Huifang Luo , Ping Du , Wenyan Qin , Yiyi Hu , Zhen Xian , Changsong Lin , Peiwu Li , Yang Song , Xiangwei Yang
{"title":"Intradermal acupuncture in the treatment of rheumatoid arthritis with liver and kidney deficiency syndrome – A sham-controlled, randomized, clinical trial","authors":"Huifang Luo , Ping Du , Wenyan Qin , Yiyi Hu , Zhen Xian , Changsong Lin , Peiwu Li , Yang Song , Xiangwei Yang","doi":"10.1016/j.ctim.2024.103037","DOIUrl":"https://doi.org/10.1016/j.ctim.2024.103037","url":null,"abstract":"<div><h3>Background and purpose</h3><p>Rheumatoid arthritis (RA) is called “immortal cancer”, and it affects the quality of life, disability rate and even the survival of patients. This study aimed to observe the clinical efficacy, and adverse reactions of intradermal acupuncture (IA) in the treatment of RA patients with liver and kidney deficiency syndrome.</p></div><div><h3>Materials and methods</h3><p>132 RA patients were split into an IA group and a sham IA group at a 1:1 ratio. Both groups were assessed before and after the intervention with the assessments: a traditional Chinese medicine (TCM) syndrome evaluation, the Health Assessment Questionnaire (HAQ), the Disease Activity Score 28 (DAS28) and serum C-reactive protein (CRP).</p></div><div><h3>Results</h3><p>There was a statistically significant difference in TCM syndrome evaluation, HAQ, DAS28, and CRP between both groups before and after treatment (<em>P</em> < 0.01). The improvement of TCM syndrome evaluation (95% <em>CI</em> [1.14(0.38–1.89)]; <em>P</em> = 0.001), HAQ (95% <em>CI</em> [2.00(1.00–3.00)]; <em>P</em> = 0.003), and DAS28 (95% <em>CI</em> [0.11(0.02–0.20)]; <em>P</em> = 0.021) in the IA group was more obvious than that in the sham IA group (<em>P</em> < 0.05), except for CRP (95% <em>CI</em> [0.50(− 2.09 to 7.08)], <em>P</em> = 0.786). The difference in CRP outcome changes between the two groups was not statistically significant (<em>P</em> > 0.05). Both groups had comparable results in the implementation of RA in the upper and lower extremity acupoints and did not differ due to different sites (IA group: <em>P</em> = 0.852; sham IA group: <em>P</em> = 0.861). The comparison of effective rate of the upper limb as well as that of the lower limb was statistically significant (<em>P</em> = 0.001). Besides, patients reported no adverse effects.</p></div><div><h3>Conclusion</h3><p>The IA intervention was associated with a promising effect on the decrease in RA disease activity and delayed overall disease progression.</p></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0965229924000256/pdfft?md5=9dffba969dbaa5db1ee0e86a752929e1&pid=1-s2.0-S0965229924000256-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140539904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tingting Lu , Bin Liu , Cuncun Lu , Zouxi Du , Kehu Yang , Long Ge
{"title":"Reporting quality of acupuncture overviews: A methodological investigation based on the PRIOR statement","authors":"Tingting Lu , Bin Liu , Cuncun Lu , Zouxi Du , Kehu Yang , Long Ge","doi":"10.1016/j.ctim.2024.103034","DOIUrl":"10.1016/j.ctim.2024.103034","url":null,"abstract":"<div><h3>Objective</h3><p>Acupuncture overviews are increasing rapidly; however, their reporting quality is yet unclear. We aimed to investigate the reporting quality of relevant overviews according to the preferred reporting items for overviews of reviews (PRIOR) statement.</p></div><div><h3>Methods</h3><p>We systematically searched PubMed from inception to August 16, 2022 for overviews on acupuncture therapies. Reporting quality of included overviews was evaluated using the PRIOR statement, and the results were cross-checked. Multiple linear regression analysis was used to assess the predictors of the reporting completeness. GraphPad 9.4 was utilized to generate an evidence map, Excel 2019 was used to extract and manage data, and R 4.2.3 was used for data analysis.</p></div><div><h3>Results</h3><p>A total of 49 overviews published from 2006 to 2022 were included, of which China ranked first with 38 overviews. The most frequently searched database was PubMed/ Medline (n = 48, 98%), and commonly used methodological quality assessment tool was AMSTAR-2 (n = 14, 29%). The overarching themes centered on acupuncture for obstetrics, gynecology, reproductive diseases, as well as depression, anxiety, and insomnia. Reporting quality needs to be improved involving the definition of systematic reviews (SRs), overlap of primary studies and SRs, methods for managing discrepant data across SRs, risk of bias in primary studies, heterogeneity, and sensitivity analysis of synthesized results, reporting bias assessment, and registration and protocol. Moreover, publication in recent years and receiving funding support were significantly associated with higher overall reporting quality score (<em>P</em> < 0.05).</p></div><div><h3>Conclusion</h3><p>Based on the PRIOR statement, this methodological study indicates that the reporting quality of the included acupuncture overviews is poor. In the future, authors of overviews are encouraged to use the PRIOR statement for standardized reporting. Furthermore, it is recommended that journal editors mandate the inclusion of this statement in authors’ reports and require a complete PRIOR checklist.</p></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0965229924000220/pdfft?md5=c7575e4a220e0cbb1137a40e795af125&pid=1-s2.0-S0965229924000220-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140193482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oh-Bin Kwon , Dong Wook Hwang , Dong-Hyeob Kang , Sang-Joon Yoo , Do-Hoon Lee , Minjin Kwon , Seon-Woo Jang , Hyun-Woo Cho , Sang Don Kim , Kyong Sun Park , Eun-San Kim , Yoon Jae Lee , Doori Kim , In-Hyuk Ha
{"title":"Effectiveness of lumbar motion style acupuncture treatment on inpatients with acute low back pain: A pragmatic, randomized controlled trial","authors":"Oh-Bin Kwon , Dong Wook Hwang , Dong-Hyeob Kang , Sang-Joon Yoo , Do-Hoon Lee , Minjin Kwon , Seon-Woo Jang , Hyun-Woo Cho , Sang Don Kim , Kyong Sun Park , Eun-San Kim , Yoon Jae Lee , Doori Kim , In-Hyuk Ha","doi":"10.1016/j.ctim.2024.103035","DOIUrl":"10.1016/j.ctim.2024.103035","url":null,"abstract":"<div><h3>Background and purpose</h3><p>This parallel, single-center, pragmatic, randomized controlled study aimed to investigate the effectiveness and safety of motion style acupuncture treatment (MSAT; a combination of acupuncture and Doin therapy) to reduce pain and improve the functional disability of patients with acute low back pain (aLBP) due to road traffic accidents.</p></div><div><h3>Materials and Methods</h3><p>Ninety-six patients with aLBP admitted to the Haeundae Jaseng Hospital of Korean Medicine in South Korea due to traffic accidents were treated with integrative Korean medicine (IKM) with additional 3-day MSAT sessions during hospitalization (MSAT group, 48 patients) or without (control group, 48 patients), and followed up for 90 days.</p></div><div><h3>Results</h3><p>The mean numeric rating scale (NRS) scores of low back pain (LBP) of the MSAT and control groups were both 6.7 (95% confidence interval [CI]: 6.3, 7.1) at baseline. After completing the third round of all applicable treatment sessions (the primary endpoint in this study), the mean NRS scores of the MSAT and control groups were 3.76 (95% CI: 3.54, 3.99) and 5.32 (95% CI: 5.09, 5.55), respectively. The difference in the mean NRS score between the two groups was 1.56 (95% CI: 1.25, 1.87).</p></div><div><h3>Conclusion</h3><p>IKM treatment combined with MSAT can reduce pain and improve the range of motion of patients with aLBP.</p></div><div><h3>Trial registration</h3><p>This trial is registered at ClinicalTrial.gov (NCT04956458).</p></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0965229924000232/pdfft?md5=b14ec800fc780b1f2d2f82fc15bf7167&pid=1-s2.0-S0965229924000232-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140183955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Siyang Peng , Linghao Meng , Ruiying Fang , Qiqi Shen , Yukun Tian , Anni Xiong , Shaohong Li , Yajing Yang , Weiqian Chang , Jinxia Ni , Wenzeng Zhu
{"title":"Current state of research on exercise for the treatment of myasthenia gravis: A scoping review","authors":"Siyang Peng , Linghao Meng , Ruiying Fang , Qiqi Shen , Yukun Tian , Anni Xiong , Shaohong Li , Yajing Yang , Weiqian Chang , Jinxia Ni , Wenzeng Zhu","doi":"10.1016/j.ctim.2024.103033","DOIUrl":"10.1016/j.ctim.2024.103033","url":null,"abstract":"<div><h3>Objective</h3><p>To provide a comprehensive overview of existing evidence, research gaps, and future research priorities concerning the treatment of myasthenia gravis (MG) using exercise therapies.</p></div><div><h3>Method</h3><p>Clinical studies on exercise treatment for MG were searched in nine databases to conduct a scoping review. Two independent researchers screened the literature and comprehensively analyzed the characteristics and limitations of the included articles.</p></div><div><h3>Results</h3><p>A total of 5725 studies were retrieved, of which 24 were included. The included studies were conducted in 16 different countries/regions and 456 patients were enrolled. Study designs included both interventional and observational studies. Exercise interventions included aerobic exercise, resistance exercise, balance training, and stretch training, and are typically administered in conjunction with medication, usual care, or some other interventions. The intensity, frequency, and duration of exercise interventions varied hugely among studies. Six-minute walk test, adverse events, muscle strength, MG quality of life-15 scale, forced vital capacity, quantitative MG scale, and MG activities of daily living scale were the most frequently used outcomes. All studies reported results in favor of the efficacy and safety of exercise in MG, and exercise-related adverse events were reported in two studies.</p></div><div><h3>Conclusion</h3><p>This scoping review provides an overview of the evidence concerning exercise treatment for MG. Key gaps in evidence include a limited number of participants, complex interventions, variability in outcome selection, and insufficient reporting in publications. The promotion of exercise treatment for MG still encounters several obstacles. A larger population, rigorous study design and conduction, standardized interventions and outcomes, and standardized reporting are essential.</p></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0965229924000219/pdfft?md5=a359bf80e898fc05cff9f36a9705b1a1&pid=1-s2.0-S0965229924000219-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140065034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jingqi Yang , Zhuoping Deng , Shichun Pei , Nan Zhang
{"title":"A feasibility study on indoor therapeutic horticulture to alleviate sleep and anxiety problems: The impact of plants and activity choice on its therapeutic effect","authors":"Jingqi Yang , Zhuoping Deng , Shichun Pei , Nan Zhang","doi":"10.1016/j.ctim.2024.103032","DOIUrl":"10.1016/j.ctim.2024.103032","url":null,"abstract":"<div><h3>Introduction</h3><p>Therapeutic horticulture (TH) is increasingly being applied for sub-health or patient mental health care. Whether plant and activity type will affect TH’s effectiveness is unclear.</p></div><div><h3>Aim</h3><p>To evaluate the feasibility of an indoor TH for alleviating the anxiety symptoms and sleeping problems of people with poor sleep quality, and explore the potential affection of plant and activity type on health benefits.</p></div><div><h3>Method</h3><p>Thirty subjects (all with sleep problems and half with anxiety problems) were randomly assigned to three groups to do horticultural activities with ornamental plants, general aromatic plants, or aromatic plants with reported mental health functions, respectively. Six indoor TH activities were then held sequentially within two weeks. Psychological scales, subjective feedback questionnaires, and physiological indicators were used as evaluation indexes before and after horticulture activities.</p></div><div><h3>Results</h3><p>The TH relieved subjects' sleep and anxiety problems and was particularly effective in alleviating anxiety among people with high anxiety levels. Using ornamental plants was more effective in relieving stress while functional aromatic plants performed better in sleep improvement and satisfaction to TH. Each horticultural activity could improve mood state but showed different effects on the vitality of the participants.</p></div><div><h3>Conclusion</h3><p>The above findings provided some basis for the potential benefits of selecting plants and activities based on psychological care needs in the development of TH plans. Future research that expands upon the current project is warranted. A larger sample size is beneficial for obtaining more powerful statistical results.</p></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0965229924000207/pdfft?md5=ed10debcec24e43c24b94473efa0a285&pid=1-s2.0-S0965229924000207-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140058832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jennifer Kawi , Chao Hsing Yeh , Lauren Grant , Xinran Huang , Hulin Wu , Chunyan Hua , Paul Christo
{"title":"Retention, adherence, and acceptability testing of a digital health intervention in a 3-group randomized controlled trial for chronic musculoskeletal pain","authors":"Jennifer Kawi , Chao Hsing Yeh , Lauren Grant , Xinran Huang , Hulin Wu , Chunyan Hua , Paul Christo","doi":"10.1016/j.ctim.2024.103030","DOIUrl":"10.1016/j.ctim.2024.103030","url":null,"abstract":"<div><h3>Objectives</h3><p>Evaluate a digital health intervention using Auricular Point Acupressure (APA) for chronic musculoskeletal pain in terms of participant retention, adherence, acceptability, and satisfaction. Chronic musculoskeletal pain is a global concern and there are persistent challenges in pain management. Despite the value of digital health interventions, these interventions need to be fully evaluated for feasibility.</p></div><div><h3>Methods</h3><p>We conducted a 3-group, longitudinal, randomized controlled trial (RCT). After Institutional Review Board approval, we posted recruitment flyers in a university, healthcare clinics, and community settings. Participants were randomized into an in-person + app group (<em>n</em> = 8), virtual + app group (<em>n</em> = 7), and a wait-list, education-enhanced control group (<em>n</em> = 8), evaluating our outcomes using standard feasibility measures. The 4-week intervention consisted of virtual sessions, telecommunications, and our APA app, followed by a 3-month follow-up.</p></div><div><h3>Results</h3><p>Data from 22 participants were subsequently analyzed (95.7%). All app participants adhered to the study protocol and used APA at the minimum recommended frequency and duration. The virtual + app group used APA more during the intervention and follow-up periods. All app participants found the intervention to be acceptable and at least 80% overall were satisfied with APA at the 3-month follow-up. There were no adverse events reported.</p></div><div><h3>Conclusions</h3><p>Our digital health intervention was found to be acceptable and sustainable; participants adhered to and were satisfied with the intervention providing support for a larger RCT.</p></div><div><h3>Clinical Trial</h3><p>#: NCT05020470</p></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0965229924000189/pdfft?md5=0965e1355678f278e3eb4d3b5f82f23e&pid=1-s2.0-S0965229924000189-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140027596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rebecca Büttner , Melanie Schwermer , Thomas Ostermann , Alfred Längler , Tycho Zuzak
{"title":"Expert consensus-based clinical recommendation for an integrative anthroposophic treatment approach to acute tonsillitis in childhood","authors":"Rebecca Büttner , Melanie Schwermer , Thomas Ostermann , Alfred Längler , Tycho Zuzak","doi":"10.1016/j.ctim.2024.103031","DOIUrl":"10.1016/j.ctim.2024.103031","url":null,"abstract":"<div><h3>Background</h3><p>Medical guidelines are an important basis for qualitative and cost-effective patient care. However, there is a lack of clinical recommendations in anthroposophic medicine (AM), an integrative medicine approach frequently practised in Europe. Acute tonsillitis, which includes tonsillopharyngitis, is a common childhood disease. that is mostly caused by a viral infection. Symptomatic treatment is therefore of high importance, and AM can offer several therapy options.</p></div><div><h3>Methods</h3><p>53 physicians from Germany, Spain, Netherlands, Switzerland, Austria, and Hungary with at least one year of experience in anthroposophic paediatric medicine were invited to participate in an online Delphi process. The process comprises five survey rounds starting with open-ended questions and ending with final statements, which need 75% agreement of experts to reach consensus. Expert answers were evaluated by two independent reviewers using MAXQDA and Excel.</p></div><div><h3>Results</h3><p>Response rate was between 28% and 45%. The developed recommendation included 15 subtopics. These covered clinical, diagnostic, therapeutic and psychosocial aspects of acute tonsillitis. Six subtopics achieved a high consensus <em>(>90%)</em> and nine subtopics achieved consensus (<em>75–90%</em>).</p></div><div><h3>Conclusion</h3><p>The clinical recommendation for acute tonsillitis in children aims to simplify everyday patient care and provide decision-making support when considering and prescribing anthroposophic therapies. Moreover, the recommendation makes AM more transparent for physicians, parents, and maybe political stakeholders as well.</p></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0965229924000190/pdfft?md5=d9c19f9d36372ed3d66a2067a5882e49&pid=1-s2.0-S0965229924000190-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140021091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tong Wu , Luolin Zhou , Xinru Liao , Yuewen He , Ronglin Xu , Daihong Luo
{"title":"Efficacy and safety of chinese herbal foot bath for hypertension: A systematic review and meta-analysis","authors":"Tong Wu , Luolin Zhou , Xinru Liao , Yuewen He , Ronglin Xu , Daihong Luo","doi":"10.1016/j.ctim.2024.103029","DOIUrl":"10.1016/j.ctim.2024.103029","url":null,"abstract":"<div><h3>Background</h3><p>Hypertension is a prevalent condition with significant impacts on human health. Chinese herbal foot bath, a traditional Chinese medicine treatment, is believed to help manage hypertension.</p></div><div><h3>Objective</h3><p>This systematic review aims to assess the efficacy of combining Chinese herbal foot bath with conventional treatment for hypertension.</p></div><div><h3>Methods</h3><p>A thorough search across eight databases was conducted to identify relevant studies on Chinese herbal foot bath for hypertension. Randomized controlled trials examining the benefits and risks of using Chinese herbal foot bath combined with conventional treatment for hypertension were included. Blood pressure changes before and after the Chinese herbal foot bath were assessed, and outcomes were analyzed using Review Manager 5.3 software. The certainty of evidence was evaluated using the GRADE tool.</p></div><div><h3>Results</h3><p>Compared to conventional treatment, Chinese herbal foot bath combined with conventional treatment demonstrated greater effectiveness in reducing systolic blood pressure (MD 6.69, 95% CI: 5.86 to 7.53, p < 0.00001) and diastolic blood pressure (MD 5.83, 95% CI: 5.23 to 6.43, p < 0.00001), which reported fewer adverse effects.These studies commonly present issues such as inadequate randomization, lack of blinding, and absence of independent testing for the purity or potency of herbs.</p></div><div><h3>Conclusion</h3><p>The meta-analysis suggests that Chinese herbal foot bath combined with conventional treatment may effectively manage hypertension, with few adverse effects. However, high-quality clinical trials are still needed to confirm these findings due to methodological weaknesses in randomization, blinding, long-term follow-up, and independent testing for the purity and potency of herbs.</p></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0965229924000177/pdfft?md5=ae4993240fd816716634bf9596899586&pid=1-s2.0-S0965229924000177-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139943982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Symptoms are combated but the disease remains untreated – Comment on the editorial by Kamran Abbasi et al.","authors":"O.R. van Loon , A.J. (Tom) van Loon","doi":"10.1016/j.ctim.2024.103015","DOIUrl":"10.1016/j.ctim.2024.103015","url":null,"abstract":"","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0965229924000037/pdfft?md5=f7b3cc199b0178ddfa6455146426897b&pid=1-s2.0-S0965229924000037-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139711757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effects of dried okra extract on lipid profile, renal function and some RAGE-related inflammatory genes expression in patients with diabetic nephropathy: A randomized controlled trial","authors":"Nazgol Bahreini , Maryam Saghafi-Asl , Omid Nikpayam , Ehsan Safaei , Vahideh Sadra , Laleh Fakhr , Hanieh Beyrampour-Basmenj , Parina Asgharian , Mohammad Asghari- Jafarabadi","doi":"10.1016/j.ctim.2024.103027","DOIUrl":"10.1016/j.ctim.2024.103027","url":null,"abstract":"<div><h3>Background</h3><p>Diabetic nephropathy (DN) is a common complication of type 2 diabetes. Okra <em>(Abelmoschus esculentus L)</em> is reported to have anti-diabetic effects. The present study aimed to investigate the effects of dried okra extract (DOE) supplementation on lipid profile, renal function indices, and expression of inflammatory genes, as well as serum level of soluble Receptor for Advanced glycation end products (sRAGE) in patients with DN.</p></div><div><h3>Methods</h3><p>In this triple-blind randomized placebo-controlled clinical trial, 64 eligible patients with DN received either 125 mg of DOE or placebo daily along with DN-related nutritional recommendations for 10 weeks. Changes in kidney indices including proteinuria and estimated glomerular filtration rate (eGFR), lipid profile, serum SRAGE, as well as the expression of RAGE, ICAM-1, and IL-1 genes were measured over 10 weeks.</p></div><div><h3>Results</h3><p>After adjustment for the potential confounders, between-group analyses showed no significant differences in terms of lipid profile, kidney function indices, sRAGE, and RAGE-related inflammatory genes expression after 10 weeks.</p></div><div><h3>Conclusion</h3><p>Daily 125 mg DOE along with nutritional recommendations on top of usual care did not lead to significant changes in renal function indices, lipid profile, and inflammatory genes expression in patients with DN.</p></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0965229924000153/pdfft?md5=7052aa3d03830cc60b045b8481af2fdb&pid=1-s2.0-S0965229924000153-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139711756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}