Complementary therapies in medicine最新文献

{"title":"Effects of dance intervention on health-related outcomes in patients with depression in Mainland China: A network meta-analysis","authors":"Lili Mo ,&nbsp;Diying Liao ,&nbsp;Jianwei She ,&nbsp;Bangbang Yan ,&nbsp;Maowei Chen","doi":"10.1016/j.ctim.2025.103253","DOIUrl":"10.1016/j.ctim.2025.103253","url":null,"abstract":"<div><h3>Objective</h3><div>The objective of this study was to systematically analyze the effects of different dance or dance integrated with other modalities on depressed patients in China to identify the most effective dance-based intervention.</div></div><div><h3>Methods</h3><div>Eight databases were searched for screening randomized controlled trials. Quality assessment was performed with the Rob-2 and network meta-analysis was conducted with Stata 17.0.</div></div><div><h3>Results</h3><div>Nineteen studies were included. Dance movement therapy(DMT) combined with Chinese dance elements(CDE) was ranked as the most effective intervention for depression (SUCRA=99.7 %). DMT combined with drugs was the most effective intervention for anxiety (SUCRA=87.7 %) and self-efficacy (SUCRA=78.8 %). Drawing therapy combined with dance intervention and drugs was the most effective intervention for improving quality of life (SUCRA=98.2 %). DMT combined with psychological intervention and drugs was the most effective intervention for positive coping (SUCRA=90.9 %). Egger’s test confirmed the robustness of this research.</div></div><div><h3>Conclusions</h3><div>DMT combined with CDE demonstrated the highest efficacy in improving depression, highlighting the importance of incorporating regional culture into dance therapy. DMT combined with drugs showed the most substantial improvements in anxiety and self-efficacy, reinforcing the recommendation that patients should keep pharmacological treatment. Drawing therapy combined with dance intervention and drugs had the most significant impact on quality of life, suggesting that patients should be encouraged to do more activities. DMT combined with psychological intervention and drugs was the most effective for positive coping. This indicates that psychological counseling is also important. To address multifaceted challenges, targeted intervention should be developed to meet diverse and complex needs comprehensively for patients.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"94 ","pages":"Article 103253"},"PeriodicalIF":3.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145217444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multidimensional factors associated with treatment adherence in Type II diabetes: The roles of spiritual well-being and mindfulness","authors":"Bugse Yuceer ,&nbsp;Fatma Ilknur Cinar","doi":"10.1016/j.ctim.2025.103251","DOIUrl":"10.1016/j.ctim.2025.103251","url":null,"abstract":"<div><h3>Background and purpose</h3><div>Type II Diabetes Mellitus (DM) is a multifaceted, chronic metabolic condition requiring persistent adherence to treatment for effective management. Previous research has largely emphasized medical and behavioral determinants of adherence, while psychological and spiritual factors remain underexplored. Addressing this gap, the present study examines multidimensional factors associated with treatment adherence among individuals with Type II DM, within the framework of the Multidimensional Adherence Model (MAM), with a particular focus on the roles of mindfulness and spiritual well-being.</div></div><div><h3>Materials and methods</h3><div>A cross-sectional design was employed, involving 125 patients with Type II DM. Data were collected based on five dimensions within the MAM framework. The study utilized validated instruments, including the Patient Information Form, Mindful Attention Awareness Scale, Functional Assessment of Chronic Illness Therapy–Spiritual Well-Being Scale, Treatment Adherence in Type II DM Scale. The data were analysed using descriptive and correlational statistics and structural equation modelling. In this hypothesized model, the independent variable was mindfulness, the mediator was spiritual well-being, and the dependent variable was treatment adherence.</div></div><div><h3>Results</h3><div>Treatment adherence was significantly related to patient-related, socio-economic, healthcare system, and condition-related factors. Higher levels of mindfulness and spiritual well-being were positively associated with improved adherence behaviors. Notably, spiritual well-being demonstrated statistically significant indirect association in the link between mindfulness and treatment adherence.</div></div><div><h3>Conclusion</h3><div>This study highlights the need for a patient-centered approach to Type II DM care, integrating psychological and spiritual dimensions alongside medical management. Mindfulness and spiritual well-being emerged as key correlates of adherence, emphasizing the importance of holistic care in diabetes treatment.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"94 ","pages":"Article 103251"},"PeriodicalIF":3.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of massage therapy for constipation in children with cerebral palsy: A systematic review and meta-analysis","authors":"Mengqi Li ,&nbsp;Guorui Ding ,&nbsp;Ruobing Lan ,&nbsp;Yu Li ,&nbsp;Shuying Guan ,&nbsp;Xiaolei Lu ,&nbsp;Yuxing Zhang ,&nbsp;Duo Zhao","doi":"10.1016/j.ctim.2025.103254","DOIUrl":"10.1016/j.ctim.2025.103254","url":null,"abstract":"<div><h3>Background</h3><div>Constipation affects 75 % of children with cerebral palsy (CP). While massage is a safe non-invasive intervention, its clinical adoption remains limited due to insufficient evidence of its efficacy.</div></div><div><h3>Objective</h3><div>To evaluate the efficacy and safety of massage for CP-related constipation through meta-analysis.</div></div><div><h3>Methods</h3><div>Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we searched seven databases for randomised controlled trials (RCTs) on pediatric CP-related constipation treated with massage. Eligible RCTs underwent Cochrane risk-of-bias assessment. Meta-analysis using Stata evaluated the overall efficacy, defecation parameters, and heterogeneity sources.</div></div><div><h3>Results</h3><div>A total of 11 RCTs involving 728 patients were included. The results of the meta-analysis showed that, compared with traditional therapy alone, massage was more effective in treating constipation in children with CP. This difference was statistically significant (<em>p &lt; 0.05</em>), as evaluated by the overall effective rate (RR, Relative Risk = 1.23; 95 % CI, 95 % Confidence Interval = 1.14, 1.33), defecation frequency (MD, Mean Difference = 1.57; 95 % CI = 0.40, 2.75), defecation time (MD = -3.23; 95 % CI = -3.82, -2.64), and stool form score (SMD, Standardized Mean Difference = 0.66; 95 % CI = 0.39, 0.94), confirming the superior efficacy of massage over conventional therapy. However, both interventions showed comparable effects on defecation difficulty (<em>p &gt; 0.05</em>). The baseline patient characteristics, duration and techniques of the massage, and efficacy of the control group intervention may be the sources of heterogeneity.</div></div><div><h3>Conclusion</h3><div>Massage therapy improves constipation symptoms in children with CP. These results require validation through larger, high-quality RCTs given the sample size limitations of the current study.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"94 ","pages":"Article 103254"},"PeriodicalIF":3.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145250174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcutaneous auricular vagus nerve stimulation for functional dyspepsia: A systematic review and meta-analysis","authors":"Boram Lee ,&nbsp;Chan-Young Kwon ,&nbsp;Yoon Kyoung Jeong ,&nbsp;Roberta Sclocco ,&nbsp;Braden Kuo ,&nbsp;Vitaly Napadow ,&nbsp;Jun-Hwan Lee ,&nbsp;Hojun Kim","doi":"10.1016/j.ctim.2025.103243","DOIUrl":"10.1016/j.ctim.2025.103243","url":null,"abstract":"<div><h3>Background</h3><div>Transcutaneous auricular vagus nerve stimulation (taVNS) is a potential noninvasive treatment for functional dyspepsia (FD). We aimed to systematically analyze the clinical evidence of taVNS for FD.</div></div><div><h3>Methods</h3><div>Eight databases were searched to identify randomized controlled trials (RCTs) using taVNS in patients with FD published by June 27, 2024. The primary outcome was dyspepsia symptoms, whereas the secondary outcomes were the total effective rate (TER), quality of life, anxiety, depression, and incidence of adverse events. The certainty of the evidence was assessed using the GRADE methodology. Detailed information on the taVNS parameters and the suggested underlying mechanism were also extracted.</div></div><div><h3>Results</h3><div>Six RCTs with 716 participants were included. Compared to the sham intervention, taVNS significantly improved dyspepsia symptoms, quality of life, and clinician-rated anxiety and depression with moderate certainty of evidence. The TER based on dyspepsia symptoms was also significantly higher with high certainty of evidence. When taVNS was used as an add-on therapy, dyspepsia symptoms were significantly improved with moderate certainty of evidence. No serious adverse events related to taVNS were reported. The stimulation sites for taVNS were concha and tragus, with common pulse frequencies of 25 or 20 Hz twice a day for 2–4 weeks. Gastric accommodation, electrogastrogram, heart rate variability, and functional magnetic resonance imaging were measured to explore the mechanism of taVNS.</div></div><div><h3>Conclusions</h3><div>Considering the certainty of the evidence, taVNS can improve dyspepsia symptoms, quality of life, anxiety, and depression in patients with FD without serious adverse events. Additional high-quality studies are needed to establish optimal treatment protocols.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"94 ","pages":"Article 103243"},"PeriodicalIF":3.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How important are meditation and spirituality in Reiki practice?","authors":"Ann Linda Baldwin ,&nbsp;Vicky McLelland ,&nbsp;Duncan Cross ,&nbsp;Nicole Braveman","doi":"10.1016/j.ctim.2025.103246","DOIUrl":"10.1016/j.ctim.2025.103246","url":null,"abstract":"<div><h3>Objective</h3><div>Meditation and spirituality can enhance the well-being of allopathic healthcare providers and the quality of care they deliver but little is known about holistic healers, such as Reiki practitioners. Two surveys were developed to ascertain whether Reiki practitioners routinely use meditative and spiritual disciplines to strengthen their practice.</div></div><div><h3>Method</h3><div>The surveys were promoted through email using Mailchimp and Facebook to all members of UK Reiki Federation (about 1800) and through several other Facebook groups with a global reach. An online survey tool, SurveyMonkey, was used to collect the survey data and MS Excel to analyze it.</div></div><div><h3>Results</h3><div>Most respondents were white, heterosexual females, middle aged or older, residing in the UK or USA, trained to Reiki Master level. Over one third were Christian and another third affiliated with various non-established beliefs. Most participants experienced a spiritual connection when they practiced Reiki, which opened them to a higher power, and they thought this connection enhanced their self-development. Seventy-nine percent believed that Reiki spirit guides provide personal guidance, support, and assistance. Ninety-five percent meditated weekly from one to seven times a week and most believed that meditation increased their connection and ability to channel, Reiki.</div></div><div><h3>Conclusion</h3><div>Most respondents to the surveys routinely use meditation and spiritual connection to strengthen their Reiki practice and enhance their ability to channel Reiki to patients or clients. This information may stimulate inclusion of meditation and spirituality in the training of holistic healthcare professionals and help them communicate more effectively with their clients.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"94 ","pages":"Article 103246"},"PeriodicalIF":3.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI-assisted drawing therapy for children with ADHD: A randomised controlled trial","authors":"Jing Xu ,&nbsp;Runqing Lin ,&nbsp;Aijia Zhang ,&nbsp;Qiang Chen ,&nbsp;Dexin Li ,&nbsp;Jiajie Chen ,&nbsp;Minglu Song ,&nbsp;Shumei Chen ,&nbsp;Bingjiao Yang ,&nbsp;Linyang Li ,&nbsp;Haotian Xu ,&nbsp;Jinlin Peng ,&nbsp;Yanrong Tang ,&nbsp;Wenhua Yang ,&nbsp;Xuexing Luo ,&nbsp;Xiang Zhou ,&nbsp;Jue Wang ,&nbsp;Guanghui Huang","doi":"10.1016/j.ctim.2025.103262","DOIUrl":"10.1016/j.ctim.2025.103262","url":null,"abstract":"<div><h3>Objective</h3><div>This randomized controlled trial evaluated the efficacy of AI-assisted drawing therapy for children with ADHD, comparing its impact on core symptoms and functional impairments against traditional drawing interventions while assessing engagement and the rapeuticoutcomes.</div></div><div><h3>Methods</h3><div>Forty-one children (ages 7–10) with ADHD were randomized into AI-assisted (n = 19) or traditional drawing therapy (n = 22) groups (Trial registered in ChiCTR: ChiCTR2400089640). The AI intervention employed a process that captured children's drawings, converted them into keywords, generated AI responses based on those keywords, and provided feedback to the children, while the control group received therapist-guided verbal feedback. SNAP-IV-26(Swanson, Nolan and Pelham-IV rating scales) and WFIRS-P(Weiss Functional Impairment Rating Scales-Parent) scales assessed at baseline (T1) and post-intervention (T2) at a 24-week interval, with data analyzed using independent t-tests (p &lt; 0.05).</div></div><div><h3>Results</h3><div>Both AI-assisted and traditional drawing therapies significantly reduced core ADHD symptoms. In the before-and-after comparison within the group, the AI group showed targeted improvements in attention (p = 0.039) and oppositional defiant behaviour (p = 0.025), while traditional therapy produced broader symptom reductions across all domains (p &lt; 0.05). Between-group comparisons showed that the AI-assisted group achieved greater improvement in inattention (Δ = −1.09, p = 0.035), whereas the traditional drawing group improved more on oppositional defiant behavior (Δ=+1.706, p = 0.010) and the SNAP-IV total score (Δ=+4.777, p = 0.041). On the WFIRS-P, the AI group showed advantages for the Family domain (p = 0.041) and the total score (p = 0.047), while Self-Concept favored the traditional drawing group (p = 0.036).</div></div><div><h3>Conclusion</h3><div>AI-assisted, drawing-based art therapy produced greater improvement in the pre-specified primary outcome (SNAP-IV inattention) and select WFIRS-P domains (e.g., Family, total score), whereas conventional drawing therapy yielded broader reductions in oppositional defiant symptoms and the overall SNAP-IV severity. Effects were modest and domain-specific; larger, multi-center trials are needed to confirm efficacy and identify which children benefit most.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"94 ","pages":"Article 103262"},"PeriodicalIF":3.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145298973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor regarding “Effects of intermittent fasting diet in overweight and obese postmenopausal women with rheumatoid arthritis: A randomized controlled clinical trial” by Ranjbar et al.","authors":"Zhe-Kai Ying,&nbsp;Tian-Chen Lin,&nbsp;Jian-Nong Wu","doi":"10.1016/j.ctim.2025.103248","DOIUrl":"10.1016/j.ctim.2025.103248","url":null,"abstract":"","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"94 ","pages":"Article 103248"},"PeriodicalIF":3.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145106554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of aromatherapy on sleep quality in hospitalized cardiac patients: A systematic review and meta-analysis of randomized controlled trials","authors":"Cui Ye ,&nbsp;Xuan Huang ,&nbsp;Ziyu Wang ,&nbsp;Shufang Zuo ,&nbsp;Lu Lin","doi":"10.1016/j.ctim.2025.103247","DOIUrl":"10.1016/j.ctim.2025.103247","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate the effects of aromatherapy on sleep quality in hospitalized cardiac patients, taking into account factors such as participant age, type of essential oil, dosage, treatment duration, and daily frequency of use.</div></div><div><h3>Methods</h3><div>A systematic search and screening of literature on the effects of aromatherapy on sleep quality in hospitalized cardiac patients, published as randomized controlled trials (RCTs) in Chinese and English from inception to 8 August, 2025, was conducted across eight databases, including PubMed, Web of Science, Embase, Cochrane Library, CNKI, CBM, VIP, and Wanfang. The methodological quality of the included studies was independently and critically assessed by two reviewers using the Cochrane Risk of Bias Assessment Tool for RCTs. Relevant data were extracted using pre-designed forms and analyzed with STATA 17.0.</div></div><div><h3>Results</h3><div>A total of nine studies comprising 13 trials with 740 hospitalized cardiac patients were included. The results indicated that aromatherapy with single essential oils was moderately effective in improving sleep quality in these patients [SMD = -0.74, 95 % CI (-1.06, − 0.42), <em>p</em> = 0.003]. Subgroup analyses revealed significant improvements when patients were aged ≥ 60 years [SMD = -1.08, 95 %CI (-1.91,-0.24), P = 0.012], when Rosa damascena essential oil was used [SMD = -1.43, 95 %CI (-2.73,-0.13), P = 0.031], when the dosage was &gt; 3 drops [SMD = -1.10, 95 %CI (-1.87,-0.32), P = 0.005], or when the treatment duration was ≥ 3 days [SMD = -0.99, 95 %CI (-1.59,-0.38), P = 0.001]. No adverse events were reported.</div></div><div><h3>Conclusion</h3><div>This study reveals that single essential oils are effective in improving sleep quality in hospitalized cardiac patients and can be recommended as a complementary therapy to improve sleep quality in this population.</div></div><div><h3>Registration</h3><div>PROSPERO: CRD42024535895.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"94 ","pages":"Article 103247"},"PeriodicalIF":3.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Baduanjin on cognitive performance and upper limb function in patients receiving chemotherapy after breast cancer surgery: A randomized controlled trial","authors":"Xiaolin Wei ,&nbsp;Dan Liu ,&nbsp;Ruzhen Yuan ,&nbsp;Wei Zheng ,&nbsp;Kunpeng Li ,&nbsp;Caiqin Wu","doi":"10.1016/j.ctim.2025.103252","DOIUrl":"10.1016/j.ctim.2025.103252","url":null,"abstract":"<div><h3>Background</h3><div>Post-operative breast cancer patients undergoing chemotherapy frequently experience concurrent upper limb dysfunction and chemotherapy-related cognitive impairment, creating a synergistic burden that complicates rehabilitation. Existing interventions often target these issues in isolation. Baduanjin, a traditional Chinese mind-body exercise, integrates physical movement with cognitive engagement, making it a promising candidate for addressing both domains simultaneously. However, robust evidence from randomized controlled trials (RCTs) was lacking. This RCT aimed to evaluate the effects of Baduanjin on both cognitive performance and upper limb function in this population.</div></div><div><h3>Methods</h3><div>A two-arm, randomized controlled trial was conducted. Seventy women diagnosed with breast cancer and scheduled for chemotherapy were randomly assigned to either a 12-week supervised Baduanjin exercise group or a control group receiving usual care. Subjective cognitive function was assessed using the Functional Assessment of Cancer Therapy-Cognitive Function (FACT-Cog). The neuropsychological test battery included the Auditory Verbal Learning Test (AVLT), the Trail Making Test (TMT), and the Digit Symbol Substitution Test (DSST). Upper limb function was assessed using the Constant-Murley Score (CMS). All assessments were performed at baseline (T0), Week 4 (T1), Week 8 (T2), and Week 12 (T3).</div></div><div><h3>Results</h3><div>Compared to the control group, the Baduanjin group demonstrated significant improvements in total FACT-Cog scores (<em>F</em>=17.710, <em>p</em> &lt; 0.001), perceived cognitive impairments (<em>F</em>=20.085, <em>p</em> &lt; 0.001), and perceived cognitive abilities (<em>F</em>=5.116, <em>p</em> = 0.027). A statistically significant group effect was observed for AVLT6 (<em>F</em>=13.862, <em>p</em> &lt; 0.001). In addition, significant differences were observed between the two groups in shoulder function (<em>p</em> = 0.004, 95 % CI: 1.09, 5.59) and ROM (<em>p</em> = 0.002, 95 % CI: 0.87, 3.98).</div></div><div><h3>Conclusion</h3><div>A 12-week Baduanjin exercise intervention significantly improved subjective cognitive complaints and shoulder function in breast cancer patients undergoing post-operative chemotherapy. The findings support Baduanjin as a safe, feasible, and beneficial adjunct therapy that can concurrently address two prevalent and distressing sequelae of breast cancer treatment.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"94 ","pages":"Article 103252"},"PeriodicalIF":3.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145224987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spirulina’s impacts on cardiovascular health: Insights from a systematic meta-analysis of RCT","authors":"Hamidreza Shiri ,&nbsp;Ali Akbar Soleimani ,&nbsp;Behnam Omidi Sarajar ,&nbsp;Abdolkarim Talebi Taheri ,&nbsp;Fataneh Esmaeili ,&nbsp;Mohammad Hadi Nematollahi ,&nbsp;Mahmood Alizadeh Sani","doi":"10.1016/j.ctim.2025.103242","DOIUrl":"10.1016/j.ctim.2025.103242","url":null,"abstract":"<div><h3>Introduction</h3><div>CVDs are considered the major public health concern and mortality in the world. Common treatments have some side effects and require low-risk treatments, such as herbal medicine. Spirulina is a filamentous microalga that has improved cardiometabolic parameters.</div></div><div><h3>Methods</h3><div>Systematic searches were conducted in Scopus, ISI Web of Science, and PubMed/Medline databases up to 20 January 2025 to identify RCTs based on the PRISMA checklist and PICOS criteria (People &gt; 18 years, Intervention: spirulina, Comparison: placebo /control, Outcomes: TG, TC, LDL-C, HDL-C, FBG, HbA1c, insulin, HOMA-IR, SBP, DBP, BMI, weight, hs-CRP, IL-6, TNF-α, and Study: RCTs). Meta- analysis was utilized by random-effects models, and the GRADE criteria ensured the certainty of results.</div></div><div><h3>Result</h3><div>The results of 35 trials (45 effect sizes) show that spirulina intake improved glucose homeostasis (FBG; WMD: −5.51 (mg/dl); <em>P</em> = 0.001, HOMA-IR; WMD: −0.68; <em>P</em> &lt; 0.001, and insulin; WMD: −0.86 (ng/ml); <em>P</em> = 0.002), decreased dyslipidemia (TG; WMD: −14.75 (mg/dl); <em>P</em> &lt; 0.001, TC: WMD: −11.5 (mg/dl); <em>P</em> &lt; 0.001, LDL-C; WMD: −7.69 (mg/dl); <em>P</em> &lt; 0.001, and HDL-C; WMD: 1.9 (mg/dl); <em>P</em> &lt; 0.001), decreased blood pressure (SBP; WMD: −3.85 mmHg, <em>P</em> = 0.002, and DBP; WMD: −3.09 mmHg, <em>P</em> &lt; 0.001), reduced anthropometric indexes (weight; WMD: −1.78 kg; <em>P</em> = 0.003, and BMI; WMD: −0.58 kg/m²; <em>P</em> = 0.001), and decreased inflammation (TNF-α; WMD: −0.46 pg/ml; <em>P</em> = 0.01, IL-6; WMD: −0.58 pg/ml; <em>P</em> &lt; 0.001, and hs-CRP; WMD: −0.86 mg/L; <em>P</em> = 0.002). Based on GRADE analysis, LDL-C, FBG, and HbA1c had of low quality, while the outcome for weight was of high quality. Furthermore, other parameters had moderate-quality outcomes.</div></div><div><h3>Conclusion</h3><div>This study demonstrates that spirulina supplementation effectively reduces the risk of CVD in adults by improving glucose homeostasis, dyslipidemia, blood pressure, anthropometric indexes, and inflammation. So, intake of spirulina is an adjunct or complementary to improve cardiometabolic profiles.</div></div><div><h3>Trial registration</h3><div>PROSPERO registration cod: (CRD42024626090)</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"94 ","pages":"Article 103242"},"PeriodicalIF":3.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145059937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}