Complementary therapies in medicine最新文献

{"title":"The effects of Sitting Baduanjin intervention based on the COM-B model for elderly patients with osteoporosis after vertebroplasty: A randomized controlled trial","authors":"Lidan Yang ,&nbsp;Fang Lu ,&nbsp;Jing Chen ,&nbsp;Jiali Wu ,&nbsp;Jia Li ,&nbsp;Jiangtao OuYang ,&nbsp;Can Zheng ,&nbsp;Jingbei Zhang ,&nbsp;Xujuan Zheng","doi":"10.1016/j.ctim.2025.103275","DOIUrl":"10.1016/j.ctim.2025.103275","url":null,"abstract":"<div><h3>Background</h3><div>Osteoporosis and osteoporotic vertebral fractures can cause decreased quality of life and increased hospitalization, morbidity, and mortality for older people. Sitting Baduanjin (SBDJ) is suitable for frail elderly patients, but its application to elderly osteoporosis patients after vertebroplasty has not yet been explored.</div></div><div><h3>Methods</h3><div>A randomized controlled trial was conducted with 123 participants from a hospital in China. Participants were randomly assigned to one of three groups: control (n = 41, routine care), SBDJ (n = 41, routine care plus five weekly 30-minute sessions of SBDJ), and SBDJ-based on the COM-B model (SBDJ-CB, n = 41). The SBDJ-CB group received additional interventions, including monthly 30-minute face-to-face lectures, daily practice videos via a WeChat group, weekly online instructions, and monthly 30-minute focus group meetings. The primary outcomes were osteoporosis self-efficacy, measured using the Osteoporosis Self-efficacy Scale (OSES), and quality of life, assessed by the 12-item Short-Form Health Survey (SF-12). Secondary outcomes included bone mineral density (BMD), measured via dual-energy X-ray absorptiometry (DXA), and biochemical markers of bone metabolism analyzed from blood samples. Data were collected at baseline (T0), three-month intervention (T1), and six-month intervention (T2). Statistical analyses were performed using Generalized Estimating Equation (GEE) and Analysis of Variance (ANOVA) to evaluate intervention effects.</div></div><div><h3>Results</h3><div>Both intervention groups showed higher osteoporosis self-efficacy, physical, and mental scores at T1 and T2 (all <em>P</em> &lt; 0.001), and greater BMD and osteogenic activity at T2 compared to the control group. The SBDJ-CB group had significantly better outcomes than the SBDJ group (all <em>P</em> &lt; 0.05). At T2, only the SBDJ-CB group exhibited significantly lower osteoclastic activity than the control group (<em>P</em> &lt; 0.001). The SBDJ-CB group also had a higher rate of osteoporosis remission and practice compliance at T2 than the SBDJ group (all <em>P</em> &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>The SBDJ intervention demonstrated efficacy in enhancing self-efficacy, psychophysical health, and bone health among elderly osteoporosis patients post-vertebroplasty. Notably, the SBDJ-CB achieved superior outcomes and is recommended as a priority intervention for postoperative rehabilitation.</div><div>Trial registration: ChiCTR2500095266, registration date:2025.01.03</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"95 ","pages":"Article 103275"},"PeriodicalIF":3.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145408344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Health Qigong Walking Practice on anxiety and serum metabolites in patients with Type 2 Diabetes Mellitus: A randomized controlled trial","authors":"Lizhen Gan ,&nbsp;Qi Tang ,&nbsp;Zhi Zhang ,&nbsp;Carrere Rivera Camille ,&nbsp;Aníbal Simón Sandoval ,&nbsp;Xinyi He ,&nbsp;Lutao Li ,&nbsp;Jian Hu ,&nbsp;Qingbo Wei ,&nbsp;Yunchuan Wu","doi":"10.1016/j.ctim.2025.103283","DOIUrl":"10.1016/j.ctim.2025.103283","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of this study is to evaluate the clinical efficacy of Health Qigong Walking Practice in alleviating anxiety and improving metabolic profiles in patients with type 2 diabetes mellitus (T2DM), and to explore the underlying mechanisms using serum metabolomics.</div></div><div><h3>Methods</h3><div>60 patients with a diagnosis of T2DM with anxiety were randomly assigned to a health education group (HEG), an aerobic exercise group (AEG), and a Health Qigong Walking Practice group （HQWPG） (n = 20 per group) using a table of random numbers. Self-Rating Anxiety Scale (SAS) scores and glucose-lipid metabolism markers—including fasting blood glucose (FBG), 2-hour postprandial blood glucose (PBG), glycosylated hemoglobin (HbA1c), triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL), and low-density lipoprotein (LDL)—were assessed before and after a 12-week intervention. Untargeted serum metabolomics was conducted in the QTG to identify differential metabolites and metabolic pathways.</div></div><div><h3>Results</h3><div>After 12 weeks, both the HQWPG and AEG showed significant reductions in anxiety scores compared to the HEG (P &lt; 0.05). However, the HQWPG demonstrated significantly greater improvements in glycemic control, particularly in PBG, compared to both control groups (P &lt; 0.05). While conventional aerobic exercise showed limited effects on metabolic markers in this study, the holistic nature of Health Qigong Walking Practice, integrating movement, breathwork, and mindfulness, likely provided additional regulatory benefits. Metabolomics in the HQWPG revealed significant changes in metabolites, including glycyltyrosine, N-acetylmethionine, and glutamic acid, and pathway analysis highlighted alterations in histidine metabolism and nitrogen metabolism.</div></div><div><h3>Conclusion</h3><div>Health Qigong Walking Practice significantly reduces anxiety and improves glucose-lipid metabolism in T2DM patients with anxiety. Its superiority over standard aerobic exercise in glycemic control may be mediated through the integrated regulation of movement, breath, and mind, which modulates key amino acid and nitrogen metabolism pathways. This mind-body intervention offers a promising adjunctive therapy for T2DM.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"95 ","pages":"Article 103283"},"PeriodicalIF":3.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145426574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short- and long-term effects of inhaled lavender essential oil on anxiety, fatigue, blood pressure, and sleep quality in middle-aged adults with hypertension: A randomized placebo-controlled pilot study","authors":"Yi-Ren Wang ,&nbsp;Ying-Chih Ho ,&nbsp;Yueh-Chiao Yeh","doi":"10.1016/j.ctim.2025.103296","DOIUrl":"10.1016/j.ctim.2025.103296","url":null,"abstract":"<div><h3>Background</h3><div>Hypertension commonly manifests with anxiety, fatigue, and sleep disturbances that negatively impact quality of life. Lavender essential oil is widely used in complementary therapies for its anxiolytic, hypotensive, and sedative properties. This study aimed to investigate the short- and long-term effects of inhaled lavender essential oil, delivered via a magnetic face mask clip, on psychological and physiological outcomes in middle-aged adults with hypertension.</div></div><div><h3>Methods</h3><div>Fifty-eight hypertensive adults aged 40–60 years were randomly assigned to either an intervention group (lavender essential oil, <em>n</em> = 30) or a placebo group (sweet almond oil, <em>n</em> = 28). Assessments were conducted at baseline, immediately after a single 15-minute inhalation session, and following daily 15-minute sessions over seven consecutive days. Outcome measures included the State-Trait Anxiety Inventory (STAI), Chalder Fatigue Questionnaire (CFQ), systolic (SBP) and diastolic blood pressure (DBP), and the Verran and Snyder-Halpern Sleep Scale (VHS).</div></div><div><h3>Results</h3><div>At baseline, both groups were demographically comparable. Immediately post-intervention, the aroma group showed significantly greater reductions in anxiety (STAI: −15.7 vs. −0.9, <em>p</em> &lt; .001) and SBP (<em>p</em> = .025). After seven days, the intervention group demonstrated significant improvements across all measures: STAI (−15.6 vs. −0.6, <em>p</em> &lt; .001), fatigue (CFQ: −4.8 vs. −0.9, <em>p</em> = .011), SBP (<em>p</em> = .002) and DBP (<em>p</em> = .033), and sleep quality (VHS: +165.0 vs. +4.7, <em>p</em> &lt; .001).</div></div><div><h3>Conclusion</h3><div>Inhalation of lavender essential oil via a mask clip may serve as an effective complementary approach for improving emotional and physiological outcomes in hypertensive adults.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"95 ","pages":"Article 103296"},"PeriodicalIF":3.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145430510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of tDCS on postoperative opioid consumption and pain after general anesthesia: A systematic review and meta-analysis of randomized controlled trials","authors":"Qiu-Song Shen ,&nbsp;Qiao Wang ,&nbsp;Hou-Ming Kan ,&nbsp;Xin-Li Shi ,&nbsp;Nai-Fa Li ,&nbsp;Xu Zhang","doi":"10.1016/j.ctim.2025.103303","DOIUrl":"10.1016/j.ctim.2025.103303","url":null,"abstract":"<div><h3>Background</h3><div>Transcranial direct current stimulation (tDCS), as a supplementary plan during the perioperative period, is currently a novel exploration of using neuromodulation techniques to improve postoperative symptoms.</div></div><div><h3>Methods</h3><div>We searched Embase, PubMed, EBSCO, Web of Science, Scopus, and Cochrane Library databases on February 17, 2025. The primary outcomes included postoperative opioid drug consumption and pain score. The secondary outcomes included fatigue, anxiety, depression, quality of recovery, sleep quality, and adverse events. The study was conducted using Review Manager 5.4 software.</div></div><div><h3>Results</h3><div>We ultimately included 13 trials, including 827 participants (442 in the real tDCS group and 385 in the sham group). Within these trials, two had some concerns, and eleven were low-risk. In terms of primary outcomes, tDCS could significantly reduce postoperative opioid consumption (SMD = −0.52, 95 %CI = [-0.77, −0.27]; <em>P</em> ＜ 0.001), pain score (SMD = −0.48, 95 %CI = [-0.66, −0.29], <em>P</em> &lt; 0.001). For secondary outcome, tDCS led to a significant decrease in the fatigue score (SMD = −4.35, 95 %CI = [-4.73, −3.98], <em>P</em> ＜ 0.001). However, there were no statistically differences in anxiety (SMD = −0.98, 95 % CI = [-2.16, 0.21], <em>P</em> = 0.110). tDCS could increase adverse event (RR = 3.88, 95 % CI = [1.64, 9.19], <em>P</em> = 0.002), but these events were mild and temporary. Due to the limited number of trials on postoperative recovery quality, depression, and sleep quality, we conducted only a review and did not include these outcomes in the meta-analysis.</div></div><div><h3>Conclusions</h3><div>tDCS can reduce postoperative opioid consumption and effectively alleviate postoperative pain. Regarding secondary outcomes, although the results suggest it may reduce postoperative fatigue, this conclusion requires further validation due to the limited number of studies included.More studies are needed in the future to provide evidence on the effects of tDCS on fatigue, anxiety, depression, quality of recovery and sleep quality.</div></div><div><h3>Keypoints</h3><div><ul><li><span>•</span><span><div>Question: Does the use of tDCS during the perioperative period help diminish postoperative opioid use and alleviate pain scores?</div></span></li></ul><ul><li><span>•</span><span><div>Findings: The current evidence suggests using tDCS during the perioperative period to reduce postoperative opioid consumption and lower pain scores.</div></span></li></ul></div><div><ul><li><span>•</span><span><div>Meaning: tDCS is currently a key focus in exploring neuromodulation techniques to improve postoperative symptoms.</div></span></li></ul></div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"95 ","pages":"Article 103303"},"PeriodicalIF":3.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145430534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of exercise interventions on sleep quality in patients with emotion-related insomnia (ERI)：A systematic review and network meta-analysis","authors":"Baoyi Ouyang ,&nbsp;Jianan Gao ,&nbsp;Xiaojie Zhou ,&nbsp;Liang Gao ,&nbsp;Hui He","doi":"10.1016/j.ctim.2025.103298","DOIUrl":"10.1016/j.ctim.2025.103298","url":null,"abstract":"<div><div>This meta-analysis consequently endeavors to methodically evaluate the impact of exercise interventions on sleep quality measures in populations affected by ERI.The study intends to develop an evidence-based prioritization framework for exercise types, offering support for the customization of exercise prescriptions in clinical practice.</div></div><div><h3>Methods</h3><div>This study was evaluated by literature search in five databases, and analyses were subsequently conducted using Review Manager 5.3 and STATA 18.0. Furthermore, a meta-regression analysis was employed to examine the potential moderating effects of exercise intervention characteristics.</div></div><div><h3>Results</h3><div>Pairwise meta-analysis demonstrated that exercise significantly improved subjective sleep quality [SMD = -0.83, (95 % CI = −1.17, −0.49),P &lt; 0.001].Network meta-analysis revealed that several exercise types are potentially effective interventions for enhancing subjective sleep quality: aerobic exercise (AE) (SMD = −0.66, 95 % CI: −1.19, −0.14, p &lt; 0.05), combined exercise (CE) (SMD = −1.17, 95 % CI: −2.07, −0.26, p &lt; 0.05), and Body and mind exercise (BM) (SMD = −0.71, 95 % CI: −1.35, −0.07, p &lt; 0.05). Among these, CE [SMD = -1.17, 95 % CI: −2.07, −0.26, p &lt; 0.05; SUCRA = 77.9 %] was identified as the most likely modality for improving subjective sleep quality.Meta-regression analysis indicated that exercise cycles (β = −0.470, p &lt; 0.05) and exercise frequency (β = −0.940, p &lt; 0.05) may be significant moderators influencing the effect of exercise on sleep onset latency (SOL).</div></div><div><h3>Conclusion</h3><div>Exercise was effective in improving subjective sleep quality.CE, AE, and BM may represent preferential modalities for enhancing subjective sleep quality, with CE potentially constituting the most effective intervention.exercise frequency and exercise cycles are identified as potential significant moderators influencing the improvement of SOL.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"95 ","pages":"Article 103298"},"PeriodicalIF":3.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145430608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term farming lifestyle strongly associated with lower sarcopenia prevalence in older Adults: A cross-sectional study in an urban-rural transition zone","authors":"Yang Zhoujian ,&nbsp;Zhang Haihong ,&nbsp;Zhao Hui ,&nbsp;Zhou Qi ,&nbsp;Wu Zhufeng ,&nbsp;Shen Haihong ,&nbsp;Lv Jun ,&nbsp;Li Aihua ,&nbsp;Zhang Huan ,&nbsp;Li Hong ,&nbsp;Wang Jiachen ,&nbsp;Wang Shanjin","doi":"10.1016/j.ctim.2025.103268","DOIUrl":"10.1016/j.ctim.2025.103268","url":null,"abstract":"<div><h3>Objective</h3><div>In the context of rapid urbanization and escalating population aging, lifestyle factors play a critical role in sarcopenia development. This study aimed to clarify the prevalence of sarcopenia in elderly adults in the urban-rural transition zone of southern Pudong, Shanghai, and explore the association between lifestyle factors (with a focus on long-term farming history) and sarcopenia.</div></div><div><h3>Methods</h3><div>A cross-sectional study was conducted between January and November 2024, recruiting 654 community-dwelling individuals aged ≥ 60 years (mean age 69.43 ± 3.42 years) via convenience sampling from local health centers. Sarcopenia was diagnosed according to the 2023 Chinese Consensus criteria, based on assessments of muscle mass using bioelectrical impedance analysis (BIA), grip strength, and gait speed. Information on demographics, comorbidities, and pre-retirement primary occupation (categorized as farming vs. other non-farming) was collected through structured interviews. A farming lifestyle was defined as having engaged in agriculture as a primary occupation for at least 20 years. Multivariate logistic regression was used to identify independent factors associated with sarcopenia.</div></div><div><h3>Results</h3><div>The overall prevalence of sarcopenia was 6.42 % (42/654), with no significant difference between sexes (6.21 % in men vs. 6.63 % in women, <em>P</em> = 0.841). In univariate analysis, a history of farming (<em>P</em> &lt; 0.001) and diabetes (<em>P</em> &lt; 0.001) were significantly associated with sarcopenia. After adjusting for potential confounders in the multivariate logistic regression model, a long-term farming history emerged as a strong, independent protective factor against sarcopenia (adjusted Odds Ratio aOR = 0.050, 95 % Confidence Interval CI: 0.021–0.119, <em>P</em> &lt; 0.001). The association between diabetes and sarcopenia was no longer statistically significant in the adjusted model (aOR = 0.749, 95 % CI: 0.293–2.088, <em>P</em> = 0.545).</div></div><div><h3>Conclusion</h3><div>The prevalence of sarcopenia in this urban-rural transition zone is lower than in highly urbanized centers in China. A long-term farming lifestyle is strongly and independently associated with a reduced risk of sarcopenia in this population. This finding highlights the potential protective effects of traditional agricultural lifestyle patterns and suggests that public health strategies for sarcopenia prevention should prioritize integrated, activity-diverse, and culturally relevant interventions.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"95 ","pages":"Article 103268"},"PeriodicalIF":3.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145336480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Switching minds: A theoretical model of cognitive speed gaps, emotional reactivity, and behavioural self-regulation","authors":"Aloysius Tay","doi":"10.1016/j.ctim.2025.103273","DOIUrl":"10.1016/j.ctim.2025.103273","url":null,"abstract":"<div><h3>Objectives</h3><div>Although emotional dysregulation and behavioural impulsivity are common traits across clinical and non-clinical populations; current cognitive models frequently overlook the timing dynamics underlying such phenomena. This paper introduces the Tay Reactive-Reflective Processing Model (T-RRPM) to address this gap.</div></div><div><h3>Methods</h3><div>T-RRPM is a theoretical framework based on the mind-body interaction. It is a novel mechanism of emotional regulation failure: a cognitive speed mismatch between the fast-reacting subconscious mind and the slower, deliberative conscious mind. The model conceptualises the subconscious as a developmentally younger, emotionally reactive system akin to a “5 –10 year-old child”, and the conscious mind viewed as a rational Chief Executive Officer (CEO). When emotionally-salient stimuli are experienced, the subconscious responds rapidly with patterned emotional impulses, often before the conscious mind can reflect and intervene.</div></div><div><h3>Results</h3><div>This regulatory lag results in emotional flooding, impulsive behaviours, and internal conflict—even in individuals with insight or self-awareness. By foregrounding cognitive timing and subconscious age, T-RRPM contributes a mechanistic explanation of how emotional regulation often fails in real time.</div></div><div><h3>Conclusions</h3><div>The model offers testable hypotheses and practical applications across the fields of psychotherapy, education, trauma recovery, and behavioural coaching. T-RRPM also supports the development of timing-based self-regulation strategies, reframing reactive behaviour not as moral failure but as a remediable misalignment between inner systems. This paper contributes a novel conceptual mechanism for emotional regulation failure based on cognitive latency. This theoretical model has broad relevance across psychotherapy, trauma-informed practice, behavioural coaching, and integrative health modalities.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"95 ","pages":"Article 103273"},"PeriodicalIF":3.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145414216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Binaural beats for perioperative anxiety and pain: A systematic review and meta-analysis","authors":"Jialin Xiong,&nbsp;Xin Jiang,&nbsp;Binyang Cai,&nbsp;Li Zhao,&nbsp;Qiang Zhang,&nbsp;Jie Luo","doi":"10.1016/j.ctim.2025.103299","DOIUrl":"10.1016/j.ctim.2025.103299","url":null,"abstract":"<div><h3>Background</h3><div>Perioperative anxiety has a high prevalence, exacerbating hemodynamic fluctuations and postoperative pain. Compared with conventional music therapy, binaural beats (BB) audio distinctively modulates emotional pathways via cortical entrainment, potentially offering superior anxiolytic and analgesic efficacy in surgical settings.</div></div><div><h3>Objective</h3><div>This meta-analysis aimed to evaluate the effects of BB audio on perioperative anxiety, pain, and hemodynamic parameters in patients undergoing surgical procedures.</div></div><div><h3>Methods</h3><div>Randomized controlled trials (RCTs) published from database inception to December 2024 were retrieved from MEDLINE (via PubMed), Embase, Cochrane Central Register of Controlled Trials (CENTRAL), and Web of Science. Studies examining the effects of perioperative BB audio on anxiety, pain, and hemodynamic parameters in surgical patients were included. The primary outcome was anxiety levels (measured by standardized scales). Secondary outcomes included pain, changes in hemodynamic parameters (systolic blood pressure, diastolic blood pressure, and heart rate), and incidence of adverse events (nausea, vomiting, dizziness, hearing impairment, etc.).</div></div><div><h3>Results</h3><div>Out of 318 studies initially identified, 15 studies were included. Compared to blank audio controls, BB significantly reduced perioperative anxiety (14 trials, n = 1047; SMD = − 1.38, 95 % CI: − 1.89 to − 0.87, P &lt; 0.0001, I² = 91.6 %), postoperative pain (5 trials, n = 433; SMD = − 0.61, 95 % CI: − 1.03 to − 0.19, P = 0.0024, I² = 75.8 %), systolic blood pressure (6 trials, n = 436; MD = − 5.57 mmHg, 95 % CI: − 8.71 to − 2.44, P = 0.3041, I² = 17 %), and heart rate (MD = − 3.37 bpm, 95 % CI: − 5.45 to − 1.29, P = 0.3253, I² = 13.9 %), though effects on diastolic blood pressure were not significant (MD = − 2.33 mmHg, 95 % CI: −5.19 to 0.52, P = 0.0334, I² = 58.7 %). When compared to non-binaural beats (non-BB) audio, BB demonstrated superior reductions in anxiety (8 trials, n = 598; SMD = − 1.01, 95 % CI: − 1.99 to − 0.03, P &lt; 0.0001; I² = 95.4 %) and postoperative pain (3 trials, n = 265; SMD = − 0.52, 95 % CI: − 0.77 to − 0.28, P = 0.9235, I² = 0 %).</div></div><div><h3>Conclusion</h3><div>Perioperative BB audio significantly reduces anxiety, alleviates pain, and stabilizes key hemodynamic parameters (systolic blood pressure, heart rate), outperforming non-BB audio. BB audio represents a promising non-pharmacological intervention, though inter-trial heterogeneity was substantial. Protocol standardization requires further high-quality RCTs.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"95 ","pages":"Article 103299"},"PeriodicalIF":3.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145426444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical efficacy of chinese manual therapy for lumbar disc herniation: A systematic review and meta-analysis","authors":"De-ta Chen ,&nbsp;Hai-xia Zhu ,&nbsp;Zi-jian Wan ,&nbsp;Tian-you Fan ,&nbsp;Jing-liang Gu ,&nbsp;Xin-hua Zhan ,&nbsp;Xiao-ping Sheng","doi":"10.1016/j.ctim.2025.103285","DOIUrl":"10.1016/j.ctim.2025.103285","url":null,"abstract":"<div><h3>Objective</h3><div>To systematically evaluate and meta-analyze the clinical efficacy of manual therapy for lumbar disc herniation (LDH), with emphasis on its effects on pain relief, functional recovery, and inflammatory modulation.</div></div><div><h3>Methods</h3><div>A comprehensive search of both Chinese and international databases was performed to identify 47 randomized controlled trials (RCTs) of manual therapy for LDH. Meta-analyses were conducted using RevMan 5.4 and Stata 18.0. Primary outcomes included clinical effectiveness, pain scores, functional measures assessed by the Japanese Orthopaedic Association (JOA) score and the Oswestry Disability Index (ODI), and inflammatory cytokines (TNF-α, IL-1β, IL-6). Sensitivity analyses, publication bias assessment, and GRADE evidence grading were also performed.</div></div><div><h3>Results</h3><div>A total of 4480 patients were included. Manual therapy was associated with superior clinical effectiveness (RR = 1.20, 95 % CI: 1.15–1.25), significant reductions in pain scores (SMD = 1.23, 95 % CI: 0.98–1.49), and improved functional outcomes (JOA SMD = 1.42, 95 % CI: 1.07–1.77; mean ODI reduction: 14.47 points). Limited evidence also suggested reductions in inflammatory markers, including TNF-α (SMD = 2.25), IL-1β (SMD = 1.45), and IL-6 (SMD = 0.66). Sensitivity analyses confirmed robustness of the pooled results, while publication bias was minimal. According to GRADE, the certainty of evidence was moderate for pain relief and clinical effectiveness and low for other outcomes.</div></div><div><h3>Conclusion</h3><div>Manual therapy demonstrates consistent short-term benefits for patients with LDH across multiple domains, including pain, function, and inflammation. However, since most included trials were conducted in China and were of low-to-moderate methodological quality, the certainty of evidence should be considered moderate to low, and findings should be interpreted with caution. Further high-quality, multi-center international RCTs are warranted to strengthen the evidence base.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"95 ","pages":"Article 103285"},"PeriodicalIF":3.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145430602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of lumbar spinal manipulation on pain and quadriceps strength in patellofemoral pain syndrome: A randomized controlled trial","authors":"Jinhee Won ,&nbsp;Yongwoo Lee","doi":"10.1016/j.ctim.2025.103301","DOIUrl":"10.1016/j.ctim.2025.103301","url":null,"abstract":"<div><h3>Background</h3><div>Patellofemoral pain syndrome (PFPS) is a prevalent musculoskeletal condition associated with anterior knee pain and functional limitations. Conventional conservative approaches such as exercise and taping often provide inconsistent relief. Spinal manipulation, a manual therapy technique frequently used in complementary medicine, has demonstrated neurophysiological effects on pain modulation and motor control, but its application in PFPS remains underexplored.</div></div><div><h3>Objective</h3><div>This randomized controlled trial investigated the effects of lumbar spinal manipulation on pain and quadriceps strength in individuals with PFPS.</div></div><div><h3>Methods</h3><div>Thirty participants with clinically diagnosed PFPS were randomly allocated to a lumbar spinal manipulation group (n = 15) or a placebo group (n = 15). Interventions were administered twice weekly for four weeks. Outcome measures included pressure pain threshold, knee joint position sense, dynamic balance (Y-balance test), and quadriceps strength, assessed pre- and post-intervention. Paired and independent t-tests were used for within- and between-group comparisons (p &lt; 0.05).</div></div><div><h3>Results</h3><div>Significant within-group improvements were observed in all outcomes except proprioception at 60° in the manipulation group, and in all but proprioception in the placebo group (p &lt; 0.05). Compared to placebo, lumbar spinal manipulation resulted in significantly greater improvements in pain reduction and quadriceps muscle strength (p &lt; 0.05). No significant between-group differences were noted in proprioception or dynamic balance.</div></div><div><h3>Conclusion</h3><div>Lumbar spinal manipulation appears to be an effective intervention for alleviating pain and enhancing quadriceps strength in patients with PFPS. Although its impact on proprioception and balance was limited, the findings support its clinical relevance in integrative management strategies for PFPS.</div></div><div><h3>Trial Registration</h3><div>Korea Clinical Trial Registry (KCT0010483)</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"95 ","pages":"Article 103301"},"PeriodicalIF":3.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145430582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}