Complementary therapies in medicine最新文献

{"title":"Effect of transcutaneous electrical acupoint stimulation at different frequencies on mild hypertension: A randomized controlled trial","authors":"Ling-Hui Ma ,&nbsp;Jing-Yun Xiu ,&nbsp;Liang-Xiao Ma ,&nbsp;Qin-Yong Zhang ,&nbsp;Xiu-Yan Wang ,&nbsp;Tian-Yi Sun ,&nbsp;Xu Qian ,&nbsp;Meng-Yu Chen ,&nbsp;Jia-Ling He","doi":"10.1016/j.ctim.2024.103103","DOIUrl":"10.1016/j.ctim.2024.103103","url":null,"abstract":"<div><h3>Background</h3><div>Transcutaneous electrical acupoint stimulation (TEAS) may contribute to blood pressure (BP) control, but the evidence remains insufficient. Our objectives were to evaluate the impact of TEAS on hypertension and determine the optimal frequency.</div></div><div><h3>Methods</h3><div>A total of 120 hypertensive patients were randomly allocated to the TEAS-2Hz group, TEAS-10Hz group, or usual care control group in a 1:1:1 ratio. All patients were advised to continue their usual antihypertensive regimen. Additionally, patients in the TEAS groups received TEAS therapy 3 times per week for 4 weeks, with a 4-week follow-up.</div></div><div><h3>Results</h3><div>The primary outcome was the change in systolic BP (SBP) from baseline to week 4. Secondary outcomes included changes in diastolic BP (DBP), mean arterial pressure (MAP), heart rate (HR), heart rate variability (HRV), and 12-item health survey (SF-12) at different time points. Both TEAS groups showed reductions in SBP relative to control (TEAS-2Hz group vs. control, −4.70 mmHg [95 % CI, −7.00 to −2.40 mmHg]; P &lt; 0.001; TEAS-10Hz group vs. control, −8.66 mmHg [95 % CI, −10.97 to −6.36 mmHg]; P &lt; 0.001). TEAS-10Hz provided a significant decrease in SBP than TEAS-2Hz (-3.96 mmHg [95 % CI, −1.66 to −6.26 mmHg]; P&lt; 0.001). TEAS groups also exhibited reductions in DBP, MAP, HR, LF/HF ratio（LF/HF）, very low frequency (VLF), and normalized low frequency (LF norm), and an increase in normalized high frequency (HF norm) than control. No differences were observed among groups in low frequency (LF), high frequency (HF), total power (TP), very low frequency (VLF), and SF-12.</div></div><div><h3>Conclusion</h3><div>TEAS might be a promising adjunctive therapy for hypertension, and the recommended frequency is 10 Hz, which should be confirmed in larger trials.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"87 ","pages":"Article 103103"},"PeriodicalIF":3.3,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142496422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and effectiveness of weighted blankets for symptom management in patients with mental disorders: A systematic review and meta-analysis of randomized controlled trials","authors":"Yanli Zhao ,&nbsp;Qiushi Zhang ,&nbsp;Zhihua Liu ,&nbsp;Zhongjian Zhao ,&nbsp;Qinghua Zhu","doi":"10.1016/j.ctim.2024.103104","DOIUrl":"10.1016/j.ctim.2024.103104","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;The current practice guideline regarding treatment for insomnia and sleep disturbances among children and adolescents with autism spectrum disorder (ASD) has been published and it suggests that the use of weighted blankets might not be an evidence-informed practice. However, limited guidance and evidence synthesis exist on the overall effectiveness of a weighted blanket for symptom management among patients with mental disorders, although it has been routinely recommended and prescribed for this population in many mental health care settings.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;To systematically evaluate and synthesize existing data on the safety and effectiveness of weighted blankets for symptom management among patients with mental disorders.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;Comprehensive retrieval of published, unpublished, or ongoing studies was carried out across a series of bibliographic databases, grey literature sources, and clinical trial registry platforms, along with manual screening of the reference lists of the included studies or relevant reviews. Randomized controlled trials (RCTs) were included if they compared a weighted blanket intervention and a control condition among patients with mental disorders. Two reviewers independently extracted the data using a pre-specified form and assessed the methodological quality of the included studies with the revised Cochrane ‘Risk of Bias’ (RoB 2) tool. Review Manager (RevMan) 5.3 software was used to conduct the meta-analysis when possible. Subgroup and sensitivity analyses, where appropriate, were conducted to explore the robustness of the pooled effect estimates.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Eight studies involving a total of 426 patients were included in this review. Half of the included studies were rated as having a high risk of bias, primarily due to the failure to blind participants for participant-reported measures. No serious adverse events were reported with the application of weighted blankets. The meta-analysis of five studies revealed that the use of weighted blankets induced a small magnitude decrease (standardized mean difference within studies [SMD]= 0.40) in anxiety management. The pooled estimate of three studies reporting the effect of weighted blankets on insomnia revealed a nonsignificant difference between the two groups (mean difference [MD] = −1.92, 95 % confidence interval [CI] = −3.92–0.09, p = 0.06). However, the leave-one-out sensitivity analysis of the two remaining homogeneous studies revealed that patients who used weighted blankets had reduced insomnia severity index (ISI) scores (MD = −2.78, 95 % CI = −4.44 to −1.12, p = 0.001). Additionally, a study without available data for inclusion in the meta-analysis also reported a positive effect in reducing the ISI score. Due to the heterogeneity across studies, summary estimates for the effects of weighted blankets on fatigue and depression were not computed. However, pr","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"87 ","pages":"Article 103104"},"PeriodicalIF":3.3,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142496423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of acupuncture-related treatments on blood lipid levels in patients with coronary heart disease: A comprehensive review and network meta-analysis","authors":"Yuting Cui ,&nbsp;Ziyun Li ,&nbsp;Ping Gao ,&nbsp;Weiming Xu ,&nbsp;Jingqing Hu","doi":"10.1016/j.ctim.2024.103096","DOIUrl":"10.1016/j.ctim.2024.103096","url":null,"abstract":"<div><h3>Background</h3><div>Dyslipidemia is considered a substantial risk factor for coronary heart disease (CHD). Blood lipid levels in patients with CHD influence cardiovascular events. Therefore, it is critical to monitor and control these levels. As a traditional, complementary alternative therapy, acupuncture regulates blood lipid levels in patients with CHD. More acupuncture-related treatments are currently available. However, systematic reviews or evidence-based summaries have yet to be conducted.</div></div><div><h3>Methods</h3><div>This study included a randomized controlled trial of the effects of acupuncture-related therapies on blood lipid levels in CHD patients. The outcome indicators were changes in the TC, TG, LDL-C, and HDL-C levels. Two independent reviewers extracted data from PubMed, Web of Science, EMBASE, Cochrane Library, Medline (Ovid), China Knowledge Network, Wanfang, Vipshop, and SinoMed databases until January 7 2024. The literature quality was assessed using RevMan 5.4.1. The data were analyzed using the Frequentist network meta-analysis with STATA 15.1 software. Network meta-analysis was used to compare direct and indirect evidence, and a cumulative ranking curve (SUCRA) was used to evaluate the curative effect. For consistency, global inconsistency and ring-inconsistency test evaluations were used. The Cochrane bias risk assessment tool was used to assess quality.</div></div><div><h3>Results</h3><div>Fourteen studies with 1416 patients were included in the study. The evidence network shows that there are many studies on acupuncture and warm acupuncture. According to the direct comparison and SUCRA ranking, acupuncture reduced TC [− 1.82 (− 3.36, − 0.28)], heat-sensitized moxibustion lowered TG [− 2.12 (− 3.55, − 0.69)], LDL-C [− 1.37 (− 2.09, − 0.66)], and increased HDL-C [0.87 (0.52, 1.22)]. These two interventions were the first in the SUCRA ranking. The inconsistency analysis revealed that direct evidence corresponded with indirect evidence. There were some methodological defects in the included studies, and some studies did not implement blinding methods, had small sample sizes or other problems.</div></div><div><h3>Conclusions</h3><div>Heat-sensitized moxibustion significantly lowered TG and LDL-C levels and elevated HDL-C levels. Acupuncture significantly reduced TC levels. Heat-sensitized moxibustion is a more effective intervention than other acupuncture-related treatments for regulating blood lipid levels in patients with CHD. However, this study has several limitations, and clinical practice should be performed as needed.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"87 ","pages":"Article 103096"},"PeriodicalIF":3.3,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research trends of traditional Chinese non-pharmacological therapy in the management of overweight and obesity from 2004 to 2023: A bibliometric study","authors":"Zhiyuan Bian ,&nbsp;Leilei Ren ,&nbsp;Jin Bian","doi":"10.1016/j.ctim.2024.103099","DOIUrl":"10.1016/j.ctim.2024.103099","url":null,"abstract":"<div><h3>Objective</h3><div>Traditional Chinese non-pharmacological therapy has gained popularity in the management of overweight and obesity. This study aims to reveal trends and hotspots of global research on traditional Chinese non-pharmacological therapies for overweight and obesity.</div></div><div><h3>Methods</h3><div>Publications on traditional Chinese non-pharmacological therapies for overweight and obesity between 2004 and 2023 were searched from the Web of Science Core Collection. Bibliometric analyses and visualization were performed using VOSviewer, CiteSpace, and R software.</div></div><div><h3>Results</h3><div>A total of 566 publications from 246 journals were included in this study. Annual number of publications and cited times in the field were generally increasing. China contributed the most publications, followed by the United States and Republic of Korea, and Chengdu University of Traditional Chinese Medicine from China had the highest number of publications among institutions. Stener-Victorin E was not only the most productive author but also, along with Cabioglu MT, the most cited authors. Evidence-Based Complementary and Alternative Medicine was both the largest source journal and the most cited journal. The highly cited references mainly consists of clinical trials, narrative reviews and systematic reviews focusing on acupuncture therapy. Keywords analysis indicated that acupuncture therapy and traditional Chinese exercise constituted the main components of traditional Chinese non-pharmacological therapy in weight management.</div></div><div><h3>Conclusions</h3><div>This study revealed a growing interest in traditional Chinese non-pharmacological therapies for managing overweight and obesity, with acupuncture therapies and traditional Chinese exercises as the main research focuses. This study offers insights into traditional Chinese non-pharmacological therapies in weight management, and may benefit further research.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"87 ","pages":"Article 103099"},"PeriodicalIF":3.3,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142444712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding and enhancing post-stroke recovery: Insights from a nested qualitative study within the MindFit Project randomized clinical trial","authors":"Adrià Bermudo-Gallaguet ,&nbsp;Jofre Bielsa-Pascual ,&nbsp;Rosa García-Sierra ,&nbsp;Maria Feijoo-Cid ,&nbsp;Antonia Arreciado Marañon ,&nbsp;Mar Ariza ,&nbsp;Daniela Agudelo ,&nbsp;Neus Camins-Vila ,&nbsp;Maria Boldó ,&nbsp;Maria José Durà Mata ,&nbsp;Alberto García-Molina ,&nbsp;Pere Torán-Monserrat ,&nbsp;Maria Mataró","doi":"10.1016/j.ctim.2024.103100","DOIUrl":"10.1016/j.ctim.2024.103100","url":null,"abstract":"<div><h3>Background</h3><div>Stroke survivors experience a wide range of physical, cognitive, and emotional challenges. In the MindFit Project, a randomized clinical trial, 141 chronic stroke patients were divided into three groups: mindfulness-based stress reduction (MBSR) with computerized cognitive training (CCT), physical exercise (PE) with CCT, and CCT alone. The interventions were conducted remotely over 12 weeks, including online group and individual sessions.</div></div><div><h3>Objective</h3><div>This exploratory nested qualitative study aimed to investigate chronic stroke survivors’ experiences, opinions, and perceived changes due to the interventions within the MindFit Project. The secondary objective was to describe the broader experience of their recovery journey.</div></div><div><h3>Methods</h3><div>Twenty-seven participants were recruited through purposive sampling and engaged in semi-structured one-on-one interviews. Twelve received MBSR+CCT, nine received PE+CCT, and six received CCT-only. The interviews were recorded, transcribed, and analyzed using thematic analysis.</div></div><div><h3>Results</h3><div>Participants shared insights into their lives after stroke, including emotional and physical challenges, coping mechanisms, and the impact of societal perceptions. The interventions were generally positively valued, with MBSR aiding in emotional regulation, PE enhancing physical capabilities, and CCT improving cognition. The group setting provided valuable peer support and motivation, although some participants noted challenges owing to the heterogeneity. The telematic format was also appreciated for its accessibility, although it posed challenges to personal interaction and intervention supervision.</div></div><div><h3>Conclusions</h3><div>Our study emphasizes the complexity of stroke recovery and the importance of holistic, patient-centered rehabilitation approaches. It also highlights the value of combining physical and non-physical interventions in a group setting, along with the potential of remote platforms to enhance the accessibility of rehabilitation programs. These findings generate hypotheses for future randomized clinical trials aimed at improving post-stroke recovery.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"87 ","pages":"Article 103100"},"PeriodicalIF":3.3,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tuina versus physiotherapy or a combination of both for the management of chronic nonspecific low back pain: A randomized controlled trial","authors":"Qingyu Ma ,&nbsp;Xuan Zhou ,&nbsp;Huifang Liang ,&nbsp;Yu Guo ,&nbsp;Kejie He ,&nbsp;Longbin Shen ,&nbsp;Qiao Fan ,&nbsp;Juan Yang ,&nbsp;Tan Ia Choo Celia ,&nbsp;Brent A. Bauer ,&nbsp;Jiaxu Chen","doi":"10.1016/j.ctim.2024.103098","DOIUrl":"10.1016/j.ctim.2024.103098","url":null,"abstract":"<div><h3>Objective</h3><div>To rigorously evaluate the short-term and long-term effectiveness of <em>Tuina</em> (TN), alone and in combination with physiotherapy (PT), for Chronic nonspecific low back pain (CNLBP) through a comprehensive, high-quality clinical trial.</div></div><div><h3>Methods</h3><div>This randomized, single-blind trial was conducted from September 2020 to July 2023, involving 204 CNLBP patients from the First Affiliated Hospital of Jinan University. Participants underwent a baseline assessment, 6 treatment sessions over 8 weeks, a post-treatment evaluation in the 9th week, and a 20-week follow-up. Participants were randomly assigned to TN, PT, or a combination of TN and PT (TP) groups. Each treatment involved 6 sessions with a minimum 7-day interval, each lasting 30 minutes. Primary outcome was the change in Visual Analog Scale (VAS) for pain. Secondary outcomes included the Oswestry Disability Index (ODI), 36-Item Short Form Health Survey (SF-36), Range of Motion (ROM) of the spine, Traditional Chinese Medicine Syndrome Scale (TCMSS), and adverse events (AE).</div></div><div><h3>Results</h3><div>Among the 204 participants, 67.16 % were female, and 88.73 % completed the 20-week follow-up. All groups showed significant reductions in VAS scores post-treatment and at follow-up. Secondary outcomes improved significantly, with notable decreases in ODI and TCMSS scores. Pairwise comparisons within groups indicated statistical significance, particularly in ODI scores, with clinical relevance. No significant differences were found between the groups. ROM and SF-36 showed statistical but not clinical significance. Only one AE (0.49 %) was reported, with no severe incidents.</div></div><div><h3>Conclusion</h3><div>All treatment groups, including TN, TP, and PT, demonstrated significant reductions in VAS scores for CNLBP patients, with effects lasting up to 20 weeks. While TN and TP showed substantial improvements in secondary outcomes, particularly in ODI scores, no significant differences were found between the groups. These findings suggest that all treatments can be effective for managing CNLBP, supporting clinical practitioners in selecting appropriate interventions for patients, especially for those unable to engage in active exercises, utilizing passive movements like TN to enhance health outcomes.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"86 ","pages":"Article 103098"},"PeriodicalIF":3.3,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142433872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A large-scale, international cross-sectional survey of published pediatrics authors: Perceptions of complementary, alternative, and integrative medicine","authors":"Jeremy Y. Ng ,&nbsp;Gursimran Deol ,&nbsp;Dennis Anheyer ,&nbsp;Holger Cramer","doi":"10.1016/j.ctim.2024.103097","DOIUrl":"10.1016/j.ctim.2024.103097","url":null,"abstract":"<div><h3>Background</h3><div>The use of complementary, alternative, and integrative medicine (CAIM) is commonly used among pediatric patients for various conditions. Pediatrics clinicians’ and researchers’ perceptions towards the incorporation of CAIM therapies have varied. This study aims to investigate the perceptions of both pediatrics researchers and clinicians regarding CAIM.</div></div><div><h3>Methods</h3><div>We conducted a large-scale, international cross-sectional online survey with published pediatrics authors who have published their work in pediatrics medical journals that are indexed in MEDLINE. In total, 34 494 researchers and clinicians were invited to complete the survey. The survey recorded respondents’ perceptions on various CAIM therapies. Descriptive statistics were generated from the quantitative survey results. A thematic analysis was conducted for responses to open ended questions.</div></div><div><h3>Results</h3><div>In total, 731 pediatrics clinicians and/or researchers responded to the survey, with about half of the respondents being faculty members/principal investigators (56.10 %) and/or clinicians (43.45 %) and from the Americas (46.56 %) or Europe (30.53 %). Over half of the respondents viewed mind-body therapies favourably (62.01 %) and the fewest respondents held favourable perceptions of biofield therapies (6.98 %). Respondents agreed or strongly agreed that there is value in conducting further research on CAIM therapies (85.52 %) and disagreed or strongly disagreed that they felt comfortable recommending most CAIM therapies to patients (64.83 %). A thematic analysis of our findings demonstrates that many pediatrics clinicians and/or researchers support further research on CAIM.</div></div><div><h3>Conclusion</h3><div>The findings from this study demonstrate that pediatrics clinicians and researchers have varying perceptions towards CAIM therapies. Respondents had the most positive perceptions of mind-body therapies and felt they did not have adequate training on CAIM. Further research is needed to establish more evidence-based educational resources on CAIM.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"87 ","pages":"Article 103097"},"PeriodicalIF":3.3,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142399635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review of Selenium as a complementary treatment in cancer patients","authors":"Felix Krannich ,&nbsp;Ralph Mücke ,&nbsp;Jens Büntzel ,&nbsp;Lutz Schomburg ,&nbsp;Oliver Micke ,&nbsp;Jutta Hübner ,&nbsp;Jennifer Dörfler","doi":"10.1016/j.ctim.2024.103095","DOIUrl":"10.1016/j.ctim.2024.103095","url":null,"abstract":"<div><h3>Background</h3><div>Selenium, a trace element with antioxidant properties, has been widely studied for its benefits in cancer treatment. This systematic review aims to critically evaluate existing evidence on the effectiveness of selenium as a complementary treatment in cancer patients.</div></div><div><h3>Method</h3><div>In May 2023, a systematic search was conducted searching five electronic databases (Embase, Cochrane, PsychInfo, CINAHL and Medline) to find studies concerning the use, effectiveness and potential harm of selenium substitution therapy on adult cancer patients undergoing cancer treatment. Including and excluding patient criteria were defined beforehand.</div></div><div><h3>Results</h3><div>From 4511 search results, 12 studies in 14 publications with 2483 patients were included in this systematic review. Types of cancer covered in the reviewed studies are non-Hodgkin lymphoma, head and neck cancer, thyroid cancer, acute myeloid or acute lymphocytic leukaemia, stage I non-small lung cancer, breast cancer, cervical and endometrial cancer, prostate cancer and non-invasive urothelial carcinoma. Common outcomes were PSA change, radiotherapy associated toxicities, overall survival (OS), recurrence free interval (RFI) and quality of life (QoL). Most studies showed some concerns in the risk of bias evaluation. The results were heterogeneous: Regarding radiotherapy toxicities, patients with sufficient levels of Se at baseline do not profit of Se supplementation, while those with a deficiency of Se at baseline have significantly reduced toxicities on some scales. Regardless blood levels of Se, no benefit was found for OS, Recurrence Free Interval, Progression Free Interval, Quality of life and PSA compared to control/placebo group.</div></div><div><h3>Conclusion</h3><div>Due to the very heterogeneous results and methodical limitations of the included studies, a clear statement regarding the effectiveness of Se supplementation is not possible, whereas cancer patients with a Se deficiency could profit from a Se supplementation during radio- or chemotherapy. Further studies should define Se deficiency as inclusion criterion and analyze levels of Se during time of intervention.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"86 ","pages":"Article 103095"},"PeriodicalIF":3.3,"publicationDate":"2024-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142388670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A bibliometric analysis and visualization of literature on the relationship between vitamin D and obesity over the last two decades","authors":"Jie Xiong,&nbsp;Xuemei Luo,&nbsp;Liqun Liu,&nbsp;Xiaoxiang Gong","doi":"10.1016/j.ctim.2024.103093","DOIUrl":"10.1016/j.ctim.2024.103093","url":null,"abstract":"<div><h3>Objective</h3><div>The purpose of this study was to employ bibliometric analysis to visualize hot spots and evolving trends in the studies on the relationship between vitamin D and obesity.</div></div><div><h3>Methods</h3><div>From the Web of Science Core Collection database, articles on vitamin D and obesity from 2001 to 2021 were retrieved. For the bibliometric visualization analysis, CiteSpace was employed. Some of the figures were created using GraphPad software.</div></div><div><h3>Results</h3><div>4454 pieces of articles and reviews were found, with an average citation of 30.68 times. There are many more published papers in the area of \"nutrition dietetics\" (1166, 26.179 %). The United States possesses the largest number of publications (1297, 29.12 %) and demonstrates definitive leadership in this field. The League of European Research Universities generates a higher percentage of publications (256, 5.748 %) than other institutions. Major studies are funded by the United States Department of Health and Human Services (531, 11.922 %) and the National Institutes of Health, USA (528, 11.855 %). The top five keywords with the highest co-occurrence frequency are “obesity” (1260), “vitamin d” (943), “insulin resistance” (651), “risk” (642), and “d deficiency” (636). The biggest keyword cluster was #0 \"adolescent\" among the 18 keyword clusters. The three latest keywords in the keyword burst were \"mineral density\"、\"d insufficiency\" and \"25 hydroxyvitamin d concentration\".</div></div><div><h3>Conclusion</h3><div>This bibliometric analysis shows an overview of the current status of the research on the association between vitamin D and obesity. The prevalence of vitamin D deficiency and the relationship between vitamin D and metabolic syndrome in obese individuals remains hot topics. We speculate that the effect of obesity on vitamin D levels and bone mineral density, and the influence of vitamin D insufficiency on various body systems in obese populations will be future trends.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"86 ","pages":"Article 103093"},"PeriodicalIF":3.3,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142371186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects and safety of the traditional Chinese exercise baduanjin on depression and anxiety in COVID-19 patients: A systematic review and meta-analysis","authors":"Yan Huang ,&nbsp;Xiao Xu ,&nbsp;Bishal Kumar Chaurasiya ,&nbsp;Prudence Bizimana ,&nbsp;Mei-Juan Qian ,&nbsp;Epipode Ntawuyamara","doi":"10.1016/j.ctim.2024.103094","DOIUrl":"10.1016/j.ctim.2024.103094","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Aim&lt;/h3&gt;&lt;div&gt;This systematic review and meta-analysis aimed to assess the safety and efficacy of Baduanjin, a traditional Chinese exercise (TCM), for reducing depression and anxiety in individuals suffering from coronavirus disease 2019 (COVID-19).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;Nineteen databases were searched from their inception through August 2024 to gather data for this study. The focus of this study was randomized controlled trials (RCTs) in which Baduanjin was administered for the treatment of COVID-19 patients with depression and anxiety. The study included various types of Baduanjin exercise, whether used alone or in conjunction with other treatment modalities, for the control group. The comparators included a waitlist control, usual care, health education and supportive counseling, psychosocial support therapy, pharmacotherapies, and other common exercises. The exclusion criteria for trials were trials comparing different treatment durations, different treatment frequencies, and different types of Baduanjin exercise. Moreover, other traditional Chinese medicine (TCM) therapeutic methods applied in either the intervention or control group were also excluded. Throughout the entire study, the selection process, data extraction and quantitative analysis were carried out in strict adherence to all relevant guidelines. The Cochrane criteria for risk of bias were used to assess the methodological quality of the trials. In our review, a meta-analysis was performed using the software STATA MP14.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;After conducting a meta-analysis, eight RCTs were found to have satisfied the inclusion criteria. The effects of Baduanjin exercise on self-rating anxiety scale (SAS) scores were investigated in five RCTs comprising a total of 228 patients. Analysis of the results revealed that the combination of Baduanjin exercises and conventional therapies led to a statistically significant reduction in SAS scores [MD=-3.21 (95 % CI= −3.64, −2.79), &lt;em&gt;P&lt;/em&gt;&lt; 0.001] compared to conventional therapies alone. Moreover, this systematic review explored the effect of Baduanjin exercise on self-rating depression scale (SDS) scores (three RCTs involving 83 participants), Hamilton Anxiety Rating Scale (HAM-A) scores (one RCT involving 103 participants), Patient Health Questionnaire (PHQ-9) scores (one RCT involving 70 participants) and Generalized Anxiety Disorder-7 (GAD-7) scores (one RCT involving 59 participants) for patients with COVID-19. The results showed that, in addition to conventional therapies, Baduanjin exercise had a more favorable impact on reducing the SDS score [mean difference (MD) =-2.86 (95 % CI=4.11, −1.61), &lt;em&gt;P&lt;/em&gt;=0.025], &lt;em&gt;P&lt;/em&gt;HQ-9 score [MD=-5.31, 95 % CI=-8.73, −1.89), &lt;em&gt;P&lt;/em&gt;=0.002] and HAM-A score [MD=-3.00, 95 % CI=-5.33, −0.67], &lt;em&gt;P&lt;/em&gt;=0.010] in patients with COVID-19 than did the use of conventional therapies alone. Furthermore, the combination of Baduanjin exercise and conven","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"86 ","pages":"Article 103094"},"PeriodicalIF":3.3,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142358799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}