Complementary therapies in medicine最新文献

{"title":"The safety and effectiveness of tDCS for epileptic patients: A systematic review and meta-analysis","authors":"Xiao-Tong Ding ,&nbsp;Ming-Yu Hu ,&nbsp;Chi Wang ,&nbsp;Wei-Ye Kang ,&nbsp;Jin-Zhao Huang ,&nbsp;Rui-Yu Wang ,&nbsp;Qiu-Song Shen ,&nbsp;Hou-Ming Kan","doi":"10.1016/j.ctim.2025.103142","DOIUrl":"10.1016/j.ctim.2025.103142","url":null,"abstract":"<div><h3>Background and purpose</h3><div>Although transcranial direct current stimulation (tDCS) has been used in the treatment of epilepsy for many years, further research is needed on the efficacy and safety of tDCS treatment. This systematic review and meta-analysis aimed to explore the effectiveness of tDCS on seizure frequency (SF), epileptiform discharges, depression, anxiety, and cognitive function in epilepsy.</div></div><div><h3>Materials and methods</h3><div>We searched the Cochrane Library, PubMed, Embase, Scopus, and Web of Science databases from inception to 9 September 2024. The primary outcomes included SF. The secondary outcomes included epileptiform discharges, depression, anxiety, cognitive function, and adverse events. The meta-analysis was conducted using Review Manager 5.4 software.</div></div><div><h3>Results</h3><div>12 trials were included, 356 participants (219 in the tDCS group and 137 in the sham group). Among the included studies, three were of high risk, two were of some concern, and seven were of low risk. For the primary outcome metrics, tDCS can reduce the frequency of epileptic seizures (SMD = − 0.63, 95 % CI = [-0.90, − 0.36], <em>P</em> <em>&lt;</em> 0.00001). For secondary outcome measures, there are no statistical differences between the tDCS group and the sham group in epileptiform discharges (SMD = − 0.27, 95 % CI = [-0.71, 0.16], <em>P</em> = 0.22) and adverse events (MD = 1.30, 95 % CI = [0.49, 3.45], <em>P</em> = 0.60). The outcomes of tDCS treatment for depression and anxiety were inconsistent. tDCS did not enhance or impair cognitive function.</div></div><div><h3>Conclusion</h3><div>tDCS can reduce SF but has no effect on epileptiform discharges in patients with epilepsy. The current evidence is limited to support tDCS treatment for depression, anxiety, and cognitive function in epilepsy patients. Future studies should be standardized and personalized, ensure higher methodological rigor, and probe long-term effects to prove the findings further.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"89 ","pages":"Article 103142"},"PeriodicalIF":3.3,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143179608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of Snoezelen intervention on problem behaviors in children with cerebral palsy: A randomized controlled trial","authors":"Mina Kim ,&nbsp;Sook-Hee Yi ,&nbsp;Jee-Sun Lee ,&nbsp;Ji-Young Lee ,&nbsp;Yun-Tae Hwang ,&nbsp;Jeong-Soo Kim","doi":"10.1016/j.ctim.2025.103139","DOIUrl":"10.1016/j.ctim.2025.103139","url":null,"abstract":"<div><h3>Aim</h3><div>To evaluate the effect of Snoezelen intervention on problem behaviors in children with cerebral palsy (CP) and to analyze its correlation with motor function, as measured by the Gross Motor Function Classification System (GMFCS).</div></div><div><h3>Method</h3><div>This study is registered under the Clinical Research Information Service (CRIS) with the registration number KCT0002794. The unique protocol ID for this trial is SRH2018R-01. A randomized controlled trial with 28 children (aged 2–5 years) with CP was conducted. The experimental group received Snoezelen intervention three times a week for four weeks. Problem behaviors were assessed using the CBCL 1.5–5 and K-PSI, and motor function was assessed using the GMFCS.</div></div><div><h3>Results</h3><div>The experimental group showed a significant reduction in emotionally reactive behavior (p = 0.044). A strong negative correlation (Spearman's ρ = −0.744, p = 0.002) was found between GMFCS scores and changes in emotionally reactive behavior.</div></div><div><h3>Interpretation</h3><div>The Snoezelen intervention may reduce emotional reactivity and enhance emotional stability in children with CP, although its effectiveness may vary depending on the level of motor impairment. Further research is needed to confirm these findings.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"89 ","pages":"Article 103139"},"PeriodicalIF":3.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143122344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of acupuncture-related intervention on chemotherapy-induced peripheral neuropathy and quality of life: An umbrella review","authors":"Mei-Ling Yeh ,&nbsp;Chin-Che Hsu ,&nbsp;Matthew Lin ,&nbsp;Chuan-Ju Lin ,&nbsp;Jaung-Geng Lin","doi":"10.1016/j.ctim.2025.103131","DOIUrl":"10.1016/j.ctim.2025.103131","url":null,"abstract":"<div><h3>Background</h3><div>Numerous studies have explored the role of acupuncture-related treatments in alleviating chemotherapy-induced peripheral neuropathy (CIPN) and improving the quality of life for patients with cancer, resulting in mixed findings. This umbrella review aimed to synthesize existing systematic reviews (SRs) to deliver an updated assessment of the certainty of evidence concerning the effects of acupuncture-related treatments on CIPN and quality of life among a diverse group of patients with cancer.</div></div><div><h3>Methods</h3><div>This umbrella review considered eligible SRs published on one of nine electronic databases between inception and August 2024. It included adult patients with cancer of any stage who were undergoing chemotherapy. Interventions encompassed acupuncture, either alone or with electrical stimulation or moxibustion, and transcutaneous electrical acupoint/nerve stimulation (TEAS). The outcomes analyzed were changes in CIPN, nerve conduction velocity (NCV), and quality of life.</div></div><div><h3>Results</h3><div>The outcomes were evaluated using data obtained from 14 SRs that demonstrated moderate to high methodological and reporting quality. The findings showed that acupuncture (either alone or combined with electrical stimulation) and TEAS effectively alleviated CIPN symptoms, reduced CIPN pain, improved NCV, and enhanced quality of life.</div></div><div><h3>Conclusion</h3><div>The findings of this umbrella review indicate that these benefits were usually noticeable by the second week of treatment, persisted until the sixth week, and then gradually declined. Sensory nerve recovery occurred more rapidly than motor nerve recovery, often within 1.5 weeks. Although acupuncture combined with moxibustion or acupressure also enhanced patient outcomes, there was insufficient information available for further study analysis.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"89 ","pages":"Article 103131"},"PeriodicalIF":3.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143122343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcutaneous electrical acupoint stimulation for hypertension complicated by anxiety or sleep disorders: a pilot randomized controlled trial.","authors":"Xue-Ying Bao, Cun-Zhi Liu, Zi-Tong Qian, Lu Wang, Jian-Feng Tu, Bin-Yan Li, Xiao Wang, Fang Wan, Zhi-Han Li, Zhao-Yi Liu, Liang-Xiao Ma, Li-Qiong Wang","doi":"10.1016/j.ctim.2025.103138","DOIUrl":"https://doi.org/10.1016/j.ctim.2025.103138","url":null,"abstract":"<p><strong>Background: </strong>Hypertension is often accompanied by anxiety and sleep disorders, which further complicate the disease. This study aimed to evaluate the feasibility and effectiveness of transcutaneous electrical acupoint stimulation (TEAS) in patients with hypertension and anxiety or sleep disorders.</p><p><strong>Methods: </strong>Eligible participants were randomly assigned to the 10Hz TEAS, 2Hz TEAS, or routine treatment groups in a 1:1:1 ratio. Participants continued their routine treatment during the trial, while those in the two TEAS groups received 12 sessions of 30-min TEAS treatment with different stimulation frequencies. The feasibility parameters were successful screening probability, enrollment rate, and dropout rate. The primary outcome was the change in office systolic blood pressure from baseline to week four. Secondary outcomes included changes in office diastolic blood pressure, heart rate, Pittsburgh Sleep Quality Index score, and Generalized Anxiety Disorder 7-item scale score from baseline to week four.</p><p><strong>Results: </strong>Eighty-eight participants (age 58.0 [51.0, 63.0] years; 49 women) were randomized. The successful screening probability was 56.1%, the enrollment rate was 3.1 participants per week, and the dropout rate was 14.8%. The change in office systolic blood pressure from baseline to week four was -2.8 ± 13.6mm Hg, -6.4 ± 10.0mm Hg, and -7.2 ± 11.2mm Hg, respectively, in the 10Hz TEAS, 2Hz TEAS, and routine treatment groups (P=0.332). No significant differences were noted, except for a change in the Pittsburgh Sleep Quality Index score (P=0.014). Both 10Hz (P=0.024) and 2Hz TEAS (P=0.039) significantly improved sleep quality compared to routine treatment.</p><p><strong>Conclusions: </strong>In patients with hypertension having anxiety or sleep disorders, this study did not demonstrate the superiority of TEAS over routine treatment but did show an improvement in sleep quality and a downward trend in diastolic blood pressure. Therefore, a largescale trial is warranted.</p>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":" ","pages":"103138"},"PeriodicalIF":3.3,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Language function improvement and cortical activity alteration using scalp acupuncture coupled with speech-language training in post-stroke aphasia: A randomised controlled study","authors":"Bingbing Lin ,&nbsp;Jinglei Ni ,&nbsp;Xiao Xiong ,&nbsp;Lanlan Zhang ,&nbsp;Jian Song ,&nbsp;Mengxue Wang ,&nbsp;Linsong Chai ,&nbsp;Yunshi Huang ,&nbsp;Jia Huang","doi":"10.1016/j.ctim.2025.103137","DOIUrl":"10.1016/j.ctim.2025.103137","url":null,"abstract":"<div><h3>Background</h3><div>Scalp acupuncture is commonly used as a complementary treatment to improve language function in patients with post-stroke aphasia. Our objectives were to evaluate the impact of scalp acupuncture on the cerebral cortex of post-stroke aphasia patients.</div></div><div><h3>Methods</h3><div>This assessor-blinded, parallel-arm design, single-center, randomized clinical trial recruited 64 patients with post-stroke aphasia. They were randomly assigned to either the acupuncture group (n = 32) or the control group (n = 32). The primary outcome measure was the Western Aphasia Battery (WAB) score, while the secondary outcome was the oxygenated haemoglobin (OxyHb) index, which represents cortical activity as measured by functional near-infrared spectroscopy (fNIRS). All assessments were performed at baseline and post-intervention.</div></div><div><h3>Results</h3><div>The acupuncture group showed significant improvements in WAB subscales (Spontaneous Speech, Comprehension, Repetition, Naming, and AQ) with all changes statistically significant (<em>P</em> &lt; 0.001). The acupuncture group also showed higher OxyHb indices in the left frontopolar area, left fusiform gyrus, and left pars opercularis (<em>P</em> &lt; 0.05). Additionally, OxyHb D-values were significantly greater in the left frontopolar area and right superior temporal gyrus (<em>P</em> &lt; 0.05) compared to the control group. Among non-global aphasia patients, acupuncture improved comprehension and naming tasks, with lower OxyHb in the right visual association cortex and angular gyrus (<em>P</em> &lt; 0.05). In global aphasia patients, improvements were seen in the AQ and Repetition scores, with higher OxyHb in the right inferior prefrontal gyrus (<em>P</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Adjuvant scalp acupuncture enhances the effectiveness of speech-language therapy in treating repetition and naming impairments in patients with post-stroke aphasia. Additionally, it may modulate cortical activation in the left frontopolar area, left fusiform gyrus, left pars opercularis, and right superior temporal gyrus, and induces different cortical alteration patterns in global and non-global aphasia.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"89 ","pages":"Article 103137"},"PeriodicalIF":3.3,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the feasibility of a spiritual healing intervention for adults with moderate depression: A pilot randomized controlled trial","authors":"Trine Stub ,&nbsp;Anne Helen Hansen ,&nbsp;Audun Campell Irgens ,&nbsp;Olav Knudsen-Baas ,&nbsp;Agnete E. Kristoffersen","doi":"10.1016/j.ctim.2025.103133","DOIUrl":"10.1016/j.ctim.2025.103133","url":null,"abstract":"<div><h3>Background</h3><div>Many individuals with depression explore complementary and alternative medicine, including spiritual healing. This pilot randomized controlled trial (RCT) aimed to assess the feasibility of a study that integrated spiritual healing with standard care versus standard care alone for adults with moderate depression.</div></div><div><h3>Method</h3><div>In this pilot RCT with two parallel groups, 28 adult patients with depression were randomized to receive either spiritual healing alongside usual care (n = 14) or usual care alone (n = 14). The healing session was highly individualized. The healer positioned her hands over various areas of the client's body (head, chest, knee, hip, and feet) intending to adjust the energy flow within the client. Outcomes were measured by changes in the Beck Depression Inventory for Primary Care (BDI) scores pre-and post-intervention. Participants' experiences with spiritual healing were explored through a process evaluation. .</div></div><div><h3>Results</h3><div>The BDI scores captured significant changes in depression severity, with the intervention group showing the greatest mean difference from baseline (BDI 23.0) to week 16 (BDI 14.9), compared to the control group which worsened from baseline (BDI 24.2) to week 16 (BDI 26.7). In addition, participants expressed satisfaction with the study components and procedures, and all completed the questionnaires at designated times. Recruiting from clinical practice proved suboptimal due to conflicts with primary care physicians' schedules leading to fewer participants in the study than planned. Measures to minimize loss to follow-up were effective.</div></div><div><h3>Conclusion</h3><div>Spiritual healing may be a beneficial option for individuals who suffer from moderate depression. The participants in this study were satisfied with the spiritual healing treatment, and adherence rates were high. Future RCTs should consider recruiting participants through different avenues to enhance research feasibility to alleviate the burden on family care physicians' offices.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"89 ","pages":"Article 103133"},"PeriodicalIF":3.3,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring manual therapy in the management of irritable bowel syndrome in adults: A scoping review","authors":"Natalia Płóciennik-Korycka ,&nbsp;Sara Maria Pani ,&nbsp;Bogumiła Bruc ,&nbsp;Paolo Contu ,&nbsp;Magdalena Wrzesińska","doi":"10.1016/j.ctim.2025.103136","DOIUrl":"10.1016/j.ctim.2025.103136","url":null,"abstract":"<div><h3>Introduction</h3><div>IBS is a prevalent gut-brain interaction disorder characterized by abdominal pain and altered bowel habits, significantly affecting quality of life (QoL). IBS contributes to substantial work absenteeism and economic burdens and often coexists with other somatic and psychiatric conditions, with psychological well-being being a critical determinant of QoL. IBS sufferers often turn to MT due to dissatisfaction with conventional treatments. However, no comprehensive review has assessed the evidence for MT in treating IBS.</div></div><div><h3>Objective</h3><div>The objective of this review is to identify and map the available evidence on the effects of various manual therapy (MT) techniques on the biopsychosocial functioning, well-being, and QoL of individuals with irritable bowel syndrome (IBS).</div></div><div><h3>Methods</h3><div>A comprehensive search was conducted in PubMed, Embase, and Scopus. Studies involving adults with IBS and investigating the effects of MT on biological, psychological, and social outcomes, well-being, or QoL were included. A scoping review was conducted following PRISMA-ScR guidelines. Study quality was assessed using The National Heart, Lung and Blood Institute (NHLBI) Study Quality Assessment Tools. The protocol for this review was registered with the Open Science Framework and is available at <span><span>https://doi.org/10.17605/OSF.IO/QN4WU</span><svg><path></path></svg></span>.</div></div><div><h3>Results</h3><div>Of 730 records identified, 30 studies met the inclusion criteria (9 trials, 21 reviews). The interventions reviewed included osteopathic manipulative treatment (OMT), acupuncture, acupressure, reflexology, traditional Chinese spinal orthopaedic manipulation, and Tuina. The most frequently assessed outcomes were biological and psychological variables, as well as QoL, with well-being being the least commonly examined.</div></div><div><h3>Conclusions</h3><div>Although the results suggest potential benefits of MT in IBS treatment, they should be interpreted with caution due to the lack of robust trials, inconsistent findings, and occasional adverse events. High-quality randomized controlled trials and standardized outcome measures are necessary to validate these therapies and improve IBS management.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"89 ","pages":"Article 103136"},"PeriodicalIF":3.3,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic effects of probiotics on symptoms of irritability/emotional lability associated with neurodevelopmental conditions: A systematic review and meta-analysis of placebo-controlled trials","authors":"Ping-Wen Huang ,&nbsp;Chen Chia-Min ,&nbsp;Cheuk-Kwan Sun ,&nbsp;Yu-Shian Cheng ,&nbsp;Yen-Hsiang Tang ,&nbsp;Cheng Liu ,&nbsp;Kuo-Chuan Hung","doi":"10.1016/j.ctim.2025.103132","DOIUrl":"10.1016/j.ctim.2025.103132","url":null,"abstract":"<div><h3>Objectives</h3><div>The current study aimed at investigating the efficacies of probiotics in alleviating the symptoms of irritability/emotional lability in individuals with a neurodevelopmental condition.</div></div><div><h3>Methods</h3><div>Randomized placebo-controlled trials were identified through searching major electronic databases from inception to December, 2023. The outcome of interests included improvements in the symptoms of irritability/emotional lability. Outcomes were quantitatively expressed as effect size (ES) based on standardized mean difference (SMD) with 95 % confidence interval (CI).</div></div><div><h3>Results</h3><div>Seven studies with 1479 participants were included in this meta-analysis. The primary results revealed a significant improvement in the symptoms of irritability/emotional lability in individuals with neurodevelopmental conditions receiving probiotics compared with the placebos (SMD= −0.17, <em>p</em> = 0.03). Subgroup analyses demonstrated an association between a significant improvement in the symptoms of irritability/emotional lability and the use probiotics relative to placebos only in studies using multiple-strain probiotics (SMD=-0.19, <em>p</em> = 0.04, three studies with 452 participant) but not in those adopting single-strain regimens.</div></div><div><h3>Conclusions</h3><div>Our study supported the use of probiotics for alleviating the symptoms of irritability/emotional lability in individuals with neurodevelopmental conditions, mainly in those receiving multiple-strain probiotics as supplements. Nevertheless, the limited number of studies targeting irritability as their primary outcomes, and most did not investigate other confounding factors such as dietary habits or consumption of other nutritional supplements may impair the robustness of evidence. Our results, which were derived from a limited number of available trials, warrant further large-scale clinical investigations for verification.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"89 ","pages":"Article 103132"},"PeriodicalIF":3.3,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of Hibiscus sabdariffa in cardiometabolic health: An overview of reviews and updated dose-response meta-analysis","authors":"Mostafa Norouzzadeh ,&nbsp;Minoo Hasan Rashedi ,&nbsp;Mohammad Hesam Azizi ,&nbsp;Farshad Teymoori ,&nbsp;Zohreh Maghsoomi ,&nbsp;Farzad Shidfar","doi":"10.1016/j.ctim.2025.103135","DOIUrl":"10.1016/j.ctim.2025.103135","url":null,"abstract":"<div><h3>Background</h3><div>Conventional treatments for cardiometabolic diseases face limitations related to cost, efficacy, and side effects. <em>Hibiscus sabdariffa</em> (HS) is a common food product and a potential alternative. However, previous studies have shown inconsistent results and lacked assessments of result certainty, intervention safety, and subgroup analysis credibility. This study evaluated the efficacy and safety of HS on blood pressure (BP), lipid profiles, glycemic control, anthropometric parameters, inflammatory markers, oxidative stress indicators, and liver enzymes.</div></div><div><h3>Methods</h3><div>To conduct this umbrella review, a systematic search of eligible meta-analyses was performed up to May 2024. The random-effects model was used to synthesize results from individual trials. Quality, certainty, and credibility of evidence were evaluated using the Cochrane Risk of Bias tool, AMSTAR-II, GRADE, and ICEMAN frameworks.</div></div><div><h3>Results</h3><div>Data from 26 randomized controlled trials involving 1797 participants revealed that HS dose-dependently reduced systolic and diastolic BP compared to placebo and other teas. Although no significant differences were found between HS and antihypertensive drugs, HS showed moderate credibility for therapeutic BP reduction (&gt; 10 mmHg), especially in individuals over 50 years, in trials lasting over four weeks, and in those with a low risk of bias. HS also reduced total cholesterol, LDL-C, fasting blood glucose, and increased HDL-C. A minor, clinically insignificant increase in aspartate aminotransferase was observed without elevating adverse event risks.</div></div><div><h3>Conclusions</h3><div>HS showed BP-lowering effects comparable to antihypertensive drugs and beneficial impacts on lipid and glycemic profiles. Although HS is generally considered safe, long-term and therapeutic dosing safety requires careful monitoring.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"89 ","pages":"Article 103135"},"PeriodicalIF":3.3,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traditional Chinese exercises for the treatment of neuropsychiatric symptoms in Parkinson’s disease: A systematic review and meta-analysis","authors":"Weiqiang Tan ,&nbsp;Zhaoquan Pan ,&nbsp;Jiawei He ,&nbsp;Tiexiong Wu ,&nbsp;Feng Wu ,&nbsp;Yachen Xu ,&nbsp;Lisha Liu ,&nbsp;Ziyu Yang ,&nbsp;Chunrui Li ,&nbsp;Yuechen Hu ,&nbsp;Muxi Liao","doi":"10.1016/j.ctim.2025.103134","DOIUrl":"10.1016/j.ctim.2025.103134","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;To systematically evaluate the efficacy of traditional Chinese exercises (TCEs) for neuropsychiatric symptoms (NPSs) in patients with Parkinson’s disease.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;A comprehensive literature search was performed across eight databases, including PubMed, Cochrane Library, Embase, Web of Science (WoS), SinoMed, China National Knowledge Infrastructure (CNKI), China Science and Technology Periodical Database (VIP), and Wanfang Database, covering studies published from their inception up to April 23, 2024. The search focused on identifying randomized controlled trials (RCTs) assessing the effectiveness of TCEs for NPSs in PD patients.&lt;/div&gt;&lt;div&gt;The authors independently performed literature screening and data extraction. Meta-analysis was executed employing Review Manager V.5.3 software, and Stata 17.0 was used to detect publication bias and perform sensitivity analysis. GRADEpro GDT was used to grade the certainty of each outcome evidence.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Eighteen studies involving 937 participants were included. The meta-analysis showed significant improvements in depression-related scales (standardized mean difference (SMD) = –1.30, 95 % confidence interval (CI): –2.10 to –0.49, &lt;em&gt;p&lt;/em&gt; = 0.002), anxiety-related scales (SMD = –1.11, 95 %CI: –2.14 to –0.08, &lt;em&gt;p&lt;/em&gt; = 0.03), sleep disorder-related scales (SMD = –0.71, 95 %CI: –0.99 to –0.43, &lt;em&gt;p&lt;/em&gt; &lt; 0.00001), and cognition-related scales (SMD = 0.91, 95 %CI: 0.44–1.38, &lt;em&gt;p&lt;/em&gt; = 0.0001). Quality of life also improved (SMD = –1.35, 95 % CI: –2.38 to –0.31, &lt;em&gt;p&lt;/em&gt; = 0.01; SMD = 0.99, 95 % CI: 0.54–1.43, &lt;em&gt;p&lt;/em&gt; &lt; 0.0001). Subgroup analyses grounded in the duration of the intervention suggested that interventions lasting up to 12 weeks showed more significant anti-depression and anti-anxiety effects while those lasting beyond 12 weeks demonstrated greater improvements in sleep quality and cognitive function. Additionally, subgroup analyses based on the type of intervention revealed that both using TCEs alone and the combination of TCEs with conventional medications showed greater effects on anti-depression and cognitive function, while the latter yield more significant anti-anxiety effects. However, no statistical significance was found for fatigue-related scales. The clinical trials included in this review also lacked a thorough description of the randomization process, and only a small proportion reported adequate allocation concealment procedures, raising concerns about potential selection bias. Moreover, owing to the inherent characteristics of TCEs, blinding both participants and practitioners is challenging, which may result in performance bias. Additionally, the absence of blinding could allow assessors’ subjective influences to affect the outcomes, leading to detection bias. The overall quality of the evidence, as assessed according to the GRADE criteria, was rated as very low or low for most ","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"89 ","pages":"Article 103134"},"PeriodicalIF":3.3,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}