治疗间质性肺病患者呼吸困难的在线正念干预（eMBI）：随机临床试验。

IF 3.3 3区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Complementary therapies in medicine Pub Date : 2024-10-31 DOI:10.1016/j.ctim.2024.103106

Siliana Maria Duarte Miranda , Sara de Pinho Cunha Paiva , Luiz Fernando Ferreira Pereira , Gabriela Patrus Ananias de Assis Pires , Andrew Nogueira Albuquerque Leal , Giane Amorim Ribeiro-Samora , Eliane Viana Mancuzo

{"title":"治疗间质性肺病患者呼吸困难的在线正念干预（eMBI）：随机临床试验。","authors":"Siliana Maria Duarte Miranda , Sara de Pinho Cunha Paiva , Luiz Fernando Ferreira Pereira , Gabriela Patrus Ananias de Assis Pires , Andrew Nogueira Albuquerque Leal , Giane Amorim Ribeiro-Samora , Eliane Viana Mancuzo","doi":"10.1016/j.ctim.2024.103106","DOIUrl":null,"url":null,"abstract":"<div><h3>Rationale</h3><div>Dyspnea and cough are frequent symptoms in ILD patients. The management of these symptoms is challenging, and evidence-based therapies are lacking.</div></div><div><h3>Objectives</h3><div>To evaluate the effect of an online Mindfulness-Based Intervention (eMBI) on reducing dyspnea in patients affected by different ILDs.</div></div><div><h3>Methods</h3><div>This study was a prospective, open-label, controlled trial that included patients ≥18 years and a modified Medical Research Council (mMRC) dyspnea scale score of ≥ 1. Patients were randomized into either the eMBI or the control group (CG) for 8 weeks. The primary outcome was the change in the dyspnea mMRC scale. The Leicester Cough Questionnaire (LCQ), King's Brief Interstitial Lung Disease (K-BILD) questionnaire, and Depression, Anxiety, and Stress Scale (DASS-21) were performed before and after the eight weeks. All analyses were conducted on an intention-to-treat basis. The study was registered at the Brazilian Registry of Clinical Trials (ReBEC), RBR-3s4mf9y.</div></div><div><h3>Results</h3><div>24 patients in the eMBI and 25 in the CG completed the intervention. In the eMBI group, compared to the control group, there was a greater proportion of patients with a reduction in dyspnea according to the mMRC scale score (48.9 % versus, 15.4 %, p = 0.001). There was no significant difference between the groups in the LCQ (p = 0.666), or in the K-BILD (p = 0.108), depression (p = 0.08), or anxiety (p = 0.869 or stress (p = 0.789). No moderate or severe adverse events were observed in either group.</div></div><div><h3>Conclusions</h3><div>Eight weeks eMBI is a potentially viable and safe approach, that can help manage dyspnea in ILD patients.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"87 ","pages":"Article 103106"},"PeriodicalIF":3.3000,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Online Mindfulness-Based Intervention (eMBI) in management of dyspnea in patients with interstitial lung disease: A randomized clinical trial\",\"authors\":\"Siliana Maria Duarte Miranda , Sara de Pinho Cunha Paiva , Luiz Fernando Ferreira Pereira , Gabriela Patrus Ananias de Assis Pires , Andrew Nogueira Albuquerque Leal , Giane Amorim Ribeiro-Samora , Eliane Viana Mancuzo\",\"doi\":\"10.1016/j.ctim.2024.103106\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Rationale</h3><div>Dyspnea and cough are frequent symptoms in ILD patients. The management of these symptoms is challenging, and evidence-based therapies are lacking.</div></div><div><h3>Objectives</h3><div>To evaluate the effect of an online Mindfulness-Based Intervention (eMBI) on reducing dyspnea in patients affected by different ILDs.</div></div><div><h3>Methods</h3><div>This study was a prospective, open-label, controlled trial that included patients ≥18 years and a modified Medical Research Council (mMRC) dyspnea scale score of ≥ 1. Patients were randomized into either the eMBI or the control group (CG) for 8 weeks. The primary outcome was the change in the dyspnea mMRC scale. The Leicester Cough Questionnaire (LCQ), King's Brief Interstitial Lung Disease (K-BILD) questionnaire, and Depression, Anxiety, and Stress Scale (DASS-21) were performed before and after the eight weeks. All analyses were conducted on an intention-to-treat basis. The study was registered at the Brazilian Registry of Clinical Trials (ReBEC), RBR-3s4mf9y.</div></div><div><h3>Results</h3><div>24 patients in the eMBI and 25 in the CG completed the intervention. In the eMBI group, compared to the control group, there was a greater proportion of patients with a reduction in dyspnea according to the mMRC scale score (48.9 % versus, 15.4 %, p = 0.001). There was no significant difference between the groups in the LCQ (p = 0.666), or in the K-BILD (p = 0.108), depression (p = 0.08), or anxiety (p = 0.869 or stress (p = 0.789). No moderate or severe adverse events were observed in either group.</div></div><div><h3>Conclusions</h3><div>Eight weeks eMBI is a potentially viable and safe approach, that can help manage dyspnea in ILD patients.</div></div>\",\"PeriodicalId\":10545,\"journal\":{\"name\":\"Complementary therapies in medicine\",\"volume\":\"87 \",\"pages\":\"Article 103106\"},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2024-10-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Complementary therapies in medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0965229924000943\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"INTEGRATIVE & COMPLEMENTARY MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Complementary therapies in medicine","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0965229924000943","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"INTEGRATIVE & COMPLEMENTARY MEDICINE","Score":null,"Total":0}

引用次数: 0

摘要

理由：呼吸困难和咳嗽是 ILD 患者经常出现的症状。这些症状的治疗具有挑战性，而且缺乏循证疗法：评估在线正念干预（eMBI）对减轻不同 ILD 患者呼吸困难的效果：本研究是一项前瞻性、开放标签、对照试验，研究对象包括年龄≥18岁、改良医学研究委员会（mMRC）呼吸困难量表评分≥1分的患者。患者被随机分配到 eMBI 或对照组（CG），为期 8 周。主要结果是呼吸困难 mMRC 量表的变化。八周前和八周后分别进行了莱斯特咳嗽问卷（LCQ）、国王间质性肺病简明问卷（K-BILD）以及抑郁、焦虑和压力量表（DASS-21）。所有分析均在意向治疗的基础上进行。研究在巴西临床试验注册中心（ReBEC）注册，编号为RBR-3s4mf9y。结果：24名eMBI患者和25名CG患者完成了干预。与对照组相比，根据 mMRC 量表评分，eMBI 组呼吸困难减轻的患者比例更高（48.9% 对 15.4%，p = 0.001）。两组患者在 LCQ（p = 0.666）、K-BILD（p = 0.108）、抑郁（p = 0.08）或焦虑（p = 0.869 或压力（p = 0.789）方面没有明显差异。两组患者均未出现中度或严重不良反应：为期八周的 eMBI 是一种潜在可行且安全的方法，有助于控制 ILD 患者的呼吸困难。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Online Mindfulness-Based Intervention (eMBI) in management of dyspnea in patients with interstitial lung disease: A randomized clinical trial

Rationale

Dyspnea and cough are frequent symptoms in ILD patients. The management of these symptoms is challenging, and evidence-based therapies are lacking.

Objectives

To evaluate the effect of an online Mindfulness-Based Intervention (eMBI) on reducing dyspnea in patients affected by different ILDs.

Methods

This study was a prospective, open-label, controlled trial that included patients ≥18 years and a modified Medical Research Council (mMRC) dyspnea scale score of ≥ 1. Patients were randomized into either the eMBI or the control group (CG) for 8 weeks. The primary outcome was the change in the dyspnea mMRC scale. The Leicester Cough Questionnaire (LCQ), King's Brief Interstitial Lung Disease (K-BILD) questionnaire, and Depression, Anxiety, and Stress Scale (DASS-21) were performed before and after the eight weeks. All analyses were conducted on an intention-to-treat basis. The study was registered at the Brazilian Registry of Clinical Trials (ReBEC), RBR-3s4mf9y.

Results

24 patients in the eMBI and 25 in the CG completed the intervention. In the eMBI group, compared to the control group, there was a greater proportion of patients with a reduction in dyspnea according to the mMRC scale score (48.9 % versus, 15.4 %, p = 0.001). There was no significant difference between the groups in the LCQ (p = 0.666), or in the K-BILD (p = 0.108), depression (p = 0.08), or anxiety (p = 0.869 or stress (p = 0.789). No moderate or severe adverse events were observed in either group.

Conclusions

Eight weeks eMBI is a potentially viable and safe approach, that can help manage dyspnea in ILD patients.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Complementary therapies in medicine 医学-全科医学与补充医学

CiteScore

8.60

自引率

2.80%

发文量

101

审稿时长

112 days

期刊介绍： Complementary Therapies in Medicine is an international, peer-reviewed journal that has considerable appeal to anyone who seeks objective and critical information on complementary therapies or who wishes to deepen their understanding of these approaches. It will be of particular interest to healthcare practitioners including family practitioners, complementary therapists, nurses, and physiotherapists; to academics including social scientists and CAM researchers; to healthcare managers; and to patients. Complementary Therapies in Medicine aims to publish valid, relevant and rigorous research and serious discussion articles with the main purpose of improving healthcare.