Comparison of the effects of Echium amoenum and Melissa officinalis on hypertension in stage 1 hypertensive patients: A randomized, triple-blind, three-arm clinical trial

IF 4 3区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Complementary therapies in medicine Pub Date : 2025-12-01 Epub Date: 2025-10-14 DOI:10.1016/j.ctim.2025.103266

Melika Jafari Dehnayebi , Pouya Zeidy , Soheila Shamsikhani , Mehdi Salehi , Mehdi Safarabadi

{"title":"Comparison of the effects of Echium amoenum and Melissa officinalis on hypertension in stage 1 hypertensive patients: A randomized, triple-blind, three-arm clinical trial","authors":"Melika Jafari Dehnayebi , Pouya Zeidy , Soheila Shamsikhani , Mehdi Salehi , Mehdi Safarabadi","doi":"10.1016/j.ctim.2025.103266","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Hypertension is one of the most prevalent chronic diseases worldwide, and stage 1 hypertension provides a critical window for implementing non-pharmacological interventions. Herbal remedies such as Melissa officinalis and Echium amoenum have shown promising effects on cardiovascular health.</div></div><div><h3>Methods</h3><div>In this randomized, triple-blind clinical trial, 105 patients with stage 1 hypertension were randomly assigned to three groups: Melissa officinalis (n = 35), Echium amoenum (n = 35), and control (n = 35). Participants received 10 mL of the assigned extract or placebo daily for four weeks. Systolic and diastolic blood pressure were measured weekly. Data were analyzed using SPSS version 26. The Shapiro-Wilk test indicated that the distribution of blood pressure values was not normal (p < 0.05); therefore, non-parametric tests were used</div></div><div><h3>Results</h3><div>Significant within-group reductions in both SBP and DBP were observed in the Melissa officinalis and Echium amoenum groups (p < 0.001). The Melissa officinalis group had the greatest decrease in SBP (8 mmHg) and DBP (4 mmHg). Between-group comparisons showed significant differences favoring Melissa officinalis over both other groups at weeks 2, 3, and 4 (p < 0.001).</div></div><div><h3>Conclusion</h3><div>Both Melissa officinalis and Echium amoenum effectively reduced blood pressure in patients with stage 1 hypertension, with Melissa officinalis demonstrating superior efficacy. These findings support the use of Melissa officinalis as a complementary treatment for hypertension management.</div></div>","PeriodicalId":10545,"journal":{"name":"Complementary therapies in medicine","volume":"95 ","pages":"Article 103266"},"PeriodicalIF":4.0000,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Complementary therapies in medicine","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0965229925001426","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/10/14 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"INTEGRATIVE & COMPLEMENTARY MEDICINE","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Hypertension is one of the most prevalent chronic diseases worldwide, and stage 1 hypertension provides a critical window for implementing non-pharmacological interventions. Herbal remedies such as Melissa officinalis and Echium amoenum have shown promising effects on cardiovascular health.

Methods

In this randomized, triple-blind clinical trial, 105 patients with stage 1 hypertension were randomly assigned to three groups: Melissa officinalis (n = 35), Echium amoenum (n = 35), and control (n = 35). Participants received 10 mL of the assigned extract or placebo daily for four weeks. Systolic and diastolic blood pressure were measured weekly. Data were analyzed using SPSS version 26. The Shapiro-Wilk test indicated that the distribution of blood pressure values was not normal (p < 0.05); therefore, non-parametric tests were used

Results

Significant within-group reductions in both SBP and DBP were observed in the Melissa officinalis and Echium amoenum groups (p < 0.001). The Melissa officinalis group had the greatest decrease in SBP (8 mmHg) and DBP (4 mmHg). Between-group comparisons showed significant differences favoring Melissa officinalis over both other groups at weeks 2, 3, and 4 (p < 0.001).

Conclusion

Both Melissa officinalis and Echium amoenum effectively reduced blood pressure in patients with stage 1 hypertension, with Melissa officinalis demonstrating superior efficacy. These findings support the use of Melissa officinalis as a complementary treatment for hypertension management.

查看原文本刊更多论文

标题：比较阿莫兰和梅利莎对1期高血压患者高血压的影响：一项随机、三盲、三组临床试验。

背景：高血压是世界范围内最普遍的慢性疾病之一，1期高血压为实施非药物干预提供了一个关键窗口。草药，如梅利莎officinalis和Echium amoenum已经显示出对心血管健康有希望的效果。方法：随机三盲临床试验，105例1期高血压患者随机分为三组：梅利莎（n = 35）、阿莫兰（n = 35）和对照组（n = 35）。参与者每天服用10mL指定提取物或安慰剂，持续四周。每周测量收缩压和舒张压。数据分析采用SPSS version 26。Shapiro-Wilk检验显示血压值分布不正常（p < 0.05）；结果：Melissa officinalis组和ececumumum组的收缩压和舒张压均显著降低（p < 0.001）。梅莉莎组收缩压（8mmHg）和舒张压（4mmHg）下降幅度最大。组间比较显示，在第2、3和4周时，Melissa officinalis优于其他两组（p < 0.001）。结论：复方艾草和阿莫艾草均能有效降低1期高血压患者的血压，且复方艾草疗效更优。这些发现支持将梅利莎作为高血压管理的补充治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Complementary therapies in medicine 医学-全科医学与补充医学

CiteScore

8.60

自引率

2.80%

发文量

101

审稿时长

112 days

期刊介绍： Complementary Therapies in Medicine is an international, peer-reviewed journal that has considerable appeal to anyone who seeks objective and critical information on complementary therapies or who wishes to deepen their understanding of these approaches. It will be of particular interest to healthcare practitioners including family practitioners, complementary therapists, nurses, and physiotherapists; to academics including social scientists and CAM researchers; to healthcare managers; and to patients. Complementary Therapies in Medicine aims to publish valid, relevant and rigorous research and serious discussion articles with the main purpose of improving healthcare.