalable, screening-compatible cell-free platforms. Here, we establish a robust high-throughput screening using human lysates that bypasses cellular cytotoxic effects. After screening ~28,000 small molecules, we identified known and a novel translation inhibitor, including NT-2, a trichothecene mycotoxin produced by the pathogenic Fusarium sporotrichioides. NT-2 suppressed protein synthesis in human cells and yeast lysates, while sparing translation in bacteria and intact yeast cells. Cryo-EM at 1.76 Å revealed NT-2 bound at the peptidyl transferase center of the human 60S ribosome. In addition, cryoEM classification of NT-2 treated cells shows ribosomes in an inactive eEF2/SERBP1-bound dormant state. Together, these results expose NT-2 as a previously unrecognized environmental inhibitor of mammalian protein synthesis and demonstrate the power of cell-free translation screening to reveal new inhibitors with unexpected ribosome fates.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"9 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13601500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149030090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evolutionary dynamics of plant cell wall-degrading enzymes reflects feeding ecology in weevils. 植物细胞壁降解酶的进化动态反映了象鼻虫取食生态。

IF 5.8 1区生物学

Communications Biology Pub Date : 2026-09-23 DOI: 10.1038/s42003-026-10927-0

Na Ra Shin, Roy Kirsch, Heiko Vogel, Alexander Riedel, Martin Kaltenpoth, Yannick Pauchet

{"title":"Evolutionary dynamics of plant cell wall-degrading enzymes reflects feeding ecology in weevils.","authors":"Na Ra Shin, Roy Kirsch, Heiko Vogel, Alexander Riedel, Martin Kaltenpoth, Yannick Pauchet","doi":"10.1038/s42003-026-10927-0","DOIUrl":"10.1038/s42003-026-10927-0","url":null,"abstract":"Many herbivorous beetles depend on plant cell wall-degrading enzymes (PCWDEs) to access the nutritious plant cell content. However, the evolution of PCWDEs in weevils, the most diverse lineage of herbivores, remains poorly understood. Using transcriptomic and genomic analyses of 45 weevil species spanning the majority of existing subfamilies, we identified a total of 13 different PCWDE families, revealing high variability between species. Interestingly, the PCWDE repertoires tracked dietary specialization, with convergent reductions in fungivorous taxa. Furthermore, PCWDE gene family dynamics were driven by both larval and adult specialized herbivory on different plant organs. Despite this complex evolutionary history, phylogenetic analyses place core PCWDE functionalities at the base of the Phytophaga (weevils, leaf beetles, and longhorn beetles) and reveal subsequent horizontal gene transfer (HGT) events from various donors during early Phytophaga diversification. These findings demonstrate that HGTs, gene duplications, and losses shaped PCWDE diversity and facilitated the ecological success of weevils.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"9 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13601563/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149030145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0